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Pyrimidine ribonucleotides can be synthesize in two ways, de novo biosynthesis and salvaging pathways. In salvaging pathways nucleosides from RNA and DNA breakdown can reenter pyrimidine ribonucleotide de novo biosynthesis.
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S04145
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s18" initialAmount="0.0" name="ADP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ADP
Synonym:  Synonym not specified
Accession:  S04154
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ADP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s19" initialAmount="0.0" name="Cytosine_br_deaminase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Cytosine deaminase
Synonym:  Synonym not specified
Accession:  P03155
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r1"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s20" initialAmount="0.0" name="Uridine_br_phosphorylase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Uridine phosphorylase
Synonym:  Synonym not specified
Accession:  P03152
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r2"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s21" initialAmount="0.0" name="Uridine kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Uridine kinase
Synonym:  Synonym not specified
Accession:  P03150
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r4"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s22" initialAmount="0.0" name="Uracil phosphoribosyl_br_ transferase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Uracil phosphoribosyltransferase
Synonym:  Synonym not specified
Accession:  P03151
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r3"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s23" initialAmount="0.0" name="Cytodine deaminase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Cytidine deaminase
Synonym:  Synonym not specified
Accession:  P03154
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r5"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s24" initialAmount="0.0" name="Cytidine kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Cytidine kinase
Synonym:  Synonym not specified
Accession:  P03149
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r6"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s25" initialAmount="0.0" name="Cytidylate kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Cytidylate kinase
Synonym:  Synonym not specified
Accession:  P03153
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r7"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s26" initialAmount="0.0" name="CDP kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CDP kinase
Synonym:  Synonym not specified
Accession:  P03156
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r8"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
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<annotation>
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<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
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<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
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</celldesigner:listOfProductLinks>
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</annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
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<annotation>
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</annotation>
</modifierSpeciesReference>
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<annotation>
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</celldesigner:listOfReactantLinks>
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</celldesigner:listOfProductLinks>
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<celldesigner:editPoints>0.3333333333333335,0.0 0.6666666666666667,0.0</celldesigner:editPoints>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
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</annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</modifierSpeciesReference>
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</reaction>
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<annotation>
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<celldesigner:baseProducts>s7</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
<celldesigner:offset x="-3.0" y="6.0"/>
<celldesigner:editPoints>0.3333333333333335,-2.220446049250313E-16 0.6666666666666667,-2.220446049250313E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
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</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
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<annotation>
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<annotation>
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</annotation>
</modifierSpeciesReference>
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</reaction>
<reaction id="r5" reversible="false">
<annotation>
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<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
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</annotation>
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<annotation>
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<annotation>
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</speciesReference>
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<annotation>
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<annotation>
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</annotation>
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</reaction>
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<annotation>
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</celldesigner:listOfReactantLinks>
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<annotation>
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<annotation>
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</reaction>
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<annotation>
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<annotation>
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<annotation>
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</model>
</sbml>

