2.3 SQUARE SQUARE SQUARE SQUARE OVAL OVAL inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Vitamin D Receptor Retinoid X Receptor Ferridoxin Ferridoxin Reductase Vitamin D 24-hydroxylase Vitamin D 1_alpha_-hydroxylase Nucleus Cell Mitochondrion Skin Liver Kidney Long Name: 1,25-dihydroxyvitamin D Synonym: Synonym not specified Accession: S04864 inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D Long Name: 1,25-dihydroxyvitamin D Synonym: Synonym not specified Accession: S04864 inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D Long Name: O2 Synonym: Synonym not specified Accession: U05599 inside ION O_sub_2 Long Name: H2O Synonym: Synonym not specified Accession: U05602 inside ION H_sub_2O Long Name: NADPH Synonym: Synonym not specified Accession: U05605 inside ION NADPH Long Name: NADP+ Synonym: Synonym not specified Accession: U05604 inside ION NADP+ Long Name: 25-hydroxy-vitamin D Synonym: Synonym not specified Accession: S04868 inside SIMPLE_MOLECULE 25-hydroxy-vitamin D Long Name: Vitamin D Receptor Synonym: Synonym not specified Accession: P04606 inside PROTEIN p5 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05595 Heterodimer Member Info: 1,25-dihydroxyvitamin D#SIMPLE_MOLECULE#1,25-dihydroxyvitamin D#S04864##;VDR#PROTEIN#Vitamin D Receptor#P04606## inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D PROTEIN p5 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05597 Heterodimer Member Info: 1,25-dihydroxyvitamin D#SIMPLE_MOLECULE#1,25-dihydroxyvitamin D#S04864##;VDR#PROTEIN#Vitamin D Receptor#P04606## inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D PROTEIN p5 Long Name: Retinoid X Receptor, Alpha Synonym: Synonym not specified Accession: P04602 inside PROTEIN p6 Long Name: Ferredoxin Synonym: ADX,FDX Accession: P04607 inside PROTEIN p3 Long Name: Ferredoxin Reductase Synonym: ADXR,adrenodoxin reductase Accession: P04604 inside PROTEIN p4 Long Name: Vitamin D 24-Hydroxylase Synonym: CP24,CYP24,CYP42A1,cytochrome P450 24A1 Accession: P04608 inside PROTEIN p2 Long Name: Vitamin D 1-alpha-hydroxylase Synonym: CYP1,CYP27B1,P450c1,VDDR Accession: P04603 inside PROTEIN p1 Long Name: Differentiation Synonym: Synonym not specified Accession: U05600 inside PHENOTYPE Differentiation Long Name: 24-Hydroxylase Synonym: CP24,CYP24,CYP42A1,cytochrome P450 24A1 Accession: G04688 inside GENE 24-Hydroxylase Long Name: Growth Inhibition Synonym: Synonym not specified Accession: U05601 inside PHENOTYPE Growth Inhibition Long Name: Long name not specified Synonym: Synonym not specified Accession: U05598 Heterodimer Member Info: RXR#PROTEIN#Retinoid X Receptor, Alpha#P04602##;1,25-dihydroxyvitamin D#SIMPLE_MOLECULE#1,25-dihydroxyvitamin D#S04864##;VDR#PROTEIN#Vitamin D Receptor#P04606## inside PROTEIN p6 PROTEIN p5 SIMPLE_MOLECULE 1,25-dihydroxyvitamin D Long Name: 25-hydroxyvitamin D Synonym: Synonym not specified Accession: S04861 inside SIMPLE_MOLECULE 25-hydroxyvitamin D Long Name: UV Irradiation Synonym: Synonym not specified Accession: U05603 inside PHENOTYPE UV Irradiation Long Name: Vitamin D3 Synonym: Synonym not specified Accession: S04867 inside SIMPLE_MOLECULE Vitamin D3 Long Name: 25-hydroxy-vitamin D Synonym: Synonym not specified Accession: S04868 inside SIMPLE_MOLECULE 25-hydroxy-vitamin D Long Name: 25-hydroxy-vitamin D Synonym: Synonym not specified Accession: S04868 inside SIMPLE_MOLECULE 25-hydroxy-vitamin D Long Name: 1,25-dihydroxyvitamin D Synonym: Synonym not specified Accession: S04864 inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D Long Name: Vitamin D 1-alpha-hydroxylase Synonym: CYP1,CYP27B1,P450c1,VDDR Accession: P04603 inside PROTEIN p1 Long Name: Vitamin D 25-Hydroxylase Synonym: CYP27A1,cytochrome P450 27A1 Accession: P04601 inside PROTEIN p7 Long Name: O2 Synonym: Synonym not specified Accession: U05599 inside ION O_sub_2 Long Name: H2O Synonym: Synonym not specified Accession: U05602 inside ION H_sub_2O Long Name: NADP+ Synonym: Synonym not specified Accession: U05604 inside ION NADP+ Long Name: NADPH Synonym: Synonym not specified Accession: U05605 inside ION NADPH Long Name: 25-hydroxy-vitamin D3 Synonym: Synonym not specified Accession: S04866 inside SIMPLE_MOLECULE 25-hydroxy-vitamin D_sub_3 Long Name: Vitamin D3 Synonym: Synonym not specified Accession: S04867 inside SIMPLE_MOLECULE Vitamin D_sub_3 Long Name: Pre-Vitamin D3 Synonym: Synonym not specified Accession: S04869 inside SIMPLE_MOLECULE Pre-Vitamin D_sub_3 Long Name: 1,25-dihydroxyvitamin D3 Synonym: Synonym not specified Accession: S04863 inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D_sub_3 Long Name: 1,24,25-hydroxyvitamin D3 Synonym: Synonym not specified Accession: S04865 inside SIMPLE_MOLECULE 1,24,25-hydroxyvitamin D_sub_3 Long Name: Vitamin D binding protein Synonym: GC,VDBG,VDBP Accession: P04600 inside PROTEIN p9 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05596 Heterodimer Member Info: DBP#PROTEIN#Vitamin D binding protein#P04600#GC|VDBG|VDBP#;1,25-dihydroxyvitamin D#SIMPLE_MOLECULE#1,25-dihydroxyvitamin D#S04864## inside PROTEIN p9 SIMPLE_MOLECULE 1,25-dihydroxyvitamin D Long Name: Vitamin D response element containing genes Synonym: Synonym not specified Accession: G04687 inside GENE VDRE Long Name: cytochrome P450 reductase Synonym: CYPOR,P450 (cytochrome) oxidoreductase,POR Accession: P04605 inside PROTEIN p8 TRANSPORT s2 s3 0.3333333333333332,-8.326672684688674E-17 0.6666666666666663,-1.942890293094024E-16 a2 a3 TRANSPORT s1 s20 0.3333333333333337,-8.881784197001252E-16 0.6666666666666672,-4.440892098500626E-16 a1 a4 TRANSPORT s20 s5 0.33333333333333326,0.0 0.6666666666666665,0.0 a4 a5 STATE_TRANSITION s5 s7 0.33333333333333326,-2.220446049250313E-16 0.6666666666666665,-6.661338147750939E-16 a5 a11 a7 a12 a9 STATE_TRANSITION s7 s8 0.33333333333333304,2.4424906541753444E-15 0.6666666666666661,5.551115123125783E-15 a7 a13 a8 a14 a10 STATE_TRANSITION s9 s9 0.33333333333333304,0.0 0.6666666666666665,0.0 a15 a9 a17 STATE_TRANSITION s10 s10 0.33333333333333304,1.7763568394002505E-15 0.6666666666666665,1.7763568394002505E-15 a16 a10 a17 STATE_TRANSITION s15 s15 0.3333333333333333,0.0 0.666666666666667,-8.881784197001252E-16 a19 a20 a17 a21 a18 HETERODIMER_ASSOCIATION s21,s3 s23 0.33333333333333304,0.0 0.6666666666666665,0.0 0.33333333333333326,-4.440892098500626E-16 0.6666666666666665,0.0 0.3333333333333326,0.0 0.6666666666666665,0.0 0.3333333333333336,0.3333333333333335 a23 a3 a27 TRANSPORT s23 s24 0.33333333333333304,-1.2836953722228372E-16 0.666666666666667,-2.393918396847994E-16 a27 a28 KNOWN_TRANSITION_OMITTED s29 s10 0.3333333333333335,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 a35 a16 HETERODIMER_ASSOCIATION s25,s24 s33 0.333333333333357,-1.4210854715202004E-14 0.6666666666666673,0.0 0.33333333333333215,-4.440892098500626E-16 0.6666666666666661,4.440892098500626E-16 0.3333333333333348,-8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16 0.33333333333333304,0.33333333333333304 a29 a28 a39 TRANSCRIPTIONAL_ACTIVATION s33 s34 0.33333333333333437,0.0 0.666666666666667,8.881784197001252E-16 a39 a40 TRANSCRIPTIONAL_INHIBITION s33 s34 0.2852597692436998,0.24146492936245423 0.686785311847574,0.21128284287193821 a39 a40 UNKNOWN_TRANSITION s34 s27 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16 a40 a33 UNKNOWN_TRANSITION s34 s28 0.33333333333333215,0.0 0.6666666666666661,-1.7763568394002505E-15 a40 a34 STATE_TRANSITION s35 s36 0.33333333333333304,0.0 0.6666666666666661,1.6653345369377348E-16 a41 a42 a43 TRANSPORT s36 s38 0.3333333333333335,-2.220446049250313E-16 0.666666666666667,-6.661338147750939E-16 a42 a44 STATE_TRANSITION s38 s39 0.3333333333333335,0.0 0.6666666666666665,-1.7763568394002505E-15 a44 a53 a50 a45 a51 a52 a49 a54 STATE_TRANSITION s40 s41 0.33333333333333326,0.0 0.6666666666666667,0.0 a46 a47 a48 TRANSPORT s41 s2 0.3333333333333336,-4.440892098500626E-16 0.6666666666666667,-8.881784197001252E-16 a47 a2 TRANSPORT s39 s40 0.3333333333333335,-1.6653345369377348E-16 0.6666666666666665,-3.885780586188048E-16 a45 a46 TRANSPORT s39 s1 0.33333333333333326,-4.440892098500626E-16 0.6666666666666663,0.0 a45 a1 HETERODIMER_ASSOCIATION s49,s41 s55 0.33333333333333304,5.828670879282072E-16 0.6666666666666661,-3.0531133177191805E-16 0.3333333333333335,2.220446049250313E-16 0.6666666666666661,0.0 0.33333333333333326,4.440892098500626E-16 0.6666666666666667,0.0 0.33333333333333326,0.33333333333333326 a55 a47 a63 TRANSCRIPTIONAL_ACTIVATION s33 s29 0.3333333333333332,-8.881784197001252E-16 0.6666666666666663,0.0 a39 a35 TRANSPORT s7 s3 0.33333333333333304,-2.220446049250313E-16 0.6666666666666663,-2.220446049250313E-16 a7 a3