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<![CDATA[
Not only does pyruvate join the glycolytic pathway to the TCA cycle, but it is also linked to amino acid metabolism by the transamination reaction and to lipid metabolism by its decarboxylation to acetyl-coA.  Another imporatnt feature of the role played by pyruvate is the fact that it is produced in the cytoplasm but both its decarboxylation to acetyl-coA and its carboxylation oxaloacetate take place in the mitochondrial matrix.  Thus, pyruvate provides the link between metabolism in the cytoplasm and the pathways that are restricted to the mitochondrial matrix.
free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal
free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm
free text=Human Metabolism by Ramsey Bronk
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</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p48</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r63"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s142" initialAmount="0.0" name="NADP_super_+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NADP+
Synonym:  Synonym not specified
Accession:  S04115
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADP_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s143" initialAmount="0.0" name="NADPH + H_super_+_endsuper_+ CO_sub_2_endsub">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NADPH + H++ CO2
Synonym:  Synonym not specified
Accession:  S04108
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADPH + H_super_+_endsuper_+ CO_sub_2_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s144" initialAmount="0.0" name="Malic enzyme">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Malic enzyme
Synonym:  Synonym not specified
Accession:  P03136
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p49</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r64"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s145" initialAmount="0.0" name="Aminotransefrase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Aminotransferase
Synonym:  Synonym not specified
Accession:  P03134
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p50</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r73"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s152" initialAmount="0.0" name="ADP + P_sub_i_endsub">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ADP + Pi
Synonym:  Synonym not specified
Accession:  S04106
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ADP + P_sub_i_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s157" initialAmount="0.0" name="NAD_super_+_endsuper_ + CoA-SH">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NAD+ + CoA-SH
Synonym:  Synonym not specified
Accession:  S04105
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NAD_super_+_endsuper_ + CoA-SH</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s158" initialAmount="0.0" name="ATP + HCO_sub_3_endsub_ _super_-">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP + HCO3 -
Synonym:  Synonym not specified
Accession:  S04107
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP + HCO_sub_3_endsub_ _super_-</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s159" initialAmount="0.0" name="NADH + CO_sub_2_endsub">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NADH + CO2
Synonym:  Synonym not specified
Accession:  S04116
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADH + CO_sub_2_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s160" initialAmount="0.0" name="Pyruvate_br_Dehydrogenase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Pyruvate Dehydrogenase
Synonym:  Synonym not specified
Accession:  P03133
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p54</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r68"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s147" initialAmount="0.0" name="Malate_br_Dehydrogenase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Malate Dehydrogenase
Synonym:  Synonym not specified
Accession:  P03138
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p55</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r66"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s161" initialAmount="0.0" name="Citrate Synthetase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Citrate Synthetase
Synonym:  Synonym not specified
Accession:  P03141
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p56</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r75"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s162" initialAmount="0.0" name="ATP + CoA-SH">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP + CoA-SH
Synonym:  Synonym not specified
Accession:  S04099
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP + CoA-SH</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s163" initialAmount="0.0" name="Pyruvate Carboxylase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Pyruvate Carboxylase
Synonym:  Synonym not specified
Accession:  P03140
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p57</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r67"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s164" initialAmount="0.0" name="Citrate Lyase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Citrate Lyase
Synonym:  Synonym not specified
Accession:  P03137
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p58</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r72"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s165" initialAmount="0.0" name="GTP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S04109
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s166" initialAmount="0.0" name="GDP + CO_sub_2_endsub">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP + CO2
Synonym:  Synonym not specified
Accession:  S04098
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP + CO_sub_2_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s167" initialAmount="0.0" name="Phosphoenolpyruvate_br_Carboxykinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphoenolpyruvate Carboxykinase
Synonym:  PEPCK
Accession:  P03135
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p59</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r76"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="r62" reversible="false">
<annotation>
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<celldesigner:baseProducts>s130</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a128" reactant="s136" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a129" product="s137" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333337,0.0 0.6666666666666666,1.1102230246251565E-16</celldesigner:editPoints>
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</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s136">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
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<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333304,-4.440892098500626E-16 0.6666666666666665,-2.220446049250313E-16</celldesigner:editPoints>
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</annotation>
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<annotation>
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</speciesReference>
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<annotation>
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<annotation>
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</annotation>
</modifierSpeciesReference>
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</reaction>
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<annotation>
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<celldesigner:listOfReactantLinks>
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<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
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<annotation>
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</speciesReference>
</listOfReactants>
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<annotation>
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</speciesReference>
</listOfProducts>
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<annotation>
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</reaction>
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<annotation>
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<annotation>
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</speciesReference>
</listOfProducts>
</reaction>
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<annotation>
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<celldesigner:listOfReactantLinks>
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<celldesigner:listOfProductLinks>
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</reaction>
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</reaction>
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<annotation>
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<celldesigner:listOfProductLinks>
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