2.3 SQUARE SQUARE_CLOSEUP_SOUTHEAST SQUARE_CLOSEUP_NORTH SQUARE SQUARE SQUARE inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive synaptic vessicle nerve terminal Neuronal Cytosol vessicle lysosome Long Name: Vesicular Glutamate Transporter Synonym: Synonym not specified Accession: P01021 transmembrane PROTEIN p17 Long Name: excitatory amino acid transporter Synonym: EAAT1,GLAST1,GLT-1 Accession: P01011 transmembrane PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05359 Heterodimer Member Info: Ca2+ channel#ION#Ca2+#U02434##;SNARE Complex#PROTEIN#N-ethylmaleimide-sensitive factor attachment protein receptor#P01013#SNARE# transmembrane PROTEIN p10 ION Ca_super_2+ Long Name: cAMP Synonym: Synonym not specified Accession: S01753 inside SIMPLE_MOLECULE cAMP Long Name: steps omitted Synonym: Synonym not specified Accession: U02440 inside PHENOTYPE steps omitted Long Name: Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3 Synonym: GRM2,GRM3,mGlu 2,mGlu 3,mGlu2,mGlu3,mGluR2,mGluR3 Accession: P01014 transmembrane PROTEIN p12 Long Name: Glutamate Synonym: Synonym not specified Accession: S01752 inside SIMPLE_MOLECULE Glutamate Long Name: Ca2+ Synonym: Synonym not specified Accession: U02434 inside ION Ca_super_2+ Long Name: Glutamate Synonym: Synonym not specified Accession: S01752 inside SIMPLE_MOLECULE Glutamate Long Name: AMPA/Kainate Receptor Synonym: AMPA Receptor,Kainate Receptor Accession: P01025 transmembrane PROTEIN p15 Long Name: K+ Synonym: Synonym not specified Accession: U02435 inside ION K_super_+ Long Name: Na+ Synonym: Synonym not specified Accession: U02438 inside ION Na_super_+ Long Name: K+ Synonym: Synonym not specified Accession: U02435 inside ION K_super_+ Long Name: Ca2+ Synonym: Synonym not specified Accession: U02434 inside ION Ca_super_2+ Long Name: Glutamate receptor, ionotropic, AMPA 1 Synonym: AMPA,AMPA R,GRIA1,glu1,glur1 Accession: P01018 transmembrane PROTEIN p18 Long Name: Glutamate receptor, ionotropic, AMPA 2 Synonym: AMPA,AMPA R,GRIA2,glu2,glur2 Accession: P01017 transmembrane PROTEIN p19 Long Name: Glutamate receptor, ionotropic, AMPA 3 Synonym: AMPA,AMPA R,GRIA2,glu3,glur3 Accession: P01016 transmembrane PROTEIN p20 Long Name: Glutamate receptor, ionotropic, AMPA 4 Synonym: AMPA,AMPA R,GRIA4,glu4,glur4 Accession: P01015 transmembrane PROTEIN p21 Long Name: Kainate Receptor Synonym: Synonym not specified Accession: P01026 transmembrane PROTEIN p23 Long Name: glutamate receptor, ionotropic, kainate 1 Synonym: EAA3,EEA3,GLR5,GLUR5,GRIK1 Accession: P01004 transmembrane PROTEIN p24 Long Name: Glutamate receptor, ionotropic kainate 2 Synonym: EAA4,Excitatory amino acid receptor 4,GRIK2,GluR-6,GluR6,Glutamate receptor 6 Accession: P01003 transmembrane PROTEIN p25 Long Name: glutamate receptor, ionotropic, kainate 3 Synonym: EAA5,GLR7,GLUR7,GRIK3,excitatory amino acid receptor 5 Accession: P01002 transmembrane PROTEIN p26 Long Name: glutamate receptor, ionotropic, kainate 4 Synonym: EAA4,GRIK4,excitatory amino acid receptor 4 Accession: P01001 transmembrane PROTEIN p27 Long Name: Kainate Receptor Synonym: Synonym not specified Accession: P01026 transmembrane PROTEIN p23 Long Name: N-Ethylmaleimide-sensitive fusion protein Synonym: Synonym not specified Accession: P01020 inside PROTEIN p29 Long Name: AMPA Receptor Synonym: AMPA Receptor Accession: P01019 transmembrane PROTEIN p22 Long Name: Glutamate receptor, ionotropic kainate 5 Synonym: EAA2,Excitatory amino acid receptor 2 Accession: P01000 transmembrane PROTEIN p28 Long Name: stargazin Synonym: TARP Accession: P00998 inside PROTEIN p32 Long Name: Long Name: PICK1, CaMKII, GRIP1, CaMKIINalpha Synonym: Synonym not specified Accession: U05361 Heterodimer Member Info: PICK#PROTEIN#protein that interacts with C kinase 1#P01012#GRIP1#;CaMKII#PROTEIN#calcium/calmodulin-dependent protein kinase II#P01023#CaMKIINalpha|GRIP1|protein that interacts with C kinase 1# inside PROTEIN p30 PROTEIN p31 Long Name: Glutamate/NMDA receptor epsilon 1 subunit / e 1 subunit Synonym: GRIN2A,N-methyl D-aspartate receptor subtype 2A,NMDAR2A Accession: P01008 transmembrane PROTEIN p35 Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01024 transmembrane PROTEIN p14 Long Name: NMDA targeting to synaptic membrane is likely very important for neuronal plasticity. Synonym: Synonym not specified Accession: U02441 inside PHENOTYPE ? Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01024 inside PROTEIN p14 Long Name: AMPA Receptor Synonym: AMPA Receptor Accession: P01019 inside PROTEIN p22 Long Name: Kainate Receptor Synonym: Synonym not specified Accession: P01026 inside PROTEIN p23 Long Name: a150_degraded Synonym: Synonym not specified Accession: U02436 inside DEGRADED a150_degraded Long Name: a151_degraded Synonym: Synonym not specified Accession: U02437 inside DEGRADED a151_degraded Long Name: a152_degraded Synonym: Synonym not specified Accession: U02439 inside DEGRADED a152_degraded Long Name: Glutamate/NMDA receptor zeta 1 subunit / z 1 subunit Synonym: GLURZ1,GRIN1,NR1 Accession: P01010 transmembrane PROTEIN p37 Long Name: N-methyl D-aspartate receptor subtype 2C Synonym: Glutamate [NMDA] receptor subunit epsilon 3,NMDAR2C Accession: P01006 transmembrane PROTEIN p34 Long Name: Glutamate/NMDA receptor epsilon 4 subunit / e 4 subunit Synonym: Glutamate/NMDA receptor epsilon 4 subunit / e 4 subunit Accession: P01005 transmembrane PROTEIN p36 Long Name: Glutamate/NMDA receptor epsilon 2 subunit / e 2 subunit Synonym: Glutamate/NMDA receptor epsilon 2 subunit / e 2 subunit Accession: P01007 transmembrane PROTEIN p38 Long Name: NR3 Synonym: NMDAR-L Accession: P01009 transmembrane PROTEIN p39 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05357 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01752##;mGluR 2/3#PROTEIN#Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3#P01014#GRM2|GRM3|mGlu 2|mGlu 3|mGlu2|mGlu3|mGluR2|mGluR3# transmembrane PROTEIN p12 SIMPLE_MOLECULE Glutamate Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01013 transmembrane PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05355 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01752##;Vglut#PROTEIN#Vesicular Glutamate Transporter#P01021## transmembrane PROTEIN p17 SIMPLE_MOLECULE Glutamate Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05356 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01752##;EAAT#PROTEIN#excitatory amino acid transporter#P01011#EAAT1|GLAST1|GLT-1# transmembrane PROTEIN p16 SIMPLE_MOLECULE Glutamate Long Name: Glutamate Synonym: Synonym not specified Accession: S01752 inside SIMPLE_MOLECULE Glutamate Long Name: Ca2+ Synonym: Synonym not specified Accession: U02434 inside ION Ca_super_2+ Long Name: Na+ Synonym: Synonym not specified Accession: U02438 inside ION Na_super_+ Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05363 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01752##;KA#PROTEIN#Kainate Receptor#P01026## transmembrane PROTEIN p23 SIMPLE_MOLECULE Glutamate Long Name: PSD95 Synonym: DLG4 Accession: P00999 inside PROTEIN p33 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05358 Heterodimer Member Info: PSD95#PROTEIN#PSD95#P00999#DLG4#;NMDA#PROTEIN#N-methyl-D-aspartate Receptor#P01024#NMDA|NMDA Receptor# transmembrane PROTEIN p14 PROTEIN p33 Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01024 transmembrane PROTEIN p14 Long Name: Long Name: AMPA Receptor Synonym: Synonym not specified Accession: U05360 Heterodimer Member Info: Glu4#PROTEIN#Glutamate receptor, ionotropic, AMPA 4#P01015#AMPA|AMPA R|GRIA4|glu4|glur4#;Glu2#PROTEIN#Glutamate receptor, ionotropic, AMPA 2#P01017#AMPA|AMPA R|GRIA2|glu2|glur2#;Glu1#PROTEIN#Glutamate receptor, ionotropic, AMPA 1#P01018#AMPA|AMPA R|GRIA1|glu1|glur1# transmembrane PROTEIN p21 PROTEIN p19 PROTEIN p18 Long Name: Long Name: AMPA Receptor Synonym: Synonym not specified Accession: U05362 Heterodimer Member Info: Glu4#PROTEIN#Glutamate receptor, ionotropic, AMPA 4#P01015#AMPA|AMPA R|GRIA4|glu4|glur4#;Glu3#PROTEIN#Glutamate receptor, ionotropic, AMPA 3#P01016#AMPA|AMPA R|GRIA2|glu3|glur3#;Glu2#PROTEIN#Glutamate receptor, ionotropic, AMPA 2#P01017#AMPA|AMPA R|GRIA2|glu2|glur2# transmembrane PROTEIN p21 PROTEIN p20 PROTEIN p19 Long Name: Calcium Channel Synonym: Ca++ Channel,Ca2+ channel Accession: P01022 transmembrane PROTEIN p7 TRANSPORT s58 s104 0.33333333333333326,-2.220446049250313E-16 0.7121175489653686,0.010167877792596425 a64 a65 a87 STATE_TRANSITION s103 s103 0.3333333333333339,-2.220446049250313E-16 0.6666666666666665,-8.881784197001252E-16 a61 a87 a101 KNOWN_TRANSITION_OMITTED s100 s101 0.33333333333333304,0.0 0.666666666666667,0.0 a100 a101 TRANSPORT s102 s4 0.02085339189263724,-0.04441044732659538 0.7303588358476228,-0.3917046087821108 a72 a4 TRANSPORT s58 s121 -0.012386216563921248,-0.1548833452599392 0.863584848256171,-0.17708557818364667 a119 a120 TRANSPORT s116 s120 0.3333333333333339,0.0 0.666666666666667,-8.881784197001252E-16 a117 a116 TRANSPORT s117 s119 0.0657723549796152,0.09239771921974738 0.7002384170258731,0.14304721407156062 a111 a115 TRANSPORT s116 s120 0.26794696181755917,0.22695563795904605 1.0081048987606116,0.28631959175788246 a110 a118 ? TRANSPORT s127 s108 0.01684278839617903,0.0036383763651508527 0.24321649230988784,-0.09589321149086094 a126 a94 a149 HETERODIMER_ASSOCIATION s145,s144 s150 0.05791232628660481,-0.27191422257101205 1.0079783083360665,-0.10921787965816687 0.3333333333333326,-3.552713678800501E-15 0.6666666666666656,-3.552713678800501E-15 0.33333333333333326,0.0 0.6666666666666667,-8.881784197001252E-16 -4.619480265728811,0.9848573661586566 a144 a143 a148 HETERODIMER_ASSOCIATION s147,s146 s150 0.044888574805038495,-0.21546452020464368 0.6933806054000557,-0.10629743169910988 0.3333333333333348,0.0 0.6666666666666679,0.0 0.33333333333333415,8.881784197001252E-16 0.6666666666666667,8.881784197001252E-16 -2.7503202285939423,1.006700167504187 a146 a145 a148 TRANSPORT s127 s154 0.33333333333333326,-8.881784197001252E-16 0.6666666666666665,-1.7763568394002505E-15 a126 a152 TRANSPORT s150 s152 0.24113469474363347,0.4802634652058728 0.5180812900523646,0.34327923439141106 a148 a150 STATE_TRANSITION s152 s158 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 a150 a157 STATE_TRANSITION s153 s160 -0.2525841459990419,-0.17027497957270388 0.5707485262151861,-0.042892791592782586 a151 a159 STATE_TRANSITION s154 s161 0.3333333333333335,0.0 0.666666666666667,0.0 a152 a160 HETERODIMER_ASSOCIATION s143,s162 s150 0.3333333333333335,1.7763568394002505E-15 0.6666666666666665,0.0 0.04041983670135174,-0.25943366607481977 0.9508950189700158,-0.10650975383668637 0.3333333333333335,0.0 0.6666666666666665,0.0 6.510930547494674,0.9650802863223058 a142 a161 a148 HETERODIMER_ASSOCIATION s4,s77 s169 0.26645326080984333,-0.0012530320850351329 0.6419774012123598,-0.0173360898459054 0.33333333333333304,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 0.33333333333333304,-4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 -1.4424932264206092,1.8615077621558278 a4 a91 a167 KNOWN_TRANSITION_OMITTED s169 s100 0.3333333333333339,1.1102230246251565E-16 0.666666666666667,3.3306690738754696E-16 a167 a100 HETERODIMER_ASSOCIATION s171,s104 s99 0.33333333333333326,-3.552713678800501E-15 0.6666666666666667,-1.7763568394002505E-15 0.33333333333333304,-1.1102230246251565E-16 0.666666666666667,1.1102230246251565E-16 0.3333333333333335,0.0 0.6666666666666665,-4.440892098500626E-16 0.3333333333333339,0.33333333333333326 a169 a65 a99 HETERODIMER_ASSOCIATION s95,s105 s174 0.33333333333333315,0.0 0.6666666666666666,0.0 0.33333333333333304,0.0 0.6666666666666665,-4.440892098500626E-16 0.3333333333333339,-6.661338147750939E-16 0.6666666666666661,-2.220446049250313E-16 0.33333333333333304,0.3333333333333339 a171 a97 a173 DISSOCIATION s174 s95,s102 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.3333333333333339,4.440892098500626E-16 0.666666666666667,-2.220446049250313E-16 0.33333333333333304,-3.3306690738754696E-16 0.666666666666667,-1.1102230246251565E-16 0.3333333333333335,0.33333333333333304 a173 a171 a72 HETERODIMER_ASSOCIATION s90,s4 s178 0.33333333333333304,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 0.33333333333333304,-4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 0.3333333333333073,5.6843418860808015E-14 -2.4530914224786002,-1.4327030523621147 0.3333333333333335,0.33333333333333315 a96 a4 a176 DISSOCIATION s178 s105,s90 0.3333333333333339,5.551115123125783E-17 0.6666666666666661,-3.885780586188048E-16 0.33333333333333326,4.440892098500626E-16 0.6666666666666665,4.440892098500626E-16 0.3333333333333339,-4.440892098500626E-16 0.6666666666666672,0.0 0.3333333333333335,0.33333333333333304 a176 a97 a96 HETERODIMER_ASSOCIATION s133,s4 s185 0.33333333333333304,8.881784197001252E-16 0.6666666666666665,0.0 0.33333333333333304,1.8041124150158794E-16 0.666666666666667,-2.636779683484747E-16 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,0.0 0.3333333333333335,0.33333333333333326 a133 a4 a180 TRANSPORT s117 s119 0.13278786637572493,0.186720267685196 0.8216793578694936,0.19591709832256576 a113 a114 STATE_TRANSITION s189 s107 0.33438574679670197,-0.02152141093870874 0.6666666666666665,-4.440892098500626E-16 a186 a103 HETERODIMER_ASSOCIATION s4,s189 s107 0.3333333333333339,2.220446049250313E-16 0.666666666666667,1.1102230246251565E-16 0.3333333333333339,-8.881784197001252E-16 0.6666666666666696,-8.881784197001252E-16 0.33333333333333304,-4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 -0.22710858800313716,0.6797052657943259 a4 a186 a103 TRANSPORT s150 s189 0.3333333333333335,-2.220446049250313E-16 0.6666666666666665,0.0 a148 a185 a186 HETERODIMER_ASSOCIATION s129,s128 s127 0.33333333333333215,-1.3322676295501878E-15 0.6666666666666679,-1.3322676295501878E-15 0.3333333333333339,8.881784197001252E-16 0.6666666666666643,0.0 0.33333333333333215,0.0 0.666666666666667,0.0 4.847909604519778,1.028248587570622 a128 a127 a129 a130 a132 a126 TRANSPORT s212 s136 0.4574291446266332,0.2025035497878842 0.7143794712534937,0.21979982108781904 a209 a136 a139 TRANSPORT s217 s108 0.22526155101619416,-0.23521583274329094 0.6666666666666667,-4.440892098500626E-16 a214 a94 a135 TRANSPORT s136 s108 0.33333333333333337,-6.217248937900877E-15 0.6666666666666667,-1.2434497875801753E-14 a136 a94 a140 TRANSPORT s217 s153 0.08486850391237444,-0.15225637486027277 0.918844178802825,-0.20002308970639593 a214 a151 TRANSPORT s212 s153 0.1669489276308676,-0.12605881723180778 1.00190867503504,-0.1663613694564927 a209 a151 HETERODIMER_ASSOCIATION s4,s108 s108 0.3333333333333339,0.0 0.666666666666667,-8.881784197001252E-16 0.3333333333333339,0.0 0.6666666666666674,0.0 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-4.440892098500626E-16 0.33333333333333315,0.3333333333333335 a4 a94 a102 HETERODIMER_ASSOCIATION s123,s125 s212 0.3333333333333339,4.440892098500626E-16 0.6666666666666661,0.0 0.33333333333333215,0.0 0.6666666666666661,0.0 0.33333333333333215,2.220446049250313E-16 0.6666666666666652,1.1102230246251565E-16 0.33333333333333315,0.3333333333333335 a122 a124 a121 a209 HETERODIMER_ASSOCIATION s125,s124 s217 0.3333333333333304,0.0 0.6666666666666661,-8.881784197001252E-16 0.3333333333333339,0.0 0.6666666666666661,0.0 0.3333333333333339,0.0 0.666666666666667,0.0 0.3333333333333339,0.3333333333333335 a196 a123 a197 a214