2.2 SQUARE_CLOSEUP_NORTH SQUARE_CLOSEUP_NORTHEAST OVAL OVAL inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive active inactive active inactive active inactive active inactive active inactive inactive inactive inactive inactive inactive active inactive active inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Synapse of striatal medium spiny neuron Nucleus Mitochondrion Endocytosed vesicle Long Name: Huntingtin Synonym: Synonym not specified Accession: P00766 inside PROTEIN p1 Long Name: Brain-derived neurotrophic factor Synonym: Synonym not specified Accession: P00795 inside PROTEIN p4 Long Name: Caspase 3 Synonym: Synonym not specified Accession: P00812 inside PROTEIN p3 Long Name: Kainate receptor Synonym: Synonym not specified Accession: P00796 transmembrane PROTEIN p10 Long Name: N-methyl-d-aspartate receptor Synonym: Synonym not specified Accession: P00778 transmembrane PROTEIN p11 Long Name: Long Name: Ca2+ Synonym: Synonym not specified Accession: U05300 inside ION Ca_super_2+_endsuper Long Name: Long Name: Ca2+ Synonym: Synonym not specified Accession: U05300 inside ION Ca_super_2+_endsuper Long Name: Mitogen activated protein kinase kinase 4 Synonym: MEK4,MKK4 Accession: P00787 inside PROTEIN p13 Long Name: Mitogen activated protein kinase kinase 7 Synonym: MKK7 Accession: P00784 inside PROTEIN p14 Long Name: Stress signalling kinase 1 Synonym: Synonym not specified Accession: P00792 inside PROTEIN p15 Long Name: c-Jun N-terminal kinase 2 Synonym: Synonym not specified Accession: P00799 inside PROTEIN p16 Long Name: c-Jun Synonym: Synonym not specified Accession: P00776 inside PROTEIN p17 Long Name: c-Jun Synonym: Synonym not specified Accession: P00776 inside PROTEIN p17 Long Name: Truncated Htt Synonym: Synonym not specified Accession: P00761 inside PROTEIN p19 Long Name: Disease-associated mutant huntingtin containing polyglutamine expansion Synonym: Synonym not specified Accession: P00800 inside PROTEIN p2 Long Name: Disease-associated mutant huntingtin containing polyglutamine expansion Synonym: Synonym not specified Accession: P00800 inside PROTEIN p2 8 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05292 Heterodimer Member Info: Htt#PROTEIN#Huntingtin#P00766##;PolyQ Htt#PROTEIN#Disease-associated mutant huntingtin containing polyglutamine expansion#P00800## inside PROTEIN p1 PROTEIN p2 8 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05296 Heterodimer Member Info: PSD-95#PROTEIN#Postsynaptic density 95#P00789##;PolyQ Htt#PROTEIN#Disease-associated mutant huntingtin containing polyglutamine expansion#P00800## inside PROTEIN p7 PROTEIN p2 Long Name: Disease-associated mutant huntingtin containing polyglutamine expansion Synonym: Synonym not specified Accession: P00800 inside PROTEIN p2 Long Name: Thymoma Viral Proto-Oncogene 1 Synonym: PKB,PKB/Akt,Pkb alpha Accession: P00805 inside PROTEIN p20 Long Name: Protein fragment Synonym: Synonym not specified Accession: P00791 inside PROTEIN p22 Long Name: Caspase 6 Synonym: Synonym not specified Accession: P00809 inside PROTEIN p23 Long Name: Calpain Synonym: Synonym not specified Accession: P00788 inside PROTEIN p24 Long Name: Iron Synonym: Synonym not specified Accession: U02360 inside ION Iron Long Name: Mixed lineage kinase 2 Synonym: MAPKKK10 Accession: P00764 inside PROTEIN p12 Long Name: Mixed lineage kinase 2 Synonym: MAPKKK10 Accession: P00764 inside PROTEIN p12 Long Name: Long Name: Ca2+ Synonym: Synonym not specified Accession: U05300 inside ION Ca_super_2+_endsuper Long Name: Cytochrome c Synonym: Synonym not specified Accession: P00785 inside PROTEIN p25 Long Name: Cytochrome c Synonym: Synonym not specified Accession: P00785 inside PROTEIN p25 Long Name: Apoptotic protease activating factor-1 Synonym: Synonym not specified Accession: P00768 inside PROTEIN p26 Long Name: Oxidative stress Synonym: Synonym not specified Accession: U02357 inside PHENOTYPE Oxidative_br_stress Long Name: Disease-associated mutant huntingtin containing polyglutamine expansion Synonym: Synonym not specified Accession: P00800 outerSurface PROTEIN p2 Long Name: Gene transcription Synonym: Synonym not specified Accession: U02352 inside PHENOTYPE Gene_br_transcription Long Name: Disease-associated mutant huntingtin containing polyglutamine expansion Synonym: Synonym not specified Accession: P00800 inside PROTEIN p2 Long Name: CREB binding protein Synonym: Synonym not specified Accession: P00777 inside PROTEIN p28 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05284 Heterodimer Member Info: CBP#PROTEIN#CREB binding protein#P00777##;PolyQ Htt#PROTEIN#Disease-associated mutant huntingtin containing polyglutamine expansion#P00800## inside PROTEIN p28 PROTEIN p2 Long Name: Disease-associated mutant huntingtin containing polyglutamine expansion Synonym: Synonym not specified Accession: P00800 inside PROTEIN p2 8 Long Name: P53 tumor suppressor phosphoprotein Synonym: TP53 Accession: P00797 inside PROTEIN p29 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05285 Heterodimer Member Info: Htt#PROTEIN#Huntingtin#P00766##;TBP#PROTEIN#Tata binding protein#P00779##;Sp1#PROTEIN#Sp1#P00803##;TAFII130#PROTEIN#TAFII130#P00806## inside PROTEIN p34 PROTEIN p1 PROTEIN p35 PROTEIN p36 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05282 Heterodimer Member Info: Htt#PROTEIN#Huntingtin#P00766##;N-CoR#PROTEIN#Nuclear receptor co-repressor#P00770##;Sin3A#PROTEIN#Sin3A#P00771## inside PROTEIN p37 PROTEIN p1 PROTEIN p38 Long Name: Truncated Htt Synonym: Synonym not specified Accession: P00761 inside PROTEIN p19 8 Long Name: Membrane depolarization Synonym: Synonym not specified Accession: U02354 inside PHENOTYPE Membrane_br_depolarization Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05290 Heterodimer Member Info: PolyQ Htt#PROTEIN#Disease-associated mutant huntingtin containing polyglutamine expansion#P00800##;GAPDH#PROTEIN#Glyceraldehyde-3-phosphate dehydrogenase#P00810#G3PD# inside PROTEIN p2 PROTEIN p40 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05283 Heterodimer Member Info: PolyQ Htt#PROTEIN#Disease-associated mutant huntingtin containing polyglutamine expansion#P00800##;GAPDH#PROTEIN#Glyceraldehyde-3-phosphate dehydrogenase#P00810#G3PD# inside PROTEIN p2 PROTEIN p40 Long Name: Glyceraldehyde-3-phosphate dehydrogenase Synonym: G3PD Accession: P00810 inside PROTEIN p40 Long Name: Glyceraldehyde-3-phosphate dehydrogenase Synonym: G3PD Accession: P00810 inside PROTEIN p40 Long Name: Apoptosis Synonym: Synonym not specified Accession: U02353 inside PHENOTYPE Apoptosis Long Name: Huntington interacting protein-1 Synonym: Synonym not specified Accession: P00765 inside PROTEIN p43 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05295 Heterodimer Member Info: Hip-1#PROTEIN#Huntington interacting protein-1#P00765##;Htt#PROTEIN#Huntingtin#P00766## inside PROTEIN p1 PROTEIN p43 Long Name: Hip1 protein interactor Synonym: Synonym not specified Accession: P00794 inside PROTEIN p44 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05297 Heterodimer Member Info: Hip-1#PROTEIN#Huntington interacting protein-1#P00765##;Hippi#PROTEIN#Hip1 protein interactor#P00794## inside PROTEIN p43 PROTEIN p44 Long Name: Pro-caspase 8 Synonym: Synonym not specified Accession: P00767 inside PROTEIN p45 Long Name: Caspase 8 Synonym: Synonym not specified Accession: P00808 inside PROTEIN p46 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05286 Heterodimer Member Info: HAP1#PROTEIN#Huntingtin's associated protein#P00762##;Htt#PROTEIN#Huntingtin#P00766##;Dynein complex#PROTEIN#Dynein complex#P00774##;Microtubule#PROTEIN#Microtubule#P00780##;Dynactin#PROTEIN#Dynactin#P00781## outerSurface PROTEIN p49 PROTEIN p50 PROTEIN p51 PROTEIN p48 PROTEIN p1 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05291 Heterodimer Member Info: Htt#PROTEIN#Huntingtin#P00766##;N-Wasp#PROTEIN#neural Wiskott-Aldrich syndrome protein #P00769##;PACSIN-1#PROTEIN#Protein kinase C and casein kinase substrate in neurons 1#P00802##;Synaptojanin#PROTEIN#Synaptojanin#P00804##;SH3GL3#PROTEIN#Src homology region 3-containing Grb2-like protein 3#P00813## outerSurface PROTEIN p1 PROTEIN p58 PROTEIN p56 PROTEIN p55 PROTEIN p57 Long Name: Actin-related protein 2 and 3 complex Synonym: Synonym not specified Accession: P00811 inside PROTEIN p59 Long Name: Actin Synonym: F-actin Accession: P00807 inside PROTEIN p60 Long Name: Actin Synonym: F-actin Accession: P00807 inside PROTEIN p60 8 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05289 Heterodimer Member Info: Hip-12#PROTEIN#Huntingtin interacting protein 12#P00763##;Hip-1#PROTEIN#Huntington interacting protein-1#P00765## inside PROTEIN p52 PROTEIN p43 Long Name: Clathrin Synonym: Synonym not specified Accession: P00798 inside PROTEIN p53 Long Name: alpha-Adaptin Synonym: Synonym not specified Accession: P00782 inside PROTEIN p54 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05293 Heterodimer Member Info: Hip-12#PROTEIN#Huntingtin interacting protein 12#P00763##;Hip-1#PROTEIN#Huntington interacting protein-1#P00765##;Htt#PROTEIN#Huntingtin#P00766##;alpha-Adaptin#PROTEIN#alpha-Adaptin#P00782##;Clathrin#PROTEIN#Clathrin#P00798##;Actin#PROTEIN#Actin#P00807#F-actin# inside PROTEIN p52 PROTEIN p43 PROTEIN p53 PROTEIN p54 PROTEIN p1 PROTEIN p60 8 Long Name: beta-Tubulin Synonym: Synonym not specified Accession: P00790 inside PROTEIN p61 Long Name: beta-Tubulin Synonym: Synonym not specified Accession: P00790 inside PROTEIN p61 2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05299 Heterodimer Member Info: Htt#PROTEIN#Huntingtin#P00766##;FIP-2#PROTEIN#FIP-2#P00772##;Rab8#PROTEIN#Rab8#P00783## inside PROTEIN p62 PROTEIN p63 PROTEIN p1 Long Name: GDP Synonym: Synonym not specified Accession: U02358 inside ION GDP Long Name: GTP Synonym: Synonym not specified Accession: U02356 inside ION GTP Long Name: Long Name: Rho family, small GTP binding protein Synonym: Synonym not specified Accession: U05288 Heterodimer Member Info: Rac#PROTEIN#Rac#P00775##;GDP#ION#GDP#U02358## inside PROTEIN p68 ION GDP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05294 Heterodimer Member Info: Rac#PROTEIN#Rac#P00775##;GTP#ION#GTP#U02356## inside PROTEIN p68 ION GTP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05281 Heterodimer Member Info: HAP1#PROTEIN#Huntingtin's associated protein#P00762##;Htt#PROTEIN#Huntingtin#P00766##;Duo#PROTEIN#Huntingtin-associated protein interacting protein#P00773#Kalirin#;NMDA receptor#PROTEIN#N-methyl-d-aspartate receptor#P00778##;PSD-95#PROTEIN#Postsynaptic density 95#P00789##;Kainate receptor#PROTEIN#Kainate receptor#P00796## transmembrane PROTEIN p11 PROTEIN p7 PROTEIN p10 PROTEIN p1 PROTEIN p48 PROTEIN p69 Long Name: Huntingtin-associated protein interacting protein Synonym: Kalirin Accession: P00773 inside PROTEIN p69 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05298 Heterodimer Member Info: HAP1#PROTEIN#Huntingtin's associated protein#P00762##;Htt#PROTEIN#Huntingtin#P00766## inside PROTEIN p1 PROTEIN p48 Long Name: Fos protein Synonym: c-fos Accession: P00801 inside PROTEIN p27 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05280 Heterodimer Member Info: c-Jun#PROTEIN#c-Jun#P00776##;Fos protein#PROTEIN#Fos protein#P00801#c-fos# inside PROTEIN p27 PROTEIN p17 Long Name: Retrograde transport Synonym: Synonym not specified Accession: U02359 inside PHENOTYPE Retrograde_br_transport Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05287 Heterodimer Member Info: ARF#PROTEIN#ADP-ribosylation factor#P00786##;Arfaptin-2#PROTEIN#Arfaptin-2#P00793#POR1# inside PROTEIN p41 PROTEIN p42 Long Name: Brain-derived neurotrophic factor Synonym: Synonym not specified Accession: G01531 inside GENE BDNF Long Name: Proline oxidase Synonym: Synonym not specified Accession: G01529 inside GENE Proline_br_oxidase Long Name: Bcl-2-binding component 3 Synonym: Synonym not specified Accession: G01534 inside GENE PUMA Long Name: Tumor protein p53 inducible protein 3 Synonym: Synonym not specified Accession: G01535 inside GENE PIG3 Long Name: Bcl-2-associated X protein Synonym: Synonym not specified Accession: G01533 inside GENE Bax Long Name: Polyglutamine expanded mutant huntingtin Synonym: Synonym not specified Accession: G01532 inside GENE PolyQ HTT Long Name: Huntingtin Synonym: Synonym not specified Accession: G01530 inside GENE HTT STATE_TRANSITION s8 s8 0.33333333333333304,0.0 0.666666666666667,8.881784197001252E-16 a3 a4 STATE_TRANSITION s2 s5 0.33333333333333215,8.881784197001252E-16 0.6666666666666652,8.881784197001252E-16 a2 a6 HETERODIMER_ASSOCIATION s1,s5 s6 0.3333333333333339,0.0 0.6666666666666661,-4.440892098500626E-16 0.33333333333333304,0.0 0.666666666666667,8.881784197001252E-16 0.33333333333333304,0.0 0.666666666666667,0.0 0.33333333333333326,0.33333333333333304 a1 a6 a9 INHIBITION s1 s4 0.3333333333333335,0.0 0.6666666666666674,8.881784197001252E-16 a1 a5 TRANSPORT s19 s22 0.33333333333333326,0.0 0.6666666666666667,0.0 a27 a30 TRANSPORT s19 s22 0.33333333333333326,0.0 0.6666666666666667,2.220446049250313E-16 a29 a28 STATE_TRANSITION s23 s23 0.33333333333333326,0.0 0.6666666666666667,4.440892098500626E-16 a31 a32 STATE_TRANSITION s24 s24 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,-1.3322676295501878E-15 a33 a34 STATE_TRANSITION s25 s25 0.3333333333333335,-4.440892098500626E-16 0.6666666666666674,4.440892098500626E-16 a35 a36 STATE_TRANSITION s26 s26 0.3333333333333339,2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 a37 a38 STATE_TRANSITION s27 s27 0.3333333333333335,-8.881784197001252E-16 0.6666666666666669,-1.3322676295501878E-15 a39 a40 STATE_TRANSITION s28 s29 0.33333333333333337,2.6645352591003757E-15 0.6666666666666669,3.552713678800501E-15 a41 a42 STATE_TRANSITION s2 s32 0.33333333333333215,0.0 0.6666666666666661,8.881784197001252E-16 a2 a45 TRUNCATION s1 s31,s35 0.3333333333333339,8.881784197001252E-16 0.666666666666667,0.0 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.3333333333333326,0.0 0.6666666666666665,1.7763568394002505E-15 0.3333333333333339,0.3333333333333339 a1 a44 a48 STATE_TRANSITION s37 s37 0.3333333333333339,0.0 0.6666666666666679,-4.440892098500626E-16 a50 a51 STATE_TRANSITION s23 s39 0.33333333333333326,-2.220446049250313E-16 0.6666666666666667,-2.220446049250313E-16 a32 a53 TRANSPORT s40 s22 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 a54 a55 TRANSPORT s41 s42 0.3333333333333348,0.0 0.6666666666666679,8.881784197001252E-16 a56 a57 STATE_TRANSITION s43 s43 0.3333333333333339,-8.881784197001252E-16 0.6666666666666661,-1.7763568394002505E-15 a58 a59 HETERODIMER_ASSOCIATION s49,s29 s50 0.33333333333333304,1.7763568394002505E-15 0.6666666666666661,0.0 0.3333333333333339,0.0 0.6666666666666661,0.0 0.3333333333333304,6.661338147750939E-16 0.6666666666666661,2.220446049250313E-16 0.33333333333333215,0.33333333333333304 a64 a42 a67 HETERODIMER_ASSOCIATION s52,s51 s53 0.3333333333333339,0.0 0.6666666666666661,0.0 0.3333333333333339,1.7763568394002505E-15 0.6666666666666661,1.7763568394002505E-15 0.33333333333333304,1.7763568394002505E-15 0.666666666666667,0.0 0.33333333333333304,0.33333333333333337 a69 a68 a72 STATE_TRANSITION s51 s54 0.33333333333333326,1.7763568394002505E-15 0.6666666666666665,3.552713678800501E-15 a68 a73 STATE_TRANSITION s55 s55 0.3333333333333335,0.0 0.6666666666666665,-1.7763568394002505E-15 a74 a75 TRANSCRIPTIONAL_ACTIVATION s55 s58 0.3333333333333335,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 a75 a78 TRANSCRIPTIONAL_ACTIVATION s55 s57 0.3333333333333336,1.7763568394002505E-15 0.6666666666666666,1.7763568394002505E-15 a75 a77 TRANSCRIPTIONAL_ACTIVATION s55 s59 0.33333333333333304,0.0 0.6666666666666652,0.0 a75 a79 TRANSCRIPTIONAL_ACTIVATION s55 s56 0.33333333333333215,5.551115123125783E-17 0.6666666666666661,-1.6653345369377348E-16 a75 a76 STATE_TRANSITION s31 s76 0.3333333333333357,8.881784197001252E-16 0.6666666666666661,1.7763568394002505E-15 a44 a102 STATE_TRANSITION s46 s87 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666661,0.0 a61 a113 TRANSPORT s94 s95 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-2.220446049250313E-16 a120 a121 DISSOCIATION s95 s97,s51 0.33333333333333215,1.7763568394002505E-15 0.6666666666666661,1.7763568394002505E-15 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666665,-1.7763568394002505E-15 0.33333333333333215,-8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16 0.33333333333333326,0.3333333333333339 a121 a124 a68 HETERODIMER_ASSOCIATION s47,s98 s94 0.3333333333333337,8.881784197001252E-16 0.6666666666666672,8.881784197001252E-16 0.3333333333333339,0.0 0.6666666666666661,-8.881784197001252E-16 0.33333333333333304,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 0.33333333333333215,0.3333333333333339 a62 a125 a120 HETERODIMER_ASSOCIATION s105,s102 s106 0.3333333333333339,0.0 0.666666666666667,0.0 0.3333333333333339,0.0 0.6666666666666696,0.0 0.3333333333333357,-3.552713678800501E-15 0.6666666666666679,-3.552713678800501E-15 0.3333333333333339,0.3333333333333339 a136 a134 a139 TRUNCATION s107 s108,s35 0.33333333333333215,8.881784197001252E-16 0.6666666666666679,2.6645352591003757E-15 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666661,-1.7763568394002505E-15 0.33333333333333215,0.0 0.6666666666666661,0.0 0.33333333333333304,0.3333333333333357 a140 a141 a142 KNOWN_TRANSITION_OMITTED s108 s4 0.3333333333333326,0.0 0.6666666666666665,8.881784197001252E-16 a141 a5 KNOWN_TRANSITION_OMITTED s43 s4 0.3333333333333335,0.0 0.666666666666667,0.0 a59 a5 KNOWN_TRANSITION_OMITTED s7 s4 0.33333333333333215,8.326672684688674E-17 0.6666666666666661,8.326672684688674E-17 a10 a5 KNOWN_TRANSITION_OMITTED s39 s4 0.33333333333333315,1.1102230246251565E-16 0.6666666666666664,2.220446049250313E-16 a53 a5 KNOWN_TRANSITION_OMITTED s8 s4 0.33333333333333304,-2.220446049250313E-16 0.6666666666666665,0.0 a4 a5 STATE_TRANSITION s137 s137 0.33333333333333304,1.3322676295501878E-15 0.6666666666666661,2.220446049250313E-15 a174 a175 STATE_TRANSITION s138 s139 0.3333333333333357,0.0 0.6666666666666679,4.440892098500626E-16 a176 a177 KNOWN_TRANSITION_OMITTED s47 s46 0.3333333333333339,-8.881784197001252E-16 0.6666666666666679,0.0 a62 a61 STATE_TRANSITION s167 s168 0.33333333333333215,8.881784197001252E-16 0.6666666666666643,8.881784197001252E-16 a224 a225 STATE_TRANSITION s186 s187 0.33333333333333304,-2.220446049250313E-16 0.666666666666667,-6.661338147750939E-16 a258 a257 a259 a254 HETERODIMER_ASSOCIATION s215,s2 s14 0.3333333333333335,2.220446049250313E-16 0.7781599016282694,0.07681891060715529 0.3333333333333339,-4.440892098500626E-16 -0.10816266745112557,0.01668368160168221 0.33333333333333215,0.0 0.6666666666666661,0.0 0.8961294540462319,0.05367212625626916 a295 a21 a22 DISSOCIATION s215 s224,s14 0.33333333333333304,0.0 0.6666666666666661,8.881784197001252E-16 0.33333333333333215,0.0 0.6666666666666679,-8.881784197001252E-16 0.3333333333333331,8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16 0.33333333333333215,0.3333333333333337 a295 a307 a22 a308 a25 a26 HETERODIMER_ASSOCIATION s102,s1 s104 0.3333333333333357,0.0 0.6666666666666679,0.0 0.33333333333333237,0.0 0.6666666666666667,-1.7763568394002505E-15 0.33333333333333304,0.0 0.666666666666667,0.0 0.3333333333333339,0.33333333333333215 a134 a1 a135 HETERODIMER_ASSOCIATION s139,s123 s166 0.3333333333333339,0.0 0.6666666666666661,1.7763568394002505E-15 0.3333333333333357,0.0 0.6666666666666679,0.0 0.33333333333333437,1.7763568394002505E-15 0.6666666666666665,1.7763568394002505E-15 0.33333333333333304,0.3333333333333335 a177 a218 a217 a216 a201 a223 STATE_TRANSITION s121 s226 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666679,-1.7763568394002505E-15 a155 a309 TRANSCRIPTIONAL_ACTIVATION s50 s48 0.3333333333333335,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 a67 a63 TRANSCRIPTIONAL_INHIBITION s75 s48 0.33333333333333304,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 a101 a63 TRANSCRIPTIONAL_ACTIVATION s70 s48 0.3333333333333339,0.0 0.666666666666667,0.0 a96 a63 TRANSCRIPTIONAL_ACTIVATION s52 s48 0.3333333333333339,0.0 0.6666666666666679,-4.440892098500626E-16 a69 a63 TRANSCRIPTIONAL_ACTIVATION s1 s230 0.3333333333333348,-1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 a1 a313 UNKNOWN_TRANSITION s230 s7 0.33333333333333215,-8.881784197001252E-16 0.6666666666666679,8.881784197001252E-16 a313 a10 TRANSCRIPTIONAL_ACTIVATION s38 s231 0.33333333333333304,0.0 0.6666666666666661,0.0 a52 a314 TRANSCRIPTIONAL_ACTIVATION s38 s232 0.3333333333333357,0.0 0.6666666666666679,0.0 a52 a315 UNKNOWN_TRANSITION s232 s2 0.3333333333333357,0.0 0.6666666666666661,0.0 a315 a2 UNKNOWN_TRANSITION s231 s1 0.3333333333333339,4.440892098500626E-16 0.6666666666666679,-4.440892098500626E-16 a314 a1