2.2 SQUARE_CLOSEUP_NORTH SQUARE inactive active inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive active active inactive inactive active inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive cytosol nucleus Long Name: p38 MAP Kinase Synonym: CSBP1,EXIP,MAPK14,Mxi2,RK,SAPK2A Accession: P01135 inside PROTEIN p3 Long Name: jun sarcoma virus 17 oncogene homolog Synonym: Synonym not specified Accession: P01132 inside PROTEIN p4 Long Name: jun sarcoma virus 17 oncogene homolog Synonym: Synonym not specified Accession: P01132 inside PROTEIN p4 Long Name: Cell Survival Synonym: Synonym not specified Accession: U02518 inside PHENOTYPE Cell_br_Survival Long Name: Cell Death Synonym: Synonym not specified Accession: U02517 inside PHENOTYPE Cell_br_Death Long Name: apoptosis signal regulating kinase 1 Synonym: MAP/ERK KINASE KINASE 5,MAPKKK5,MEKK5 Accession: P01139 inside PROTEIN p8 Long Name: thioredoxin Synonym: Synonym not specified Accession: P01122 inside PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05439 Heterodimer Member Info: TRX#PROTEIN#thioredoxin#P01122##;ASK-1#PROTEIN#apoptosis signal regulating kinase 1#P01139#MAP/ERK KINASE KINASE 5|MAPKKK5|MEKK5# inside PROTEIN p7 PROTEIN p8 Long Name: MKK4 Synonym: JNKK,MAPKK4,MEK4,PRKMK4,SEK1 Accession: P01138 inside PROTEIN p9 Long Name: MKK4 Synonym: JNKK,MAPKK4,MEK4,PRKMK4,SEK1 Accession: P01138 inside PROTEIN p9 Long Name: Map Kinase Kinase 3 and Map Kinase Kinase 6 Synonym: MAPK/ERK KINASE 3,MAPK/ERK kinase 6,MAPKK3,MAPKK6,MEK3,MEK6,PRKMK3,PRKMK6,PROTEIN KINASE MITOGEN-ACTIVATED KINASE 3 Accession: P01121 inside PROTEIN p10 Long Name: Map Kinase Kinase 3 and Map Kinase Kinase 6 Synonym: MAPK/ERK KINASE 3,MAPK/ERK kinase 6,MAPKK3,MAPKK6,MEK3,MEK6,PRKMK3,PRKMK6,PROTEIN KINASE MITOGEN-ACTIVATED KINASE 3 Accession: P01121 inside PROTEIN p10 Long Name: p38 MAP Kinase Synonym: CSBP1,EXIP,MAPK14,Mxi2,RK,SAPK2A Accession: P01135 inside PROTEIN p3 Long Name: elongation factor 2 kinase Synonym: Calmodulin-dependent protein kinase III Accession: P01127 inside PROTEIN p11 Long Name: Translation Synonym: Synonym not specified Accession: U02516 inside PHENOTYPE Translation Long Name: p38 MAP Kinase Synonym: CSBP1,EXIP,MAPK14,Mxi2,RK,SAPK2A Accession: P01135 inside PROTEIN p3 Long Name: ELK-1 protein Synonym: ELK1 member of ETS oncogene family Accession: P01136 inside PROTEIN p15 Long Name: ELK-1 protein Synonym: ELK1 member of ETS oncogene family Accession: P01136 inside PROTEIN p15 Long Name: Activating Transcription Factor 2 Synonym: CRE-BP1,TREB7,cAMP responsive element binding protein 2 Accession: P01126 inside PROTEIN p16 Long Name: Activating Transcription Factor 2 Synonym: CRE-BP1,TREB7,cAMP responsive element binding protein 2 Accession: P01126 inside PROTEIN p16 Long Name: ATP Synonym: Synonym not specified Accession: S01797 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01798 inside SIMPLE_MOLECULE ADP Long Name: MAPK-interacting kinases 1/2 Synonym: GPRK7,MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1,MKNK1,MKNK2,MNK1,MNK2 Accession: P01137 inside PROTEIN p12 Long Name: MAPK-interacting kinases 1/2 Synonym: GPRK7,MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1,MKNK1,MKNK2,MNK1,MNK2 Accession: P01137 inside PROTEIN p12 Long Name: MAP Kinase Phosphatases Synonym: HePTP,M3/6,MKP-1,MKP-2,MKP-4,MKP-5,MKP-6,PAC-1,PP2A,Wip1 Accession: P01131 inside PROTEIN p14 Long Name: cytosolic phospholipase A2, group IVA Synonym: PLA2G4,cPLA2-alpha Accession: P01134 inside PROTEIN p13 Long Name: cytosolic phospholipase A2, group IVA Synonym: PLA2G4,cPLA2-alpha Accession: P01134 inside PROTEIN p13 Long Name: gene transcription Synonym: Synonym not specified Accession: G01542 inside GENE gene_br_transcription Long Name: ADP Synonym: Synonym not specified Accession: S01798 inside SIMPLE_MOLECULE ADP Long Name: ATP Synonym: Synonym not specified Accession: S01797 inside SIMPLE_MOLECULE ATP Long Name: v-myc myelocytomatosis viral oncogene homolog Synonym: c-myc Accession: P01124 inside PROTEIN p18 Long Name: myc-associated factor X Synonym: Synonym not specified Accession: P01133 inside PROTEIN p17 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05440 Heterodimer Member Info: Myc#PROTEIN#v-myc myelocytomatosis viral oncogene homolog#P01124#c-myc#;Max#PROTEIN#myc-associated factor X#P01133## inside PROTEIN p17 PROTEIN p18 Long Name: reactive oxygen species Synonym: Synonym not specified Accession: U02515 inside UNKNOWN Oxidative Stress_br_ROS, UV Long Name: signal transducer and activator of transcription 1 Synonym: ISGF-3,STAT91 Accession: P01125 inside PROTEIN p19 Long Name: signal transducer and activator of transcription 1 Synonym: ISGF-3,STAT91 Accession: P01125 inside PROTEIN p19 Long Name: C/EBP-homologous protein Synonym: CEBPZ,DDIT3,GADD153 Accession: P01130 inside PROTEIN p20 Long Name: C/EBP-homologous protein Synonym: CEBPZ,DDIT3,GADD153 Accession: P01130 inside PROTEIN p20 Long Name: myocyte enhancer factor-2 Synonym: ADCAD1,MADS box transcription enhancer factor 2,MEF2A,MEF2B,MEF2C,MEF2D Accession: P01128 inside PROTEIN p21 Long Name: myocyte enhancer factor-2 Synonym: ADCAD1,MADS box transcription enhancer factor 2,MEF2A,MEF2B,MEF2C,MEF2D Accession: P01128 inside PROTEIN p21 Long Name: c-jun N-terminal kinases 1 and 2 Synonym: JNK1,JNK2,JNK55,MAPK8,MAPK9,SAPK1 Accession: P01129 inside PROTEIN p2 Long Name: c-jun N-terminal kinases 1 and 2 Synonym: JNK1,JNK2,JNK55,MAPK8,MAPK9,SAPK1 Accession: P01129 inside PROTEIN p2 Long Name: c-jun N-terminal kinases 1 and 2 Synonym: JNK1,JNK2,JNK55,MAPK8,MAPK9,SAPK1 Accession: P01129 inside PROTEIN p2 Long Name: b-cell lymphoma protein-2 Synonym: Synonym not specified Accession: P01123 inside PROTEIN p22 Long Name: b-cell lymphoma protein-2 Synonym: Synonym not specified Accession: P01123 inside PROTEIN p22 Long Name: Unknown Synonym: Synonym not specified Accession: U02514 inside UNKNOWN Unknown STATE_TRANSITION s6 s7 0.3333333333333335,-2.6645352591003757E-15 0.666666666666667,-5.773159728050814E-15 a6 a68 a7 a69 KNOWN_TRANSITION_OMITTED s14 s15 0.33333333333333304,0.0 0.666666666666667,0.0 a16 a17 KNOWN_TRANSITION_OMITTED s14 s16 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-8.881784197001252E-16 a16 a18 DISSOCIATION s22 s18,s19 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.33333333333333304,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 0.3333333333333339,0.0 0.6666666666666665,0.0 -0.029098409243653478,0.5050033860410696 a29 a28 a23 STATE_TRANSITION s4 s23 0.33333333333333304,0.0 0.6666666666666661,-2.220446049250313E-16 a30 a60 a4 a66 STATE_TRANSITION s24 s25 0.3333333333333334,0.0 0.6666666666666667,0.0 a31 a61 a32 a67 STATE_TRANSITION s26 s27 0.3333333333333335,-2.220446049250313E-16 0.6666666666666665,-6.661338147750939E-16 a33 a56 a34 a57 STATE_TRANSITION s5 s28 0.3333333333333335,0.0 0.666666666666667,0.0 a5 a59 a35 a65 INHIBITION s28 s29 0.3333333333333333,0.0 0.6666666666666665,0.0 a35 a36 STATE_TRANSITION s30 s49 0.33333333333333437,0.0 0.666666666666667,0.0 a37 a58 a40 a64 STATE_TRANSITION s31 s50 0.3333333333333334,-8.881784197001252E-16 0.666666666666667,0.0 a42 a62 a38 a63 STATE_TRANSITION s38 s40 0.33333333333333304,4.440892098500626E-16 0.6666666666666661,4.440892098500626E-16 a49 a71 a48 a70 TRANSCRIPTIONAL_ACTIVATION s40 s14 0.33333333333333326,-4.440892098500626E-16 0.6666666666666665,-4.440892098500626E-16 a48 a16 STATE_TRANSITION s41 s43 0.3333333333333339,-4.440892098500626E-16 0.6666666666666679,-8.881784197001252E-16 a50 a72 a51 a73 TRANSCRIPTIONAL_ACTIVATION s43 s14 0.33333333333333304,0.0 0.6666666666666665,-4.440892098500626E-16 a51 a16 HETERODIMER_ASSOCIATION s54,s53 s56 0.3333333333333348,-3.552713678800501E-15 0.666666666666667,-3.552713678800501E-15 0.3333333333333286,1.7763568394002505E-15 0.6666666666666643,0.0 0.3333333333333375,0.0 0.6666666666666679,0.0 0.3333333333333357,0.3333333333333339 a75 a74 a79 a78 a80 TRANSCRIPTIONAL_ACTIVATION s56 s14 0.3333333333333335,-4.440892098500626E-16 0.666666666666667,0.0 a78 a16 STATE_TRANSITION s57 s58 0.3333333333333339,0.0 0.6666666666666661,0.0 a81 a83 a82 a84 TRANSCRIPTIONAL_ACTIVATION s58 s14 0.33333333333333215,4.440892098500626E-16 0.6666666666666679,-4.440892098500626E-16 a82 a16 STATE_TRANSITION s60 s61 0.33333333333333304,3.552713678800501E-15 0.6666666666666661,1.7763568394002505E-15 a86 a89 a87 a88 TRANSCRIPTIONAL_ACTIVATION s61 s14 0.3333333333333335,-4.440892098500626E-16 0.6666666666666667,-4.440892098500626E-16 a87 a16 STATE_TRANSITION s62 s63 0.3333333333333339,0.0 0.6666666666666661,0.0 a90 a93 a91 a92 TRANSCRIPTIONAL_ACTIVATION s63 s14 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,-4.440892098500626E-16 a91 a16 TRANSCRIPTIONAL_ACTIVATION s7 s14 0.33333333333333337,0.0 0.6666666666666667,2.220446049250313E-16 a7 a16 STATE_TRANSITION s67 s68 0.3333333333333326,-2.220446049250313E-16 0.6666666666666665,-4.996003610813204E-16 a97 a99 a98 a100 TRANSPORT s28 s34 0.3333333333333334,-2.220446049250313E-16 0.6666666666666667,-2.220446049250313E-16 a35 a43 TRANSPORT s23 s65 0.33333333333333304,0.0 0.6666666666666665,-4.440892098500626E-16 a4 a45 TRANSLATIONAL_INHIBITION s29 s32 0.3333333333333339,-2.220446049250313E-16 0.666666666666667,-3.3306690738754696E-16 a36 a39 TRANSLATIONAL_ACTIVATION s49 s32 0.33333333333333304,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 a40 a39 KNOWN_TRANSITION_OMITTED s34 s69 0.3333333333333339,8.881784197001252E-16 0.6666666666666661,1.7763568394002505E-15 a43 a101