2.2 SQUARE_CLOSEUP_NORTHEAST OVAL OVAL OVAL OVAL OVAL OVAL inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active Receiving cell Endosome lipid raft nucleus lysosome Long Name: ATP Synonym: Synonym not specified Accession: S01691 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01693 inside SIMPLE_MOLECULE ADP Long Name: Patched Synonym: Ptc,Ptc1 Accession: P00689 transmembrane PROTEIN p1 Long Name: a31_degraded Synonym: Synonym not specified Accession: U02280 inside DEGRADED a31_degraded Long Name: e.g., ptc Synonym: Synonym not specified Accession: G01526 inside GENE Hedgehog target gene Long Name: GSK3 Synonym: Glycogen synthase kinase3,Glycogen synthase kinase3 beta,sgg,shaggy,zeste-white 3 Accession: P00692 inside PROTEIN p13 Long Name: Slimb Synonym: Supernumerary limbs,beta TRCP,beta transducin Accession: P00683 inside PROTEIN p16 Long Name: Proteasome Synonym: Synonym not specified Accession: P00695 inside PROTEIN p17 Long Name: Debra Synonym: Dbr,Determiner of breaking down of Ci Activator Accession: P00694 inside PROTEIN p18 Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01692 inside SIMPLE_MOLECULE Ubiquitin Long Name: a202_degraded Synonym: Synonym not specified Accession: U02281 inside DEGRADED a202_degraded Long Name: Sap18 Synonym: Sin3-associated polypeptide 18 Accession: P00697 inside PROTEIN p21 Long Name: PKA Synonym: Protein kinase A,cAMP-dependent Protein Kinase A Accession: P00682 inside PROTEIN p8 Long Name: Hedgehog Synonym: Hh,Shh,Sonic hedgehog Accession: P00688 inside PROTEIN p3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05221 Heterodimer Member Info: Hedgehog#PROTEIN#Hedgehog#P00688#Hh|Shh|Sonic hedgehog#;Patched#PROTEIN#Patched#P00689#Ptc|Ptc1# transmembrane PROTEIN p1 PROTEIN p3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05219 Heterodimer Member Info: Hedgehog#PROTEIN#Hedgehog#P00688#Hh|Shh|Sonic hedgehog#;Patched#PROTEIN#Patched#P00689#Ptc|Ptc1# transmembrane PROTEIN p1 PROTEIN p3 Long Name: Long Name: Smoothened Synonym: Synonym not specified Accession: U05226 Heterodimer Member Info: Smoothened#PROTEIN#Smoothened#P00685#Smo#;Fused#PROTEIN#Fused#P00686#Fu#;Costal2#PROTEIN#Costal2#P00698#Cos-2|Cos2|Costal-2# transmembrane PROTEIN p4 PROTEIN p5 PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05228 Heterodimer Member Info: Smoothened#PROTEIN#Smoothened#P00685#Smo#;Fused#PROTEIN#Fused#P00686#Fu#;Costal2#PROTEIN#Costal2#P00698#Cos-2|Cos2|Costal-2# transmembrane PROTEIN p4 PROTEIN p2 PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05229 Heterodimer Member Info: Smoothened#PROTEIN#Smoothened#P00685#Smo#;Fused#PROTEIN#Fused#P00686#Fu#;Costal2#PROTEIN#Costal2#P00698#Cos-2|Cos2|Costal-2# transmembrane PROTEIN p4 PROTEIN p5 PROTEIN p2 Long Name: CBP Synonym: CREB binding protein,p300 Accession: P00691 inside PROTEIN p11 Long Name: Microtubule Synonym: Synonym not specified Accession: P00696 inside PROTEIN p10 Long Name: Casine kinase I Synonym: CKI,Doubletime Accession: P00681 inside PROTEIN p14 Long Name: Cubitus interruptus Synonym: Ci,CiFL,Gli1,Gli2,Gli3 Accession: P00690 inside PROTEIN p6 Long Name: Long Name: Su(fu) Synonym: Synonym not specified Accession: U05218 Heterodimer Member Info: Cubitus interruptus#PROTEIN#Cubitus interruptus#P00690#Ci|CiFL|Gli1|Gli2|Gli3#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# inside PROTEIN p12 PROTEIN p6 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05225 Heterodimer Member Info: Cubitus interruptus#PROTEIN#Cubitus interruptus#P00690#Ci|CiFL|Gli1|Gli2|Gli3#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# inside PROTEIN p12 PROTEIN p6 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05227 Heterodimer Member Info: Cubitus interruptus#PROTEIN#Cubitus interruptus#P00690#Ci|CiFL|Gli1|Gli2|Gli3#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# inside PROTEIN p12 PROTEIN p6 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05222 Heterodimer Member Info: Slimb#PROTEIN#Slimb#P00683#Supernumerary limbs|beta TRCP|beta transducin#;Cubitus interruptus#PROTEIN#Cubitus interruptus#P00690#Ci|CiFL|Gli1|Gli2|Gli3#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# inside PROTEIN p6 PROTEIN p12 PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05224 Heterodimer Member Info: Slimb#PROTEIN#Slimb#P00683#Supernumerary limbs|beta TRCP|beta transducin#;Cubitus interruptus#PROTEIN#Cubitus interruptus#P00690#Ci|CiFL|Gli1|Gli2|Gli3#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# inside PROTEIN p12 PROTEIN p16 PROTEIN p6 Long Name: Cubitus interruptus Synonym: Ci,CiFL,Gli1,Gli2,Gli3 Accession: P00690 inside PROTEIN p6 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05232 Heterodimer Member Info: MIcrotubule#PROTEIN#MIcrotubule#P00684#microtubules|tubulin|tubulin alpha|tubulin beta#;Smoothened#PROTEIN#Smoothened#P00685#Smo#;Fused#PROTEIN#Fused#P00686#Fu#;Cubitus interruptus#PROTEIN#Cubitus interruptus#P00690#Ci|CiFL|Gli1|Gli2|Gli3#;Costal2#PROTEIN#Costal2#P00698#Cos-2|Cos2|Costal-2#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# transmembrane PROTEIN p4 PROTEIN p5 PROTEIN p12 PROTEIN p6 PROTEIN p2 PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05223 Heterodimer Member Info: Smoothened#PROTEIN#Smoothened#P00685#Smo#;Fused#PROTEIN#Fused#P00686#Fu#;Cubitus interruptus#PROTEIN#Cubitus interruptus#P00690#Ci|CiFL|Gli1|Gli2|Gli3#;Costal2#PROTEIN#Costal2#P00698#Cos-2|Cos2|Costal-2#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# transmembrane PROTEIN p12 PROTEIN p5 PROTEIN p6 PROTEIN p4 PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05231 Heterodimer Member Info: Cubitus interruptus#PROTEIN#Cubitus interruptus#P00690#Ci|CiFL|Gli1|Gli2|Gli3#;CBP#PROTEIN#CBP#P00691#CREB binding protein|p300# inside PROTEIN p11 PROTEIN p6 Long Name: Long Name: Cubitus interruptus repressor Synonym: Synonym not specified Accession: U05230 Heterodimer Member Info: Cubitus interruptus repressor#PROTEIN#Cubitus interruptus repressor#P00687#CiR#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# inside PROTEIN p20 PROTEIN p12 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05220 Heterodimer Member Info: Cubitus interruptus repressor#PROTEIN#Cubitus interruptus repressor#P00687#CiR#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# inside PROTEIN p20 PROTEIN p12 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05217 Heterodimer Member Info: Cubitus interruptus repressor#PROTEIN#Cubitus interruptus repressor#P00687#CiR#;Sap18#PROTEIN#Sap18#P00697#Sin3-associated polypeptide 18#;Su(fu)#PROTEIN#Su(fu)#P00699#Suppressor of Fused# inside PROTEIN p21 PROTEIN p12 PROTEIN p20 Long Name: Ubiquitin ligase Synonym: Synonym not specified Accession: P00693 inside PROTEIN p19 HETERODIMER_ASSOCIATION s7,s1 s21 0.33333333333333304,0.0 0.666666666666667,-4.440892098500626E-16 0.3333333333333336,0.0 0.6666666666666666,0.0 0.33333333333333326,-4.440892098500626E-16 0.6666666666666665,-8.881784197001252E-16 0.3333333333333335,0.3333333333333333 a26 a25 a30 TRANSPORT s21 s22 0.33333333333333337,0.0 0.6666666666666669,0.0 a30 a31 STATE_TRANSITION s22 s27 0.33333333333333326,0.0 0.6666666666666665,0.0 a31 a36 TRANSPORT s69 s46 0.3333333333333335,0.0 0.6666666666666661,1.1102230246251565E-16 a95 a55 STATE_TRANSITION s46 s48 0.3333333333333335,-2.4424906541753444E-15 0.666666666666667,-5.10702591327572E-15 a55 a12 a57 a13 DISSOCIATION s84 s68,s88 0.33333333333333304,0.0 0.6666666666666667,0.0 0.33333333333333215,8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 0.33333333333333304,-4.440892098500626E-16 0.6666666666666667,-4.440892098500626E-16 0.33333333333333215,0.3333333333333339 a115 a94 a123 DISSOCIATION s88 s89,s69 0.3333333333333339,-4.440892098500626E-16 0.6666666666666661,0.0 0.3333333333333339,-8.881784197001252E-16 0.6666666666666661,0.0 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.3333333333333335,0.33333333333333326 a123 a124 a95 TRANSPORT s89 s70 0.3333333333333339,-2.220446049250313E-16 0.666666666666667,-4.440892098500626E-16 a124 a46 STATE_TRANSITION s89 s102 0.33333333333333215,4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 a149 a153 a150 a154 STATE_TRANSITION s102 s103 0.33333333333333304,0.0 0.666666666666667,-8.881784197001252E-16 a150 a157 a155 a151 a158 a156 HETERODIMER_ASSOCIATION s105,s103 s113 0.33333333333333304,0.0 0.6666666666666665,0.0 0.3333333333333304,0.0 0.6666666666666643,0.0 0.33333333333333215,0.0 0.6666666666666643,-1.7763568394002505E-15 0.33333333333333215,0.3333333333333357 a159 a151 a175 STATE_TRANSITION s113 s118 0.3333333333333339,8.881784197001252E-16 0.6666666666666679,8.881784197001252E-16 a175 a184 a183 STATE_TRANSITION s118 s127 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-8.881784197001252E-16 a183 a199 TRANSPORT s127 s128 0.3333333333333335,0.0 0.666666666666667,0.0 a199 a200 STATE_TRANSITION s130 s131 0.3333333333333339,0.0 0.6666666666666661,0.0 a202 a203 INHIBITION s21 s107 0.33333333333333315,5.551115123125783E-17 0.6666666666666667,1.6653345369377348E-16 a30 a161 STATE_TRANSITION s84 s89 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,-4.440892098500626E-16 a115 a149 HETERODIMER_ASSOCIATION s135,s128 s140 0.3333333333333339,0.0 0.6666666666666661,-1.7763568394002505E-15 0.33333333333333215,3.552713678800501E-15 0.6666666666666679,0.0 0.33333333333333215,0.0 0.6666666666666661,1.7763568394002505E-15 0.33333333333333215,0.3333333333333348 a215 a200 a222 TRANSCRIPTIONAL_INHIBITION s140 s75 0.3333333333333357,0.0 0.6666666666666679,0.0 a222 a102 STATE_TRANSITION s70 s70 0.33333333333333215,-4.440892098500626E-16 0.6666666666666679,4.440892098500626E-16 a46 a223 HETERODIMER_ASSOCIATION s70,s71 s143 0.3333333333333326,0.0 0.6666666666666665,0.0 0.3333333333333357,3.552713678800501E-15 0.6666666666666679,1.7763568394002505E-15 0.3333333333333339,8.881784197001252E-16 0.6666666666666679,0.0 0.3333333333333357,0.33333333333333215 a223 a96 a227 TRANSCRIPTIONAL_ACTIVATION s143 s75 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666643,-1.7763568394002505E-15 a227 a102 TRANSPORT s89 s130 0.3333333333333337,0.0 0.666666666666667,2.220446049250313E-16 a149 a202