2.3 active active inactive inactive inactive inactive active inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active active inactive inactive inactive Long Name: Ub Synonym: Synonym not specified Accession: S01885 inside SIMPLE_MOLECULE Ub Long Name: a7_degraded Synonym: Synonym not specified Accession: U02710 inside DEGRADED a7_degraded Long Name: Oncogenes Synonym: Synonym not specified Accession: P01487 inside PROTEIN p3 Long Name: Alternative reading frame (tumor-suppresor protein) Synonym: Cyclin-dependent kinase inhibitor 2A,p14ARF(humans),p19ARF (mouse) Accession: P01482 Pathway Link: P04393|P04576|Ras Pathway*P04398|P04655|p53 pathway feedback loops 2 inside PROTEIN p4 Long Name: V-akt murine thymoma viral oncogene homolog Synonym: PKB,Protein kinase B Accession: P01486 Pathway Link: P00033|P00894|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04641|p53 pathway by glucose deprivation*P04398|P04665|p53 pathway feedback loops 2 inside PROTEIN p6 Long Name: V-akt murine thymoma viral oncogene homolog Synonym: PKB,Protein kinase B Accession: P01486 Pathway Link: P00033|P00894|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04641|p53 pathway by glucose deprivation*P04398|P04665|p53 pathway feedback loops 2 inside PROTEIN p6 Long Name: Reactive oxygen species Synonym: Synonym not specified Accession: S01884 inside SIMPLE_MOLECULE Reactive oxygen_br_species Long Name: Apoptosis Synonym: Synonym not specified Accession: U02711 inside PHENOTYPE Apoptosis Long Name: Tumor suppression Synonym: Synonym not specified Accession: U02713 inside PHENOTYPE Tumor suppression Long Name: Survival Synonym: Synonym not specified Accession: U02714 inside PHENOTYPE Survival Long Name: Phosphatase and tensin homolog deleted on chromosome 10 Synonym: Synonym not specified Accession: P01480 inside PROTEIN p24 Long Name: Checkpoint kinase 2 Synonym: Synonym not specified Accession: P01484 inside PROTEIN p25 Long Name: Checkpoint kinase 2 Synonym: Synonym not specified Accession: P01484 inside PROTEIN p25 Long Name: Ataxia telangiectasia mutated (ATM) and Rad3-related (ATR) Synonym: Synonym not specified Accession: P01481 inside PROTEIN p7 Long Name: Ataxia telangiectasia mutated (ATM) and Rad3-related (ATR) Synonym: Synonym not specified Accession: P01481 inside PROTEIN p7 Long Name: Cyclin-dependent kinase inhibitor 1A Synonym: p21CIP1,p21WAF1 Accession: G01580 inside GENE p21 Long Name: Growth arrest and DNA-damage-inducible, alpha Synonym: Synonym not specified Accession: G01575 inside GENE GADD45 Long Name: 14-3-3 sigma Synonym: Synonym not specified Accession: G01576 inside GENE 14-3-3 Long Name: Reprimo Synonym: Synonym not specified Accession: G01570 inside GENE Reprimo Long Name: Scotin Synonym: Synonym not specified Accession: G01578 inside GENE Scotin Long Name: p53-induced death-domain-containing protein Synonym: Synonym not specified Accession: G01573 inside GENE PIDD Long Name: BCL2-associated X protein Synonym: Synonym not specified Accession: G01581 inside GENE BAX Long Name: APO-1 or CD95 Synonym: APO-1, CD95 Accession: G01571 inside GENE FAS Long Name: p53-regulated Apoptosis-Inducing Protein 1 Synonym: Synonym not specified Accession: G01564 inside GENE P53AIP1 Long Name: KILLER/death receptor (DR)5 Synonym: Synonym not specified Accession: G01568 inside GENE KILLER/DR5 Long Name: p53 apoptosis effector related to PMP-22 Synonym: Synonym not specified Accession: G01565 inside GENE PERP Long Name: NOXA Synonym: Synonym not specified Accession: G01572 inside GENE NOXA Long Name: Thrombospondin-1 Synonym: Synonym not specified Accession: G01566 inside GENE TSP1 Long Name: Glioma-derived angiogenesis inhibitory factor Synonym: Synonym not specified Accession: G01577 inside GENE GD-AIF Long Name: inhibition of angiogenesis (BAI1) Synonym: Synonym not specified Accession: G01567 inside GENE BAL1 Long Name: Maspin Synonym: Mp Accession: G01569 inside GENE Maspin Long Name: PTEN Synonym: Synonym not specified Accession: G01579 inside GENE PTEN Long Name: Mdm2 Synonym: Synonym not specified Accession: G01563 inside GENE Mdm2 Long Name: ARF Synonym: Cyclin-dependent kinase inhibitor 2A,p14ARF(humans),p19ARF (mouse) Accession: G01574 inside GENE ARF Long Name: Survival Signals Synonym: Synonym not specified Accession: U05669 inside PHENOTYPE Survival Signals Long Name: P300 Synonym: E1A-binding protein, 300-kD,EP300 Accession: P04611 inside PROTEIN p26 Long Name: Histon deacetylase 1 Synonym: HD1,RPD3-like Accession: P04612 inside PROTEIN p27 Long Name: Sin3 Synonym: Synonym not specified Accession: P04622 inside PROTEIN p28 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05653 Heterodimer Member Info: HDAC1#PROTEIN#Histon deacetylase 1;#P04612#HD1|RPD3-like;Sin3#PROTEIN#OMIM: 607776#P04622 inside PROTEIN p28 PROTEIN p27 Long Name: Metastasis-associated 2 Synonym: MTA1L1,MTA2,Metastasis-associated protein 1-like,PID Accession: P04615 inside PROTEIN p29 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05655 Heterodimer Member Info: HDAC1#PROTEIN#Histon deacetylase 1;#P04612#HD1|RPD3-like;MTA2#PROTEIN#Metastasis-associated 2;#P04615#MTA1L1|MTA2|Metastasis-associated protein 1-like|PID inside PROTEIN p27 PROTEIN p29 Long Name: E2F transcription factor 1 Synonym: Transcription factor E2F Accession: P04627 inside PROTEIN p30 Long Name: p53 Synonym: Synonym not specified Accession: P01485 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1 inside PROTEIN p1 Long Name: p53 Synonym: Synonym not specified Accession: P01485 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1 inside PROTEIN p1 Long Name: p53 Synonym: Synonym not specified Accession: P01485 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1 inside PROTEIN p1 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05652 Heterodimer Member Info: E2F-1#PROTEIN#E2F-1#P04627;ARF#PROTEIN#Alternative reading frame (tumor-suppresor protein)#P01482#p14ARF(humans) inside PROTEIN p4 PROTEIN p30 Long Name: Sirtuin Synonym: Sir2 Accession: P04632 inside PROTEIN p31 Long Name: Protein phosphatase 2A Synonym: Synonym not specified Accession: P04630 inside PROTEIN p32 Long Name: DNA Damage Stress Synonym: Synonym not specified Accession: U02715 inside PHENOTYPE DNA Damage_br_Stress_br_telomere shortening_br_UV Long Name: PI3-K Synonym: PI3-K,PI3K,Phosphoinositide 3-OH-kinase,Phosphoinositide 3-kinase Accession: P04609 inside PROTEIN p14 Long Name: PiP2 Synonym: Synonym not specified Accession: S04871 inside SIMPLE_MOLECULE PiP2 Long Name: PiP3 Synonym: Synonym not specified Accession: S04870 inside SIMPLE_MOLECULE PiP3 Long Name: p110alpha Synonym: P110-alpha,PIK3CA Accession: G04694 inside GENE p110_alpha_ Long Name: Phosphatidylinositol 3-kinase, catalytic subunit, alpha Synonym: P110-alpha,PIK3CA Accession: P04633 inside PROTEIN p33 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05651 Heterodimer Member Info: PI3-K#PROTEIN#PI3-K#P04609;P110alpha#PROTEIN#P110alpha#P04633 inside PROTEIN p33 PROTEIN p14 Long Name: 3-phosphoinositide-dependent protein kinase 1 and 2 Synonym: Synonym not specified Accession: P04616 inside PROTEIN p17 Long Name: Cyclin-dependent kinase inhibitor 1A Synonym: CDK-interacting protein 1,CDKN1A,CIP1,Waf1,Wildteype p53-activated fragment 1,p21 Accession: P04631 inside PROTEIN p34 Long Name: p53 Synonym: Synonym not specified Accession: G04702 inside GENE p53 Long Name: CREB binding protein Synonym: CREB binding protein Accession: P04623 inside PROTEIN p35 Long Name: TRAF Synonym: TRAP Accession: P04620 inside PROTEIN p36 Long Name: p300/CBP-associated factor Synonym: P/CAF Accession: P04629 inside PROTEIN p37 Long Name: Insulin IGF pathway PKB cascade Synonym: Synonym not specified Accession: U05663 inside PHENOTYPE Insulin IGF pathway_br_PKB cascade Long Name: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia Synonym: Synonym not specified Accession: U05668 inside PHENOTYPE Spindle damage_br_rNTP depletion_br_Nitric oxide and inflammation_br_Hypoxia Long Name: a101_degraded Synonym: Synonym not specified Accession: U05661 inside DEGRADED a101_degraded Long Name: Long name not specified Synonym: Synonym not specified Accession: U05656 Heterodimer Member Info: Cyclin E#PROTEIN#Cyclin E#P04610;Cdk2#PROTEIN#Cdk2#P04625 inside PROTEIN p39 PROTEIN p38 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05654 Heterodimer Member Info: Cyclin E#PROTEIN#Cyclin E#P04610;Cdk2#PROTEIN#Cdk2#P04625;P21#PROTEIN#Cycline-dependent kinase inhibitor 1A;#P04631#CDK-interacting protein 1|CDKN1A|CIP1|Waf1|Wildteype p53-activated fragment 1|p21 inside PROTEIN p34 PROTEIN p39 PROTEIN p38 Long Name: G1-S Synonym: Synonym not specified Accession: U05671 inside PHENOTYPE G1_minus_S Long Name: Growth arrest-and DNA-damage-inducible, alpha Synonym: Synonym not specified Accession: P04626 inside PROTEIN p40 Long Name: B99 Synonym: Gtse1 Accession: G04697 inside GENE B99 Long Name: G2- and S- phase expressed gene 1 Synonym: Gtse1 Accession: P04613 inside PROTEIN p41 Long Name: Cell division cycle 2 Synonym: Cdk1,Cell cycle controller,Cyclin-dependent kinase 1,P34 Accession: P04634 inside PROTEIN p42 Long Name: PIGs Synonym: Synonym not specified Accession: G04698 inside GENE PIGs Long Name: p53-upregulated modulator of apoptosis Synonym: BBC3,Bcl2-binding component 3 Accession: G04695 inside GENE PUMA Long Name: Apoptotic protease activating factor 1 Synonym: Synonym not specified Accession: G04703 inside GENE Apaf Long Name: Seven in absentia homolog 1 Synonym: Synonym not specified Accession: G04696 inside GENE Siah Long Name: 14-3-3 Synonym: Synonym not specified Accession: P04628 inside PROTEIN p43 Long Name: Reprimo Synonym: Synonym not specified Accession: P04621 inside PROTEIN p44 Long Name: Cyclin B Synonym: Synonym not specified Accession: P04614 inside PROTEIN p45 Long Name: Cell division cycle 25C Synonym: Mitosis incucer CDC25 Accession: P04624 inside PROTEIN p46 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05657 Heterodimer Member Info: Cyclin B#PROTEIN#Cyclin B#P04614;Cdc25C#PROTEIN#Cell division cycle 25C;#P04624#Mitosis incucer CDC25;Cdc2#PROTEIN#Cell division cycle 2;#P04634#Cdk1|Cell cycle controller|Cyclin-dependent kinase 1|P34 inside PROTEIN p46 PROTEIN p45 PROTEIN p42 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05650 Heterodimer Member Info: B99#PROTEIN#PMID: 11313928#P04613;GADD45#PROTEIN#Growth arrest-and DNA damage-inducible gene GADD45;#P04626 inside PROTEIN p40 PROTEIN p41 Long Name: G2-M Synonym: Synonym not specified Accession: U05660 inside PHENOTYPE G2-M Long Name: Cell Cycle Arrest Synonym: Synonym not specified Accession: U05665 inside PHENOTYPE Cell Cycle Arrest Long Name: Insulin-like growth factor-binding protein 3 Synonym: IBP3,IGFBP3 Accession: G04691 inside GENE IGF_minus_BP3 Long Name: Wildtype p53-induced gene Synonym: WIG1,p53-activated gene 608 Accession: G04690 inside GENE PAG608 Long Name: Plasminogen activator inhibitor 1 Synonym: Serpine 1 Accession: G04700 inside GENE PAI Long Name: BAI-1 Synonym: Synonym not specified Accession: G04699 inside GENE BAI_minus_1 Long Name: Kangai 1 Synonym: CD82,Leukocyte surface antigen R2,SAR2,ST6,Suppressor of tumorigenicity 6 Accession: G04704 inside GENE KAI Long Name: Prevention of new blood vessel formation Synonym: Synonym not specified Accession: U02716 inside PHENOTYPE Inhibition_space_of_space_Angiogenesis_br_and_space_Metastasis Long Name: DNA damage-binding protein 2 Synonym: DDB2 Accession: G04705 inside GENE p48 Long Name: p53-inducible ribonucleotide reductase small subunit 2-like Synonym: RRM2B,Ribonucleotide reductase, M2 B,p53R2 Accession: G04692 inside GENE R2 Long Name: DNA Repair Synonym: Synonym not specified Accession: U05662 inside PHENOTYPE DNA Repair Long Name: Cyclin G Synonym: CCNG,Cyclin G1 Accession: G04689 inside GENE Cyclin G Long Name: Wildtype p53-induced phosphatase Synonym: PPM1D,protein phosphatase, magnesium-dependent, 1, delta isoform Accession: G04693 inside GENE Wip1 Long Name: ? Synonym: Synonym not specified Accession: U05659 inside UNKNOWN ? Long Name: Promyelocytic leukemia protein Synonym: Synonym not specified Accession: P04618 inside PROTEIN p50 Long Name: Small ubiquitin-like modifier 1 Synonym: PIC1,SMT3 homolog 3,SUMO1,Sentrin,UBL1,Ubiquitin-like 1 Accession: P04635 inside PROTEIN p51 Long Name: High mobility group protein 1 Synonym: Amphoterin,HMGB1,High mobility group box 1,Nonhistone chromosomal protein HMG1 Accession: P04619 inside PROTEIN p52 Long Name: WRN gene Synonym: DNA helicase, RECQ-like, type 3,RECQ3,RECQL2 Accession: P04617 inside PROTEIN p53 Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P01483 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1 inside PROTEIN p2 Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P01483 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1 inside PROTEIN p2 Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P01483 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1 inside PROTEIN p2 Long Name: p53 Synonym: Synonym not specified Accession: P01485 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1 inside PROTEIN p1 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05658 Heterodimer Member Info: p53#PROTEIN#p53#P01485;Mdm2#PROTEIN#mouse double minute 2#P01483 inside PROTEIN p2 PROTEIN p1 Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P01483 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1 inside PROTEIN p2 Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P01483 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1 inside PROTEIN p2 Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P01483 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1 inside PROTEIN p2 Long Name: a167_degraded Synonym: Synonym not specified Accession: U05667 inside DEGRADED a167_degraded Long Name: PML Synonym: Synonym not specified Accession: G04701 inside GENE PML Long Name: Senescence Synonym: Synonym not specified Accession: U05666 inside PHENOTYPE Senescence Long Name: Aging Synonym: Synonym not specified Accession: U05670 inside PHENOTYPE Aging Long Name: Feedback loops Synonym: Synonym not specified Accession: U05664 inside PHENOTYPE Feedback loops STATE_TRANSITION s5 s6 0.33333333333333304,0.0 0.666666666666667,0.0 a7 a10 STATE_TRANSITION s10 s11 0.33333333333333304,-1.7763568394002505E-15 0.666666666666667,-3.552713678800501E-15 a14 a15 a97 STATE_TRANSITION s84 s138 0.3333333333333336,4.440892098500626E-16 0.6666666666666666,0.0 a16 a2 a15 STATE_TRANSITION s15 s42 0.33333333333333304,0.0 0.6666666666666665,0.0 a20 a19 a47 STATE_TRANSITION s1 s16 0.33333333333333304,5.329070518200751E-15 0.666666666666667,1.1102230246251565E-14 a21 a1 a19 a46 UNKNOWN_TRANSITION s33 s35 0.33333333333333304,0.0 0.6666666666666661,0.0 a38 a40 UNKNOWN_TRANSITION s34 s37 0.33333333333333304,0.0 0.6666666666666665,0.0 a39 a42 UNKNOWN_TRANSITION s35 s37 0.33333333333333304,0.0 0.666666666666667,-8.881784197001252E-16 a40 a42 UNKNOWN_TRANSITION s36 s37 0.3333333333333335,0.0 0.6666666666666667,0.0 a41 a42 UNKNOWN_TRANSITION s6 s38 0.33333333333333315,0.0 0.6666666666666666,-4.440892098500626E-16 a10 a43 STATE_TRANSITION s40 s41 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,1.7763568394002505E-15 a45 a46 STATE_TRANSITION s40 s41 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,1.7763568394002505E-15 a45 a46 a19 TRANSCRIPTIONAL_ACTIVATION s16 s44 0.27122121097427687,-0.2691749493246762 0.8878385818851771,0.12602524591988784 a1 a48 TRANSCRIPTIONAL_ACTIVATION s16 s45 0.3423104334161031,-0.22089508673550817 0.8255196949949198,0.09970734331488584 a1 a49 TRANSCRIPTIONAL_ACTIVATION s16 s47 0.28560063114820977,-0.25689608576656053 0.8606420996355462,0.12157527331430185 a1 a51 TRANSCRIPTIONAL_ACTIVATION s16 s48 0.38300359275388296,-0.2395127986255765 0.8841057407545501,0.06697439786042536 a1 a52 TRANSCRIPTIONAL_ACTIVATION s16 s56 0.3333333333333339,0.0 0.6666666666666679,0.0 a1 a60 TRANSCRIPTIONAL_ACTIVATION s16 s53 0.44556838685072897,-0.04161092291305368 0.6666666666666665,0.0 a1 a57 TRANSCRIPTIONAL_ACTIVATION s16 s55 0.4250229827716616,0.061923843886935614 0.7457731022841021,-0.006827257206853288 a1 a59 TRANSCRIPTIONAL_ACTIVATION s16 s51 0.4189224662662421,-0.05426954652895333 0.7090163650349168,0.036679810842120464 a1 a55 TRANSCRIPTIONAL_ACTIVATION s16 s49 0.44067732226690515,0.0903500322041404 0.7833367812206766,-0.029467130248542306 a1 a53 TRANSCRIPTIONAL_ACTIVATION s16 s50 0.4023511701728233,-0.12148228072884937 0.747937601385239,0.07107725194711545 a1 a54 TRANSCRIPTIONAL_ACTIVATION s16 s52 0.39392091057811496,-0.14934420664661463 0.7868055233096377,0.08181538910862152 a1 a56 TRANSCRIPTIONAL_ACTIVATION s16 s54 0.38661809655115476,-0.10799743969707287 0.7377263501472116,0.05650456763084888 a1 a58 TRANSCRIPTIONAL_ACTIVATION s16 s57 0.3217242414667747,0.20377309189328652 0.8271392413553096,-0.047792147914850036 a1 a61 TRANSCRIPTIONAL_ACTIVATION s16 s58 0.3286089706911799,0.15767092643701885 0.6805574016804099,-0.048564321095422414 a1 a62 TRANSCRIPTIONAL_ACTIVATION s16 s59 0.3335236884986583,0.16493640558235234 0.722736459017066,-0.060518608661478956 a1 a63 TRANSCRIPTIONAL_ACTIVATION s16 s60 0.3416212028067642,0.18211326567280772 0.7662219054120987,-0.05518804465684157 a1 a64 TRANSCRIPTIONAL_ACTIVATION s16 s61 0.3333333333333337,8.881784197001252E-16 0.6666666666666672,0.0 a1 a65 TRANSCRIPTIONAL_ACTIVATION s16 s62 0.3333333333333335,0.0 0.666666666666667,2.220446049250313E-16 a1 a66 TRANSCRIPTIONAL_ACTIVATION s7 s63 0.33333333333333337,-2.220446049250313E-16 0.6666666666666667,-2.220446049250313E-16 a11 a67 STATE_TRANSITION s1 s65 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-1.5543122344752192E-15 a21 a69 a68 STATE_TRANSITION s65 s1 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-1.7763568394002505E-15 a69 a21 a86 HETERODIMER_ASSOCIATION s66,s67 s68 0.33333333333333215,0.0 0.6666666666666643,3.552713678800501E-15 0.3333333333333286,8.881784197001252E-16 0.6666666666666714,-8.881784197001252E-16 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666696,1.7763568394002505E-15 0.3333333333333144,0.3333333333333357 a70 a71 a74 HETERODIMER_ASSOCIATION s66,s69 s70 0.3333333333333339,-3.552713678800501E-15 0.6666666666666661,-3.552713678800501E-15 0.3333333333333428,7.105427357601002E-15 0.6666666666666714,7.105427357601002E-15 0.3333333333333339,0.0 0.6666666666666661,0.0 0.3333333333333286,0.33333333333333215 a70 a76 a78 TRANSCRIPTIONAL_INHIBITION s16 s63 0.6830230803753785,-0.17380265399463102 0.9000027895852742,-0.11193083417857974 a1 a67 TRANSCRIPTIONAL_ACTIVATION s71 s63 0.33333333333333315,2.220446049250313E-16 0.6666666666666665,2.220446049250313E-16 a80 a67 HETERODIMER_ASSOCIATION s71,s8 s73 0.3333333333333326,-1.1102230246251565E-16 0.6666666666666665,2.220446049250313E-16 0.3333333333333335,-4.440892098500626E-16 0.6666666666666667,-8.881784197001252E-16 0.3333333333333335,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 0.33333333333333337,0.33333333333333304 a80 a12 a85 STATE_TRANSITION s16 s1 0.33333333333333326,3.3306690738754696E-16 0.6666666666666667,7.771561172376096E-16 a1 a21 a87 STATE_TRANSITION s77 s78 0.3333333333333335,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 a89 a90 a95 STATE_TRANSITION s78 s77 0.33333333333333304,2.220446049250313E-16 0.6666666666666665,2.220446049250313E-16 a90 a89 a44 TRANSCRIPTIONAL_INHIBITION s16 s79 0.33333333333333326,4.440892098500626E-16 0.6666666666666665,4.440892098500626E-16 a1 a91 HETERODIMER_ASSOCIATION s76,s80 s81 0.3333333333333339,3.552713678800501E-15 0.6666666666666661,3.552713678800501E-15 0.3333333333333304,0.0 0.6666666666666661,0.0 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666661,-1.7763568394002505E-15 0.33333333333333215,0.33333333333333304 a94 a92 a95 STATE_TRANSITION s82 s82 0.3333333333333335,8.881784197001252E-16 0.6666666666666669,1.3322676295501878E-15 a96 a97 a90 INHIBITION s8 s84 0.3333333333333335,0.0 0.6666666666666665,2.220446049250313E-16 a12 a16 STATE_TRANSITION s139 s85 0.33333333333333304,0.0 0.6666666666666661,-4.440892098500626E-16 a100 a101 a100 TRANSCRIPTIONAL_INHIBITION s68 s86 0.33333333333333215,-4.440892098500626E-16 0.6666666666666674,0.0 a74 a102 TRANSCRIPTIONAL_INHIBITION s70 s86 0.33333333333333304,0.0 0.6666666666666661,2.220446049250313E-16 a78 a102 TRANSCRIPTIONAL_ACTIVATION s89 s86 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 a105 a102 TRANSCRIPTIONAL_ACTIVATION s88 s86 0.33333333333333337,8.881784197001252E-16 0.6666666666666666,8.881784197001252E-16 a104 a102 TRANSCRIPTIONAL_ACTIVATION s87 s86 0.33333333333333326,4.440892098500626E-16 0.6666666666666665,0.0 a103 a102 KNOWN_TRANSITION_OMITTED s9 s90 0.33333333333333304,0.0 0.6666666666666665,0.0 a13 a106 KNOWN_TRANSITION_OMITTED s90 s76 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