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This diagram represents several receptors and signaling pathways that have been identified as key mediators of angiogenesis, which is the process of blood vessel generation and maturation.
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<annotation>
<celldesigner:name>ER</celldesigner:name>
</annotation>
</compartment>
<compartment name="c5" outside="c1" volume="1.0">
<annotation>
<celldesigner:name>Nuclear membrane</celldesigner:name>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species compartment="c1" initialAmount="0.0" name="s1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Vascular Endothelial Growth Factor Receptor-2
Synonym:  FLK1,KDR,Kinase Insert Domain Receptor,Tyrosine Kinase Growth Factor Receptor
Accession:  P00222
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s3">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Tie-2
Synonym:  TEK,TEK Tyrosine Kinase
Accession:  P00247
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s4">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Platelet-Derived Growth Factor Receptor
Synonym:  PDGFRA,PDGFRB
Accession:  P00230
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s5">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Fibroblast Growth Factor Receptor-1
Synonym:  FGFR-1,FLG,FLT2,FMS-Like Gene,FMS-Like Tyrosine Kinase 2
Accession:  P00186
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s6">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Frizzled
Synonym:  Synonym not specified
Accession:  P00189
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s7">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ephrin Receptor
Synonym:  Eph
Accession:  P00212
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s8">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protease Activated Receptor
Synonym:  NR1I2,Nuclear Receptor Subfamily 1, Group I, Member 2,PXR,Pregnane X Receptor,SXR,Steroid and Xenobiotic Receptor
Accession:  P00192
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r151"/>
<celldesigner:catalyzed reaction="r156"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s9">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Notch Receptor
Synonym:  Synonym not specified
Accession:  P00255
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s11">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Rho GTPase
Synonym:  CDC42,Cell Division Cycle 42
Accession:  P00245
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s12">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  p38 Mitogen-Activated Protein Kinase
Synonym:  CSAID-Binding Protein1,CSBP1,Cytokine-Suppressive Anti-inflammatory Drug-Binding Protein 1,MAPK14,MXI2,Mitogen-Activated Protein Kinase 14,RK,SAPK2A,Stress-Activated Protein Kinase 2A,p38,p38 MAP Kinase,p38-Alpha
Accession:  P00182
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r293"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s13">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Mitogen-Activated Protein Kinase-Activating Protein Kinase-2 and 3
Synonym:  3PK,MAPKAP Kinase 2/3,MAPKAP2/3
Accession:  P00244
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r292"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s14">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Heat-Shock Protein 27
Synonym:  HSPB1
Accession:  P00231
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s20">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Paxillin
Synonym:  PXN
Accession:  P00194
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s21">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Src Kinase
Synonym:  Avian Sarcoma Viral Oncogene,Src Oncogene
Accession:  P00184
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p21</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s22">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  VEGFR-Associated Protein
Synonym:  SH2 Domain Protein 2A,SH2D2A,T-Cell SH2 Domain Containing Adaptor Protein,TSAD,VRAP
Accession:  P00196
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p22</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s24">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Shc-like protein
Synonym:  Shc Adaptor Homolog
Accession:  P00202
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p24</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s26">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Sphingosine Kinase
Synonym:  SPHK
Accession:  P00229
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p26</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r281"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s32">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Cytosolic Phospholipase A2
Synonym:  PLA2
Accession:  P00251
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p32</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s35">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphatidylinositol (3,4,5)-triphosphate
Synonym:  Synonym not specified
Accession:  S01597
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>PIP3</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r140"/>
<celldesigner:catalyzed reaction="r296"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" initialAmount="0.0" name="s40">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Calcium
Synonym:  Synonym not specified
Accession:  U05038
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca_super_2+_endsuper</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s41">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Vascular Endothelial Growth Factor
Synonym:  VEGF-A
Accession:  P00241
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p33</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s42">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Angiopoietin-1
Synonym:  Synonym not specified
Accession:  P00248
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p34</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s43">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Angiopoietin-2
Synonym:  Synonym not specified
Accession:  P00246
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p35</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s44">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Vascular Endothelial Protein Tyrosine Phosphatase
Synonym:  PTPRB,Protein-Tyrosine Phosphatase, Receptor-Type, Beta
Accession:  P00250
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p36</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s45">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Growth Factor Receptor-Bound Protein 2
Synonym:  ASH Protein,Abundant SRC Homology,Adaptor Protein 2
Accession:  P00234
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p37</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s46">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ras GTPase-Activating Protein
Synonym:  GAP,GTPase-Activating Protein,Guanosine Triphosphatase-Activating Protein,RAS p21 Protein Activator 1,RASA1
Accession:  P00190
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p38</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s47">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Docking Protein-R
Synonym:  Synonym not specified
Accession:  P00180
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p39</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r270"/>
<celldesigner:catalyzed reaction="r274"/>
<celldesigner:catalyzed reaction="r280"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s48">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Nck Adaptor Protein
Synonym:  Synonym not specified
Accession:  P00215
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p40</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r269"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s49">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  p21-Activated Kinase
Synonym:  PAK
Accession:  P00249
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p41</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s50">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Growth Factor Receptor-Bound Protein 14
Synonym:  Adaptor Protein 14
Accession:  P00197
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p42</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s51">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Growth Factor Receptor-Bound Protein 7
Synonym:  Adaptor Protein 7
Accession:  P00228
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p43</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r261"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s54">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Baculoviral IAP Repeat-Containing Protein 5
Synonym:  API4,Apoptosis inhibitor 4,BIRC5
Accession:  P00198
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p46</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s55">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Tyrosine Phosphatase Shp2
Synonym:  PTP2C,PTPN11,Protein-Tyrosine Phosphatase 2C,Protein-Tyrosine Phosphatase, Nonreceptor-Type, 11,Shp2
Accession:  P00181
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p47</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r225"/>
<celldesigner:catalyzed reaction="r261"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s61">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Janus Kinase 1
Synonym:  Synonym not specified
Accession:  P00185
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p48</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r177"/>
<celldesigner:catalyzed reaction="r178"/>
<celldesigner:catalyzed reaction="r253"/>
<celldesigner:catalyzed reaction="r254"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s62">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Signal Transducer and Activator of Transcription 1
Synonym:  Synonym not specified
Accession:  P00218
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p49</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s63">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Signal Transducer and Activator of Transcription 3
Synonym:  APRF,Acute-Phase Response Factor
Accession:  P00217
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p50</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s10">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphatidylinositol 3-Kinase
Synonym:  PI(3)K
Accession:  P00236
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r259"/>
<celldesigner:catalyzed reaction="r261"/>
<celldesigner:catalyzed reaction="r301"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" initialAmount="0.0" name="s65">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  IP3
Synonym:  Synonym not specified
Accession:  S01596
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>IP3</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s71">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  c-Jun N-terminal Kinase Kinase 1
Synonym:  MAP2K4,MAPK/ERK Kinase 4,MAPKK4,MEK4,MKK4,Mitogen-Activated Protein Kinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1
Accession:  P00199
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p51</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r153"/>
<celldesigner:catalyzed reaction="r246"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s72">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  c-Jun N-Terminal Kinase 1
Synonym:  MAPK8,Mitogen-Activated Protein Kinase 8,PRKM8,Protein Kinase, Mitogen-Activated, 8,SAPK1,Stress-Activated Protein Kinase 1
Accession:  P00221
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p52</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r154"/>
<celldesigner:catalyzed reaction="r248"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s73">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  c-Fos Transcription Factor
Synonym:  Oncogene FOS,v-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog
Accession:  P00235
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p53</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s74">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  c-Jun Transcription Factor
Synonym:  AP-1,Activator Protein 1,Oncogene Jun,v-Jun Avian Sarcoma Virus 17 Oncogene Homolog
Accession:  P00220
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p54</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s75">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTPase-Activating Protein
Synonym:  Guanosine Triphosphatase-Activating Protein,RAS p21 Protein Activator 1,RASA1,RASGAP
Accession:  P00205
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p55</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r230"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s78">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Src Homology Domain Containing Protein
Synonym:  SHC Transforming Protein
Accession:  P00183
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p58</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r225"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s97">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protein Kinase B
Synonym:  Oncogene Akt,PKB,Rac serine/threonine kinase
Accession:  P00223
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r255"/>
<celldesigner:catalyzed reaction="r256"/>
<celldesigner:catalyzed reaction="r295"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s98">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Bcl-2 Antagonist of Cell Death
Synonym:  BCL2-Binding Component 6,BCL2-Binding Protein,BCL2L8
Accession:  P00232
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p16</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s99">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Caspase 9
Synonym:  APAF3,Apoptotic Protease Activating Factor 3
Accession:  P00216
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p17</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s100">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  endothelial nitric oxide synthase
Synonym:  NOS3,Nitric Oxide Synthase 3,eNOS
Accession:  P00210
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p18</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s101">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Focal Adhesion Kinase
Synonym:  Cytoplasmic Protein-Tyrosine Kinase,FAK1,Focal Adhesion Kinase 1,PTK2
Accession:  P00209
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r291"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s102">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phospholipase C-gamma
Synonym:  PLC1,PLC148,PLCG1,Phospholipase C-148
Accession:  P00256
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p23</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r204"/>
<celldesigner:catalyzed reaction="r284"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s105">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Raf Oncogene
Synonym:  CRAF,Oncogene MIL,Raf,Transforming Replication-Defective Murine Retrovirus 3611-MSV,v-Raf-1 Murine Leukemia Viral Oncogene Homolog
Accession:  P00243
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p28</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r182"/>
<celldesigner:catalyzed reaction="r232"/>
<celldesigner:catalyzed reaction="r279"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s106">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Mitogen Activated Protein Kinase Kinase
Synonym:  MAP kinase kinase,MAP/ERK Kinase,MAP2K,MAPKK,MKK,PRKMK,Protein Kinase, Mitogen-Activated, Kinase
Accession:  P00225
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p29</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r183"/>
<celldesigner:catalyzed reaction="r233"/>
<celldesigner:catalyzed reaction="r244"/>
<celldesigner:catalyzed reaction="r278"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s107">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Extracellular regulated kinase
Synonym:  JNK-Activated Kinase1,JNKK1,MAP2K4,MAPK/ERK Kinase 4,MAPKK4,MEK4,MKK4,Mitogen-Activated ProteinKinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1
Accession:  P00203
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p30</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r176"/>
<celldesigner:catalyzed reaction="r234"/>
<celldesigner:catalyzed reaction="r275"/>
<celldesigner:catalyzed reaction="r276"/>
<celldesigner:catalyzed reaction="r277"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s108">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Calcium
Synonym:  Synonym not specified
Accession:  U05038
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca_super_2+_endsuper</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s109">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphatidylinositol (4,5)-diphosphate
Synonym:  Synonym not specified
Accession:  S01598
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>PIP2</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s111">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  IP3
Synonym:  Synonym not specified
Accession:  S01596
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>IP3</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s112">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Growth Factor Receptor-Bound Protein 2
Synonym:  ASH Protein,Abundant SRC Homology,Adaptor Protein 2
Accession:  P00252
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p56</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r226"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s113">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Son of Sevenless, Drosophila, Homolog 1
Synonym:  SOS1 Guanine Nucleotide Exchange Factor
Accession:  P00193
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p57</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r230"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s114">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1
Synonym:  Ets1 Oncogene
Accession:  P00188
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p31</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s115">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Mitogen-Activated Kinase Kinase Kinase 1
Synonym:  MAP/ERK Kinase Kinase 1,MAP3K1,MAPKKK1,MEK kinase
Accession:  P00208
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p59</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r152"/>
<celldesigner:catalyzed reaction="r245"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s117">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Platelet-Derived Growth Factor
Synonym:  PDGFA,PDGFB,PDGFC,PDGFD
Accession:  P00224
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p60</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s118">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Fibroblast Growth Factor
Synonym:  ECGF,Endothelial Cell Growth Factor,HBGF,Heparin-Binding Growth Factor
Accession:  P00213
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p61</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s119">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Crk oncogene
Synonym:  CRKII
Accession:  P00207
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p62</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r223"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s124">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phospholiase A2
Synonym:  CPLA2,PLA2
Accession:  P00227
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p64</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s125">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phospholipase D
Synonym:  Synonym not specified
Accession:  P00204
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p65</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s126">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Wingless-Type MMTV Integration Site Family
Synonym:  Wnt
Accession:  P00206
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p66</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s127">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Frizzled-Related Protein
Synonym:  Frzb,SARP,SFRP,Secreted Apoptosis-Related Protein,Secreted Frizzled-Related Protein
Accession:  P00237
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p67</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s128">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dishelvelled
Synonym:  Dvl
Accession:  P00200
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p68</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s129">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Adenomatous Polyposis of the Colon
Synonym:  FAP,FPC,Familial Adenomatous Polyposis,Familial Polyposis of the Colon
Accession:  P00195
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p69</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s130">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Glycogen Synthase Kinase 3-beta
Synonym:  GSK3-beta
Accession:  P00211
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p70</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s131">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Axis inhibitor 1
Synonym:  Fused
Accession:  P00253
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p71</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s133">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  T-Cell Transcription Factor
Synonym:  TCF4,Transcription Factor 7-Like 2
Accession:  P00242
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p73</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s140">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Tissue Factor
Synonym:  Coagulation Factor III,F3,Tissue Thromboplastin
Accession:  P00191
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p75</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r147"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s141">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Factor VIIa
Synonym:  Coagulation Factor VII
Accession:  P00201
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p76</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r147"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s142">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Rho guanosine triphosphatase
Synonym:  RAS Homolog Gene Family,Rho,Rho GTPase
Accession:  P00254
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p77</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r157"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s143">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Delta
Synonym:  Dll,JAG,JAGL,Jagged,Ser,Serrate
Accession:  P00226
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p78</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s144">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CBF1, Suppressor of Hairless, Lag-1 Transcription Factor Family
Synonym:  C Promoter-Binding Factor 1,CBF1,IGKJRB,Immunoglobulin Kappa J Region Recombination Signal-Binding Protein,RBPJK,RBPSUH,Recombination Signal-Binding Protein 1 for J-Kappa,Recombination Signal-Binding Protein Suppressor of Hairless
Accession:  P00233
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p79</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s145">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Hypoxia Inducible Factor-1
Synonym:  MOP1,Member of PAS Superfamily 1
Accession:  P00214
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p80</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s148">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05031
Heterodimer Member Info:  Delta/Serrate#PROTEIN#Delta#P00226#Dll|JAG|JAGL|Jagged|Ser|Serrate#;Notch#PROTEIN#Notch Receptor#P00255##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p78</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r146"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c5" initialAmount="0.0" name="s154">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05033
Heterodimer Member Info:  c-Jun#PROTEIN#c-Jun Transcription Factor#P00220#AP-1|Activator Protein 1|Oncogene Jun|v-Jun Avian Sarcoma Virus 17 Oncogene Homolog#;c-Fos#PROTEIN#c-Fos Transcription Factor#P00235#Oncogene FOS|v-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p54</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p53</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s157">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ephrin
Synonym:  EFL,EFN,EPH-Related Receptor Tyrosine Kinase Ligand,EPLG,LERK,Ligand of EPH-Related Kinase
Accession:  P00239
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p74</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s158">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ras
Synonym:  H-Ras,K-Ras,N-Ras,p21
Accession:  P00238
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p27</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r181"/>
<celldesigner:catalyzed reaction="r231"/>
<celldesigner:catalyzed reaction="r280"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s159">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05036
Heterodimer Member Info:  EphR#PROTEIN#Ephrin Receptor#P00212#Eph#;Eph#PROTEIN#Ephrin#P00239#EFL|EFN|EPH-Related Receptor Tyrosine Kinase Ligand|EPLG|LERK|Ligand of EPH-Related Kinase#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p74</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r175"/>
<celldesigner:catalyzed reaction="r179"/>
<celldesigner:catalyzed reaction="r180"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s163">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05035
Heterodimer Member Info:  Fzd#PROTEIN#Frizzled#P00189##;Wnt#PROTEIN#Wingless-Type MMTV Integration Site Family#P00206#Wnt#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p66</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r188"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s165">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05027
Heterodimer Member Info:  APC#PROTEIN#Adenomatous Polyposis of the Colon#P00195#FAP|FPC|Familial Adenomatous Polyposis|Familial Polyposis of the Colon#;GSK3beta#PROTEIN#Glycogen Synthase Kinase 3-beta#P00211#GSK3-beta#;Axin#PROTEIN#Axis inhibitor 1#P00253#Fused#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p71</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p69</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p70</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s132">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Beta-catenin
Synonym:  Beta,CTNNB,Cadherin-Associated Protein
Accession:  P00187
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p72</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r189"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s168">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphatidylinositol (4,5)-diphosphate
Synonym:  Synonym not specified
Accession:  S01598
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>PIP2</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s171">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protein Kinase C
Synonym:  Synonym not specified
Accession:  P00219
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r206"/>
<celldesigner:catalyzed reaction="r207"/>
<celldesigner:catalyzed reaction="r280"/>
<celldesigner:catalyzed reaction="r283"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s172">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05037
Heterodimer Member Info:  FGFR-1#PROTEIN#Fibroblast Growth Factor Receptor-1#P00186#FGFR-1|FLG|FLT2|FMS-Like Gene|FMS-Like Tyrosine Kinase 2#;FGF#PROTEIN#Fibroblast Growth Factor#P00213#ECGF|Endothelial Cell Growth Factor|HBGF|Heparin-Binding Growth Factor#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p61</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r203"/>
<celldesigner:catalyzed reaction="r220"/>
<celldesigner:catalyzed reaction="r221"/>
<celldesigner:catalyzed reaction="r222"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s174">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  DAG
Synonym:  Synonym not specified
Accession:  S01599
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>DAG</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r205"/>
<celldesigner:catalyzed reaction="r282"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s181">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05030
Heterodimer Member Info:  PDGF#PROTEIN#Platelet-Derived Growth Factor#P00224#PDGFA|PDGFB|PDGFC|PDGFD#;PDGFR#PROTEIN#Platelet-Derived Growth Factor Receptor#P00230#PDGFRA|PDGFRB#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p60</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r203"/>
<celldesigner:catalyzed reaction="r222"/>
<celldesigner:catalyzed reaction="r225"/>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05029
Heterodimer Member Info:  Ca2+#ION#Long Name:  Calcium#U05038##;eNOS#PROTEIN#endothelial nitric oxide synthase#P00210#NOS3|Nitric Oxide Synthase 3|eNOS#
</body>
</html>
</notes>
<annotation>
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<celldesigner:listOfHeterodimerEntries>
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</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s196">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05028
Heterodimer Member Info:  Tie2#PROTEIN#Tie-2#P00247#TEK|TEK Tyrosine Kinase#;Ang-1#PROTEIN#Angiopoietin-1#P00248##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
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</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s199">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Fibroblast Growth Factor Receptor Substrate 2
Synonym:  FRS2-Alpha,FRS2A,SNT,SNT1,SUC1-Associated Neurotrophic Factor Target 1
Accession:  P00240
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</html>
</notes>
<annotation>
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<celldesigner:speciesIdentity>
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</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s203">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05034
Heterodimer Member Info:  Ca2+#ION#Long Name:  Calcium#U05038##;cPLA2#PROTEIN#Cytosolic Phospholipase A2#P00251#PLA2#
</body>
</html>
</notes>
<annotation>
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</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s206">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05032
Heterodimer Member Info:  VEGFR-2#PROTEIN#Vascular Endothelial Growth Factor Receptor-2#P00222#FLK1|KDR|Kinase Insert Domain Receptor|Tyrosine Kinase Growth Factor Receptor#;VEGF#PROTEIN#Vascular Endothelial Growth Factor#P00241#VEGF-A#
</body>
</html>
</notes>
<annotation>
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