2.2 OVAL SQUARE_CLOSEUP_NORTHWEST SQUARE_CLOSEUP_NORTH active inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active inactive active inactive inactive inactive inactive inactive active inactive active active active active active inactive active active inactive inactive inactive active inactive inactive active inactive inactive ER Nucleus Cytoplasm Long Name: Vascular Endothelial Growth Factor Receptor-2 Synonym: Flk-1,KDR,Kinase Insert Domain Receptor,Tyrosine Kinase Growth Factor Receptor Accession: P01403 transmembrane PROTEIN p1 Long Name: Vascular Endothelial Growth Factor Synonym: VEGF-A Accession: P01406 inside PROTEIN p2 Long Name: Caspase 9 Synonym: APAF3,Apoptotic Protease Activating Factor 3 Accession: P01410 inside PROTEIN p9 Long Name: Bcl-2 antagonist of cell death Synonym: BCL2-Binding Component 6,BCL2-Binding Protein,BCL2L8 Accession: P01416 inside PROTEIN p10 Long Name: endothelial nitric oxide synthase Synonym: NOS3,Nitric Oxide Synthase 3,eNOS Accession: P01422 inside PROTEIN p11 Long Name: VEGFR-Associated Protein Synonym: SH2 Domain Protein 2A,SH2D2A,T-Cell SH2 Domain-Containing Adaptor Protein,TSAD Accession: P01405 inside PROTEIN p14 Long Name: Phosphatidylinositol (3,4,5)-triphosphate Synonym: Synonym not specified Accession: S01873 inside SIMPLE_MOLECULE PIP3 Long Name: sn-1,2-diacylglycerol Synonym: Synonym not specified Accession: S01872 inside SIMPLE_MOLECULE DAG Long Name: Inositol (1,4,5)-triphosphate Synonym: Synonym not specified Accession: S01874 inside SIMPLE_MOLECULE IP3 Long Name: v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 Synonym: Ets1 Oncogene Accession: P01419 inside PROTEIN p25 Long Name: Hypoxia-Inducible Factor 1 Synonym: MOP1,Member of PAS Superfamily 1 Accession: P01401 inside PROTEIN p26 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05586 Heterodimer Member Info: VEGFR-2#PROTEIN#Vascular Endothelial Growth Factor Receptor-2#P01403#Flk-1|KDR|Kinase Insert Domain Receptor|Tyrosine Kinase Growth Factor Receptor#;VEGF#PROTEIN#Vascular Endothelial Growth Factor#P01406#VEGF-A# transmembrane PROTEIN p1 PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05587 Heterodimer Member Info: Ca2+#ION#Long Name: Ca2+#U05589##;eNOS#PROTEIN#endothelial nitric oxide synthase#P01422#NOS3|Nitric Oxide Synthase 3|eNOS# inside PROTEIN p11 ION Ca_super_2+_endsuper Long Name: Phosphatidylinositol 3-Kinase Synonym: Synonym not specified Accession: P01413 inside PROTEIN p3 Long Name: p38 Mitogen-Activated Protein Kinase Synonym: CSAID-Binding Protein 1,CSBP1,Cytokine-Suppressive Anti-Inflammatory Drug-Binding Protein 1,MAPK14,MXI2,Mitogen-Activated Protein Kinase 14,RK,SAPK2A,Stress-Activated Protein Kinase 2A,p38,p38-Alpha Accession: P01423 inside PROTEIN p4 Long Name: Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 and 3 Synonym: 3PK,MAPKAP KINASE 2/3,MAPKAP3 Accession: P01415 inside PROTEIN p5 Long Name: Heat-Shock Protein 27 Synonym: HSPB1 Accession: P01412 inside PROTEIN p6 Long Name: Rho GTPase Synonym: CDC42,Cell Division Cycle 42 Accession: P01421 inside PROTEIN p7 Long Name: Thymoma Viral Proto-Oncogene Synonym: Oncogene Akt,PKB,Protein Kinase B,RAC Serine/Threonine Protein Kinase Accession: P01408 inside PROTEIN p8 Long Name: Focal Adhesion Kinase Synonym: Cytoplasmic Protein-Tyrosine Kinase ,FAK1,Focal Adhesion Kinase 1,PTK2 Accession: P01420 inside PROTEIN p12 Long Name: Paxillin Synonym: PXN Accession: P01418 inside PROTEIN p13 Long Name: Phospholipase C-gamma Synonym: PHOSPHOLIPASE C-148,PLC1,PLC148,PLCG1 Accession: P01414 inside PROTEIN p15 Long Name: Shc-Like Protein Synonym: Shc Adaptor Homolog Accession: P01424 inside PROTEIN p16 Long Name: Protein Kinase C Synonym: Synonym not specified Accession: P01425 inside PROTEIN p17 Long Name: Sphingosine Kinase Synonym: SPHK Accession: P01404 inside PROTEIN p18 Long Name: Ras Synonym: H-Ras,K-Ras,N-Ras,p21 Accession: P01411 inside PROTEIN p19 Long Name: Raf Oncogene Synonym: CRAF,Oncogene MIL,Oncogene Raf1,Transforming Replication-Defective Murine Retrovirus 3611-MSV,v-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 Accession: P01417 inside PROTEIN p20 Long Name: MAPK/ERK Kinase Synonym: MAP2K,MAPKK,MKK,Mitogen-Activated Protein Kinase Kinase,PRKMK,Protein Kinase, Mitogen-Activated, Kinase Accession: P01402 inside PROTEIN p21 Long Name: Extracellular Signal-Regulated Kinase Synonym: JNK-Activated Kinase1,JNKK1,MAP2K4,MAPK/ERK KINASE 4,MAPKK4,MEK4,MKK4,Mitogen-Activated Protein Kinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1 Accession: P01407 inside PROTEIN p22 Long Name: Cytoplasmic Phospholipase A2 Synonym: CPLA2,PLA2 Accession: P01409 inside PROTEIN p24 Long Name: Long Name: PIP2 Synonym: Synonym not specified Accession: S04857 inside SIMPLE_MOLECULE PIP_sub_2_endsub Long Name: Long Name: Ca2+ Synonym: Synonym not specified Accession: U05589 inside ION Ca_super_2+_endsuper Long Name: Long Name: Ca2+ Synonym: Synonym not specified Accession: U05589 inside ION Ca_super_2+_endsuper Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05588 Heterodimer Member Info: cPLA2#PROTEIN#Cytoplasmic Phospholipase A2#P01409#CPLA2|PLA2#;Ca2+#ION#Long Name: Ca2+#U05589## inside PROTEIN p24 ION Ca_super_2+_endsuper INHIBITION s56 s9 0.3333333333333337,4.440892098500626E-16 0.6666666666666667,0.0 a8 a9 INHIBITION s56 s10 0.3333333333333335,-3.1086244689504383E-15 0.6666666666666667,-5.773159728050814E-15 a8 a10 STATE_TRANSITION s61 s61 0.3333333333333335,0.0 0.666666666666667,0.0 a46 a79 a17 STATE_TRANSITION s62 s62 0.3333333333333335,0.0 0.666666666666667,-3.552713678800501E-15 a49 a18 STATE_TRANSITION s63 s63 0.33333333333333215,0.0 0.6666666666666643,0.0 a19 a52 STATE_TRANSITION s64 s64 0.33333333333333215,0.0 0.6666666666666643,0.0 a20 a51 STATE_TRANSITION s65 s65 0.33333333333333215,0.0 0.6666666666666679,0.0 a21 a50 STATE_TRANSITION s66 s66 0.3333333333333339,-8.881784197001252E-16 0.6666666666666696,-3.552713678800501E-15 a22 a53 STATE_TRANSITION s41 s41 0.3333333333333339,0.0 0.6666666666666696,0.0 a42 a54 STATE_TRANSITION s40 s40 0.3333333333333304,1.7763568394002505E-15 0.6666666666666661,1.7763568394002505E-15 a41 a55 DISSOCIATION s68 s28,s29 0.3333333333333339,3.885780586188048E-16 0.6666666666666679,3.885780586188048E-16 0.33333333333333215,0.0 0.6666666666666679,0.0 0.3333333333333357,0.0 0.6666666666666679,-8.881784197001252E-16 0.3333333333333339,0.33333333333333304 a26 a28 a39 TRANSPORT s70 s69 0.3333333333333357,-2.220446049250313E-16 0.6666666666666679,1.1102230246251565E-15 a40 a36 HETERODIMER_ASSOCIATION s2,s1 s44 0.33333333333333304,-4.440892098500626E-16 0.6666666666666661,4.440892098500626E-16 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666665,-1.7763568394002505E-15 0.3333333333333339,-2.220446049250313E-16 0.6666666666666661,4.440892098500626E-16 0.33333333333333304,0.3333333333333335 a60 a59 a63 STATE_TRANSITION s59 s59 0.3333333333333339,0.0 0.6666666666666679,-1.7763568394002505E-15 a56 a15 STATE_TRANSITION s14 s14 0.33333333333333304,0.0 0.6666666666666661,-4.440892098500626E-16 a14 a57 STATE_TRANSITION s60 s60 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,-4.440892098500626E-16 a58 a16 STATE_TRANSITION s58 s58 0.3333333333333335,1.3322676295501878E-15 0.666666666666667,1.7763568394002505E-15 a13 a65 STATE_TRANSITION s57 s57 0.33333333333333304,4.440892098500626E-16 0.6666666666666665,1.7763568394002505E-15 a12 a64 STATE_TRANSITION s52 s52 0.3333333333333335,0.0 0.6666666666666667,0.0 a4 a66 STATE_TRANSITION s53 s53 0.33333333333333304,-4.440892098500626E-16 0.6666666666666665,0.0 a5 a67 STATE_TRANSITION s54 s54 0.3333333333333326,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 a6 a68 STATE_TRANSITION s51 s51 0.3333333333333339,0.0 0.666666666666667,-8.881784197001252E-16 a70 a3 STATE_TRANSITION s68 s27 0.3333333333333335,-2.6645352591003757E-15 0.666666666666667,-6.217248937900877E-15 a25 a27 STATE_TRANSITION s55 s55 0.3333333333333335,4.440892098500626E-16 0.666666666666667,1.3322676295501878E-15 a7 a71 STATE_TRANSITION s56 s56 0.33333333333333326,1.3322676295501878E-15 0.6666666666666667,2.6645352591003757E-15 a8 a72 STATE_TRANSITION s11 s50 0.33333333333333326,4.440892098500626E-16 0.6666666666666667,8.881784197001252E-16 a73 a76 a77 STATE_TRANSITION s67 s71 0.33333333333333304,3.552713678800501E-15 0.666666666666667,3.552713678800501E-15 a24 a31 a78