2.2 SQUARE_CLOSEUP_NORTH OVAL inactive active inactive inactive active inactive inactive inactive active active inactive inactive inactive inactive active active active active active inactive active inactive active inactive inactive inactive active inactive active active inactive inactive inactive inactive active inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive ER cytoplasm Long Name: Furin Synonym: PACE,SPC1 Accession: P00575 inside PROTEIN p6 Long Name: Endothelin 1, 2, 3, and 4 Synonym: EDN1,EDN2,EDN3,EDN4,VIC,Vasoactive instestinal contractor peptide Accession: P00588 inside PROTEIN p8 Long Name: signal peptidase Synonym: Synonym not specified Accession: P00573 inside PROTEIN p9 Long Name: Endothelin-coverting enzyme 1, 2, and 3 Synonym: Synonym not specified Accession: P00585 inside PROTEIN p10 Long Name: guanine nucleotide binding protein q polypeptide Synonym: G-protein q Accession: P00586 inside PROTEIN p11 Long Name: Long Name: calcium ion Synonym: Synonym not specified Accession: U05188 inside ION Ca_super_2_plus Long Name: diacylglycerol Synonym: Synonym not specified Accession: S01656 inside SIMPLE_MOLECULE DAG Long Name: protein kinase c Synonym: Synonym not specified Accession: P00568 inside PROTEIN p19 Long Name: phosphatidylinositol 3-kinase Synonym: 5-bisphosphate 3-kinase,Phosphatidylinositol-4 Accession: P00577 inside PROTEIN p21 Long Name: endothelial cell nitric oxide synthase Synonym: nitric oxide synthase 3 Accession: P00578 inside PROTEIN p25 Long Name: endothelial cell nitric oxide synthase Synonym: nitric oxide synthase 3 Accession: P00578 inside PROTEIN p25 Long Name: adenosine-3'-5'-cyclic monophosphate Synonym: Synonym not specified Accession: S01662 inside SIMPLE_MOLECULE cAMP Long Name: extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,mitogen-activated protein kinase,p42/44,pp42/44 Accession: P00566 inside PROTEIN p22 Long Name: adenosine-3'-5'-cyclic monophosphate -dependent kinase Synonym: protein kinase A Accession: P00570 inside PROTEIN p26 Long Name: L-arginine Synonym: Synonym not specified Accession: S01654 inside SIMPLE_MOLECULE L-Arg Long Name: L-citrulline Synonym: Synonym not specified Accession: U02235 inside ION L-Cit Long Name: Nitric oxide Synonym: Synonym not specified Accession: U02231 inside ION NO Long Name: guanylate cyclase Synonym: D2Mgh17,GTP pyrophosphate - lyase,guanylyl cyclase Accession: P00581 inside PROTEIN p27 Long Name: guanosine-3'-5'-cyclic monophosphate Synonym: Synonym not specified Accession: S01655 inside SIMPLE_MOLECULE cGMP Long Name: protein kinase, cGMP-dependent Synonym: SERINE/THREONINE-PROTEIN KINASE PKNG,STPK G,guanosine-3'-5'-cyclic monophosphate-dependent kinase,protein kinase G Accession: P00567 inside PROTEIN p28 Long Name: Cytosolic phospholipase A2 Synonym: Lysophospholipase,Phosphatidylcholine 2-acylhydrolase Accession: P00583 inside PROTEIN p29 Long Name: arachidonic acid Synonym: Synonym not specified Accession: S01657 inside SIMPLE_MOLECULE AA Long Name: glycophospholipid Synonym: Synonym not specified Accession: U02237 transmembrane ION GPL Long Name: lysophospholipid Synonym: Synonym not specified Accession: U02234 inside ION LPL Long Name: inositol 1,4,5-triphosphate Synonym: Synonym not specified Accession: S01661 inside SIMPLE_MOLECULE IP_sub_3 Long Name: Pre-pro endothelin 1, 2, 3, and 4 Synonym: Synonym not specified Accession: P00576 inside PROTEIN p13 Long Name: Pro endothelin 1, 2, 3, and 4 Synonym: Synonym not specified Accession: P00571 inside PROTEIN p14 Long Name: Big endothelin 1, 2, 3, and 4 Synonym: Synonym not specified Accession: P00574 inside PROTEIN p15 Long Name: stimulatory G protein Synonym: guanine nucleotide binding protein s polypeptide Accession: P00584 inside PROTEIN p20 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05185 Heterodimer Member Info: ET-RA/B#PROTEIN#endothelin receptor A, B#P00580##;Gs#PROTEIN#stimulatory G protein#P00584#guanine nucleotide binding protein s polypeptide# transmembrane PROTEIN p1 PROTEIN p20 Long Name: Long Name: endothelin receptor A, B Synonym: Synonym not specified Accession: U05186 Heterodimer Member Info: ET-RA/B#PROTEIN#endothelin receptor A, B#P00580##;ET1-4#PROTEIN#Endothelin 1, 2, 3, and 4#P00588#EDN1|EDN2|EDN3|EDN4|VIC|Vasoactive instestinal contractor peptide# transmembrane PROTEIN p1 PROTEIN p8 Long Name: GTP Synonym: Synonym not specified Accession: S01659 inside SIMPLE_MOLECULE GTP Long Name: ATP Synonym: Synonym not specified Accession: S01658 inside SIMPLE_MOLECULE ATP Long Name: smooth muscle cell contraction Synonym: Synonym not specified Accession: U02238 inside PHENOTYPE smooth muscle cell_br_contraction Long Name: Long Name: vaso- relaxation Synonym: Synonym not specified Accession: U05187 inside PHENOTYPE vaso_minus__br_relaxation Long Name: phosphatidyl-inositol 4,5 bisphosphate Synonym: Synonym not specified Accession: S01663 innerSurface SIMPLE_MOLECULE PIP_sub_2 Long Name: inositol 1,4,5-triphosphate receptor Synonym: Synonym not specified Accession: P00590 transmembrane PROTEIN p31 Long Name: extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,mitogen-activated protein kinase,p42/44,pp42/44 Accession: P00566 inside PROTEIN p22 Long Name: serine/threonine Raf-1 protein kinase Synonym: MAP kinase kinase kinase,c-Raf Accession: P00587 inside PROTEIN p34 Long Name: serine/threonine Raf-1 protein kinase Synonym: MAP kinase kinase kinase,c-Raf Accession: P00587 inside PROTEIN p34 Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase,ERK activator kinase,MAP kinase kinase Accession: P00572 inside PROTEIN p33 Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase,ERK activator kinase,MAP kinase kinase Accession: P00572 inside PROTEIN p33 Long Name: mitogenesis Synonym: Synonym not specified Accession: U02232 inside PHENOTYPE mitogenesis Long Name: cyclooxygenase-2 Synonym: Synonym not specified Accession: P00582 inside PROTEIN p35 Long Name: prostaglandin I2 Synonym: Synonym not specified Accession: S01660 inside SIMPLE_MOLECULE PGI_sub_2 Long Name: PLCbeta Synonym: Synonym not specified Accession: P00591 inside PROTEIN p17 Long Name: 3',5'-cyclic AMP synthetase Synonym: AH-related protein,ATP pyrophosphate-lyase,adenylyl cyclase Accession: P00569 inside PROTEIN p24 Long Name: 3',5'-cyclic AMP synthetase Synonym: AH-related protein,ATP pyrophosphate-lyase,adenylyl cyclase Accession: P00569 innerSurface PROTEIN p24 Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00589 inside PROTEIN p23 Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00589 inside PROTEIN p23 Long Name: Long Name: calcium ion Synonym: Synonym not specified Accession: U05188 inside ION Ca_super_2_plus Long Name: ? Synonym: Synonym not specified Accession: P00592 inside PROTEIN p36 Long Name: NSCC Synonym: Synonym not specified Accession: P00579 transmembrane PROTEIN p16 Long Name: Cytosolic phospholipase A2 Synonym: Lysophospholipase,Phosphatidylcholine 2-acylhydrolase Accession: P00583 innerSurface PROTEIN p29 STATE_TRANSITION s32 s33 0.3333333333333335,-2.220446049250313E-15 0.6666666666666665,-3.552713678800501E-15 a35 a36 DISSOCIATION s36 s37,s38 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-2.6645352591003757E-15 0.3333333333333326,0.0 0.6666666666666652,0.0 0.3333333333333339,-4.440892098500626E-16 0.6666666666666679,8.881784197001252E-16 0.33333333333333304,0.33333333333333304 a39 a40 a41 DISSOCIATION s44 s43,s45 0.33333333333333304,1.7763568394002505E-15 0.6666666666666665,1.7763568394002505E-15 0.3333333333333357,3.552713678800501E-15 0.6666666666666661,0.0 0.33333333333333215,0.0 0.6666666666666643,-1.7763568394002505E-15 0.33333333333333215,0.3333333333333357 a47 a46 a48 STATE_TRANSITION s77 s31 0.33333333333333304,-4.440892098500626E-16 0.6666666666666666,-1.3322676295501878E-15 a59 a33 HETERODIMER_ASSOCIATION s8,s57 s58 0.3333333333333335,0.0 0.6666666666666667,0.0 0.3333333333333339,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 0.3333333333333339,4.440892098500626E-16 0.6656496682614144,0.04792508061881051 0.44739515238309036,0.5443743419110088 a8 a65 a66 a62 STATE_TRANSITION s28 s28 0.3333333333333339,1.3322676295501878E-15 0.666666666666667,2.220446049250313E-15 a67 a30 STATE_TRANSITION s39 s39 0.33333333333333304,0.0 0.6666666666666661,-2.220446049250313E-16 a69 a42 STATE_TRANSITION s59 s40 0.33333333333333215,-8.881784197001252E-16 0.6666666666666661,0.0 a71 a43 STATE_TRANSITION s41 s41 0.3333333333333335,-8.881784197001252E-16 0.6666666666666665,-1.7763568394002505E-15 a72 a44 STATE_TRANSITION s60 s34 0.3333333333333348,0.0 0.6666666666666679,0.0 a74 a37 STATE_TRANSITION s35 s35 0.33333333333333304,8.881784197001252E-16 0.666666666666667,0.0 a73 a38 TRANSCRIPTIONAL_ACTIVATION s41 s62 0.3333333333333335,8.881784197001252E-16 0.6666666666666667,8.881784197001252E-16 a44 a76 INHIBITION s38 s61 0.33333333333333304,0.0 0.6666666666666661,4.440892098500626E-16 a41 a75 DISSOCIATION s64 s24,s46 0.33333333333333304,0.0 0.6666666666666661,0.0 0.33333333333333304,-3.552713678800501E-15 0.6666666666666687,-3.552713678800501E-15 0.33333333333333215,-8.881784197001252E-16 0.6666666666666661,0.0 0.3333333333333339,0.33333333333333215 a78 a25 a26 STATE_TRANSITION s26 s26 0.33333333333333215,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 a79 a28 STATE_TRANSITION s66 s66 0.3333333333333339,0.0 0.666666666666667,-8.881784197001252E-16 a82 a81 STATE_TRANSITION s83 s42 0.33333333333333215,1.3322676295501878E-15 0.6666666666666643,2.220446049250313E-15 a83 a45 STATE_TRANSITION s68 s29 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,2.6645352591003757E-15 a84 a31 STATE_TRANSITION s71 s72 0.3333333333333339,3.552713678800501E-15 0.6666666666666661,5.329070518200751E-15 a88 a89 STATE_TRANSITION s70 s73 0.33333333333333304,-4.884981308350689E-15 0.6666666666666661,-1.0658141036401503E-14 a87 a90 UNKNOWN_TRANSITION s29 s74 0.33333333333333304,0.0 0.6666666666666661,0.0 a31 a91 STATE_TRANSITION s43 s76 0.3333333333333335,1.7763568394002505E-15 0.6666666666666665,1.7763568394002505E-15 a46 a93 UNKNOWN_TRANSITION s76 s62 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 a93 a94 UNKNOWN_TRANSITION s35 s61 0.33333333333333326,-3.9968028886505635E-15 0.6666666666666663,-7.105427357601002E-15 a38 a75 STATE_TRANSITION s78 s78 0.33333333333333326,8.881784197001252E-16 0.6666666666666665,0.0 a95 a17 STATE_TRANSITION s30 s79 0.3333333333333339,0.0 0.666666666666667,0.0 a68 a32 STATE_TRANSITION s11 s11 0.33333333333333304,0.0 0.666666666666667,-8.881784197001252E-16 a96 a11 STATE_TRANSITION s82 s82 0.33333333333333304,1.3322676295501878E-15 0.666666666666667,2.6645352591003757E-15 a97 a16 TRANSPORT s80 s21 0.3333333333333335,1.7763568394002505E-15 0.6666666666666661,0.0 a98 a24 TRANSPORT s21 s21 0.2747244761291927,-0.11096032056301475 0.6690828880524582,-0.2544260467776587 a99 a23 TRUNCATION s13 s81,s14 0.33333333333333326,0.0 0.6666666666666665,-4.440892098500626E-16 0.3333333333333326,0.0 0.6666666666666661,-8.881784197001252E-16 0.3333333333333335,0.0 0.6666666666666665,0.0 0.09090909090909127,0.4590111642743223 a13 a100 a14 TRUNCATION s14 s81,s15 0.33333333333333304,-1.1102230246251565E-16 0.666666666666667,-1.1102230246251565E-16 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666665,0.0 0.3333333333333339,-4.440892098500626E-16 0.6666666666666674,-4.440892098500626E-16 0.031230082855321584,0.46908859145952864 a14 a102 a15 TRUNCATION s15 s81,s8 0.33333333333333304,1.1102230246251565E-16 0.6666666666666661,1.1102230246251565E-16 0.3333333333333339,0.0 0.666666666666667,-1.7763568394002505E-15 0.3333333333333339,4.440892098500626E-16 0.666666666666667,0.0 0.1818181818181812,0.4090909090909085 a15 a101 a8