<?xml version="1.0" encoding="UTF-8"?>
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<!-- 
Copyright (C) 2007 SRI International.  All Rights Reserved.
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The data herein were made in part with support under Grant Number
5 U01 DA 020830 from the National Institute on Drug Abuse at the
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<model id="PNAT">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
<![CDATA[
No pathway definition
]]>
</body>
</html>
</notes>
<annotation>
<celldesigner:modelVersion>2.5</celldesigner:modelVersion>
<celldesigner:modelDisplay sizeX="2500" sizeY="1800"/>
<celldesigner:listOfIncludedSpecies>
<celldesigner:species id="s7" name="Dopamine">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dopamine
Synonym:  Synonym not specified
Accession:  S06060
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s3</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Dopamine</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s10" name="GDP">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s30</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s25" name="D1/D5">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D1/D5
Synonym:  D1,D5
Accession:  P05948
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s8</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s27" name="D1/D5">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G protein, beta subunit
Synonym:  Guanine nucleotide-binding protein, beta subunit
Accession:  P05954
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s203</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr26</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s28" name="D1/D5">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D1/D5
Synonym:  D1,D5
Accession:  P05948
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s3</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s31" name="Dopamine">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dopamine
Synonym:  Synonym not specified
Accession:  S06060
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s30</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Dopamine</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s34" name="GDP">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  DOPA
Synonym:  Synonym not specified
Accession:  S06059
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s89</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>DOPA</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s36" name="D2/D3/D4">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s33</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s40" name="D2/D3/D4">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s29</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s101" name="DAT">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Sodium-dependent dopamine transporter
Synonym:  DA transporter,DAT
Accession:  P05962
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s94</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s102" name="dopamine">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  dopamine
Synonym:  Synonym not specified
Accession:  S06055
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s94</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>dopamine</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s115" name="VAT2">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptic vesicular amine transporter
Synonym:  Monoamine transporter,Solute carrier family 18 member 2,VAT2,Vesicular amine transporter 2
Accession:  P05960
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s89</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s137" name="D2/D3/D4">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s136</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s138" name="CLIC6">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  chloride intracellular channel 6
Synonym:  Synonym not specified
Accession:  P05968
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s136</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr18</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s148" name="D2/D3/D4">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s146</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s150" name="EPB41">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrocyte membrane protein band 4.1
Synonym:  Synonym not specified
Accession:  P05966
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s146</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr19</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s155" name="EPB41L1">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrocyte membrane protein band 4.1-like 1
Synonym:  4.1N,nonerythroid protein 4.1, neuron type
Accession:  P05953
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s154</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s156" name="D2/D3/D4">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s154</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s158" name="D2/D3/D4">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s157</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s159" name="EPB41L2">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrocyte membrane protein band 4.1-like 2
Synonym:  4.1G,nonerythroid protein 4.1, general type
Accession:  P05952
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s157</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr21</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s165" name="FLNA">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  filamin A
Synonym:  actin-binding protein 280,filamin alpha
Accession:  P05959
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s164</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr22</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s166" name="D2/D3/D4">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s164</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s170" name="GRB2">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  growth factor receptor-bound protein 2
Synonym:  Synonym not specified
Accession:  P05949
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s169</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr23</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s171" name="D2/D3/D4">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s169</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s183" name="D1/D5">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D1/D5
Synonym:  D1,D5
Accession:  P05948
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s182</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s184" name="EPB41L2">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrocyte membrane protein band 4.1-like 2
Synonym:  4.1G,nonerythroid protein 4.1, general type
Accession:  P05952
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s182</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr21</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s186" name="GNAZ">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  guanine nucleotide-binding protein, alpha z polypeptide
Synonym:  Gz alpha
Accession:  P05964
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s185</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s187" name="D1/D5">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D1/D5
Synonym:  D1,D5
Accession:  P05948
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s185</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s204" name="G_sub_s_endsub__alpha_">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gs alpha subunit
Synonym:  GNAS,guanine nucleotide-binding protein, alpha-stimulating activity polypeptide
Accession:  P05945
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s203</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s207" name="G_gamma_">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G protein, gamma subunit
Synonym:  Synonym not specified
Accession:  P05967
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s203</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr27</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s208" name="D1/D5">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D1/D5
Synonym:  D1,D5
Accession:  P05948
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s9</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s209" name="G_gamma_">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G protein, gamma subunit
Synonym:  Synonym not specified
Accession:  P05967
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s3</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr27</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
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<celldesigner:species id="s210" name="G_beta_">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G protein, beta subunit
Synonym:  Guanine nucleotide-binding protein, beta subunit
Accession:  P05954
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G protein, beta subunit
Synonym:  Guanine nucleotide-binding protein, beta subunit
Accession:  P05954
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</celldesigner:notes>
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gs alpha subunit
Synonym:  GNAS,guanine nucleotide-binding protein, alpha-stimulating activity polypeptide
Accession:  P05945
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</html>
</celldesigner:notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
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<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
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</html>
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<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
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</body>
</html>
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<annotation>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dopamine
Synonym:  Synonym not specified
Accession:  S06060
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (GDP/G-protein/ D1/D5/ Dopamine)
Synonym:  Synonym not specified
Accession:  U06148
Heterodimer Member Info:  Gsalpha#PROTEIN#Gs alpha subunit#P05945#GNAS|guanine nucleotide-binding protein, alpha-stimulating activity polypeptide#;D1/D5#PROTEIN#D1/D5#P05948#D1|D5#;Gbeta#PROTEIN#G protein, beta subunit#P05954#Guanine nucleotide-binding protein, beta subunit#;Ggamma#PROTEIN#G protein, gamma subunit#P05967##;Dopamine#SIMPLE_MOLECULE#Dopamine#S06060##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
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</annotation>
</species>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (D1/D5/ Dopamine)
Synonym:  Synonym not specified
Accession:  U06149
Heterodimer Member Info:  D1/D5#PROTEIN#D1/D5#P05948#D1|D5#;Dopamine#SIMPLE_MOLECULE#Dopamine#S06060##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
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</species>
<species compartment="c3" id="s9" initialAmount="0.0" name="Complex_br_(GDP/G-protein/_br_D1/D5)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (GDP/G-protein/ D1/D5)
Synonym:  Synonym not specified
Accession:  U06150
Heterodimer Member Info:  Gsalpha#PROTEIN#Gs alpha subunit#P05945#GNAS|guanine nucleotide-binding protein, alpha-stimulating activity polypeptide#;D1/D5#PROTEIN#D1/D5#P05948#D1|D5#;Gbeta#PROTEIN#G protein, beta subunit#P05954#Guanine nucleotide-binding protein, beta subunit#;Ggamma#PROTEIN#G protein, gamma subunit#P05967##
</body>
</html>
</notes>
<annotation>
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</species>
<species compartment="c3" id="s14" initialAmount="0.0" name="GTP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S06058
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</annotation>
</species>
<species compartment="c3" id="s15" initialAmount="0.0" name="GDP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S06061
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</species>
<species compartment="c3" id="s18" initialAmount="0.0" name="ATP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S06056
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s20" initialAmount="0.0" name="cAMP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  cAMP
Synonym:  Synonym not specified
Accession:  S06062
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cAMP</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re2"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s24" initialAmount="0.0" name="fine motor control">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  fine motor control
Synonym:  Synonym not specified
Accession:  U06169
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>UNKNOWN</celldesigner:class>
<celldesigner:name>fine motor control</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s29" initialAmount="0.0" name="Complex_br_(D2/D3/_br_D4/Dopamine)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (D2/D3/ D4/Dopamine)
Synonym:  Synonym not specified
Accession:  U06151
Heterodimer Member Info:  D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(D2/D3/_br_D4/Dopamine)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s30" initialAmount="0.0" name="Complex_br_(GDP/G-protein/_br_D2/D3/_br_D4/Dopamine)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (GDP/G-protein/ D2/D3/ D4/Dopamine)
Synonym:  Synonym not specified
Accession:  U06152
Heterodimer Member Info:  Gbeta#PROTEIN#G protein, beta subunit#P05954#Guanine nucleotide-binding protein, beta subunit#;Gialpha#PROTEIN#Gi alpha subunit#P05958##;D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#;Ggamma#PROTEIN#G protein, gamma subunit#P05967##;Dopamine#SIMPLE_MOLECULE#Dopamine#S06060##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GDP/G-protein/_br_D2/D3/_br_D4/Dopamine)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s32" initialAmount="0.0" name="depolarization">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  depolarization
Synonym:  Synonym not specified
Accession:  U06168
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>depolarization</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re16"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s33" initialAmount="0.0" name="Complex_br_(GDP/G-protein/_br_D2/D3/_br_D4)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (GDP/G-protein/ D2/D3/ D4)
Synonym:  Synonym not specified
Accession:  U06153
Heterodimer Member Info:  Gbeta#PROTEIN#G protein, beta subunit#P05954#Guanine nucleotide-binding protein, beta subunit#;Gialpha#PROTEIN#Gi alpha subunit#P05958##;D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#;Ggamma#PROTEIN#G protein, gamma subunit#P05967##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GDP/G-protein/_br_D2/D3/_br_D4)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s38" initialAmount="0.0" name="K_super_+_endsuper_ channel">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+ channel
Synonym:  Kcnk3,Potassium channel subfamily K member 3,Potassium channel subfamily K member 9,TASK-1,TASK-3,TWIK
Accession:  P05957
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s39" initialAmount="0.0" name="K_super_+_endsuper_ channel">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+ channel
Synonym:  Kcnk3,Potassium channel subfamily K member 3,Potassium channel subfamily K member 9,TASK-1,TASK-3,TWIK
Accession:  P05957
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re19"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s47" initialAmount="0.0" name="GDP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S06061
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s48" initialAmount="0.0" name="cAMP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  cAMP
Synonym:  Synonym not specified
Accession:  S06062
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cAMP</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re13"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s49" initialAmount="0.0" name="GTP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S06058
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s50" initialAmount="0.0" name="PKA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  protein kinase A
Synonym:  protein kinase A
Accession:  P05946
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re18"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s51" initialAmount="0.0" name="ATP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S06056
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s52" initialAmount="0.0" name="Dopamine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dopamine
Synonym:  Synonym not specified
Accession:  S06060
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Dopamine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s53" initialAmount="0.0" name="K+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+
Synonym:  Synonym not specified
Accession:  U06170
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s57" initialAmount="0.0" name="PKA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  protein kinase A
Synonym:  protein kinase A
Accession:  P05946
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re5"/>
<celldesigner:catalyzed reaction="re9"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" id="s58" initialAmount="0.0" name="Protein Phosphatase-1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protein Phosphatase-1
Synonym:  Synonym not specified
Accession:  P05969
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re5"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" id="s59" initialAmount="0.0" name="DARPP-32">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  dopamine- and cAMP- regulated phosphoprotein, 32-KD
Synonym:  PPP1R1B,protein phosphatase 1, regulatory subunit 1B
Accession:  P05950
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re10"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s60" initialAmount="0.0" name="ACh">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ACh
Synonym:  Synonym not specified
Accession:  S06057
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s62" initialAmount="0.0" name="SNARE Complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SNARE Complex
Synonym:  Synonym not specified
Accession:  P05956
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re6"/>
<celldesigner:catalyzed reaction="re8"/>
<celldesigner:catalyzed reaction="re17"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" id="s63" initialAmount="0.0" name="ACh">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ACh
Synonym:  Synonym not specified
Accession:  S06057
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s85" initialAmount="0.0" name="tyrosine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  tyrosine
Synonym:  Synonym not specified
Accession:  S06054
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>tyrosine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s86" initialAmount="0.0" name="TH">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Tyrosine Hydroxylase
Synonym:  TH
Accession:  P05970
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re51"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" id="s87" initialAmount="0.0" name="VAT2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptic vesicular amine transporter
Synonym:  Monoamine transporter,Solute carrier family 18 member 2,VAT2,Vesicular amine transporter 2
Accession:  P05960
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s89" initialAmount="0.0" name="Complex_br_(VAT2/DOPA)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (VAT2/DOPA)
Synonym:  Synonym not specified
Accession:  U06154
Heterodimer Member Info:  VAT2#PROTEIN#Synaptic vesicular amine transporter#P05960#Monoamine transporter|Solute carrier family 18 member 2|VAT2|Vesicular amine transporter 2#;DOPA#SIMPLE_MOLECULE#DOPA#S06059##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(VAT2/DOPA)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s91" initialAmount="0.0" name="Na_super_+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Na+
Synonym:  Synonym not specified
Accession:  U06172
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Na_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s92" initialAmount="0.0" name="DAT">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Sodium-dependent dopamine transporter
Synonym:  DA transporter,DAT
Accession:  P05962
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s94" initialAmount="0.0" name="Complex_br_(DAT/dopamine)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (DAT/dopamine)
Synonym:  Synonym not specified
Accession:  U06155
Heterodimer Member Info:  dopamine#SIMPLE_MOLECULE#dopamine#S06055##;DAT#PROTEIN#Sodium-dependent dopamine transporter#P05962#DA transporter|DAT#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(DAT/dopamine)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s95" initialAmount="0.0" name="Mg_super_2+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Mg2+
Synonym:  Synonym not specified
Accession:  U06173
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Mg_super_2+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s96" initialAmount="0.0" name="DOPA decarb.">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Aromatic L-amino acid decarboxylase
Synonym:  DOPA decarboxylase
Accession:  P05961
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re60"/>
<celldesigner:catalyzed reaction="re66"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s97" initialAmount="0.0" name="COMT">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Catechol-O-Methyl Transferase
Synonym:  COMT
Accession:  P05944
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re61"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" id="s103" initialAmount="0.0" name="DOPA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  DOPA
Synonym:  Synonym not specified
Accession:  S06059
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>DOPA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s105" initialAmount="0.0" name="dopamine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  dopamine
Synonym:  Synonym not specified
Accession:  S06055
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>dopamine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s106" initialAmount="0.0" name="Na_super_+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Na+
Synonym:  Synonym not specified
Accession:  U06172
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Na_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s107" initialAmount="0.0" name="DOPA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  DOPA
Synonym:  Synonym not specified
Accession:  S06059
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>DOPA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s108" initialAmount="0.0" name="sa3_degraded">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  sa3_degraded
Synonym:  Synonym not specified
Accession:  U06174
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>DEGRADED</celldesigner:class>
<celldesigner:name>sa3_degraded</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s110" initialAmount="0.0" name="MAO">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Monoamine Oxidase
Synonym:  MAO
Accession:  P05963
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re61"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s117" initialAmount="0.0" name="DOPA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  DOPA
Synonym:  Synonym not specified
Accession:  S06059
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>DOPA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s118" initialAmount="0.0" name="tyrosine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  tyrosine
Synonym:  Synonym not specified
Accession:  S06054
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>tyrosine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s119" initialAmount="0.0" name="TH">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Tyrosine Hydroxylase
Synonym:  TH
Accession:  P05970
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re65"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c5" id="s124" initialAmount="0.0" name="norepinephrine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  norepinephrine
Synonym:  Synonym not specified
Accession:  S06063
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>norepinephrine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s125" initialAmount="0.0" name="DBH">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dopamine beta-hydroxylase
Synonym:  DA  beta-hydroxylase,DBH,Dopamine beta-hydroxylase
Accession:  P05955
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re70"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" id="s127" initialAmount="0.0" name="CDK5">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  cyclin-dependent kinase 5
Synonym:  cell devision kinase 5
Accession:  P05951
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr17</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re9"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s129" initialAmount="0.0" name="D2/D3/D4">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4
Synonym:  D2,D3,D4
Accession:  P05965
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s135" initialAmount="0.0" name="CLIC6">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  chloride intracellular channel 6
Synonym:  Synonym not specified
Accession:  P05968
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr18</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s136" initialAmount="0.0" name="D2/D3/D4_br_CLIC6 complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4 CLIC6 complex
Synonym:  Synonym not specified
Accession:  U06156
Heterodimer Member Info:  D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#;CLIC6#PROTEIN#chloride intracellular channel 6#P05968##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>D2/D3/D4_br_CLIC6 complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s146" initialAmount="0.0" name="D2/D3/D4_br_EBP41 complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3/D4 EBP41 complex
Synonym:  Synonym not specified
Accession:  U06157
Heterodimer Member Info:  D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#;EPB41#PROTEIN#erythrocyte membrane protein band 4.1#P05966##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>D2/D3/D4_br_EBP41 complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s149" initialAmount="0.0" name="EPB41">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrocyte membrane protein band 4.1
Synonym:  Synonym not specified
Accession:  P05966
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr19</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s151" initialAmount="0.0" name="EPB41L1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrocyte membrane protein band 4.1-like 1
Synonym:  4.1N,nonerythroid protein 4.1, neuron type
Accession:  P05953
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s152" initialAmount="0.0" name="EPB41L2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrocyte membrane protein band 4.1-like 2
Synonym:  4.1G,nonerythroid protein 4.1, general type
Accession:  P05952
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr21</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s154" initialAmount="0.0" name="D2/D3_br_EPB41L1 complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3 EPB41L1 complex
Synonym:  Synonym not specified
Accession:  U06158
Heterodimer Member Info:  EPB41L1#PROTEIN#erythrocyte membrane protein band 4.1-like 1#P05953#4.1N|nonerythroid protein 4.1, neuron type#;D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>D2/D3_br_EPB41L1 complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s157" initialAmount="0.0" name="D3/EPB41L2_br_complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D3/EPB41L2 complex
Synonym:  Synonym not specified
Accession:  U06159
Heterodimer Member Info:  EPB41L2#PROTEIN#erythrocyte membrane protein band 4.1-like 2#P05952#4.1G|nonerythroid protein 4.1, general type#;D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>D3/EPB41L2_br_complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s160" initialAmount="0.0" name="K+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+
Synonym:  Synonym not specified
Accession:  U06170
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s163" initialAmount="0.0" name="FLNA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  filamin A
Synonym:  actin-binding protein 280,filamin alpha
Accession:  P05959
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr22</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s164" initialAmount="0.0" name="D2/D3_minus_FLNA_br_complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D2/D3-FLNA complex
Synonym:  Synonym not specified
Accession:  U06160
Heterodimer Member Info:  FLNA#PROTEIN#filamin A#P05959#actin-binding protein 280|filamin alpha#;D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>D2/D3_minus_FLNA_br_complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s167" initialAmount="0.0" name="GRB2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  growth factor receptor-bound protein 2
Synonym:  Synonym not specified
Accession:  P05949
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr23</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s169" initialAmount="0.0" name="D3/D4_minus_GRB2_br_complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D3/D4-GRB2 complex
Synonym:  Synonym not specified
Accession:  U06161
Heterodimer Member Info:  GRB2#PROTEIN#growth factor receptor-bound protein 2#P05949##;D2/D3/D4#PROTEIN#D2/D3/D4#P05965#D2|D3|D4#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>D3/D4_minus_GRB2_br_complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s172" initialAmount="0.0" name="D1/D5">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D1/D5
Synonym:  D1,D5
Accession:  P05948
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s177" initialAmount="0.0" name="GNAZ">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  guanine nucleotide-binding protein, alpha z polypeptide
Synonym:  Gz alpha
Accession:  P05964
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s178" initialAmount="0.0" name="EPB41L2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrocyte membrane protein band 4.1-like 2
Synonym:  4.1G,nonerythroid protein 4.1, general type
Accession:  P05952
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr21</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s182" initialAmount="0.0" name="D5_minusEPB41L2_br_complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D5_minusEPB41L2 complex
Synonym:  Synonym not specified
Accession:  U06162
Heterodimer Member Info:  D1/D5#PROTEIN#D1/D5#P05948#D1|D5#;EPB41L2#PROTEIN#erythrocyte membrane protein band 4.1-like 2#P05952#4.1G|nonerythroid protein 4.1, general type#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>D5_minusEPB41L2_br_complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s185" initialAmount="0.0" name="D5_minus_GNAZ_br_complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  D5-GNAZ complex
Synonym:  Synonym not specified
Accession:  U06163
Heterodimer Member Info:  D1/D5#PROTEIN#D1/D5#P05948#D1|D5#;GNAZ#PROTEIN#guanine nucleotide-binding protein, alpha z polypeptide#P05964#Gz alpha#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>D5_minus_GNAZ_br_complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s197" initialAmount="0.0" name="G_sub_s_endsub__alpha_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gs alpha subunit
Synonym:  GNAS,guanine nucleotide-binding protein, alpha-stimulating activity polypeptide
Accession:  P05945
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re3"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" id="s201" initialAmount="0.0" name="P">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  P
Synonym:  Synonym not specified
Accession:  U06171
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>P</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s202" initialAmount="0.0" name="G_sub_s_endsub__alpha_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gs alpha subunit
Synonym:  GNAS,guanine nucleotide-binding protein, alpha-stimulating activity polypeptide
Accession:  P05945
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s203" initialAmount="0.0" name="Complex_br_(G_sub_s_endsub__alpha_/G_beta_/_br_G_gamma_)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (Gsalpha/Gbeta/ Ggamma)
Synonym:  Synonym not specified
Accession:  U06164
Heterodimer Member Info:  Gsalpha#PROTEIN#Gs alpha subunit#P05945#GNAS|guanine nucleotide-binding protein, alpha-stimulating activity polypeptide#;Gbeta#PROTEIN#G protein, beta subunit#P05954#Guanine nucleotide-binding protein, beta subunit#;Ggamma#PROTEIN#G protein, gamma subunit#P05967##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(G_sub_s_endsub__alpha_/G_beta_/_br_G_gamma_)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s217" initialAmount="0.0" name="G_beta__slash__gamma_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gbeta/gamma
Synonym:  Synonym not specified
Accession:  U06165
Heterodimer Member Info:  Gbeta#PROTEIN#G protein, beta subunit#P05954#Guanine nucleotide-binding protein, beta subunit#;Ggamma#PROTEIN#G protein, gamma subunit#P05967##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>G_beta__slash__gamma_</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s218" initialAmount="0.0" name="AC">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  adenylate cyclase
Synonym:  adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase
Accession:  P05947
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re1"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s227" initialAmount="0.0" name="AC">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  adenylate cyclase
Synonym:  adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase
Accession:  P05947
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re12"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s241" initialAmount="0.0" name="Complex_br_(G_sub_i_endsub__alpha_/G_beta_/_br_G_gamma_)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (Gialpha/Gbeta/ Ggamma)
Synonym:  Synonym not specified
Accession:  U06166
Heterodimer Member Info:  Gbeta#PROTEIN#G protein, beta subunit#P05954#Guanine nucleotide-binding protein, beta subunit#;Gialpha#PROTEIN#Gi alpha subunit#P05958##;Ggamma#PROTEIN#G protein, gamma subunit#P05967##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(G_sub_i_endsub__alpha_/G_beta_/_br_G_gamma_)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s245" initialAmount="0.0" name="G_sub_i_endsub__alpha_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gi alpha subunit
Synonym:  Synonym not specified
Accession:  P05958
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr29</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s252" initialAmount="0.0" name="G_sub_i_endsub__alpha_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gi alpha subunit
Synonym:  Synonym not specified
Accession:  P05958
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr29</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re14"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s253" initialAmount="0.0" name="Complex_br_(G_beta_/G_gamma_)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (Gbeta/Ggamma)
Synonym:  Synonym not specified
Accession:  U06167
Heterodimer Member Info:  Gbeta#PROTEIN#G protein, beta subunit#P05954#Guanine nucleotide-binding protein, beta subunit#;Ggamma#PROTEIN#G protein, gamma subunit#P05967##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(G_beta_/G_gamma_)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s256" initialAmount="0.0" name="P">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  P
Synonym:  Synonym not specified
Accession:  U06171
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>P</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="re1" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="sa8" species="s18"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="sa12" species="s20"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.33333333333333304,-4.440892098500626E-16 0.6666666666666679,-4.440892098500626E-16</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="sa10" modifiers="s218" targetLineIndex="-1,1" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s18">
<annotation>
<celldesigner:alias>sa8</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s20">
<annotation>
<celldesigner:alias>sa12</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s218">
<annotation>
<celldesigner:alias>sa10</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re2" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="sa9" species="s57"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="sa11" species="s57"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.33333333333333304,0.0 0.666666666666667,0.0</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="sa12" modifiers="s20" targetLineIndex="-1,1" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s57">
<annotation>
<celldesigner:alias>sa9</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s57">
<annotation>
<celldesigner:alias>sa11</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s20">
<annotation>
<celldesigner:alias>sa12</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re3" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="sa6" species="s218">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="sa10" species="s218"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="sa231" modifiers="s197" targetLineIndex="-1,0" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget alias="sa231" species="s197">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s218">
<annotation>
<celldesigner:alias>sa6</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s218">
<annotation>
<celldesigner:alias>sa10</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s197">
<annotation>
<celldesigner:alias>sa231</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re4" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="csa3" species="s9">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant alias="sa3" species="s1">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="csa1" species="s3">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="horizontal"/>
<celldesigner:lineDirection arm="0" index="1" value="vertical"/>
<celldesigner:lineDirection arm="0" index="2" value="horizontal"/>
<celldesigner:lineDirection arm="1" index="0" value="vertical"/>
<celldesigner:lineDirection arm="1" index="1" value="horizontal"/>
<celldesigner:lineDirection arm="1" index="2" value="vertical"/>
<celldesigner:lineDirection arm="2" index="0" value="horizontal"/>
<celldesigner:lineDirection arm="2" index="1" value="vertical"/>
<celldesigner:lineDirection arm="2" index="2" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="2" num1="2" num2="2">0.46319961807255794,-0.061400847090217425 0.48046782900333795,0.06886818154676888 0.01778699192145239,0.14210181529281285 1.002360963950112,0.018861944989539248 0.5000000000000284,0.0 0.5000000000000284,-3.552713678800501E-15 0.05929378393114426,0.2748530478691187</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias>sa3</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>csa3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>csa1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re5" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="sa7" species="s62"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="sa16" species="s62"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.3396719397528525,0.028454476593495315 0.6696394811633777,0.01874647869692936</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="sa11" editPoints="0.07339249681162774,-0.08241068517780226" modifiers="s57" targetLineIndex="-1,1" type="UNKNOWN_CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
<celldesigner:modification aliases="sa13" editPoints="4.3562971873423173E-4,-0.0832458587958197" modifiers="s58" targetLineIndex="-1,1" type="UNKNOWN_INHIBITION">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s62">
<annotation>
<celldesigner:alias>sa7</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s62">
<annotation>
<celldesigner:alias>sa16</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s57">
<annotation>
<celldesigner:alias>sa11</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference species="s58">
<annotation>
<celldesigner:alias>sa13</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re6" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="sa15" species="s63"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="sa18" species="s60">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="sa16" modifiers="s62" targetLineIndex="-1,0" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s63">
<annotation>
<celldesigner:alias>sa15</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s60">
<annotation>
<celldesigner:alias>sa18</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s62">
<annotation>
<celldesigner:alias>sa16</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re7" reversible="false">
<annotation>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="sa18" species="s60"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="sa20" species="s24"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s60">
<annotation>
<celldesigner:alias>sa18</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s24">
<annotation>
<celldesigner:alias>sa20</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re8" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="sa1" species="s52"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="sa3" species="s1"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
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<annotation>
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<speciesReference species="s172">
<annotation>
<celldesigner:alias>sa202</celldesigner:alias>
</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>csa3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re90" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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<celldesigner:baseReactant alias="csa39" species="s241">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="csa8" species="s33">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0">-0.007531313641877091,0.43786989098972207</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s129">
<annotation>
<celldesigner:alias>sa176</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s241">
<annotation>
<celldesigner:alias>csa39</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s33">
<annotation>
<celldesigner:alias>csa8</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re91" reversible="false">
<annotation>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="csa7" species="s30">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="csa5" species="s29">
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</celldesigner:baseProduct>
<celldesigner:baseProduct alias="sa255" species="s252">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="sa33" product="s47" targetLineIndex="2,0">
<celldesigner:linkAnchor position="ENE"/>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
<celldesigner:productLink alias="csa40" product="s253" targetLineIndex="2,0">
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<celldesigner:line color="ff000000" width="1.0"/>
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</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct">
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<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
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</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0">0.43959133809536155,-0.06398949923242192</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s30">
<annotation>
<celldesigner:alias>csa7</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s49">
<annotation>
<celldesigner:alias>sa36</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s29">
<annotation>
<celldesigner:alias>csa5</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s252">
<annotation>
<celldesigner:alias>sa255</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s47">
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<celldesigner:alias>sa33</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s253">
<annotation>
<celldesigner:alias>csa40</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re92" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:baseReactant alias="sa255" species="s252">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="sa248" species="s245">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="sa258" product="s256" targetLineIndex="-1,0">
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<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s252">
<annotation>
<celldesigner:alias>sa255</celldesigner:alias>
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</speciesReference>
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<listOfProducts>
<speciesReference species="s245">
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<celldesigner:alias>sa248</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s256">
<annotation>
<celldesigner:alias>sa258</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re93" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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<celldesigner:baseReactant alias="csa40" species="s253">
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<celldesigner:baseReactant alias="sa248" species="s245">
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="csa39" species="s241">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
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<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0">0.014023041621239685,0.5678365383140054</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s253">
<annotation>
<celldesigner:alias>csa40</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s245">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s241">
<annotation>
<celldesigner:alias>csa39</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>


