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<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>2-ketoglutarate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s15" initialAmount="0.0" name="histidinol-phosphate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  histidinol-phosphate
Synonym:  Synonym not specified
Accession:  S03731
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>histidinol-phosphate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s16" initialAmount="0.0" name="PO_sub_4">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PO4
Synonym:  Synonym not specified
Accession:  S03722
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>PO_sub_4</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s17" initialAmount="0.0" name="histidinol">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  histidinol
Synonym:  Synonym not specified
Accession:  S03720
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>histidinol</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s18" initialAmount="0.0" name="histidinal">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  histidinal
Synonym:  Synonym not specified
Accession:  S03725
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>histidinal</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s19" initialAmount="0.0" name="histidine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  histidine
Synonym:  Synonym not specified
Accession:  S03727
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>histidine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s20" initialAmount="0.0" name="NAD">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NAD
Synonym:  Synonym not specified
Accession:  S03714
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NAD</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s21" initialAmount="0.0" name="NADH">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NADH
Synonym:  Synonym not specified
Accession:  S03721
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADH</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s22" initialAmount="0.0" name="ATP phosphoribosyl_br_transferase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP phosphoribosyl transferase
Synonym:  Synonym not specified
Accession:  P02987
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r1"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s23" initialAmount="0.0" name="Phosphoribosyl ATP_br_pyrophosphatase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphoribosyl ATP pyrophosphatase
Synonym:  Synonym not specified
Accession:  P02986
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r2"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s26" initialAmount="0.0" name="Imidazol glycerol_br_phosphate synthase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Imidazol glycerol phosphate synthase
Synonym:  Synonym not specified
Accession:  P02992
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r5"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s27" initialAmount="0.0" name="Imidazol glycerol_br_phosphate dehydratase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Imidazol glycerol phosphate dehydratase
Synonym:  Synonym not specified
Accession:  P02984
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r6"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s28" initialAmount="0.0" name="Histidinephosphate_br_aminotransferase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Histidinol phosphate aminotransferase
Synonym:  Synonym not specified
Accession:  P02991
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r7"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s30" initialAmount="0.0" name="Histidinol dehydrogenase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Histidinol dehydrogenase
Synonym:  Synonym not specified
Accession:  P02985
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r9"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s24" initialAmount="0.0" name="Phosphoribosyl AMP_br_cyclohydrolase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphoribosyl AMP cyclohydrolase
Synonym:  Synonym not specified
Accession:  P02989
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r3"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s31" initialAmount="0.0" name="Histidinal dehydrogenase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Histidinal dehydrogenase
Synonym:  Synonym not specified
Accession:  P02988
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r10"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s29" initialAmount="0.0" name="Histidinol-phosphatase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Histidinol-phosphatase
Synonym:  Synonym not specified
Accession:  P02990
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r8"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s7" initialAmount="0.0" name="phosphoribosylformimino-_br_AICAR-phosphate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  phosphoribosylforimino-AICAR-phosphate
Synonym:  Synonym not specified
Accession:  S03715
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>phosphoribosylformimino-_br_AICAR-phosphate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s8" initialAmount="0.0" name="phosphoribulosoylformimino-_br_AICAR phosphate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  phosphoribulosoylforimino-AICAR phosphate
Synonym:  Synonym not specified
Accession:  S03713
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>phosphoribulosoylformimino-_br_AICAR phosphate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s25" initialAmount="0.0" name="Phosphoribosylforimino-5-_br_amino-1-phosphoribosyl-4_br_imadazol carboxamide isomerase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase
Synonym:  Synonym not specified
Accession:  P02993
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r4"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="r1" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s1</celldesigner:baseReactants>
<celldesigner:baseProducts>s4</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a2" reactant="s2" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a3" product="s3" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333304,0.0 0.6666666666666665,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a30" editPoints="0.33333333333333326,5.551115123125783E-16 0.6666666666666665,1.3322676295501878E-15" modifiers="s22" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias>a1</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s2">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s4">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s22">
<annotation>
<celldesigner:alias>a30</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r2" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s4</celldesigner:baseReactants>
<celldesigner:baseProducts>s6</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a5" reactant="s5" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a6" product="s3" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333335,-2.220446049250313E-16 0.6666666666666665,-2.220446049250313E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a31" editPoints="0.33333333333333326,-4.440892098500626E-16 0.6666666666666667,-8.881784197001252E-16" modifiers="s23" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s4">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s5">
<annotation>
<celldesigner:alias>a5</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s6">
<annotation>
<celldesigner:alias>a7</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>a6</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s23">
<annotation>
<celldesigner:alias>a31</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r3" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s6</celldesigner:baseReactants>
<celldesigner:baseProducts>s7</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a8" reactant="s5" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:editPoints>0.33333333333333315,-2.220446049250313E-16 0.6666666666666666,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s6">
<annotation>
<celldesigner:alias>a7</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s5">
<annotation>
<celldesigner:alias>a8</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s7">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s24">
<annotation>
<celldesigner:alias>a32</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r4" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s7</celldesigner:baseReactants>
<celldesigner:baseProducts>s8</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333335,5.828670879282072E-16 0.6666666666666666,1.1796119636642288E-15</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s7">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s8">
<annotation>
<celldesigner:alias>a10</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s25">
<annotation>
<celldesigner:alias>a33</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r5" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s8</celldesigner:baseReactants>
<celldesigner:baseProducts>s12</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a11" reactant="s9" targetLineIndex="-1,0"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a13" product="s11" targetLineIndex="-1,0"/>
<celldesigner:productLink alias="a12" product="s10" targetLineIndex="-1,0"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3596896397190599,0.3159307303549259 0.7653300964259173,-0.21375565341532443</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s8">
<annotation>
<celldesigner:alias>a10</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>a11</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s12">
<annotation>
<celldesigner:alias>a14</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s11">
<annotation>
<celldesigner:alias>a13</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s10">
<annotation>
<celldesigner:alias>a12</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s26">
<annotation>
<celldesigner:alias>a34</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r6" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s12</celldesigner:baseReactants>
<celldesigner:baseProducts>s13</celldesigner:baseProducts>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a15" product="s5" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
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