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A series of integrated protein-protein and protein-DNA interactions and enzymatic reactions to ensure high accuracy of DNA replication.
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
Long Name:  Chromatin (DNA + Histones + Other Proteins)
Synonym:  Synonym not specified
Accession:  G01505
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
Long Name:  Chromatin (DNA + Histones + Other Proteins) Replication_Competant_State
Synonym:  Synonym not specified
Accession:  G01506
</body>
</html>
</notes>
<annotation>
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<celldesigner:speciesIdentity>
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</annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S01645
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
Long Name:  Long Name:  ADP + Pi
Synonym:  Synonym not specified
Accession:  S04781
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:name>ADP + P_sub_i_endsub</celldesigner:name>
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<species compartment="default" initialAmount="0.0" name="s23">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
Long Name:  Pol alpha
Synonym:  Synonym not specified
Accession:  P00531
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s12">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  dsDNA
Synonym:  Synonym not specified
Accession:  G01507
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Helicase
Synonym:  Helicase
Accession:  P00532
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Topoisomerase
Synonym:  Synonym not specified
Accession:  P00530
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s31">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  RPA
Synonym:  Replication Protein A
Accession:  P00537
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s33">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ssDNA
Synonym:  Synonym not specified
Accession:  G01508
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s37">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05181
Heterodimer Member Info:  Primase#PROTEIN#Primase#P00528##;Pol alpha#PROTEIN#Pol alpha#P00531##
</body>
</html>
</notes>
<annotation>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Primase
Synonym:  Synonym not specified
Accession:  P00528
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s39">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  nascent DNA
Synonym:  Synonym not specified
Accession:  G01509
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:name>nascent DNA</celldesigner:name>
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</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s40">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
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</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</celldesigner:speciesIdentity>
</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PCNA
Synonym:  Synonym not specified
Accession:  P00534
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s42">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Pol delta
Synonym:  Synonym not specified
Accession:  P00533
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s44">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  nPPi
Synonym:  Synonym not specified
Accession:  S04780
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>nPP_sub_i_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s43">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  n dNTP + Mg++
Synonym:  Synonym not specified
Accession:  S04783
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>n dNTP + Mg_super_++_endsuper</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s45">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  RNA primer
Synonym:  Synonym not specified
Accession:  G01510
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>RNA primer</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s48">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  n H2O
Synonym:  Synonym not specified
Accession:  S01649
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>n H_sub_2_endsub_O</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s49">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  n NMP
Synonym:  Synonym not specified
Accession:  S01648
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>n NMP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s50">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Histones
Synonym:  Synonym not specified
Accession:  P00527
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p18</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s51">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  DNA Topoisomerase
Synonym:  Synonym not specified
Accession:  P00536
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r69"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s52">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATPs
Synonym:  Synonym not specified
Accession:  S01646
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATPs</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s53">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  ADPs + Pi
Synonym:  Synonym not specified
Accession:  S04782
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ADPs + P_sub_i_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s58">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05180
Heterodimer Member Info:  RFC#PROTEIN#RFC#P00529#Replication Factor C#;Pol delta#PROTEIN#Pol delta#P00533##;PCNA#PROTEIN#PCNA#P00534##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s60">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  RNase H
Synonym:  Synonym not specified
Accession:  P00538
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r68"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s47">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  5' to 3' Exoribonuclease
Synonym:  Synonym not specified
Accession:  P00535
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p17</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r68"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction name="r1" reversible="false">
<annotation>
<celldesigner:name>Initiation</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s1</celldesigner:baseReactants>
<celldesigner:baseProducts>s2</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333333,1.4710455076283324E-15 0.6666666666666667,2.831068712794149E-15</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias>a1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s2">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r24" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s2,s26</celldesigner:baseReactants>
<celldesigner:baseProducts>s12</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a67" reactant="s25" targetLineIndex="1,1"/>
<celldesigner:reactantLink alias="a69" reactant="s31" targetLineIndex="1,1"/>
<celldesigner:reactantLink alias="a23" reactant="s13" targetLineIndex="2,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a24" product="s14" targetLineIndex="2,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333304,8.881784197001252E-16 0.6666666666666679,0.0 0.3333333333333339,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 0.33333333333333304,0.33333333333333326</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s2">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s26">
<annotation>
<celldesigner:alias>a68</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s25">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s31">
<annotation>
<celldesigner:alias>a69</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s13">
<annotation>
<celldesigner:alias>a23</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s12">
<annotation>
<celldesigner:alias>a21</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s14">
<annotation>
<celldesigner:alias>a24</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r52" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s33</celldesigner:baseReactants>
<celldesigner:baseProducts>s33</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a123" reactant="s37" targetLineIndex="-1,1"/>
<celldesigner:reactantLink alias="a191" reactant="s52" targetLineIndex="-1,0"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a192" product="s53" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333336,-8.881784197001252E-16 0.6666666666666671,-1.7763568394002505E-15</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s33">
<annotation>
<celldesigner:alias>a89</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s37">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s52">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s33">
<annotation>
<celldesigner:alias>a105</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s53">
<annotation>
<celldesigner:alias>a192</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r57" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s33</celldesigner:baseReactants>
<celldesigner:baseProducts>s33</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a148" reactant="s40" targetLineIndex="-1,1"/>
<celldesigner:reactantLink alias="a149" reactant="s52" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a150" product="s53" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333337,4.440892098500626E-16 0.6666666666666666,4.440892098500626E-16</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s33">
<annotation>
<celldesigner:alias>a107</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s40">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s52">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s33">
<annotation>
<celldesigner:alias>a139</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s53">
<annotation>
<celldesigner:alias>a150</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r63" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s33</celldesigner:baseReactants>
<celldesigner:baseProducts>s33</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a168" reactant="s41" targetLineIndex="-1,1"/>
<celldesigner:reactantLink alias="a170" reactant="s42" targetLineIndex="-1,1"/>
<celldesigner:reactantLink alias="a174" reactant="s43" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a175" product="s44" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-2.220446049250313E-16</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s33">
<annotation>
<celldesigner:alias>a143</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s41">
<annotation>
<celldesigner:alias>a168</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s42">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s43">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s33">
<annotation>
<celldesigner:alias>a160</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s44">
<annotation>
<celldesigner:alias>a175</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r67" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s33</celldesigner:baseReactants>
<celldesigner:baseProducts>s12</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333326,1.1102230246251565E-16 0.6666666666666665,3.3306690738754696E-16</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s33">
<annotation>
<celldesigner:alias>a157</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s12">
<annotation>
<celldesigner:alias>a176</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r68" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s12</celldesigner:baseReactants>
<celldesigner:baseProducts>s12</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a181" reactant="s48" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a182" product="s49" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333326,-2.220446049250313E-15 0.6666666666666666,-3.9968028886505635E-15</celldesigner:editPoints>
<celldesigner:listOfModification>
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<celldesigner:modification aliases="a204" editPoints="0.3333333333333339,-1.1102230246251565E-16 0.6666666666666679,3.3306690738754696E-16" modifiers="s60" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s12">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s48">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s49">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r69" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s12</celldesigner:baseReactants>
<celldesigner:baseProducts>s1</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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<celldesigner:reactantLink alias="a185" reactant="s13" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333315,2.7755575615628914E-17 0.6666666666666665,2.7755575615628914E-17</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s12">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s50">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s13">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s1">
<annotation>
<celldesigner:alias>a1</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s14">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>

