2.2 SQUARE SQUARE active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active active inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive Cytosol ER Long Name: GTP Synonym: Synonym not specified Accession: S01705 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01702 inside SIMPLE_MOLECULE GDP Long Name: Regulator of G-protein signaling Synonym: RGS Accession: P00731 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05253 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727## inside PROTEIN p5 PROTEIN p9 Long Name: Activator of G-protein signaling Synonym: AGS Accession: P00739 inside PROTEIN p12 Long Name: ATP Synonym: Synonym not specified Accession: S01703 inside SIMPLE_MOLECULE ATP Long Name: K+ Synonym: Synonym not specified Accession: U02316 inside ION K_super_+ Long Name: P Synonym: Synonym not specified Accession: U02315 inside ION P Long Name: K+ Synonym: Synonym not specified Accession: U02316 inside ION K_super_+ Long Name: G protein-activated inward rectifying potassium channel Synonym: GIRK Accession: P00743 transmembrane PROTEIN p18 Long Name: ADP Synonym: Synonym not specified Accession: S01708 inside SIMPLE_MOLECULE ADP Long Name: Arrestin Synonym: Synonym not specified Accession: P00733 inside PROTEIN p7 Long Name: Receptor endocytosis Synonym: Synonym not specified Accession: U02313 inside PHENOTYPE Receptor_space_endocytosis Long Name: Clathrin Synonym: Synonym not specified Accession: P00738 innerSurface PROTEIN p8 Long Name: Ligand Synonym: Synonym not specified Accession: S01707 inside SIMPLE_MOLECULE Ligand Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05257 Heterodimer Member Info: GqPCR#PROTEIN#Gq-protein coupled receptor#P00730#GqPCR#;Ligand#SIMPLE_MOLECULE#Ligand#S01707## transmembrane SIMPLE_MOLECULE Ligand PROTEIN p1 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05252 Heterodimer Member Info: GqPCR#PROTEIN#Gq-protein coupled receptor#P00730#GqPCR#;Arrestin#PROTEIN#Arrestin#P00733## transmembrane PROTEIN p1 PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05247 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;Goalpha#PROTEIN#Go alpha subunit#P00729## inside PROTEIN p4 PROTEIN p5 PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05248 Heterodimer Member Info: GoPCR#PROTEIN#Go-protein coupled receptor#P00725#GoPCR#;Ligand#SIMPLE_MOLECULE#Ligand#S01707## transmembrane PROTEIN p2 SIMPLE_MOLECULE Ligand Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05254 Heterodimer Member Info: GoPCR#PROTEIN#Go-protein coupled receptor#P00725#GoPCR#;Arrestin#PROTEIN#Arrestin#P00733## transmembrane PROTEIN p2 PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05251 Heterodimer Member Info: GoPCR#PROTEIN#Go-protein coupled receptor#P00725#GoPCR#;Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;Goalpha#PROTEIN#Go alpha subunit#P00729## transmembrane PROTEIN p2 PROTEIN p4 PROTEIN p5 PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05249 Heterodimer Member Info: GoPCR#PROTEIN#Go-protein coupled receptor#P00725#GoPCR#;Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;Goalpha#PROTEIN#Go alpha subunit#P00729##;Ligand#SIMPLE_MOLECULE#Ligand#S01707## transmembrane SIMPLE_MOLECULE Ligand PROTEIN p2 PROTEIN p4 PROTEIN p9 PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05255 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;Gqalpha#PROTEIN#Gq alpha subunit#P00732## inside PROTEIN p3 PROTEIN p5 PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05250 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;GqPCR#PROTEIN#Gq-protein coupled receptor#P00730#GqPCR#;Gqalpha#PROTEIN#Gq alpha subunit#P00732##;Ligand#SIMPLE_MOLECULE#Ligand#S01707## transmembrane PROTEIN p1 PROTEIN p3 PROTEIN p5 PROTEIN p9 SIMPLE_MOLECULE Ligand Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05256 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;GqPCR#PROTEIN#Gq-protein coupled receptor#P00730#GqPCR#;Gqalpha#PROTEIN#Gq alpha subunit#P00732## transmembrane PROTEIN p1 PROTEIN p3 PROTEIN p5 PROTEIN p9 Long Name: Gq-protein coupled receptor Synonym: GqPCR Accession: P00730 transmembrane PROTEIN p1 Long Name: Gq alpha subunit Synonym: Synonym not specified Accession: P00732 inside PROTEIN p3 Long Name: Gq alpha subunit Synonym: Synonym not specified Accession: P00732 inside PROTEIN p3 Long Name: Gq-protein coupled receptor Synonym: GqPCR Accession: P00730 transmembrane PROTEIN p1 Long Name: Go alpha subunit Synonym: Synonym not specified Accession: P00729 inside PROTEIN p4 Long Name: Go alpha subunit Synonym: Synonym not specified Accession: P00729 inside PROTEIN p4 Long Name: Go-protein coupled receptor Synonym: GoPCR Accession: P00725 transmembrane PROTEIN p2 Long Name: Go-protein coupled receptor Synonym: GoPCR Accession: P00725 transmembrane PROTEIN p2 Long Name: G-protein receptor kinase Synonym: Synonym not specified Accession: P00741 inside PROTEIN p31 Long Name: Phospholipase C-beta Synonym: PLC beta Accession: P00744 innerSurface PROTEIN p13 Long Name: PiP2 Synonym: Synonym not specified Accession: S01704 inside SIMPLE_MOLECULE PiP2 Long Name: IP3 Synonym: Synonym not specified Accession: S01709 inside SIMPLE_MOLECULE IP3 Long Name: Rho guanine nucleotide exchange factor Synonym: Guanine nucleotide exchange factor 115-KD,p115-RhoGEF Accession: P00728 inside PROTEIN p19 Long Name: Rho effectors Synonym: Synonym not specified Accession: U02314 inside PHENOTYPE Rho_space_effectors Long Name: Ras homolog gene family member A Synonym: ARHA,Oncogen Rho H12,RhoA,RhoH12 Accession: P00740 inside PROTEIN p20 Long Name: Ras homolog gene family member A Synonym: ARHA,Oncogen Rho H12,RhoA,RhoH12 Accession: P00740 inside PROTEIN p20 Long Name: IP3-gated calcium channel Synonym: IP3 receptor,IP3R,Inositol 1,4,5-trisphosphate receptor,Inositol trisphosphate receptor Accession: P00735 transmembrane PROTEIN p32 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02312 inside ION Ca_super_2+ Long Name: Ca2+ Synonym: Synonym not specified Accession: U02312 inside ION Ca_super_2+ Long Name: Protein kinase C Synonym: Synonym not specified Accession: P00745 inside PROTEIN p33 Long Name: Calcium and diacylglycerol-regulated guanine nucleotide exchange factor Synonym: RAS guanyl nucleotide-releasing protein 2,RASGRP2 Accession: P00736 inside PROTEIN p34 Long Name: DAG Synonym: Synonym not specified Accession: S01706 inside SIMPLE_MOLECULE DAG Long Name: Rap1 GTPase-activating protein 1 Synonym: RAP1GA1,Rap1GAP Accession: P00737 inside PROTEIN p35 Long Name: Ras associated protein 1 Synonym: KREV,Ras related protein 1 Accession: P00734 inside PROTEIN p36 Long Name: Ras associated protein 1 Synonym: KREV,Ras related protein 1 Accession: P00734 inside PROTEIN p36 Long Name: Calcium ion channel Synonym: Synonym not specified Accession: P00742 transmembrane PROTEIN p37 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02312 inside ION Ca_super_2+ STATE_TRANSITION s8 s12 0.2516477277987508,0.023061665286433275 0.5869630401347044,0.030653636051354294 a8 a13 a102 HETERODIMER_ASSOCIATION s10,s12 s23 0.3333333333333339,6.106226635438361E-16 0.6666666666666679,6.106226635438361E-16 0.3200952271064912,0.0020165189200831435 0.628792107656118,0.01412018584523178 0.3333333333333335,0.0 0.666666666666667,0.0 0.006637638610730967,0.6904166438891193 a10 a13 a17 HETERODIMER_ASSOCIATION s15,s23 s11 0.33333333333333437,0.0 0.6666666666666674,0.0 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-1.3322676295501878E-15 0.33333333333333304,1.1102230246251565E-16 0.6666666666666661,1.1102230246251565E-16 0.01218897957922671,0.48571390436098216 a19 a17 a12 HETERODIMER_ASSOCIATION s63,s11 s5 0.33333333333333304,0.0 0.6666666666666665,0.0 0.33333333333333215,4.440892098500626E-16 0.666666666666667,0.0 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,0.0 0.3333333333333326,0.33333333333333304 a14 a12 a5 STATE_TRANSITION s37 s37 0.3333333333333335,0.0 0.666666666666667,-8.881784197001252E-16 a28 a24 STATE_TRANSITION s119 s17 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666665,-1.7763568394002505E-15 a22 a21 STATE_TRANSITION s28 s28 0.33333333333333326,-1.7763568394002505E-15 0.6666666666666667,-4.440892098500626E-15 a27 a26 TRANSPORT s19 s26 0.3333333333333339,-2.220446049250313E-16 0.6666666666666661,-1.1102230246251565E-16 a30 a23 STATE_TRANSITION s24 s24 0.3333333333333339,-3.3306690738754696E-16 0.6666666666666679,-3.3306690738754696E-16 a6 a11 STATE_TRANSITION s13 s120 0.33333333333333315,-1.7763568394002505E-15 0.6666666666666666,-2.6645352591003757E-15 a16 a139 a15 a140 DISSOCIATION s1 s83,s63 0.33333333333333304,-6.661338147750939E-16 0.6666666666666661,-1.2212453270876722E-15 0.3333333333333335,0.0 0.6666666666666667,-8.881784197001252E-16 0.3333333333333335,3.885780586188048E-16 0.6666666666666665,1.6653345369377348E-16 0.6177568146484822,0.005523853622025676 a1 a35 a33 a32 a36 HETERODIMER_ASSOCIATION s65,s70 s60 0.3333333333333357,0.0 0.6666666666666679,-1.7763568394002505E-15 0.33333333333333304,0.0 0.6666666666666679,0.0 0.3333333333333339,-4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 0.10786454389335254,0.4207602308013598 a46 a51 a43 HETERODIMER_ASSOCIATION s63,s60 s77 0.3333333333333339,0.0 0.6666666666666679,0.0 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666679,-1.7763568394002505E-15 0.33333333333333215,0.0 0.6666666666666661,0.0 0.6337461773835749,0.3946567858813683 a29 a43 a60 DISSOCIATION s79 s85,s63 0.33333333333333215,-2.220446049250313E-16 0.6666666666666679,-2.220446049250313E-16 0.33333333333333215,0.0 0.6666666666666679,-8.881784197001252E-16 0.3333333333333357,-1.7763568394002505E-15 0.6666666666666679,-1.7763568394002505E-15 0.5396232279239568,0.010051354840176385 a67 a75 a69 a70 a74 HETERODIMER_ASSOCIATION s83,s32 s84 0.33333333333333326,4.440892098500626E-16 0.6666666666666663,4.440892098500626E-16 0.33333333333333304,0.0 0.666666666666667,-2.220446049250313E-16 0.3333333333333335,2.220446049250313E-16 0.6666666666666665,2.220446049250313E-16 0.174858662054165,0.39720367078268337 a33 a37 a78 UNKNOWN_TRANSITION s84 s35 0.3333333333333335,-5.551115123125783E-17 0.666666666666667,-1.6653345369377348E-16 a78 a41 HETERODIMER_ASSOCIATION s85,s32 s88 0.3333333333333357,0.0 0.6666666666666714,0.0 0.3333333333333357,0.0 0.6666666666666679,0.0 0.3333333333333357,8.881784197001252E-16 0.6666666666666643,0.0 0.33333333333333304,0.3333333333333339 a69 a80 a83 UNKNOWN_TRANSITION s88 s35 0.3333333333333333,0.0 0.6666666666666667,0.0 a83 a84 STATE_TRANSITION s66 s89 0.33333333333333215,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a87 a94 a97 HETERODIMER_ASSOCIATION s89,s10 s70 0.33333333333333304,-8.881784197001252E-16 0.6666666666666652,0.0 0.3333333333333339,0.0 0.6666666666666679,-4.440892098500626E-16 0.3333333333333339,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 0.22975678926155574,0.5956512400884719 a94 a90 a51 DISSOCIATION s77 s79,s66 0.33333333333333215,0.0 0.6666666666666661,0.0 0.3333333333333339,-8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16 0.3333333333333339,0.0 0.666666666666667,0.0 0.37505611263855254,0.23280419368672334 a60 a92 a67 a87 a90 a93 DISSOCIATION s5 s1,s8 0.3333333333333328,-4.440892098500626E-16 0.6666666666666667,-4.440892098500626E-16 0.33333333333333304,0.0 0.6666666666666665,-4.440892098500626E-16 0.3333333333333334,4.440892098500626E-16 0.6666666666666667,4.440892098500626E-16 0.36749043266900294,0.21451438292950725 a5 a2 a1 a8 a10 a4 KNOWN_TRANSITION_OMITTED s120 s121 0.33333333333333304,0.0 0.666666666666667,2.220446049250313E-16 a15 a141 STATE_TRANSITION s126 s126 0.3333333333333339,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 a142 a145 TRANSPORT s128 s130 0.3333333333333335,0.0 0.6666666666666661,0.0 a146 a148 STATE_TRANSITION s131 s131 0.3333333333333335,8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 a149 a152 STATE_TRANSITION s132 s132 0.33333333333333304,-1.7763568394002505E-15 0.666666666666667,0.0 a150 a151 STATE_TRANSITION s135 s136 0.33333333333333304,0.0 0.6666666666666661,0.0 a155 a158 a157 a159 STATE_TRANSITION s136 s135 0.3333333333333339,0.0 0.666666666666667,0.0 a157 a155 a160 STATE_TRANSITION s134 s134 0.3333333333333348,-1.7763568394002505E-15 0.6666666666666674,0.0 a156 a154 TRANSPORT s139 s130 0.3333333333333339,1.7763568394002505E-15 0.6666666666666674,-1.7763568394002505E-15 a163 a164 STATE_TRANSITION s137 s137 0.33333333333333215,1.7763568394002505E-15 0.6666666666666661,3.552713678800501E-15 a162 a161