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<![CDATA[
General Transcription Factors for RNA Polymerase II. This pathway focus on the synthesis of messenger RNA in eukaryotic cells in the nucleus.
Medline=10364255
Medline=14963331
Medline=1876184
Medline=1956398
OMIM=189972
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<celldesigner:listOfGroups/>
<celldesigner:listOfProteins>
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<celldesigner:protein id="p12" name="TFIIF" type="GENERIC"/>
<celldesigner:protein id="p8" name="RNA Polymerase II" type="GENERIC">
<celldesigner:listOfModificationResidues>
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<celldesigner:modificationResidue angle="4.05" id="rs2"/>
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<celldesigner:modificationResidue angle="5.5" id="rs4"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p3" name="TBP-associated factors" type="GENERIC"/>
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<celldesigner:protein id="p18" name="TFIIF_beta_" type="GENERIC"/>
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<celldesigner:protein id="p20" name="TFIIE" type="GENERIC"/>
<celldesigner:protein id="p21" name="TFIIE_alpha_" type="GENERIC"/>
<celldesigner:protein id="p22" name="TFIIE_beta" type="GENERIC"/>
<celldesigner:protein id="p13" name="TFIIH complex" type="GENERIC"/>
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<celldesigner:protein id="p23" name="TTF2" type="GENERIC"/>
</celldesigner:listOfProteins>
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</annotation>
<listOfCompartments>
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</listOfCompartments>
<listOfSpecies>
<species compartment="default" initialAmount="0.0" name="s10">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TATA box Promoter
Synonym:  Synonym not specified
Accession:  G01524
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>TATA box Promoter</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s12">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TBP
Synonym:  GTF2D,GTF2D1,SCA17,TATA box binding protein,TFIID,spinocerebellar ataxia 17
Accession:  P00670
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s20">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TFIIF
Synonym:  TF2F,TRANSCRIPTION FACTOR IIF
Accession:  P00665
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s22">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S01668
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s23">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ADP
Synonym:  Synonym not specified
Accession:  S01672
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ADP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s16">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  RNA Polymerase II
Synonym:  Synonym not specified
Accession:  P00660
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s26">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  RNA Polymerase II
Synonym:  Synonym not specified
Accession:  P00660
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
<celldesigner:modification residue="rs3" state="phosphorylated"/>
<celldesigner:modification residue="rs4" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s28">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TATA box Promoter                                              gene
Synonym:  Synonym not specified
Accession:  G01521
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>TATA box Promoter                                              gene                                     </celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s29">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CTP
Synonym:  Synonym not specified
Accession:  S01670
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>CTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s30">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S01671
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s31">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  UTP
Synonym:  Synonym not specified
Accession:  S01669
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>UTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s11">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TBP-associated factors
Synonym:  TATA box binding protein-associated factors
Accession:  P00658
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s34">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  General Transcription factor IIF, polypeptide 1, 74-KD
Synonym:  BTF4,GTF2F1,RAP74,TFIIF ALPHA,TRANSCRIPTION FACTOR IIF
Accession:  P00663
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p16</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s36">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TFIIFbeta
Synonym:  BETA SUBUNIT,RAP30,TF2F2,TFIIF BETA,TRANSCRIPTION FACTOR IIF
Accession:  P00667
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p18</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s15">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TFIIB
Synonym:  GTF2B,RNA polymerase II transcription factor IIB,TF2B,Transcription factor II B,general transcription factor IIB
Accession:  P00668
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s38">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TFIIE
Synonym:  TF2E,TRANSCRIPTION FACTOR IIE
Accession:  P00666
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s41">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  TFIIEbeta
Synonym:  Synonym not specified
Accession:  U05214
Heterodimer Member Info:  TFIIEbeta#PROTEIN#TFIIEbeta#P00659#GENERAL TRANSCRIPTION FACTOR IIE|GTF2E2|POLYPEPTIDE 2|TF2E2|TFIIE  BETA SUBUNIT|TRANSCRIPTION FACTOR IIE  BETA SUBUNIT#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p22</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p22</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s43">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  TFIIEalpha
Synonym:  Synonym not specified
Accession:  U05210
Heterodimer Member Info:  TFIIEalpha#PROTEIN#TFIIEalpha#P00669#ALPHA SUBUNIT|GENERAL TRANSCRIPTION FACTOR IIE|GTF2E1|POLYPEPTIDE 1|TF2E1|TFIIE|TRANSCRIPTION FACTOR IIE ALPHA SUBUNIT#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p21</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p21</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s44">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05208
Heterodimer Member Info:  TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s46">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  elongating mRNA
Synonym:  Synonym not specified
Accession:  G01525
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:name>elongating mRNA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s47">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  RNA
Synonym:  Synonym not specified
Accession:  G01522
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:name>RNA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s49">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TATA box Promoter                                              gene                                    termination
Synonym:  Synonym not specified
Accession:  G01520
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>TATA box Promoter                                              gene                                    termination     </celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s51">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  mRNA
Synonym:  Synonym not specified
Accession:  G01523
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:name>mRNA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s21">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TFIIH
Synonym:  GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1,GTF2H 62-KD SUBUNIT,GTF2H1,TFIIH 62-KD SUBUNIT,TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT
Accession:  P00664
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s37">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TFIIA
Synonym:  ALF,GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT,GTF2A1-like factor,MGC26254,TFIIA large subunit isoform ALF,TFIIA-alpha/beta-like factor,Transcription factor II A
Accession:  P00662
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s55">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05211
Heterodimer Member Info:  TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TFIIA complex#PROTEIN#TFIIA#P00662#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor|Transcription factor II A#;TATA box Promoter#GENE#TATA box Promoter#G01524##;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>TATA box Promoter</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s59">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05209
Heterodimer Member Info:  TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TFIIA complex#PROTEIN#TFIIA#P00662#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor|Transcription factor II A#;TFIIB#PROTEIN#TFIIB#P00668#GTF2B|RNA polymerase II transcription factor IIB|TF2B|Transcription factor II B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01524##;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>TATA box Promoter</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner4" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s60">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05215
Heterodimer Member Info:  RNA Polymerase II#PROTEIN#RNA Polymerase II#P00660##;TFIIF#PROTEIN#TFIIF#P00665#TF2F|TRANSCRIPTION FACTOR IIF#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s77">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05213
Heterodimer Member Info:  TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;RNA Polymerase II#PROTEIN#RNA Polymerase II#P00660##;TFIIA complex#PROTEIN#TFIIA#P00662#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor|Transcription factor II A#;TFIIH complex#PROTEIN#TFIIH#P00664#GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1|GTF2H 62-KD SUBUNIT|GTF2H1|TFIIH 62-KD SUBUNIT|TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT#;TFIIF#PROTEIN#TFIIF#P00665#TF2F|TRANSCRIPTION FACTOR IIF#;TFIIE#PROTEIN#TFIIE#P00666#TF2E|TRANSCRIPTION FACTOR IIE#;TFIIB#PROTEIN#TFIIB#P00668#GTF2B|RNA polymerase II transcription factor IIB|TF2B|Transcription factor II B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01524##;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>TATA box Promoter</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner4" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner5" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner6" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner7" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner8" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p20</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s91">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05212
Heterodimer Member Info:  TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;RNA Polymerase II#PROTEIN#RNA Polymerase II#P00660##;TFIIA complex#PROTEIN#TFIIA#P00662#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor|Transcription factor II A#;TFIIH complex#PROTEIN#TFIIH#P00664#GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1|GTF2H 62-KD SUBUNIT|GTF2H1|TFIIH 62-KD SUBUNIT|TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT#;TFIIF#PROTEIN#TFIIF#P00665#TF2F|TRANSCRIPTION FACTOR IIF#;TFIIB#PROTEIN#TFIIB#P00668#GTF2B|RNA polymerase II transcription factor IIB|TF2B|Transcription factor II B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01524##;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>TATA box Promoter</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
<celldesigner:modification residue="rs3" state="phosphorylated"/>
<celldesigner:modification residue="rs4" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner4" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner5" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner6" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner7" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s100">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05216
Heterodimer Member Info:  TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s101">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II
Synonym:  HuF2,TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II,human factor 2 lodestar protein
Accession:  P00661
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p23</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction name="r32" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s34,s36</celldesigner:baseReactants>
<celldesigner:baseProducts>s20</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,0.0 0.6666666666666634,0.0 0.33333333333333215,0.0 0.6666666666666643,1.7763568394002505E-15 0.33333333333333215,1.7763568394002505E-15 0.6666666666666652,0.0 0.33333333333333215,0.3333333333333339</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s34">
<annotation>
<celldesigner:alias>a84</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s36">
<annotation>
<celldesigner:alias>a86</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s20">
<annotation>
<celldesigner:alias>a42</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r36" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s11,s12</celldesigner:baseReactants>
<celldesigner:baseProducts>s44</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333348,-4.440892098500626E-16 0.666666666666667,-4.440892098500626E-16 0.3333333333333304,-4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 0.3333333333333335,-7.771561172376096E-16 0.6666666666666665,-1.7208456881689926E-15 0.33333333333333304,0.33333333333333304</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s11">
<annotation>
<celldesigner:alias>a18</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s12">
<annotation>
<celldesigner:alias>a19</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s44">
<annotation>
<celldesigner:alias>a106</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r41" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s43,s41</celldesigner:baseReactants>
<celldesigner:baseProducts>s38</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333304,0.0 0.6666666666666643,0.0 0.33333333333333215,0.0 0.6666666666666714,-2.6645352591003757E-15 0.3333333333333357,-8.881784197001252E-16 0.6666666666666696,-8.881784197001252E-16 0.33333333333333215,0.3333333333333339</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s43">
<annotation>
<celldesigner:alias>a113</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s41">
<annotation>
<celldesigner:alias>a114</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s38">
<annotation>
<celldesigner:alias>a112</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r53" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s10,s44</celldesigner:baseReactants>
<celldesigner:baseProducts>s55</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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