This is a redraw of an STKE pathway. Description This record contains general information about the p38 MAPK Pathway collected across species. p38 is a mitogen-activated protein kinase (MAPK) regulated by stress and cytokines. There are four p38 genes: a, b, g, and d. 2.5 Long Name: tumor necrosis factor receptor associated factor 6 Synonym: Synonym not specified Accession: P06038 s36 PROTEIN pr4 Long Name: interleukin-1 receptor Synonym: Synonym not specified Accession: P06030 s36 PROTEIN pr1 SQUARE_CLOSEUP_NORTH SQUARE inactive active inactive active active inactive inactive active active inactive active inactive active active inactive inactive active active inactive active inactive inactive active inactive inactive inactive inactive active inactive active inactive active inactive active inactive inactive inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active cytoplasm nucleus Long Name: interleukin-1 receptor Synonym: Synonym not specified Accession: P06030 transmembrane PROTEIN pr1 Long Name: tumor necrosis factor receptor associated factor 6 Synonym: Synonym not specified Accession: P06038 inside PROTEIN pr4 Long Name: IL-6R/TRAF6 complex Synonym: Synonym not specified Accession: U06207 Heterodimer Member Info: IL-1R#PROTEIN#interleukin-1 receptor#P06030##;TRAF6#PROTEIN#tumor necrosis factor receptor associated factor 6#P06038## transmembrane COMPLEX IL-6R_slash_TRAF6_br_complex Long Name: TAK1 binding protein Synonym: MAP3K7IP1,mitogen-activated protein kinase kinase kinase 7-interacting protein 1 Accession: P06035 inside PROTEIN pr5 Long Name: TAK1 binding protein 2 Synonym: MAP3K7IP2,mitogen-activated protein kinase kinase kinase 7-interacting protein 2 Accession: P06033 innerSurface PROTEIN pr6 Long Name: TAK1 binding protein 2 Synonym: MAP3K7IP2,mitogen-activated protein kinase kinase kinase 7-interacting protein 2 Accession: P06033 inside PROTEIN pr6 Long Name: TGF beta-activated kinase 1 Synonym: MAP3K7,mitogen-activated protein kinase kinase kinase 7 Accession: P06037 inside PROTEIN pr7 Long Name: p38-alpha mitogen-activated protein kinase Synonym: CSAID-binding protein 1,CSBP1,MAPK14,SAPK2A,cytokine-suppressive antiinflammatory drug-binding protein 1,mitogen-activated protein kinase 14,stress-activated protein kinase 2A Accession: P06031 inside PROTEIN pr8 Long Name: p38-alpha mitogen-activated protein kinase Synonym: CSAID-binding protein 1,CSBP1,MAPK14,SAPK2A,cytokine-suppressive antiinflammatory drug-binding protein 1,mitogen-activated protein kinase 14,stress-activated protein kinase 2A Accession: P06031 inside PROTEIN pr8 Long Name: mitogen-activated protein kinase kinase 3 Synonym: MAP2K3,MAPK/ERK kinase 3,MAPKK3,MEK3 Accession: P06036 inside PROTEIN pr10 Long Name: mitogen-activated protein kinase kinase 6 Synonym: MAP2K6,MAPK/ERK kinase 6,MAPKK6,MEK6 Accession: P06032 inside PROTEIN pr9 Long Name: mitogen-activated protein kinase kinase 6 Synonym: MAP2K6,MAPK/ERK kinase 6,MAPKK6,MEK6 Accession: P06032 inside PROTEIN pr9 Long Name: mitogen-activated protein kinase kinase 3 Synonym: MAP2K3,MAPK/ERK kinase 3,MAPKK3,MEK3 Accession: P06036 inside PROTEIN pr10 Long Name: mitogen-activated protein kinase kinase 4 Synonym: JNK-activated kinase 1,JNKK1,MAP2K4,MAPK/ERK kinase 4,MAPKK4,MEK4,SAPK/ERK kinase 1,SEK1,SERK1 Accession: P06034 inside PROTEIN pr11 Long Name: mitogen-activated protein kinase kinase 4 Synonym: JNK-activated kinase 1,JNKK1,MAP2K4,MAPK/ERK kinase 4,MAPKK4,MEK4,SAPK/ERK kinase 1,SEK1,SERK1 Accession: P06034 inside PROTEIN pr11 Long Name: mitogen-activated protein kinase kinase kinase 5 Synonym: MAP/ERK kinase kinase 5,MAPKKK5,MEKK5,apoptosis signal-regulating kinase 1 Accession: P06043 inside PROTEIN pr12 Long Name: mitogen-activated protein kinase kinase kinase 4 Synonym: MAP3K4,MAPK/ERK kinase kinase 4,MAPKKK4 Accession: P06026 inside PROTEIN pr13 Long Name: Growth arrest and DNA damage-inducible gene Synonym: DDIT1,DNA damage-inducible transcript 1 Accession: P06044 inside PROTEIN pr14 Long Name: Rac GTPase Synonym: RAS-related C3 botulinum toxin substrate Accession: P06021 inside PROTEIN pr15 Long Name: cell division cycle 42 Synonym: G25K,GTP-binding protein, 25KD Accession: P06041 inside PROTEIN pr16 Long Name: mixed lineage kinase 2 Synonym: MAP3K10,mitogen-activated protein kinase kinase kinase 10 Accession: P06028 inside PROTEIN pr17 Long Name: p38-gamma mitogen-activated protein kinase Synonym: ERK6,MAPK12,SAPK3,extracellular signal-regulated kinase 6,mitogen-activated protein kinase 12,stress-activated protein kinase 3 Accession: P06015 inside PROTEIN pr18 Long Name: p38-gamma mitogen-activated protein kinase Synonym: ERK6,MAPK12,SAPK3,extracellular signal-regulated kinase 6,mitogen-activated protein kinase 12,stress-activated protein kinase 3 Accession: P06015 inside PROTEIN pr18 Long Name: p38-delta mitogen-activated protein kinase Synonym: MAPK13,SAPK4,mitogen-activated protein kinase 13,stress-activated protein kinase 4 Accession: P06020 inside PROTEIN pr19 Long Name: p38-delta mitogen-activated protein kinase Synonym: MAPK13,SAPK4,mitogen-activated protein kinase 13,stress-activated protein kinase 4 Accession: P06020 inside PROTEIN pr19 Long Name: p38-beta mitogen-activated protein kinase Synonym: MAPK11,SAPK2B,mitogen-activated protein kinase 11,stressed-activated protein kinase 2B Accession: P06029 inside PROTEIN pr20 Long Name: p38-beta mitogen-activated protein kinase Synonym: MAPK11,SAPK2B,mitogen-activated protein kinase 11,stressed-activated protein kinase 2B Accession: P06029 inside PROTEIN pr20 Long Name: MAPK phosphatase 1 Synonym: DUSP1,dual-specificity phosphatase 1 Accession: P05922 inside PROTEIN pr21 Long Name: MAPK phosphatase 5 Synonym: DUSP10,dual-specificity phosphatase 10 Accession: P05921 inside PROTEIN pr22 Long Name: elongation factor-2 kinase Synonym: calmodulin-dependent protein kinase III Accession: P06022 inside PROTEIN pr23 Long Name: elongation factor-2 kinase Synonym: calmodulin-dependent protein kinase III Accession: P06022 inside PROTEIN pr23 Long Name: Mitogen-activated protein kinase-interacting kinase 2 Synonym: G-protein coupled receptor kinase 7,GPRK7,MAPK-interacting kinase 2,MKNK2 Accession: P06017 inside PROTEIN pr24 Long Name: mitogen-activated protein kinase-interacting kinase 1 Synonym: Synonym not specified Accession: P06018 inside PROTEIN pr25 Long Name: mitogen-activated protein kinase-interacting kinase 1 Synonym: Synonym not specified Accession: P06018 inside PROTEIN pr25 Long Name: C/EBP-homologous protein Synonym: DDIT3,DNA damage-inducible transcript 3,GADD153 Accession: P06014 inside PROTEIN pr26 Long Name: C/EBP-homologous protein Synonym: DDIT3,DNA damage-inducible transcript 3,GADD153 Accession: P06014 inside PROTEIN pr26 Long Name: myocyte enhancer factor 2 Synonym: Synonym not specified Accession: P06023 inside PROTEIN pr28 Long Name: myocyte enhancer factor 2 Synonym: Synonym not specified Accession: P06023 inside PROTEIN pr28 Long Name: ELK-1 member of EST oncogene family Synonym: Synonym not specified Accession: P06013 inside PROTEIN pr29 Long Name: ELK-1 member of EST oncogene family Synonym: Synonym not specified Accession: P06013 inside PROTEIN pr29 Long Name: MAPK-activated protein kinase 3 Synonym: 3PK Accession: P05919 inside PROTEIN pr27 Long Name: MAPK-activated protein kinase 3 Synonym: 3PK Accession: P05919 inside PROTEIN pr27 Long Name: MAPK-activated protein kinase 2 Synonym: MK2,mitogen activated protein kinase-activated protein kinase 2 Accession: P05920 inside PROTEIN pr30 Long Name: MAPK-activated protein kinase 2 Synonym: MK2,mitogen activated protein kinase-activated protein kinase 2 Accession: P05920 inside PROTEIN pr30 Long Name: mitogen- and stress-activated protein kinase 2 Synonym: 90 kDa ribosomal protein S6 kinase 4,RSKB,ribosomal protein kinase B Accession: P06039 inside PROTEIN pr31 Long Name: mitogen- and stress-activated protein kinase 2 Synonym: 90 kDa ribosomal protein S6 kinase 4,RSKB,ribosomal protein kinase B Accession: P06039 inside PROTEIN pr31 Long Name: mitogen- and stress-activated protein kinase 1 Synonym: 90 kD ribosomal protein S6 kinase 5,RPS6KA5 Accession: P06040 inside PROTEIN pr32 Long Name: mitogen- and stress-activated protein kinase 1 Synonym: 90 kD ribosomal protein S6 kinase 5,RPS6KA5 Accession: P06040 inside PROTEIN pr32 Long Name: eukaryotic initiation factor 4E Synonym: Synonym not specified Accession: P06024 inside PROTEIN pr33 Long Name: eukaryotic initiation factor 4E Synonym: Synonym not specified Accession: P06024 inside PROTEIN pr33 Long Name: serum response factor Synonym: c-fos serum response element-binding factor Accession: P06025 inside PROTEIN pr34 Long Name: serum response factor Synonym: c-fos serum response element-binding factor Accession: P06025 inside PROTEIN pr34 Long Name: cAMP response element binding protein Synonym: Synonym not specified Accession: P06027 inside PROTEIN pr35 Long Name: cAMP response element binding protein Synonym: Synonym not specified Accession: P06027 inside PROTEIN pr35 Long Name: activating transcription factor 1 Synonym: cAMP-dependent transcription factor 1 Accession: P06019 inside PROTEIN pr36 Long Name: activating transcription factor 1 Synonym: cAMP-dependent transcription factor 1 Accession: P06019 inside PROTEIN pr36 Long Name: heat shock protein 27kD Synonym: HSPB1 Accession: P06016 inside PROTEIN pr37 Long Name: heat shock protein 27kD Synonym: HSPB1 Accession: P06016 inside PROTEIN pr37 Long Name: eIF4E-binding protein 1 Synonym: Synonym not specified Accession: P06042 inside PROTEIN pr38 Long Name: eIF4E-binding protein 1 Synonym: Synonym not specified Accession: P06042 inside PROTEIN pr38 HETERODIMER_ASSOCIATION 0.09848251187465307,0.47683671581025244 sa1 sa45 csa1 STATE_TRANSITION sa49 sa50 csa1 STATE_TRANSITION sa48 sa51 csa1 STATE_TRANSITION sa53 sa54 sa50 sa51 STATE_TRANSITION sa55 sa56 sa51 sa63 sa61 TRANSPORT sa56 sa57 STATE_TRANSITION sa58 sa60 sa54 sa64 STATE_TRANSITION sa59 sa61 sa54 sa64 STATE_TRANSITION sa62 sa63 sa64 sa66 sa71 STATE_TRANSITION sa65 sa66 sa67 sa68 sa69 STATE_TRANSITION sa70 sa71 sa68 sa69 STATE_TRANSITION sa72 sa73 sa60 STATE_TRANSITION sa74 sa75 sa60 sa61 STATE_TRANSITION sa76 sa77 sa61 sa63 STATE_TRANSITION sa73 sa72 sa78 sa79 STATE_TRANSITION sa75 sa74 sa78 sa79 STATE_TRANSITION sa77 sa76 sa78 sa79 STATE_TRANSITION sa56 sa55 sa78 sa79 STATE_TRANSITION sa80 sa81 sa75 STATE_TRANSITION sa82 sa83 sa77 sa56 STATE_TRANSITION sa84 sa85 sa77 sa56 STATE_TRANSITION sa86 sa87 sa57 sa77 STATE_TRANSITION sa88 sa89 sa57 sa77 STATE_TRANSITION sa90 sa91 sa57 sa77 STATE_TRANSITION sa92 sa93 sa57 sa77 STATE_TRANSITION sa96 sa97 sa57 sa77 STATE_TRANSITION sa98 sa99 sa57 sa77 STATE_TRANSITION sa100 sa101 sa57 sa77 STATE_TRANSITION sa102 sa103 sa83 sa85 STATE_TRANSITION sa104 sa105 sa89 sa97 STATE_TRANSITION sa106 sa107 sa99 sa101 STATE_TRANSITION sa108 sa109 sa99 sa101 STATE_TRANSITION sa110 sa111 sa89 sa97 STATE_TRANSITION sa112 sa113 sa99 sa101