2.3 OVAL SQUARE_CLOSEUP_NORTHEAST SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive active active inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive active active active inactive inactive inactive active active inactive inactive active inactive active inactive active inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive active active active active inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive active active inactive active inactive inactive inactive inactive inactive active active active inactive active Endoplasmic reticulum Nucleus cytoplasm Long Name: PDGF receptor A Synonym: PDGF receptor/CSF1 receptor family,PDGFR2 Accession: P01158 transmembrane PROTEIN p1 Long Name: PDGF receptor B Synonym: PDGFRB,PDGFR,PDGFR1 Accession: P01156 transmembrane PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05454 Heterodimer Member Info: PDGF receptor B#PROTEIN#PDGF receptor B#P01156# PDGFRB|PDGFR|PDGFR1#;PDGF receptor A#PROTEIN#PDGF receptor A#P01158#PDGF receptor/CSF1 receptor family|PDGFR2# transmembrane PROTEIN p1 PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05453 Heterodimer Member Info: PDGF receptor B#PROTEIN#PDGF receptor B#P01156# PDGFRB|PDGFR|PDGFR1#;PDGF receptor A#PROTEIN#PDGF receptor A#P01158#PDGF receptor/CSF1 receptor family|PDGFR2# transmembrane PROTEIN p1 PROTEIN p2 Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 Long Name: Shc Synonym: Synonym not specified Accession: P01175 inside PROTEIN p18 Long Name: Growth Factor Receptor Binding Protein 2 Synonym: Abundant SRC homology (ASH),Grb2 Accession: P01148 inside PROTEIN p8 Long Name: Son of Sevenless Synonym: SON OF SEVENLESS,SOS Accession: P01159 inside PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05455 Heterodimer Member Info: Grb2#PROTEIN#Growth Factor Receptor Binding Protein 2#P01148#Abundant SRC homology (ASH)|Grb2#;SOS#PROTEIN#Son of Sevenless#P01159#SON OF SEVENLESS|SOS#;Shc#PROTEIN#Shc#P01175## inside PROTEIN p8 PROTEIN p18 PROTEIN p9 Long Name: GTP Synonym: Synonym not specified Accession: S01804 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01806 inside SIMPLE_MOLECULE GDP Long Name: MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1 Synonym: ONCOGENE RAF1 Accession: P01161 inside PROTEIN p12 Long Name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 Synonym: MAPK/ERK KINASE 1,MAPKK1,MKK1,PROTEIN KINASE, MITOGEN-ACTIVATED, KINASE 1 Accession: P01162 inside PROTEIN p13 Long Name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 Synonym: MAPK/ERK KINASE 1,MAPKK1,MKK1,PROTEIN KINASE, MITOGEN-ACTIVATED, KINASE 1 Accession: P01162 inside PROTEIN p13 Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P01143 inside PROTEIN p14 Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P01143 inside PROTEIN p14 Long Name: MNK1/2 Synonym: MAPK-interacting kinase 1/2,MKNK1,MNK2 Accession: P01149 inside PROTEIN p33 Long Name: MNK1/2 Synonym: MAPK-interacting kinase 1/2,MKNK1,MNK2 Accession: P01149 inside PROTEIN p33 Long Name: p90RSK Synonym: RIBOSOMAL PROTEIN S6 KINASE,RPS6KA1,RSK1,p90RSK Accession: P01142 inside PROTEIN p32 Long Name: p90RSK Synonym: RIBOSOMAL PROTEIN S6 KINASE,RPS6KA1,RSK1,p90RSK Accession: P01142 inside PROTEIN p32 Long Name: MAPKAPK2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P01157 inside PROTEIN p34 Long Name: MAPKAPK2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P01157 inside PROTEIN p34 Long Name: PIP3 Synonym: Synonym not specified Accession: S01805 inside SIMPLE_MOLECULE PIP_sub_3_endsub_ Long Name: 3'-Phosphoinositide-dependent protein kinase1/2 Synonym: PDK1,PDPK1 Accession: P01164 inside PROTEIN p16 Long Name: 3'-Phosphoinositide-dependent protein kinase1/2 Synonym: PDK1,PDPK1 Accession: P01164 inside PROTEIN p16 Long Name: cytokine-responsive IkappaB kinase Synonym: IKK,IkappaB kinase Accession: P01146 inside PROTEIN p25 Long Name: cytokine-responsive IkappaB kinase Synonym: IKK,IkappaB kinase Accession: P01146 inside PROTEIN p25 Long Name: PROTEIN KINASE B-BETA Synonym: AKT2,PKB,V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 2 Accession: P01151 inside PROTEIN p10 Long Name: PROTEIN KINASE B-BETA Synonym: AKT2,PKB,V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 2 Accession: P01151 inside PROTEIN p10 Long Name: C-terminal modulator protein Synonym: CTMP Accession: P01166 inside PROTEIN p29 Long Name: Phospholipase C, gamma Synonym: PLCG,PLCGamma,Phospholipase C-148 Accession: P01171 inside PROTEIN p3 Long Name: Phospholipase C, gamma Synonym: PLCG,PLCGamma,Phospholipase C-148 Accession: P01171 inside PROTEIN p3 Long Name: Inositol 1,4,5-triphosphate Synonym: Synonym not specified Accession: S01802 inside SIMPLE_MOLECULE IP_sub_3_endsub_ Long Name: Diacylglycerol Synonym: Synonym not specified Accession: S01800 inside SIMPLE_MOLECULE DAG Long Name: Ca2+ Synonym: Synonym not specified Accession: U02524 inside ION Ca_super_2+_endsuper_ Long Name: Ca2+ Synonym: Synonym not specified Accession: U02524 inside ION Ca_super_2+_endsuper_ Long Name: c-fos Synonym: Cellular oncogene fos,Proto-oncogene protein c-fos Accession: P01145 inside PROTEIN p35 Long Name: c-fos Synonym: Cellular oncogene fos,Proto-oncogene protein c-fos Accession: P01145 inside PROTEIN p35 Long Name: ELK Synonym: MEMBER OF ETS ONCOGENE FAMILY Accession: P01140 inside PROTEIN p15 Long Name: SRF Synonym: C-FOS SERUM RESPONSE ELEMENT-BINDING FACTOR,SERUM RESPONSE FACTOR Accession: P01165 inside PROTEIN p36 Long Name: c-Myc Synonym: Synonym not specified Accession: P01172 inside PROTEIN p30 Long Name: SRF Synonym: C-FOS SERUM RESPONSE ELEMENT-BINDING FACTOR,SERUM RESPONSE FACTOR Accession: P01165 inside PROTEIN p36 Long Name: Ets Synonym: Ets transcription factors Accession: P01167 inside PROTEIN p31 Long Name: c-Myc Synonym: Synonym not specified Accession: P01172 inside PROTEIN p30 Long Name: Ets Synonym: Ets transcription factors Accession: P01167 inside PROTEIN p31 Long Name: ELK Synonym: MEMBER OF ETS ONCOGENE FAMILY Accession: P01140 inside PROTEIN p15 Long Name: Gene transcription Synonym: Synonym not specified Accession: U02523 inside PHENOTYPE Gene transcription Long Name: c-Jun Synonym: Synonym not specified Accession: P01163 inside PROTEIN p37 Long Name: c-Jun Synonym: Synonym not specified Accession: P01163 inside PROTEIN p37 Long Name: ATP Synonym: Synonym not specified Accession: S01801 inside SIMPLE_MOLECULE ATP Long Name: MAPKAPK2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P01157 inside PROTEIN p34 Long Name: p90RSK Synonym: RIBOSOMAL PROTEIN S6 KINASE,RPS6KA1,RSK1,p90RSK Accession: P01142 inside PROTEIN p32 Long Name: ADP Synonym: Synonym not specified Accession: S01803 inside SIMPLE_MOLECULE ADP Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P01143 inside PROTEIN p14 Long Name: GSK3 Synonym: GLYCOGEN SYNTHASE KINASE 3 Accession: P01153 inside PROTEIN p17 Long Name: GSK3 Synonym: GLYCOGEN SYNTHASE KINASE 3 Accession: P01153 inside PROTEIN p17 Long Name: BAD Synonym: BCL2 ANTAGONIST OF CELL DEATH,BCL2-BINDING PROTEIN,BCL2L8 Accession: P01141 inside PROTEIN p22 Long Name: BAD Synonym: BCL2 ANTAGONIST OF CELL DEATH,BCL2-BINDING PROTEIN,BCL2L8 Accession: P01141 inside PROTEIN p22 Long Name: mTOR Synonym: FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1,FRAP,mTOR Accession: P01144 inside PROTEIN p26 Long Name: mTOR Synonym: FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1,FRAP,mTOR Accession: P01144 inside PROTEIN p26 Long Name: PROTEIN KINASE B-BETA Synonym: AKT2,PKB,V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 2 Accession: P01151 inside PROTEIN p10 Long Name: Ras GTPase Activity Protein Synonym: RasGAP Accession: P01152 inside PROTEIN p19 Long Name: Ras GTPase Activity Protein Synonym: RasGAP Accession: P01152 inside PROTEIN p19 Long Name: ATP Synonym: Synonym not specified Accession: S01801 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01803 inside SIMPLE_MOLECULE ADP Long Name: Jak Synonym: Janus kinase Accession: P01155 inside PROTEIN p4 Long Name: Jak Synonym: Janus kinase Accession: P01155 inside PROTEIN p4 Long Name: Ras Synonym: Synonym not specified Accession: P01154 inside PROTEIN p11 Long Name: PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, ALPHA Synonym: Synonym not specified Accession: P01168 inside PROTEIN p7 Long Name: PIP2 Synonym: Synonym not specified Accession: S01799 inside SIMPLE_MOLECULE PIP_sub_2_endsub_ Long Name: Protein kinase C Synonym: Synonym not specified Accession: P01150 inside PROTEIN p5 Long Name: Nck Synonym: GRB4,MELANOMA NCK PROTEIN,NCK ADAPTOR PROTEIN Accession: P01147 inside PROTEIN p38 Long Name: Nck Synonym: GRB4,MELANOMA NCK PROTEIN,NCK ADAPTOR PROTEIN Accession: P01147 inside PROTEIN p38 Long Name: Vav Synonym: family of guanine nucleotide exchange factors for Rho family GTPases Accession: P01169 inside PROTEIN p40 Long Name: Vav Synonym: family of guanine nucleotide exchange factors for Rho family GTPases Accession: P01169 inside PROTEIN p40 Long Name: GTPase-activating protein Rho Synonym: Rho-GTPase-activating protein,RhoGAP Accession: P01174 inside PROTEIN p41 Long Name: PDGF Synonym: Platelet-derived growth factor Accession: P01170 inside PROTEIN p42 Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 2 Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 2 Long Name: IP3 receptor Synonym: INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR Accession: P01160 transmembrane PROTEIN p44 Long Name: Pi Synonym: Synonym not specified Accession: U02522 inside ION P_sub_i_endsub_ Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 2 STATE_TRANSITION s7 s8 0.33333333333333326,1.3877787807814457E-15 0.6666666666666665,2.831068712794149E-15 a12 a13 STATE_TRANSITION s11 s20 0.33333333333333304,2.220446049250313E-15 0.6666666666666665,3.9968028886505635E-15 a53 a50 a52 a51 a49 STATE_TRANSITION s111 s112 0.3333333333333333,-1.3322676295501878E-15 0.6666666666666665,-2.6645352591003757E-15 a48 a44 a49 a45 a48 a13 STATE_TRANSITION s113 s113 0.33333333333333215,-8.881784197001252E-16 0.666666666666667,-1.7763568394002505E-15 a61 a59 a62 a60 a58 a161 STATE_TRANSITION s22 s22 0.3333333333333339,0.0 0.6666666666666661,0.0 a65 a66 a62 STATE_TRANSITION s23 s26 0.3333333333333339,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 a69 a73 a70 a74 a66 STATE_TRANSITION s24 s27 0.33333333333333304,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 a71 a75 a72 a76 a70 STATE_TRANSITION s113 s113 0.33333333333333304,0.0 0.6666666666666661,0.0 a62 a61 a64 a63 HETERODIMER_ASSOCIATION s10,s12 s50 0.33333333333333304,6.661338147750939E-16 0.666666666666667,0.0 0.3333333333333335,-8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 0.3333333333333335,4.440892098500626E-16 0.666666666666667,0.0 0.33333333333333304,0.3333333333333335 a56 a57 a55 a58 a13 STATE_TRANSITION s81 s83 0.33333333333333304,1.7763568394002505E-15 0.6666666666666665,5.329070518200751E-15 a80 a79 a77 a78 a72 STATE_TRANSITION s80 s84 0.3333333333333326,8.881784197001252E-16 0.6666666666666665,3.552713678800501E-15 a84 a83 a81 a82 a72 STATE_TRANSITION s82 s85 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666665,-3.552713678800501E-15 a88 a87 a85 a86 a72 STATE_TRANSITION s115 s115 0.3333333333333335,8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 a89 a90 a13 STATE_TRANSITION s116 s14 0.33333333333333304,0.0 0.666666666666667,0.0 a91 a92 a90 STATE_TRANSITION s32 s33 0.33333333333333304,4.440892098500626E-16 0.6666666666666652,4.440892098500626E-16 a95 a93 a96 a94 a92 STATE_TRANSITION s15 s34 0.33333333333333304,0.0 0.6666666666666661,0.0 a102 a103 a101 a104 a96 STATE_TRANSITION s57 s64 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666661,0.0 a100 a99 a97 a98 a101 STATE_TRANSITION s34 s15 0.33333333333333304,3.1086244689504383E-15 0.6666666666666661,6.217248937900877E-15 a101 a102 a105 a106 DISSOCIATION s116 s30,s19 0.33333333333333304,3.552713678800501E-15 0.6666666666666661,0.0 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666679,-1.7763568394002505E-15 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666679,0.0 0.3333333333333339,0.3333333333333339 a110 a112 a111 a109 STATE_TRANSITION s16 s18 0.33333333333333337,0.0 0.6666666666666667,1.7763568394002505E-15 a107 a109 a13 STATE_TRANSITION s117 s117 0.33333333333333215,-1.3322676295501878E-15 0.6666666666666679,-2.6645352591003757E-15 a108 a113 a112 TRANSPORT s36 s35 0.3333333333333339,0.0 0.666666666666667,0.0 a115 a114 a176 HETERODIMER_ASSOCIATION s1,s2 s7 0.3333333333333335,2.220446049250313E-16 0.6666666666666667,4.440892098500626E-16 0.33333333333333376,-8.881784197001252E-16 0.6666666666666667,-8.881784197001252E-16 0.33333333333333326,-1.1102230246251565E-16 0.6666666666666665,0.0 0.3333333333333335,0.33333333333333326 a1 a2 a168 a12 STATE_TRANSITION s88 s31 0.33333333333333304,-2.220446049250313E-15 0.6666666666666661,-3.552713678800501E-15 a138 a134 a122 a129 a133 STATE_TRANSITION s76 s86 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-1.7763568394002505E-15 a136 a132 a125 a127 a133 STATE_TRANSITION s77 s87 0.33333333333333304,-5.329070518200751E-15 0.666666666666667,-1.0658141036401503E-14 a135 a131 a137 a130 a133 STATE_TRANSITION s96 s98 0.33333333333333304,3.552713678800501E-15 0.6666666666666667,1.7763568394002505E-15 a118 a117 a121 STATE_TRANSITION s99 s101 0.33333333333333304,0.0 0.6666666666666665,1.7763568394002505E-15 a126 a123 a120 TRANSCRIPTIONAL_ACTIVATION s98 s102 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,0.0 a117 a139 TRANSCRIPTIONAL_ACTIVATION s101 s102 0.33333333333333304,0.0 0.6666666666666661,-8.881784197001252E-16 a123 a139 TRANSCRIPTIONAL_ACTIVATION s31 s102 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 a122 a139 TRANSCRIPTIONAL_ACTIVATION s86 s102 0.3333333333333335,0.0 0.6666666666666665,-8.881784197001252E-16 a125 a139 TRANSCRIPTIONAL_ACTIVATION s87 s102 0.33333333333333326,0.0 0.6666666666666667,0.0 a137 a139 STATE_TRANSITION s89 s90 0.3333333333333339,0.0 0.6666666666666665,0.0 a141 a142 a140 a143 a133 TRANSCRIPTIONAL_ACTIVATION s90 s102 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a140 a139 TRANSPORT s27 s97 0.33333333333333326,0.0 0.666666666666667,0.0 a72 a133 STATE_TRANSITION s103 s100 0.3333333333333339,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 a145 a146 a144 a147 a156 STATE_TRANSITION s54 s61 0.33333333333333215,0.0 0.6666666666666661,-8.881784197001252E-16 a151 a150 a148 a149 a156 STATE_TRANSITION s58 s65 0.33333333333333304,-2.6645352591003757E-15 0.6666666666666679,-4.440892098500626E-15 a155 a154 a152 a153 a156 TRANSPORT s85 s93 0.33333333333333304,-4.440892098500626E-16 0.666666666666667,0.0 a85 a120 TRANSPORT s84 s94 0.3333333333333326,0.0 0.6666666666666661,0.0 a81 a121 TRANSPORT s34 s104 0.3333333333333335,-8.881784197001252E-16 0.6666666666666674,-4.440892098500626E-16 a101 a156 STATE_TRANSITION s45 s107 0.3333333333333335,0.0 0.666666666666667,-4.440892098500626E-16 a159 a63 a13 STATE_TRANSITION s105 s118 0.3333333333333335,0.0 0.6666666666666674,0.0 a157 a161 a13 STATE_TRANSITION s108 s119 0.33333333333333304,4.440892098500626E-16 0.666666666666667,2.220446049250313E-16 a160 a162 a13 STATE_TRANSITION s120 s120 0.3333333333333339,0.0 0.666666666666667,0.0 a163 a166 a164 a167 a162 STATE_TRANSITION s20 s122 0.3333333333333337,4.440892098500626E-16 0.6666666666666667,8.881784197001252E-16 a52 a171 TRANSPORT s122 s127 0.33333333333333304,-5.551115123125783E-17 0.6666666666666661,-1.6653345369377348E-16 a171 a172 STATE_TRANSITION s127 s123 0.33333333333333304,-1.1102230246251565E-16 0.6666666666666661,-2.220446049250313E-16 a172 a119 a173 a124 a133 TRANSCRIPTIONAL_ACTIVATION s123 s102 0.33333333333333326,0.0 0.6666666666666663,0.0 a173 a139 STATE_TRANSITION s125 s125 0.3333333333333339,0.0 0.6666666666666679,0.0 a175 a176 a111