<?xml version="1.0" encoding="UTF-8"?>
<!-- Terms and Conditions -->
<!-- 
Copyright (C) 2007 SRI International.  All Rights Reserved.
This file may be copied and redistributed freely, without advance
permission, provided that these notices are reproduced with each
copy.  Your use of the data herein is solely at your own risk.
The data is not, and is not supplied as, medical information.

THIS DATA IS PROVIDED "AS IS" AND WITHOUT ANY EXPRESS OR IMPLIED
WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES
OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. IN NO
EVENT SHALL SRI BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,
SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT
LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF
USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND
ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT
OF THE USE OF THIS DATA, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH
DAMAGE.

The data herein were made in part with support under Grant Number
5 U01 DA 020830 from the National Institute on Drug Abuse at the
National Institutes of Health. 
-->

<!-- Created by SBML API 2.0(a17.0) -->
<sbml xmlns="http://www.sbml.org/sbml/level2" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" level="2" version="1">
<model id="Opioid_space_proenkephalin_space_pathway">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
<![CDATA[
No pathway definition
]]>
</body>
</html>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
No pathway definition
</body>
</html>
</notes>
<annotation>
<celldesigner:modelVersion>2.5</celldesigner:modelVersion>
<celldesigner:modelDisplay sizeX="800" sizeY="800"/>
<celldesigner:listOfIncludedSpecies>
<celldesigner:species id="s3" name="GDP">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S06104
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s10</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s8" name="G-protein">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G-protein
Synonym:  Synonym not specified
Accession:  P05994
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s10</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s15" name="GTP">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S06106
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s38</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s16" name="G-protein">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G-protein
Synonym:  Synonym not specified
Accession:  P05994
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s38</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s17" name="hyperpolarization">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  hyperpolarization
Synonym:  Synonym not specified
Accession:  U06189
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s46</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>hyperpolarization</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s18" name="fine motor control">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  fine motor control
Synonym:  Synonym not specified
Accession:  U06187
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s46</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>fine motor control</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s23" name="Enkephalin">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Enkephalin
Synonym:  Met-enkephalin ,leu-enkephalin
Accession:  P05991
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s53</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s24" name="GDP">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S06104
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s56</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s25" name="G-protein">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G-protein
Synonym:  Synonym not specified
Accession:  P05994
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s56</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s27" name="Enkephalin">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Enkephalin
Synonym:  Met-enkephalin ,leu-enkephalin
Accession:  P05991
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s56</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s57" name="Analgesic">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Analgesic
Synonym:  Synonym not specified
Accession:  U06190
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s46</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Analgesic</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s61" name="Mu or Delta_br_receptor">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  opioid receptor, delta or mu
Synonym:  Synonym not specified
Accession:  P05985
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s10</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s62" name="Mu or Delta_br_receptor">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  opioid receptor, delta or mu
Synonym:  Synonym not specified
Accession:  P05985
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s53</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s63" name="Mu or Delta_br_receptor">
<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  opioid receptor, delta or mu
Synonym:  Synonym not specified
Accession:  P05985
</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s56</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
</celldesigner:listOfIncludedSpecies>
<celldesigner:listOfCompartmentAliases>
<celldesigner:compartmentAlias compartment="c1" id="ca1">
<celldesigner:class>SQUARE_CLOSEUP_SOUTH</celldesigner:class>
<celldesigner:point x="358.0" y="260.0"/>
<celldesigner:doubleLine innerWidth="1.0" outerWidth="2.0" thickness="12.0"/>
<celldesigner:paint color="ffcccc00" scheme="Color"/>
</celldesigner:compartmentAlias>
<celldesigner:compartmentAlias compartment="c2" id="ca2">
<celldesigner:class>SQUARE_CLOSEUP_NORTH</celldesigner:class>
<celldesigner:point x="315.0" y="398.0"/>
<celldesigner:doubleLine innerWidth="1.0" outerWidth="2.0" thickness="12.0"/>
<celldesigner:paint color="ffcccc00" scheme="Color"/>
</celldesigner:compartmentAlias>
<celldesigner:compartmentAlias compartment="c3" id="ca3">
<celldesigner:class>SQUARE</celldesigner:class>
<celldesigner:bounds h="73.0" w="421.0" x="95.0" y="35.0"/>
<celldesigner:doubleLine innerWidth="1.0" outerWidth="2.0" thickness="12.0"/>
<celldesigner:paint color="ffcccc00" scheme="Color"/>
</celldesigner:compartmentAlias>
<celldesigner:compartmentAlias compartment="c4" id="ca4">
<celldesigner:class>SQUARE</celldesigner:class>
<celldesigner:bounds h="118.0" w="418.0" x="111.0" y="128.0"/>
<celldesigner:doubleLine innerWidth="1.0" outerWidth="2.0" thickness="12.0"/>
<celldesigner:paint color="ffcccc00" scheme="Color"/>
</celldesigner:compartmentAlias>
</celldesigner:listOfCompartmentAliases>
<celldesigner:listOfComplexSpeciesAliases>
<celldesigner:complexSpeciesAlias compartmentAlias="ca2" id="a9" species="s10">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="86.0" w="120.35420763500281" x="586.9613312043797" y="378.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="271.9613312043797" y="-19.75"/>
<celldesigner:boxSize height="86.0" width="120.35420763500281"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:complexSpeciesAlias>
<celldesigner:complexSpeciesAlias compartmentAlias="ca2" id="a44" species="s38">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="58.0" w="83.0" x="192.95478939669022" y="443.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-122.04521060330978" y="45.0"/>
<celldesigner:boxSize height="58.0" width="83.0"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:complexSpeciesAlias>
<celldesigner:complexSpeciesAlias compartmentAlias="ca2" id="a51" species="s46">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="94.0" w="127.0" x="70.96153846153845" y="535.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-244.03846153846155" y="137.0"/>
<celldesigner:boxSize height="94.0" width="127.0"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:complexSpeciesAlias>
<celldesigner:complexSpeciesAlias compartmentAlias="ca2" id="a60" species="s53">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="72.5" w="114.0" x="253.2360906234333" y="356.875"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-61.76390937656669" y="-41.125"/>
<celldesigner:boxSize height="72.5" width="114.0"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:complexSpeciesAlias>
<celldesigner:complexSpeciesAlias compartmentAlias="ca2" id="a63" species="s56">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="111.5" w="119.58547554630593" x="447.12297784246846" y="354.375"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="132.12297784246846" y="-43.625"/>
<celldesigner:boxSize height="111.5" width="119.58547554630593"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="2.0"/>
<celldesigner:paint color="fff7f7f7" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:complexSpeciesAlias>
</celldesigner:listOfComplexSpeciesAliases>
<celldesigner:listOfSpeciesAliases>
<celldesigner:speciesAlias compartmentAlias="ca3" id="a1" species="s1">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="22.0" w="103.0" x="185.5" y="53.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="90.5" y="18.25"/>
<celldesigner:boxSize height="22.0" width="103.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca4" id="a2" species="s2">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="21.0" w="65.0" x="338.5" y="157.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="227.5" y="29.25"/>
<celldesigner:boxSize height="21.0" width="65.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca4" id="a3" species="s9">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="21.0" w="95.0" x="191.5" y="195.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="80.5" y="67.25"/>
<celldesigner:boxSize height="21.0" width="95.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca4" id="a4" species="s4">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="32.0" w="186.0" x="202.5" y="233.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="91.5" y="105.25"/>
<celldesigner:boxSize height="32.0" width="186.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca4" id="a5" species="s5">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="20.0" w="62.0" x="159.5" y="165.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="48.5" y="37.25"/>
<celldesigner:boxSize height="20.0" width="62.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a6" species="s7">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="21.0" w="95.0" x="225.0" y="323.75"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="21.0" width="95.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca4" id="a7" species="s6">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="19.0" w="90.0" x="303.0" y="199.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="192.0" y="71.0"/>
<celldesigner:boxSize height="19.0" width="90.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a11" species="s12">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="24.0" w="27.0" x="422.55924270507734" y="470.625"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="107.55924270507734" y="72.625"/>
<celldesigner:boxSize height="24.0" width="27.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a12" species="s13">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="26.0" w="29.0" x="376.55924270507734" y="474.625"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="61.55924270507734" y="76.625"/>
<celldesigner:boxSize height="26.0" width="29.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a13" species="s14">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="36.0" w="50.0" x="404.05924270507734" y="542.625"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="89.05924270507734" y="144.625"/>
<celldesigner:boxSize height="36.0" width="50.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a17" species="s21">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="33.0" w="46.0" x="457.05924270507734" y="496.625"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="142.05924270507734" y="98.625"/>
<celldesigner:boxSize height="33.0" width="46.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a19" species="s20">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="36.0" w="50.0" x="244.05924270507734" y="561.625"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-70.94075729492266" y="163.625"/>
<celldesigner:boxSize height="36.0" width="50.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a20" species="s21">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="32.0" w="43.0" x="285.05924270507734" y="519.625"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-29.940757294922662" y="121.625"/>
<celldesigner:boxSize height="32.0" width="43.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a21" species="s22">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="19.0" w="90.0" x="435.0" y="304.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="19.0" width="90.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a46" species="s40">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="36.0" w="43.0" x="181.0" y="384.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-134.0" y="-14.0"/>
<celldesigner:boxSize height="36.0" width="43.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a47" species="s40">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="36.0" w="58.0" x="80.5" y="383.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-234.5" y="-15.0"/>
<celldesigner:boxSize height="36.0" width="58.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a48" species="s44">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="25.0" x="96.5" y="324.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="25.0" width="25.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ff9999ff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="a49" species="s48">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="25.0" x="97.5" y="431.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-217.5" y="33.5"/>
<celldesigner:boxSize height="25.0" width="25.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ff9999ff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a9" id="sa1" species="s3">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="26.0" w="29.0" x="668.6771765317771" y="432.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="81.71584532739746" y="54.0"/>
<celldesigner:boxSize height="26.0" width="29.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a9" id="sa2" species="s8">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="20.0" w="67.0" x="634.3155388393825" y="415.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="47.35420763500281" y="37.0"/>
<celldesigner:boxSize height="20.0" width="67.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a9" id="sa3" species="s61">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="33.0" w="102.0" x="597.9613312043797" y="391.25"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="11.0" y="13.0"/>
<celldesigner:boxSize height="33.0" width="102.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a44" id="sa4" species="s15">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="24.0" w="27.0" x="237.5" y="469.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="44.54521060330978" y="26.0"/>
<celldesigner:boxSize height="24.0" width="27.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a44" id="sa5" species="s16">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="20.0" w="67.0" x="200.95478939669022" y="452.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="8.0" y="9.0"/>
<celldesigner:boxSize height="20.0" width="67.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a51" id="sa6" species="s17">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="24.0" w="107.0" x="80.00000000000003" y="541.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="9.038461538461576" y="6.0"/>
<celldesigner:boxSize height="24.0" width="107.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffcc99ff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a51" id="sa7" species="s18">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="26.0" w="113.0" x="77.96153846153845" y="565.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="7.0" y="30.0"/>
<celldesigner:boxSize height="26.0" width="113.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffcc99ff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a60" id="sa8" species="s62">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="34.0" w="102.0" x="260.2360906234333" y="393.375"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="7.0" y="36.5"/>
<celldesigner:boxSize height="34.0" width="102.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a60" id="sa9" species="s23">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="33.0" w="68.0" x="277.85738605040524" y="362.875"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="24.621295426971926" y="6.0"/>
<celldesigner:boxSize height="33.0" width="68.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a63" id="sa10" species="s24">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="26.0" w="29.0" x="528.070091081169" y="433.875"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="80.94711323870058" y="79.5"/>
<celldesigner:boxSize height="26.0" width="29.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a63" id="sa11" species="s25">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="20.0" w="67.0" x="493.7084533887744" y="416.875"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="46.58547554630593" y="62.5"/>
<celldesigner:boxSize height="20.0" width="67.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a63" id="sa12" species="s63">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="31.0" w="102.0" x="454.12297784246846" y="391.875"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="7.0" y="37.5"/>
<celldesigner:boxSize height="31.0" width="102.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a63" id="sa13" species="s27">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="33.0" w="68.0" x="460.28283982259495" y="360.375"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="13.159861980126493" y="6.0"/>
<celldesigner:boxSize height="33.0" width="68.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="0.0" width="0.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="a51" id="sa32" species="s57">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="27.0" w="107.0" x="80.0" y="591.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="9.038461538461547" y="56.0"/>
<celldesigner:boxSize height="27.0" width="107.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffcc99ff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups/>
<celldesigner:listOfProteins>
<celldesigner:protein id="p13" name="proenkephalin" type="GENERIC"/>
<celldesigner:protein id="p19" name="peptide E" type="GENERIC"/>
<celldesigner:protein id="p15" name="met-Enkephalin" type="GENERIC"/>
<celldesigner:protein id="p24" name="SNARE COMPLEX" type="GENERIC"/>
<celldesigner:protein id="p20" name="peptide F" type="GENERIC"/>
<celldesigner:protein id="p1" name="leu-Enkephalin" type="GENERIC"/>
<celldesigner:protein id="p11" name="G-protein" type="GENERIC"/>
<celldesigner:protein id="p7" name="AC" type="GENERIC"/>
<celldesigner:protein id="p25" name="Enkephalin" type="GENERIC"/>
<celldesigner:protein id="p2" name="K_super_+_endsuper__br_channel" type="ION_CHANNEL"/>
<celldesigner:protein id="p6" name="Mu or Delta_br_receptor" type="RECEPTOR"/>
</celldesigner:listOfProteins>
<celldesigner:listOfGenes/>
<celldesigner:listOfRNAs/>
<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfBlockDiagrams/>
</annotation>
<listOfCompartments>
<compartment id="default"/>
<compartment id="c1" name="medium spiny neuron of striatum" outside="default">
<annotation>
<celldesigner:name>medium spiny neuron of striatum</celldesigner:name>
</annotation>
</compartment>
<compartment id="c2" name="pallidum neuron" outside="default">
<annotation>
<celldesigner:name>pallidum neuron</celldesigner:name>
</annotation>
</compartment>
<compartment id="c3" name="Golgi apparatus" outside="c1">
<annotation>
<celldesigner:name>Golgi apparatus</celldesigner:name>
</annotation>
</compartment>
<compartment id="c4" name="secretory vesicle" outside="c1">
<annotation>
<celldesigner:name>secretory vesicle</celldesigner:name>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species compartment="c3" id="s1" initialAmount="0.0" name="proenkephalin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  proenkephalin
Synonym:  Long Name:  proenkephalin,PENK
Accession:  P05995
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s2" initialAmount="0.0" name="peptide E">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  peptide E
Synonym:  Long Name:  peptide E
Accession:  P05988
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p19</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s4" initialAmount="0.0" name="SNARE COMPLEX">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SNARE COMPLEX
Synonym:  Long Name:  SNARE COMPLEX
Accession:  P05986
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p24</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re2"/>
<celldesigner:catalyzed reaction="re8"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c4" id="s5" initialAmount="0.0" name="peptide F">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  peptide F
Synonym:  Long Name:  peptide F
Accession:  P05987
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s6" initialAmount="0.0" name="leu-Enkephalin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  leu-Enkephalin
Synonym:  Long Name:  leu-Enkephalin
Accession:  P05989
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s7" initialAmount="0.0" name="met-Enkephalin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  met-Enkephalin
Synonym:  Long Name:  met-Enkephalin
Accession:  P05992
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s9" initialAmount="0.0" name="met-Enkephalin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  met-Enkephalin
Synonym:  Long Name:  met-Enkephalin
Accession:  P05992
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s12" initialAmount="0.0" name="GTP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S06106
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s13" initialAmount="0.0" name="GDP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S06104
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s14" initialAmount="0.0" name="ATP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S06105
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s20" initialAmount="0.0" name="cAMP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  cAMP
Synonym:  Synonym not specified
Accession:  S06107
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cAMP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s21" initialAmount="0.0" name="AC">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  adenylate cyclase
Synonym:  Long Name:  AC,adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase
Accession:  P05993
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re3"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s22" initialAmount="0.0" name="leu-Enkephalin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  leu-Enkephalin
Synonym:  Long Name:  leu-Enkephalin
Accession:  P05989
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s10" initialAmount="0.0" name="Complex_br_(GDP/G-protein/_br_Sigma, Mu, Kappa)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (GDP/G-protein/ Sigma, Mu, Kappa)
Synonym:  Synonym not specified
Accession:  U06182
Heterodimer Member Info:  Mu or Delta receptor#PROTEIN#opioid receptor, delta or mu#P05985##;GDP#SIMPLE_MOLECULE#GDP#S06104##;G-protein#PROTEIN#G-protein#P05994##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GDP/G-protein/_br_Sigma, Mu, Kappa)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s38" initialAmount="0.0" name="Complex_br_(GTP/G-protein)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (GTP/G-protein)
Synonym:  Synonym not specified
Accession:  U06183
Heterodimer Member Info:  GTP#SIMPLE_MOLECULE#GTP#S06106##;G-protein#PROTEIN#G-protein#P05994##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GTP/G-protein)</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re4"/>
<celldesigner:catalyzed reaction="re11"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s44" initialAmount="0.0" name="K+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+
Synonym:  Synonym not specified
Accession:  U06188
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s46" initialAmount="0.0" name="Complex_br_(hyperpolarization/fine motor control)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (hyperpolarization/fine motor control)
Synonym:  Synonym not specified
Accession:  U06184
Heterodimer Member Info:  fine motor control#PHENOTYPE#fine motor control#U06187##;hyperpolarization#PHENOTYPE#hyperpolarization#U06189##;Analgesic#PHENOTYPE#Analgesic#U06190##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(hyperpolarization/fine motor control)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s48" initialAmount="0.0" name="K+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+
Synonym:  Synonym not specified
Accession:  U06188
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s53" initialAmount="0.0" name="Complex_br_(Sigma receptor/Enkephalin)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (Sigma receptor/Enkephalin)
Synonym:  Synonym not specified
Accession:  U06185
Heterodimer Member Info:  Mu or Delta receptor#PROTEIN#opioid receptor, delta or mu#P05985##;Enkephalin#PROTEIN#Enkephalin#P05991#Met-enkephalin |leu-enkephalin#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(Sigma receptor/Enkephalin)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s56" initialAmount="0.0" name="Complex_br_(GDP/G-protein/_br_Sigma receptor/Enkephalin)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Complex (GDP/G-protein/ Sigma receptor/Enkephalin)
Synonym:  Synonym not specified
Accession:  U06186
Heterodimer Member Info:  Mu or Delta receptor#PROTEIN#opioid receptor, delta or mu#P05985##;GDP#SIMPLE_MOLECULE#GDP#S06104##;Enkephalin#PROTEIN#Enkephalin#P05991#Met-enkephalin |leu-enkephalin#;G-protein#PROTEIN#G-protein#P05994##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GDP/G-protein/_br_Sigma receptor/Enkephalin)</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s40" initialAmount="0.0" name="K+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+ channel
Synonym:  Kcnk3,Long Name:  K+ channel,Potassium channel subfamily K member 3,Potassium channel subfamily K member 9,TASK-1,TASK-3,TWIK
Accession:  P05990
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re12"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="re1" reversible="false">
<annotation>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a1" species="s1"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a2" species="s2"/>
<celldesigner:baseProduct alias="a3" species="s9"/>
</celldesigner:baseProducts>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a5" product="s5" targetLineIndex="0,0">
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
<celldesigner:productLink alias="a7" product="s6" targetLineIndex="0,0">
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="0" index="1" value="unknown"/>
<celldesigner:lineDirection arm="0" index="2" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="1" value="unknown"/>
<celldesigner:lineDirection arm="1" index="2" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="1" value="unknown"/>
<celldesigner:lineDirection arm="2" index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="2" num1="2" num2="2">0.4024957316005837,-0.11578196562064047 0.8049914632011668,-0.23156393124128094 0.22272689499224896,0.019514146658804465 0.4454537899844975,0.03902829331761404 0.37881206185640526,0.15922242239467987 0.7576241237128101,0.318444844789358 0.10216487149408016,0.4882869432298871</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias>a1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s2">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s5">
<annotation>
<celldesigner:alias>a5</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s6">
<annotation>
<celldesigner:alias>a7</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re2" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a3" species="s9"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a6" species="s7"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.29227599355584255,0.09856662187112097 0.5637782119295354,0.16805173333181656</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a4" editPoints="12.459726026943237,2.5689760480977952 13.241304331047466,2.556269934495191" modifiers="s4" targetLineIndex="-1,1" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s7">
<annotation>
<celldesigner:alias>a6</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s4">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re3" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a13" species="s14"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a19" species="s20"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.20499926977747185,-0.022048988602273667 0.4086519763224481,-0.03275849735193859</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a20" editPoints="0.7884445598066971,-0.13950631001289793 0.8957159316242009,-0.07650346032965416" modifiers="s21" targetLineIndex="-1,1" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s14">
<annotation>
<celldesigner:alias>a13</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s20">
<annotation>
<celldesigner:alias>a19</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s21">
<annotation>
<celldesigner:alias>a20</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re4" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a17" species="s21"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a20" species="s21"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.21910749194521317,-0.020357552836257398 0.43700460539115715,-0.03138174257815596</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a44" modifiers="s38" targetLineIndex="-1,1" type="INHIBITION">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s21">
<annotation>
<celldesigner:alias>a17</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s21">
<annotation>
<celldesigner:alias>a20</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s38">
<annotation>
<celldesigner:alias>a44</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re8" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a7" species="s6"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a21" species="s22"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.1878694734646782,0.35224994213786764</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a4" editPoints="1.0846869783497546,0.05945553518765134 1.5844907983635927,-0.003225387662070034" modifiers="s4" targetLineIndex="-1,0" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s6">
<annotation>
<celldesigner:alias>a7</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s22">
<annotation>
<celldesigner:alias>a21</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s4">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re11" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a46" species="s40"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a47" species="s40"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.3333333333333335,0.0 0.6666666666666669,8.881784197001252E-16</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a44" editPoints="0.3333333333333339,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16" modifiers="s38" targetLineIndex="-1,1" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s40">
<annotation>
<celldesigner:alias>a46</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s40">
<annotation>
<celldesigner:alias>a47</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s38">
<annotation>
<celldesigner:alias>a44</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re12" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a49" species="s48"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a48" species="s44"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.3333333333333339,0.0 0.666666666666667,0.0</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a47" editPoints="0.3333333333333428,3.552713678800501E-15 0.6666666666666288,0.0" modifiers="s40" targetLineIndex="-1,1" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s48">
<annotation>
<celldesigner:alias>a49</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s44">
<annotation>
<celldesigner:alias>a48</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s40">
<annotation>
<celldesigner:alias>a47</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re15" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a47" species="s40"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a51" species="s46"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.33366170029463227,-0.0023810399381694047 0.6675983124638392,-0.00675550866177721</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s40">
<annotation>
<celldesigner:alias>a47</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s46">
<annotation>
<celldesigner:alias>a51</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re17" reversible="false">
<annotation>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a19" species="s20"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a51" species="s46"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints omittedShapeIndex="1">0.33157707387325885,0.09953199637182841 0.664211447984222,0.13914391497875478</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s20">
<annotation>
<celldesigner:alias>a19</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s46">
<annotation>
<celldesigner:alias>a51</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re20" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a21" species="s22"/>
<celldesigner:baseReactant alias="a9" species="s10"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a63" species="s56"/>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a6" reactant="s7" targetLineIndex="0,2">
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="0" index="1" value="unknown"/>
<celldesigner:lineDirection arm="0" index="2" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="1" index="1" value="unknown"/>
<celldesigner:lineDirection arm="1" index="2" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="1" value="unknown"/>
<celldesigner:lineDirection arm="2" index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="2" num1="2" num2="2">0.33333333333333304,0.0 0.4752825270954215,0.0044885050139208404 0.3333333333333339,-2.220446049250313E-16 0.6666666666666661,-2.220446049250313E-16 0.33333333333333437,1.7763568394002505E-15 0.6666666666666674,0.0 0.3333333333333335,0.3333333333333345</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s22">
<annotation>
<celldesigner:alias>a21</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s10">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s7">
<annotation>
<celldesigner:alias>a6</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s56">
<annotation>
<celldesigner:alias>a63</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re21" reversible="false">
<annotation>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant alias="a63" species="s56"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct alias="a44" species="s38"/>
<celldesigner:baseProduct alias="a60" species="s53"/>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a11" reactant="s12" targetLineIndex="0,1">
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a12" product="s13" targetLineIndex="0,0">
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
<celldesigner:lineDirection arm="0" index="1" value="unknown"/>
<celldesigner:lineDirection arm="0" index="2" value="unknown"/>
<celldesigner:lineDirection arm="1" index="0" value="unknown"/>
<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="2" num1="0" num2="0">0.30257076565399466,-0.04900942307830114 0.639916774185675,-0.0892132817041702 -0.047878197099571196,0.44947184887769076</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0"/>
</annotation>
<listOfReactants>
<speciesReference species="s56">
<annotation>
<celldesigner:alias>a63</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s12">
<annotation>
<celldesigner:alias>a11</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s53">
<annotation>
<celldesigner:alias>a60</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s38">
<annotation>
<celldesigner:alias>a44</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s13">
<annotation>
<celldesigner:alias>a12</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>


