2.2 SQUARE_CLOSEUP_NORTHWEST SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active active active active nucleus Cytoplasm Long Name: Gene transcription Synonym: Synonym not specified Accession: U02446 inside PHENOTYPE Gene transcription Long Name: Suppressors of cytokine signaling Synonym: CIS,JAB ,SOCS,SSI-1 Accession: P01030 inside PROTEIN p7 Long Name: protein-tyrosine phosphatase Synonym: PTP Accession: P01033 inside PROTEIN p8 Long Name: Serine kinase Synonym: Synonym not specified Accession: P01029 inside PROTEIN p9 Long Name: Protein inhibitors of activated STATs Synonym: PIAS Accession: P01031 inside PROTEIN p10 Long Name: protein-tyrosine phosphatase Synonym: PTP Accession: P01033 inside PROTEIN p8 Long Name: Cytokine Receptor Synonym: Synonym not specified Accession: P01028 transmembrane PROTEIN p5 Long Name: Jak Synonym: Jak,Janus kinase,Tyk2 Accession: P01034 inside PROTEIN p2 Long Name: Jak Synonym: Jak,Janus kinase,Tyk2 Accession: P01034 inside PROTEIN p2 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 Long Name: ADP Synonym: Synonym not specified Accession: S01757 inside SIMPLE_MOLECULE ADP Long Name: ATP Synonym: Synonym not specified Accession: S01754 inside SIMPLE_MOLECULE ATP Long Name: ATP Synonym: Synonym not specified Accession: S01754 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01757 inside SIMPLE_MOLECULE ADP Long Name: 2 ATP Synonym: Synonym not specified Accession: S01758 inside SIMPLE_MOLECULE 2 ATP Long Name: 2 ADP Synonym: Synonym not specified Accession: S01755 inside SIMPLE_MOLECULE 2 ADP Long Name: Cytokine Synonym: Synonym not specified Accession: P01032 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05366 Heterodimer Member Info: Cytokine Receptor#PROTEIN#Cytokine Receptor#P01028##;Cytokine#PROTEIN#Cytokine#P01032## transmembrane PROTEIN p5 PROTEIN p11 Long Name: Pi Synonym: Synonym not specified Accession: S01756 inside SIMPLE_MOLECULE Pi Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05365 Heterodimer Member Info: Cytokine Receptor#PROTEIN#Cytokine Receptor#P01028##;Cytokine#PROTEIN#Cytokine#P01032##;Jak#PROTEIN#Jak#P01034#Jak|Janus kinase|Tyk2# transmembrane PROTEIN p5 PROTEIN p11 PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05364 Heterodimer Member Info: STAT#PROTEIN#Signal transducers and activators of transcription#P01027#STAT#;Cytokine Receptor#PROTEIN#Cytokine Receptor#P01028##;Cytokine#PROTEIN#Cytokine#P01032##;Jak#PROTEIN#Jak#P01034#Jak|Janus kinase|Tyk2# transmembrane PROTEIN p5 PROTEIN p11 PROTEIN p4 PROTEIN p2 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 2 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 2 Long Name: Pi Synonym: Synonym not specified Accession: U02445 inside ION Pi TRANSPORT s21 s21 0.3333333333333336,0.0 0.6666666666666671,0.0 a19 a27 STATE_TRANSITION s4 s18 0.33333333333333326,2.220446049250313E-16 0.6666666666666666,0.0 a6 a96 a8 a95 STATE_TRANSITION s18 s4 0.33333333333333337,0.0 0.6666666666666665,0.0 a8 a6 a97 HETERODIMER_ASSOCIATION s65,s23 s75 0.33333333333333326,1.1102230246251565E-16 0.666666666666667,-1.1102230246251565E-16 0.33333333333333326,0.0 0.6666666666666667,2.220446049250313E-16 0.3333333333333335,-2.220446049250313E-16 0.666666666666667,-6.661338147750939E-16 0.3333333333333336,0.33333333333333337 a108 a43 a126 HETERODIMER_ASSOCIATION s18,s75 s77 0.19190392970856895,-0.2403735601022008 0.43335061462160374,-0.20675013106397433 0.3333333333333339,-2.220446049250313E-16 0.666666666666667,2.220446049250313E-16 0.33333333333333304,0.0 0.6666666666666665,1.1102230246251565E-16 0.637545732085532,0.37838446783317803 a8 a126 a106 a131 a107 HETERODIMER_ASSOCIATION s77,s21 s81 0.33333333333333304,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 0.3333333333333335,0.0 0.666666666666667,0.0 0.33333333333333304,0.0 0.6666666666666665,0.0 0.33333333333333315,0.33333333333333326 a131 a27 a100 a136 a101 DISSOCIATION s81 s41,s77 0.33333333333333304,-8.881784197001252E-16 0.666666666666667,-1.7763568394002505E-15 0.33333333333333304,-2.220446049250313E-16 0.6666666666666665,-2.220446049250313E-16 0.3611945482150021,0.00824494715456394 0.666666666666667,5.065392549852277E-16 0.33333333333333337,0.3333333333333339 a136 a41 a131 STATE_TRANSITION s41 s82 0.33333333333333304,0.0 0.6666666666666661,4.440892098500626E-16 a41 a137 TRANSPORT s82 s83 0.3333333333333335,-4.440892098500626E-16 0.6666666666666663,0.0 a137 a138 STATE_TRANSITION s83 s49 0.3333333333333335,0.0 0.6666666666666665,0.0 a138 a73 a102 TRANSCRIPTIONAL_ACTIVATION s83 s17 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666679,-8.881784197001252E-16 a138 a35