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B cell activation entails the process by which a pre-B cell matures into a plasma cell.  The signaling pathways that regulate this conversion are complex, but center around a complex of proteins referred to as the B cell receptor, or BCR.  Ligation of the BCR by a cognate antigen initiates a number of downstream signaling events that lead, eventually, to an expansion in the number of B cells of the appropriate antigen specificity, and to their development of the ability to secrete antibody.
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<celldesigner:modificationResidue angle="0.022723360841641067" id="rs2" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p12" name="CD45" type="GENERIC"/>
<celldesigner:protein id="p2" name="Syk" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="6.153910303131443" id="rs1" name="Y"/>
<celldesigner:modificationResidue angle="0.12114301415792324" id="rs2" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p8" name="BLNK" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="3.14" id="rs1" name="Y"/>
<celldesigner:modificationResidue angle="-0.0" id="rs2" name="Y"/>
<celldesigner:modificationResidue angle="3.95137622615996" id="rs3" name="Y"/>
<celldesigner:modificationResidue angle="5.528080903700913" id="rs4" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p14" name="Grb2" type="GENERIC"/>
<celldesigner:protein id="p15" name="SOS" type="GENERIC"/>
<celldesigner:protein id="p4" name="Btk" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p19" name="IP3R" type="ION_CHANNEL"/>
<celldesigner:protein id="p20" name="PKC" type="GENERIC"/>
<celldesigner:protein id="p21" name="CRAC" type="ION_CHANNEL"/>
<celldesigner:protein id="p11" name="SHP-1" type="GENERIC"/>
<celldesigner:protein id="p23" name="Calmodulin" type="GENERIC"/>
<celldesigner:protein id="p24" name="Calcineurin" type="GENERIC"/>
<celldesigner:protein id="p25" name="NF-AT" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p29" name="Ras" type="GENERIC"/>
<celldesigner:protein id="p30" name="Raf" type="GENERIC"/>
<celldesigner:protein id="p27" name="MEK" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p28" name="ERK" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1" name="T"/>
<celldesigner:modificationResidue angle="-0.0" id="rs2" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p31" name="fos" type="GENERIC"/>
<celldesigner:protein id="p32" name="jun" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p33" name="vav" type="GENERIC"/>
<celldesigner:protein id="p34" name="Rac" type="GENERIC"/>
<celldesigner:protein id="p35" name="MEKK" type="GENERIC"/>
<celldesigner:protein id="p36" name="p38" type="GENERIC"/>
<celldesigner:protein id="p37" name="Jnk" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p9" name="CD19" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="3.14" id="rs1" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p38" name="PI3K" type="GENERIC"/>
<celldesigner:protein id="p41" name="NF-kappa B" type="GENERIC"/>
<celldesigner:protein id="p40" name="I kappa B" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p39" name="IKK" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p7" name="Ig-beta" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="4.865038308779955" id="rs1" name="Y"/>
<celldesigner:modificationResidue angle="3.7638955247770007" id="rs2" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p6" name="Ig-alpha" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="5.590543463970282" id="rs1" name="Y"/>
<celldesigner:modificationResidue angle="4.688003571211971" id="rs2" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p13" name="PLC_br_gamma2" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="0.010637896575541442" id="rs1" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
</celldesigner:listOfProteins>
<celldesigner:listOfBlockDiagrams/>
</annotation>
<listOfCompartments>
<compartment name="default" volume="1.0"/>
<compartment name="c2" outside="c4" volume="1.0">
<annotation>
<celldesigner:name>ER</celldesigner:name>
</annotation>
</compartment>
<compartment name="c3" outside="c4" volume="1.0">
<annotation>
<celldesigner:name>Nucleus</celldesigner:name>
</annotation>
</compartment>
<compartment name="c4" outside="default" volume="1.0">
<annotation>
<celldesigner:name>B cell</celldesigner:name>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species compartment="c4" initialAmount="0.0" name="s3">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Blk
Synonym:  p55blk
Accession:  P00390
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s10">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CD22
Synonym:  Synonym not specified
Accession:  P00387
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s13">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CD22
Synonym:  Synonym not specified
Accession:  P00387
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Lyn
Synonym:  Synonym not specified
Accession:  P00374
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s14">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Lyn
Synonym:  Synonym not specified
Accession:  P00374
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s29">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CD45
Synonym:  Leukocyte common antigen
Accession:  P00396
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r4"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Syk
Synonym:  Synonym not specified
Accession:  P00382
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s46">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Syk
Synonym:  Synonym not specified
Accession:  P00382
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r13"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s8">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  BLNK
Synonym:  B Cell Linker Protein,BASH,SLP-65
Accession:  P00394
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s56">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Grb2
Synonym:  Growth factor receptor-bound protein 2
Accession:  P00372
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s57">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SOS
Synonym:  Son of Sevenless
Accession:  P00379
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s66">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Btk
Synonym:  bruton's tyrosine kinase
Accession:  P00400
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s84">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PIP2
Synonym:  Synonym not specified
Accession:  S01606
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>PIP2</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s86">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  IP3
Synonym:  Synonym not specified
Accession:  S01603
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>IP3</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r80"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" initialAmount="0.0" name="s96">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  IP3R
Synonym:  IP3 Receptor,Inositol (3,4,5) triphosphate Receptor
Accession:  P00398
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r86"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s109">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PKC
Synonym:  Synonym not specified
Accession:  P00373
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s110">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  DAG
Synonym:  Synonym not specified
Accession:  S01604
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>DAG</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s11">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SHP-1
Synonym:  SH2 domain-containing phosphatase
Accession:  P00378
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s118">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05069
Heterodimer Member Info:  SHP-1#PROTEIN#SHP-1#P00378#SH2 domain-containing phosphatase#;CD22#PROTEIN#CD22#P00387##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s120">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Calmodulin
Synonym:  CaM
Accession:  P00375
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p23</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s122">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NF-AT
Synonym:  Nuclear Factor of Activated T cells
Accession:  P00367
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s123">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NF-AT
Synonym:  Nuclear Factor of Activated T cells
Accession:  P00367
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s125">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05084
Heterodimer Member Info:  Calmodulin#PROTEIN#Calmodulin#P00375#CaM#;Ca++#ION#Ca++#U02153##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p23</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca++</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca++</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r37"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s127">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05079
Heterodimer Member Info:  Ras#PROTEIN#Ras#P00376##;GDP#SIMPLE_MOLECULE#GDP#S01608##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p29</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP </celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s243">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05082
Heterodimer Member Info:  Ras#PROTEIN#Ras#P00376##;GTP#SIMPLE_MOLECULE#GTP#S01609##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p29</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s235">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  MEK
Synonym:  MAP kinase kinase,MAPK/ERK Kinase
Accession:  P00383
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p27</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s233">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Raf
Synonym:  Synonym not specified
Accession:  P00381
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p30</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s247">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  MEK
Synonym:  MAP kinase kinase,MAPK/ERK Kinase
Accession:  P00383
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p27</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r48"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s129">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NF-AT
Synonym:  Nuclear Factor of Activated T cells
Accession:  P00367
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s131">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ERK
Synonym:  Extracellular signal-regulated kinase
Accession:  P00371
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p28</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s132">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ERK
Synonym:  Extracellular signal-regulated kinase
Accession:  P00371
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p28</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s133">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ERK
Synonym:  Extracellular signal-regulated kinase
Accession:  P00371
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p28</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r50"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s142">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  fos
Synonym:  c-fos
Accession:  P00380
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p31</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s143">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  jun
Synonym:  Synonym not specified
Accession:  P00401
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p32</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s145">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  jun
Synonym:  Synonym not specified
Accession:  P00401
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p32</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s148">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05086
Heterodimer Member Info:  fos#PROTEIN#fos#P00380#c-fos#;jun#PROTEIN#jun#P00401##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p31</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p32</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s150">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05070
Heterodimer Member Info:  PKC#PROTEIN#PKC#P00373##;DAG#SIMPLE_MOLECULE#DAG#S01604##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p20</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>DAG</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r68"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s151">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  BCR-responsive genes
Synonym:  Synonym not specified
Accession:  G01496
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>BCR-responsive genes</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s152">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  B cell activation, Differentiation into plasma cell
Synonym:  Synonym not specified
Accession:  U02154
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>B cell activation; Differentiation into plasma cell</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s153">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  vav
Synonym:  Synonym not specified
Accession:  P00368
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p33</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s155">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05087
Heterodimer Member Info:  Rac#PROTEIN#Rac#P00385##;GDP#SIMPLE_MOLECULE#GDP#S01608##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p34</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s156">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05072
Heterodimer Member Info:  Rac#PROTEIN#Rac#P00385##;GTP#SIMPLE_MOLECULE#GTP#S01609##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p34</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r84"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s157">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05074
Heterodimer Member Info:  vav#PROTEIN#vav#P00368##;BLNK#PROTEIN#BLNK#P00394#B Cell Linker Protein|BASH|SLP-65#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
<celldesigner:modification residue="rs3" state="phosphorylated"/>
<celldesigner:modification residue="rs4" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p33</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r57"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s249">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  p38
Synonym:  MAP kinase
Accession:  P00384
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p36</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s250">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Jnk
Synonym:  Jun Kinase
Accession:  P00402
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p37</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s251">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Jnk
Synonym:  Jun Kinase
Accession:  P00402
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p37</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s254">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S01605
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s255">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ADP
Synonym:  Synonym not specified
Accession:  S01607
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ADP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s256">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CD19
Synonym:  Synonym not specified
Accession:  P00393
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s257">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CD19
Synonym:  Synonym not specified
Accession:  P00393
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s259">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PI3K
Synonym:  Phosphatidyl inositol 3-kinase
Accession:  P00391
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p38</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s119">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ca++
Synonym:  Synonym not specified
Accession:  U02153
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca++</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s264">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NF-kappa B
Synonym:  Nuclear Factor kappa B
Accession:  P00370
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p41</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s265">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  I kappa B
Synonym:  IkB,Inhibitor of NF-kappa B
Accession:  P00392
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p40</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s266">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05085
Heterodimer Member Info:  NF-kappa B#PROTEIN#NF-kappa B#P00370#Nuclear Factor kappa B#;I kappa B#PROTEIN#I kappa B#P00392#IkB|Inhibitor of NF-kappa B#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p41</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p40</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s262">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  IKK
Synonym:  IKBK,Inhibitor of Kappa B kinase
Accession:  P00397
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p39</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s267">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  IKK
Synonym:  IKBK,Inhibitor of Kappa B kinase
Accession:  P00397
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p39</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r67"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s268">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NF-kappa B
Synonym:  Nuclear Factor kappa B
Accession:  P00370
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p41</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s272">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05073
Heterodimer Member Info:  Ras#PROTEIN#Ras#P00376##;Raf#PROTEIN#Raf#P00381##;MEK#PROTEIN#MEK#P00383#MAP kinase kinase|MAPK/ERK Kinase#;GTP#SIMPLE_MOLECULE#GTP#S01609##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p29</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p30</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p27</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r75"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s275">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CD45
Synonym:  Leukocyte common antigen
Accession:  P00396
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s23">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05071
Heterodimer Member Info:  Ig-beta#PROTEIN#Ig-beta#P00377#CD79b|Immunoglobulin beta#;mIgM#PROTEIN#mIgM#P00389#Membrane-bound Immunoglobulin M#;Ig-alpha#PROTEIN#Ig-alpha#P00399#CD79a|immunoglobulin alpha#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s28">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05077
Heterodimer Member Info:  Ig-beta#PROTEIN#Ig-beta#P00377#CD79b|Immunoglobulin beta#;mIgM#PROTEIN#mIgM#P00389#Membrane-bound Immunoglobulin M#;Ig-alpha#PROTEIN#Ig-alpha#P00399#CD79a|immunoglobulin alpha#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s44">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05081
Heterodimer Member Info:  Lyn#PROTEIN#Lyn#P00374##;Ig-beta#PROTEIN#Ig-beta#P00377#CD79b|Immunoglobulin beta#;Syk#PROTEIN#Syk#P00382##;mIgM#PROTEIN#mIgM#P00389#Membrane-bound Immunoglobulin M#;Blk#PROTEIN#Blk#P00390#p55blk#;Ig-alpha#PROTEIN#Ig-alpha#P00399#CD79a|immunoglobulin alpha#;Btk#PROTEIN#Btk#P00400#bruton's tyrosine kinase#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner4" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner5" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner6" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s53">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05083
Heterodimer Member Info:  Lyn#PROTEIN#Lyn#P00374##;Ig-beta#PROTEIN#Ig-beta#P00377#CD79b|Immunoglobulin beta#;Syk#PROTEIN#Syk#P00382##;mIgM#PROTEIN#mIgM#P00389#Membrane-bound Immunoglobulin M#;Blk#PROTEIN#Blk#P00390#p55blk#;Ig-alpha#PROTEIN#Ig-alpha#P00399#CD79a|immunoglobulin alpha#;Btk#PROTEIN#Btk#P00400#bruton's tyrosine kinase#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner4" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner5" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner6" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r14"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s55">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PLC gamma2
Synonym:  Phospholipase C gamma 2
Accession:  P00388
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s76">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05080
Heterodimer Member Info:  Grb2#PROTEIN#Grb2#P00372#Growth factor receptor-bound protein 2#;SOS#PROTEIN#SOS#P00379#Son of Sevenless#;PLC gamma2#PROTEIN#PLC gamma2#P00388#Phospholipase C gamma 2#;BLNK#PROTEIN#BLNK#P00394#B Cell Linker Protein|BASH|SLP-65#;Btk#PROTEIN#Btk#P00400#bruton's tyrosine kinase#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
<celldesigner:modification residue="rs3" state="phosphorylated"/>
<celldesigner:modification residue="rs4" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner4" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r24"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" initialAmount="0.0" name="s295">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ca++
Synonym:  Synonym not specified
Accession:  U02153
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca++</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s296">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  p38
Synonym:  MAP kinase
Accession:  P00384
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p36</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r50"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" initialAmount="0.0" name="s297">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Jnk
Synonym:  Jun Kinase
Accession:  P00402
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p37</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r51"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s299">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05075
Heterodimer Member Info:  Lyn#PROTEIN#Lyn#P00374##;PI3K#PROTEIN#PI3K#P00391#Phosphatidyl inositol 3-kinase#;CD19#PROTEIN#CD19#P00393##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p38</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s300">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Btk
Synonym:  bruton's tyrosine kinase
Accession:  P00400
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s301">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Lyn
Synonym:  Synonym not specified
Accession:  P00374
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r1"/>
<celldesigner:catalyzed reaction="r5"/>
<celldesigner:catalyzed reaction="r7"/>
<celldesigner:catalyzed reaction="r13"/>
<celldesigner:catalyzed reaction="r22"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s302">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  BLNK
Synonym:  B Cell Linker Protein,BASH,SLP-65
Accession:  P00394
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
<celldesigner:modification residue="rs3" state="phosphorylated"/>
<celldesigner:modification residue="rs4" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s303">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S01605
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s304">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ADP
Synonym:  Synonym not specified
Accession:  S01607
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ADP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s305">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Pi
Synonym:  Synonym not specified
Accession:  S01602
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Pi</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s307">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ca++
Synonym:  Synonym not specified
Accession:  U02153
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca++</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r30"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s309">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Calcineurin
Synonym:  Synonym not specified
Accession:  P00386
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p24</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r35"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s310">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05078
Heterodimer Member Info:  Ras#PROTEIN#Ras#P00376##;Raf#PROTEIN#Raf#P00381##;GTP#SIMPLE_MOLECULE#GTP#S01609##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p29</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p30</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s311">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S01608
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s312">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S01609
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s313">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  MEKK
Synonym:  MAP Kinase kinase kinase,MEK kinase
Accession:  P00369
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p35</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r59"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s315">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05076
Heterodimer Member Info:  Grb2#PROTEIN#Grb2#P00372#Growth factor receptor-bound protein 2#;SOS#PROTEIN#SOS#P00379#Son of Sevenless#;PLC gamma2#PROTEIN#PLC gamma2#P00388#Phospholipase C gamma 2#;BLNK#PROTEIN#BLNK#P00394#B Cell Linker Protein|BASH|SLP-65#;Btk#PROTEIN#Btk#P00400#bruton's tyrosine kinase#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
<celldesigner:modification residue="rs3" state="phosphorylated"/>
<celldesigner:modification residue="rs4" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner4" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r23"/>
<celldesigner:catalyzed reaction="r42"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" initialAmount="0.0" name="s316">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CRAC
Synonym:  Calcium release-activated calcium channel
Accession:  P00395
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p21</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r83"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction name="r1" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s10</celldesigner:baseReactants>
<celldesigner:baseProducts>s13</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a18" reactant="s303" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a19" product="s304" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333339,0.0 0.666666666666667,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a17" editPoints="0.33333333333333304,0.0 0.6666666666666667,0.0" modifiers="s301" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s10">
<annotation>
<celldesigner:alias>a10</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s303">
<annotation>
<celldesigner:alias>a18</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s13">
<annotation>
<celldesigner:alias>a12</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s304">
<annotation>
<celldesigner:alias>a19</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r4" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s1</celldesigner:baseReactants>
<celldesigner:baseProducts>s14</celldesigner:baseProducts>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a46" product="s305" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333326,2.220446049250313E-16 0.6666666666666666,2.220446049250313E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a41" editPoints="0.3333333333333334,-2.220446049250313E-16 0.6666666666666667,-5.551115123125783E-16" modifiers="s29" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias>a1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s14">
<annotation>
<celldesigner:alias>a13</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s305">
<annotation>
<celldesigner:alias>a46</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r5" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s14</celldesigner:baseReactants>
<celldesigner:baseProducts>s301</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a44" reactant="s303" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a45" product="s304" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333335,0.0 0.666666666666667,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a14" editPoints="-0.6272131914989272,-0.44570805704828853 0.9927984027800845,-0.369426581115059" modifiers="s301" offsetX="-1.0" offsetY="16.0" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s14">
<annotation>
<celldesigner:alias>a13</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s303">
<annotation>
<celldesigner:alias>a44</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s301">
<annotation>
<celldesigner:alias>a14</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s304">
<annotation>
<celldesigner:alias>a45</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r7" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s28</celldesigner:baseReactants>
<celldesigner:baseProducts>s23</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a50" reactant="s303" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a51" product="s304" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333304,-1.1102230246251565E-16 0.6666666666666665,-2.220446049250313E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a14" editPoints="0.33333333333333337,4.440892098500626E-16 0.6666666666666666,2.220446049250313E-16" modifiers="s301" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s28">
<annotation>
<celldesigner:alias>a33</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s303">
<annotation>
<celldesigner:alias>a50</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s23">
<annotation>
<celldesigner:alias>a24</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s304">
<annotation>
<celldesigner:alias>a51</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r8" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s23,s3</celldesigner:baseReactants>
<celldesigner:baseProducts>s44</celldesigner:baseProducts>
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