2.2 OVAL SQUARE_CLOSEUP_NORTH inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive active inactive active inactive active inactive inactive active active inactive active active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active active inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive nucleus cell surface Long Name: Toll-like receptor 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 Synonym: TLR Accession: P01346 transmembrane PROTEIN p1 Long Name: Pathogen-associated microbial pattern Synonym: Synonym not specified Accession: S01858 inside SIMPLE_MOLECULE PAMP Long Name: IL-1 receptor-associated kinase M Synonym: IRAKM Accession: P01378 inside PROTEIN p6 Long Name: Long Name: Ubc13 Synonym: Synonym not specified Accession: U05563 Heterodimer Member Info: Uev1A#PROTEIN#Uev1A#P01376#TRAF-6-regulated IKK activator|TRIKA1|Uev1A#;Ubc13#PROTEIN#Ubc13#P01381#TRAF-6-regulated IKK activator|TRIKA1# inside PROTEIN p8 PROTEIN p9 Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01864 inside SIMPLE_MOLECULE Ubiquitin Long Name: IRAK1 Synonym: IL-1 receptor-associated kinase 1,IRAK1,Pelle Accession: P01343 inside PROTEIN p4 Long Name: IkappaB_beta kinase Synonym: IKK2 Accession: P01360 inside PROTEIN p12 Long Name: mitogen-activated protein kinase kinase 6 Synonym: MKK6 Accession: P01362 inside PROTEIN p14 Long Name: mitogen-activated protein kinase kinase 6 Synonym: MKK6 Accession: P01362 inside PROTEIN p14 Long Name: IkappaB Synonym: Inhibitor nuclear factor-kappaB,cactus Accession: P01338 inside PROTEIN p15 Long Name: Long Name: IkappaB Synonym: Synonym not specified Accession: U05567 Heterodimer Member Info: IkappaB#PROTEIN#IkappaB#P01338#Inhibitor nuclear factor-kappaB|cactus#;NF-kappaB#PROTEIN#NF-kappaB#P01354#NF-kB|nuclear factor-kappaB# inside PROTEIN p15 PROTEIN p16 Long Name: Gene trancription Synonym: Synonym not specified Accession: G01550 inside GENE Gene trancription Long Name: c-jun N-terminal kinase Synonym: JNK,c-jun N-terminal kinase Accession: P01375 inside PROTEIN p17 Long Name: c-jun N-terminal kinase Synonym: JNK,c-jun N-terminal kinase Accession: P01375 inside PROTEIN p17 Long Name: activator protein-1 Synonym: AP1,activator protein-1,c-FOS,c-JUN Accession: P01355 inside PROTEIN p18 Long Name: activator protein-1 Synonym: AP1,activator protein-1,c-FOS,c-JUN Accession: P01355 inside PROTEIN p18 Long Name: IRAK4 Synonym: IL-1 receptor-associated kinase 4,IRAK4,Pelle Accession: P01342 inside PROTEIN p3 Long Name: p38 Synonym: Synonym not specified Accession: P01352 inside PROTEIN p20 Long Name: p38 Synonym: Synonym not specified Accession: P01352 inside PROTEIN p20 Long Name: mitogen-activated protein kinase kinase 3 Synonym: MKK3,mitogen-activated protein kinase kinase 3 Accession: P01367 inside PROTEIN p21 Long Name: mitogen-activated protein kinase kinase 3 Synonym: MKK3,mitogen-activated protein kinase kinase 3 Accession: P01367 inside PROTEIN p21 Long Name: TPL2 Synonym: EST,ESTF,Ewing sarcoma transformant,MAP3K8,MAPKKK,Tumor progression locus 2,cot (cancer Osaka thyroid) oncogene,mitogen-activated protein kinase kinase kinase 8 Accession: P01364 inside PROTEIN p22 Long Name: TPL2 Synonym: EST,ESTF,Ewing sarcoma transformant,MAP3K8,MAPKKK,Tumor progression locus 2,cot (cancer Osaka thyroid) oncogene,mitogen-activated protein kinase kinase kinase 8 Accession: P01364 inside PROTEIN p22 Long Name: mitogen-activated protein kinase kinase 1 Synonym: MKK1 Accession: P01369 inside PROTEIN p23 Long Name: mitogen-activated protein kinase kinase 1 Synonym: MKK1 Accession: P01369 inside PROTEIN p23 Long Name: mitogen-activated protein kinase kinase 2 Synonym: MKK2 Accession: P01368 inside PROTEIN p24 Long Name: mitogen-activated protein kinase kinase 2 Synonym: MKK2 Accession: P01368 inside PROTEIN p24 Long Name: extracellular signal-regulated kinase 1 Synonym: ERK-1,ERK1,MAP kinase 1,MAPK1,p42 Accession: P01358 inside PROTEIN p25 Long Name: extracellular signal-regulated kinase 2 Synonym: ERK2,p44 Accession: P01356 inside PROTEIN p26 Long Name: extracellular signal-regulated kinase 1 Synonym: ERK-1,ERK1,MAP kinase 1,MAPK1,p42 Accession: P01358 inside PROTEIN p25 Long Name: extracellular signal-regulated kinase 2 Synonym: ERK2,p44 Accession: P01356 inside PROTEIN p26 Long Name: ? Synonym: Synonym not specified Accession: P01382 inside PROTEIN p27 Long Name: Long Name: Poly I:C Synonym: Synonym not specified Accession: U05568 Heterodimer Member Info: TLR3#PROTEIN#Toll-like receptor 3#P01340#TLR3|Toll-like receptor 3#;Poly I:C#SIMPLE_MOLECULE#Poly I:C#S01861## transmembrane SIMPLE_MOLECULE Poly I:C PROTEIN p34 2 Long Name: TIR domain-containing adaptor inducing interferon (IFN)-beta Synonym: TICAM-1,TIR-containing adaptor molecule ,TRIF Accession: P01344 inside PROTEIN p33 2 Long Name: myeloid differentiation factor 88 Synonym: DmMyD88 Accession: P01377 inside PROTEIN p37 2 Long Name: TIR domain-containing adaptor inducing interferon (IFN)-beta Synonym: TICAM-1,TIR-containing adaptor molecule ,TRIF Accession: P01344 inside PROTEIN p33 Long Name: TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR Synonym: ITRAF,TANK,TRAF-INTERACTING PROTEIN Accession: P01353 inside PROTEIN p38 Long Name: TANK-binding kinase 1 Synonym: TBK1 Accession: P01361 inside PROTEIN p39 Long Name: IkappaB_epsilon Kinase Synonym: IKK-epsilon Accession: P01372 inside PROTEIN p41 Long Name: IkappaB_gamma Kinase Synonym: IKK-gamma,NEMO,NF-kappaB essential modulator Accession: P01359 inside PROTEIN p42 Long Name: tumor necrosis factor (TNF) receptor-associated factor 6 Synonym: TRAF6,dTRAF,tumor necrosis factor (TNF) receptor-associated factor 6 Accession: P01371 inside PROTEIN p7 Long Name: tumor necrosis factor (TNF) receptor-associated factor 6 Synonym: TRAF6,dTRAF,tumor necrosis factor (TNF) receptor-associated factor 6 Accession: P01371 inside PROTEIN p7 Long Name: TAK1 binding protein 2 Synonym: Synonym not specified Accession: P01363 inside PROTEIN p44 Long Name: tumor necrosis factor (TNF) receptor-associated factor 6 Synonym: TRAF6,dTRAF,tumor necrosis factor (TNF) receptor-associated factor 6 Accession: P01371 inside PROTEIN p7 Long Name: transforming-growth factor beta-activated kinase 1 Synonym: MAP3K,MAPK kinase kinase,MAPKKK,TAK1,mitogen-activated protein kinase kinase kinase 7,transforming-growth factor beta-activated kinase Accession: P01370 inside PROTEIN p19 Long Name: transforming-growth factor beta-activated kinase 1 Synonym: MAP3K,MAPK kinase kinase,MAPKKK,TAK1,mitogen-activated protein kinase kinase kinase 7,transforming-growth factor beta-activated kinase Accession: P01370 inside PROTEIN p19 Long Name: Long Name: Pathogen-associated microbial pattern Synonym: Synonym not specified Accession: U05561 Heterodimer Member Info: PAMP#SIMPLE_MOLECULE#Pathogen-associated microbial pattern#S01858##;TLR2,4,7#PROTEIN#Toll-like receptor 2, 4, 7#P01351#TLR2,47# transmembrane SIMPLE_MOLECULE PAMP PROTEIN p47 2 Long Name: Toll-interacting protein Synonym: Tollip Accession: P01379 inside PROTEIN p5 Long Name: Long Name: peptidoglycan Synonym: Synonym not specified Accession: U05569 Heterodimer Member Info: PG, LP#SIMPLE_MOLECULE#peptidoglycan#S01863##;TLR1,2,6#PROTEIN#Toll-like receptor 1, 2, 6#P01380#TLR1,2,6# transmembrane SIMPLE_MOLECULE PG, LP PROTEIN p50 2 Long Name: Toll-interacting protein Synonym: Tollip Accession: P01379 inside PROTEIN p5 Long Name: IkappaB_beta kinase Synonym: IKK2 Accession: P01360 inside PROTEIN p12 Long Name: evolutionarily conserved signaling intermediate in Toll pathways Synonym: ECSIT Accession: P01349 inside PROTEIN p52 Long Name: ELK1 Synonym: ELK-1,ETS-like gene 1 Accession: P01341 inside PROTEIN p53 Long Name: ELK1 Synonym: ELK-1,ETS-like gene 1 Accession: P01341 inside PROTEIN p53 Long Name: mitogen-activated or extracellular signal-regulated kinase kinase kinase 1 Synonym: MAP3K,MEKK1 Accession: P01357 inside PROTEIN p56 Long Name: mitogen-activated protein kinase kinase 4 Synonym: MKK4 Accession: P01366 inside PROTEIN p57 Long Name: mitogen-activated protein kinase kinase 4 Synonym: MKK4 Accession: P01366 inside PROTEIN p57 Long Name: IkappaB_alpha Kinase Synonym: IKKalpha,IkappaB_alpha Kinase Accession: P01345 inside PROTEIN p51 Long Name: IkappaB_alpha Kinase Synonym: IKKalpha,IkappaB_alpha Kinase Accession: P01345 inside PROTEIN p51 Long Name: IRAK4 Synonym: IL-1 receptor-associated kinase 4,IRAK4,Pelle Accession: P01342 inside PROTEIN p3 Long Name: IRAK1 Synonym: IL-1 receptor-associated kinase 1,IRAK1,Pelle Accession: P01343 inside PROTEIN p4 Long Name: ATP Synonym: Synonym not specified Accession: S01860 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01862 inside SIMPLE_MOLECULE ADP Long Name: myeloid differentiation factor 88 Synonym: DmMyD88 Accession: P01377 inside PROTEIN p37 Long Name: A20 Synonym: tumor necrosis factor, alpha-induced protein 3 Accession: P01348 inside PROTEIN p58 Long Name: Long Name: Toll-like receptor 4 Synonym: Synonym not specified Accession: U05572 Heterodimer Member Info: TLR4#PROTEIN#Toll-like receptor 4#P01339#TLR4#;MD-2#PROTEIN#MD-2#P01347#MD2|lyphocyte antigen 96#;CD14#PROTEIN#CD14#P01373#LPS receptor|LPS-R # transmembrane PROTEIN p59 PROTEIN p48 PROTEIN p32 2 Long Name: TIR domain-containing adaptor protein Synonym: MAL,MyD88-adaptor-like,TIRAP Accession: P01350 inside PROTEIN p30 Long Name: lipopolysaccharide Synonym: Synonym not specified Accession: S01859 inside SIMPLE_MOLECULE LPS Long Name: Interferon (INF) regulatory factor 3 Synonym: IRF3 Accession: P01374 inside PROTEIN p46 Long Name: Interferon (INF) regulatory factor 3 Synonym: IRF3 Accession: P01374 inside PROTEIN p46 Long Name: IkappaB Synonym: Inhibitor nuclear factor-kappaB,cactus Accession: P01338 inside PROTEIN p15 Long Name: NF-kappaB Synonym: NF-kB,nuclear factor-kappaB Accession: P01354 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05566 Heterodimer Member Info: TANK#PROTEIN#TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR#P01353#ITRAF|TANK|TRAF-INTERACTING PROTEIN#;TBK1#PROTEIN#TANK-binding kinase 1#P01361#TBK1#;IKKepsilon#PROTEIN#IkappaB_epsilon Kinase#P01372#IKK-epsilon# inside PROTEIN p41 PROTEIN p39 PROTEIN p38 Long Name: TAK1 binding protein 2 Synonym: Synonym not specified Accession: P01363 inside PROTEIN p44 Long Name: Transforming growth factor-beta-activated kinase (TAK)-binding protein 1 (TAB1) Synonym: Synonym not specified Accession: P01365 inside PROTEIN p43 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05565 Heterodimer Member Info: TAB2#PROTEIN#TAK1 binding protein 2 #P01363##;TAB1#PROTEIN#Transforming growth factor-beta-activated kinase (TAK)-binding protein 1 (TAB1)#P01365##;TAK1#PROTEIN#transforming-growth factor beta-activated kinase 1#P01370#MAP3K|MAPK kinase kinase|MAPKKK|TAK1|mitogen-activated protein kinase kinase kinase 7|transforming-growth factor beta-activated kinase# inside PROTEIN p19 PROTEIN p44 PROTEIN p43 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05564 Heterodimer Member Info: ECSIT#PROTEIN#evolutionarily conserved signaling intermediate in Toll pathways#P01349#ECSIT#;MEKK1#PROTEIN#mitogen-activated or extracellular signal-regulated kinase kinase kinase 1#P01357#MAP3K|MEKK1#;TAB2#PROTEIN#TAK1 binding protein 2 #P01363##;TAB1#PROTEIN#Transforming growth factor-beta-activated kinase (TAK)-binding protein 1 (TAB1)#P01365##;TAK1#PROTEIN#transforming-growth factor beta-activated kinase 1#P01370#MAP3K|MAPK kinase kinase|MAPKKK|TAK1|mitogen-activated protein kinase kinase kinase 7|transforming-growth factor beta-activated kinase#;TRAF6#PROTEIN#tumor necrosis factor (TNF) receptor-associated factor 6#P01371#TRAF6|dTRAF|tumor necrosis factor (TNF) receptor-associated factor 6# inside PROTEIN p19 PROTEIN p7 PROTEIN p44 PROTEIN p43 PROTEIN p56 PROTEIN p52 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05562 Heterodimer Member Info: PAMP#SIMPLE_MOLECULE#Pathogen-associated microbial pattern#S01858##;TLR#PROTEIN#Toll-like receptor 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12#P01346#TLR# transmembrane PROTEIN p1 2 SIMPLE_MOLECULE PAMP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05570 Heterodimer Member Info: IRAK4#PROTEIN#IRAK4#P01342#IL-1 receptor-associated kinase 4|IRAK4|Pelle#;IRAK1#PROTEIN#IRAK1#P01343#IL-1 receptor-associated kinase 1|IRAK1|Pelle# inside PROTEIN p3 PROTEIN p4 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05571 Heterodimer Member Info: TIRAP#PROTEIN#TIR domain-containing adaptor protein#P01350#MAL|MyD88-adaptor-like|TIRAP#;MyD88#PROTEIN#myeloid differentiation factor 88 #P01377#DmMyD88# inside PROTEIN p30 PROTEIN p37 STATE_TRANSITION s91 s94 0.33333333333333304,0.0 0.666666666666667,0.0 a24 a29 a28 STATE_TRANSITION s29 s30 0.3333333333333339,0.0 0.666666666666667,-4.440892098500626E-16 a40 a42 a41 a43 STATE_TRANSITION s35 s34 0.3333333333333335,8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 a49 a53 a48 a54 a198 STATE_TRANSITION s38 s39 0.33333333333333337,0.0 0.6666666666666667,-1.7763568394002505E-15 a55 a57 a56 a58 TRANSCRIPTIONAL_ACTIVATION s41 s37 0.33333333333333304,0.0 0.6666666666666661,0.0 a60 a51 STATE_TRANSITION s40 s41 0.3333333333333335,4.440892098500626E-16 0.6666666666666669,8.881784197001252E-16 a59 a61 a60 a62 STATE_TRANSITION s45 s47 0.33333333333333304,0.0 0.666666666666667,0.0 a67 a71 a69 a70 STATE_TRANSITION s44 s46 0.3333333333333335,-1.7763568394002505E-15 0.666666666666667,-3.552713678800501E-15 a66 a72 a68 a73 STATE_TRANSITION s48 s49 0.33333333333333215,-2.220446049250313E-16 0.6666666666666679,-2.220446049250313E-16 a74 a150 a75 a142 STATE_TRANSITION s50 s51 0.33333333333333326,-4.440892098500626E-15 0.6666666666666667,-9.769962616701378E-15 a76 a136 a77 a141 STATE_TRANSITION s52 s53 0.3333333333333333,-8.881784197001252E-16 0.6666666666666667,-2.6645352591003757E-15 a78 a135 a79 a140 STATE_TRANSITION s54 s56 0.33333333333333337,0.0 0.6666666666666665,8.881784197001252E-16 a80 a149 a83 a147 STATE_TRANSITION s55 s57 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666669,-1.7763568394002505E-15 a81 a148 a82 a146 STATE_TRANSITION s15 s91 0.3333333333333335,4.440892098500626E-16 0.6666666666666674,8.881784197001252E-16 a113 a139 a24 a143 INHIBITION s14 s128 0.33333333333333304,-2.498001805406602E-16 0.666666666666667,-6.938893903907228E-16 a23 a92 STATE_TRANSITION s43 s96 0.3333333333333326,1.7763568394002505E-15 0.6666666666666661,0.0 a131 a138 a65 a145 KNOWN_TRANSITION_OMITTED s80 s88 0.3333333333333333,0.0 0.6666666666666667,-2.220446049250313E-16 a116 a125 STATE_TRANSITION s13 s115 0.33333333333333304,1.4432899320127035E-15 0.6666666666666661,3.1086244689504383E-15 a22 a158 a157 a160 HETERODIMER_ASSOCIATION s89,s116 s117 0.33333333333333215,0.0 0.666666666666667,-1.7763568394002505E-15 0.33333333333333237,0.0 0.6666666666666681,0.0 0.33333333333333215,0.0 0.6666666666666679,1.7763568394002505E-15 0.3333333333333357,0.3333333333333357 a126 a171 a172 STATE_TRANSITION s117 s26 0.33333333333333304,-1.7763568394002505E-15 0.666666666666667,-4.440892098500626E-15 a172 a36 a35 a37 INHIBITION s14 s127 0.33333333333333304,-1.1102230246251565E-16 0.6666666666666661,0.0 a23 a93 STATE_TRANSITION s119 s120 0.3333333333333333,-1.7763568394002505E-15 0.6666666666666667,-3.1086244689504383E-15 a174 a176 a175 a177 TRANSCRIPTIONAL_ACTIVATION s120 s37 0.33333333333333304,0.0 0.6666666666666665,4.440892098500626E-16 a175 a51 TRANSCRIPTIONAL_ACTIVATION s139 s37 0.33333333333333304,0.0 0.6666666666666664,-4.440892098500626E-16 a151 a51 STATE_TRANSITION s123 s124 0.3333333333333335,4.440892098500626E-16 0.6666666666666665,-4.440892098500626E-16 a179 a181 a180 a182 STATE_TRANSITION s116 s125 0.33333333333333304,0.0 0.6666666666666661,0.0 a171 a184 a183 a185 INHIBITION s132 s94 0.3333333333333335,4.440892098500626E-16 0.6666666666666665,8.881784197001252E-16 a186 a28 STATE_TRANSITION s100 s139 0.3333333333333357,-8.881784197001252E-16 0.6666666666666679,-1.7763568394002505E-15 a193 a194 a151 a195 TRANSCRIPTIONAL_ACTIVATION s141 s37 0.33333333333333315,-4.440892098500626E-16 0.6666666666666666,-8.881784197001252E-16 a198 a51 HETERODIMER_ASSOCIATION s86,s88 s143 0.33333333333333215,-1.1102230246251565E-15 0.6666666666666643,-2.220446049250313E-16 0.3333333333333326,0.0 0.6666666666666665,3.552713678800501E-15 0.3333333333333339,0.0 0.6666666666666679,8.881784197001252E-16 0.5660124792222367,0.4133206066477664 a201 a125 a122 a203 STATE_TRANSITION s93 s144 0.33333333333333304,0.0 0.6666666666666661,8.881784197001252E-16 a130 a137 a207 a144 HETERODIMER_ASSOCIATION s144,s145 s147 0.33333333333333215,0.0 0.6666666666666679,0.0 0.3333333333333339,0.0 0.666666666666667,0.0 0.3333333333333339,1.7763568394002505E-15 0.6666666666666679,0.0 0.3333333333333342,0.3333333333333339 a207 a208 a65 a211 HETERODIMER_ASSOCIATION s94,s147 s152 0.3333333333333348,-4.440892098500626E-16 0.6666666666666661,0.0 0.3333333333333335,0.0 0.6666666666666665,0.0 0.3333333333333339,8.881784197001252E-16 0.6666666666666661,0.0 0.33333333333333326,0.3333333333333339 a28 a211 a173 a178 a223 STATE_TRANSITION s1 s155 0.3333333333333335,6.661338147750939E-16 0.6666666666666665,8.881784197001252E-16 a1 a15 a226 STATE_TRANSITION s131 s82 0.33333333333333304,4.440892098500626E-16 0.6666666666666663,4.440892098500626E-16 a120 a119 STATE_TRANSITION s3 s127 0.3333333333333337,-6.661338147750939E-16 0.6666666666666672,-1.1102230246251565E-15 a17 a3 STATE_TRANSITION s84 s80 0.3333333333333339,-4.440892098500626E-16 0.6666666666666679,-8.881784197001252E-16 a121 a116 HETERODIMER_ASSOCIATION s21,s127 s156 0.3333333333333335,4.440892098500626E-16 0.6666666666666665,0.0 0.33333333333333337,4.440892098500626E-16 0.6666666666666662,8.881784197001252E-16 0.33333333333333304,0.0 0.666666666666667,0.0 0.33333333333333326,0.33333333333333304 a4 a3 a229 DISSOCIATION s156 s128,s127 0.3333333333333335,2.220446049250313E-16 0.666666666666667,0.0 0.33333333333333304,0.0 0.666666666666667,0.0 0.3333333333333337,1.7763568394002505E-15 0.6666666666666672,0.0 0.3333333333333326,0.3333333333333336 a229 a19 a92 a93 a20 HETERODIMER_ASSOCIATION s131,s61 s157 0.3333333333333339,1.7763568394002505E-15 0.6666666666666661,0.0 0.3333333333333339,0.0 0.6666666666666679,0.0 0.3333333333333339,-8.881784197001252E-16 0.6666666666666679,-1.7763568394002505E-15 0.33333333333333304,0.3333333333333339 a164 a88 a232