This pathway illustrates the intracellular signaling during neuronal axon growth guided by Slit through the Roundabout (Robo) transmembrane receptor. Medline=12677003 Medline=14682358 4.0 s14 PROTEIN p3 s14 PROTEIN p2 s19 PROTEIN p3 s19 PROTEIN p1 s19 PROTEIN p8 s29 PROTEIN p12 s29 PROTEIN p11 s45 PROTEIN p3 s45 PROTEIN p1 s45 PROTEIN p2 s46 PROTEIN p1 s46 PROTEIN p14 s36 PROTEIN p13 s36 PROTEIN p2 s52 PROTEIN p1 s52 PROTEIN p14 SQUARE OVAL active active active active inactive inactive inactive inactive inactive inactive inactive active active active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive cell membrane Endosome Long Name: Deleted in colorectal carcinoma Synonym: Synonym not specified Accession: P00352 transmembrane PROTEIN p2 Long Name: Slit Synonym: Synonym not specified Accession: P00342 inside PROTEIN p3 Long Name: Abelson murine leukemia viral oncogene homolog 1 Synonym: c-ABL,p150 Accession: P00347 inside PROTEIN p5 Long Name: Ras-related C3 botulinum toxin substrate Synonym: Synonym not specified Accession: P00354 inside PROTEIN p6 Long Name: Cell division cycle 42 Synonym: G25K Accession: P00349 inside PROTEIN p7 Long Name: Receptor-linked protein-tyrosine phosphatase 10D Synonym: Synonym not specified Accession: P00343 inside PROTEIN p9 Long Name: Ras homologue gene family, member A Synonym: ARH,Aplysia ras-related homolog Accession: P00355 inside PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05054 Heterodimer Member Info: Slit#PROTEIN#Slit#P00342##;DCC#PROTEIN#Deleted in colorectal carcinoma#P00352## transmembrane COMPLEX Complex_br_(Slit/DCC) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05057 Heterodimer Member Info: Slit#PROTEIN#Slit#P00342##;Robo#PROTEIN#Roundabout#P00348##;SrGAP#PROTEIN#Slit-Robo GTPase activating protein#P00350## transmembrane COMPLEX Complex_br_(Slit/Robo/_br_SrGAP) Long Name: Mammalian enabled Synonym: Ena Accession: P00345 inside PROTEIN p4 Long Name: Mammalian enabled Synonym: Ena Accession: P00345 inside PROTEIN p4 Long Name: Cytoskeletal dynamics Synonym: Synonym not specified Accession: U02126 inside PHENOTYPE Cytoskeletal dynamics Long Name: Axonal plasticity Synonym: Synonym not specified Accession: U02127 inside PHENOTYPE Axonal plasticity Long Name: Chemokine, CXC motif, receptor4 Synonym: CXC chemokine receptor 4,LAP3,LPS-associated protein 3,NPY3R,Neuropeptide Y receptor Y3 Accession: P00351 transmembrane PROTEIN p11 Long Name: Sdf1 Synonym: CXCL12,Chemokine, CXC motif, ligand 12,PBSF,Pre-B cell growth-stimulating factor,Stromal cell-derived factor1 Accession: P00346 inside PROTEIN p12 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05059 Heterodimer Member Info: Sdf1#PROTEIN#Sdf1#P00346#CXCL12|Chemokine, CXC motif, ligand 12|PBSF|Pre-B cell growth-stimulating factor|Stromal cell-derived factor1#;Cxcr4#PROTEIN#Chemokine, CXC motif, receptor4#P00351#CXC chemokine receptor 4|LAP3|LPS-associated protein 3|NPY3R|Neuropeptide Y receptor Y3# transmembrane COMPLEX Complex_br_(Sdf1/Cxcr4) Long Name: Roundabout Synonym: Synonym not specified Accession: P00348 transmembrane PROTEIN p1 Long Name: Slit-Robo GTPase activating protein Synonym: Synonym not specified Accession: P00350 inside PROTEIN p8 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05056 Heterodimer Member Info: Netrin#PROTEIN#Netrin#P00344#Netrin-1#;DCC#PROTEIN#Deleted in colorectal carcinoma#P00352## transmembrane COMPLEX Complex_br_(Netrin/DCC) Long Name: Commissureless Synonym: Synonym not specified Accession: P00353 inside PROTEIN p14 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05055 Heterodimer Member Info: Slit#PROTEIN#Slit#P00342##;Robo#PROTEIN#Roundabout#P00348##;DCC#PROTEIN#Deleted in colorectal carcinoma#P00352## transmembrane COMPLEX Complex_br_(Slit/Robo/_br_DCC) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05053 Heterodimer Member Info: Robo#PROTEIN#Roundabout#P00348##;Comm#PROTEIN#Commissureless#P00353## transmembrane COMPLEX Complex_br_(Robo/Comm) Long Name: a59_degraded Synonym: Synonym not specified Accession: U02128 inside DEGRADED a59_degraded Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05053 Heterodimer Member Info: Robo#PROTEIN#Roundabout#P00348##;Comm#PROTEIN#Commissureless#P00353## transmembrane COMPLEX Complex_br_(Robo/Comm) STATE_TRANSITION 0.2947588870420139,-0.12715458617020303 0.6537049588138588,-0.11707352438690322 a4 a25 a5 STATE_TRANSITION 0.32359376242627214,-0.11656046951685095 0.7119108262688689,-0.11538044331568464 a25 a4 a9 STATE_TRANSITION 0.3333333333333366,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 a26 a5 a22 KNOWN_TRANSITION_OMITTED 0.40560646232697195,5.9914075316847E-4 0.5610999465817139,0.005153599010290222 a27 a28 HETERODIMER_ASSOCIATION 0.4303165335295578,0.3955888682314921 a30 a29 a33 HETERODIMER_ASSOCIATION 0.23067418771923465,-0.2570999314888882 0.6779755967053469,0.27057695682333893 a3 a35 a36 a22 HETERODIMER_ASSOCIATION 0.014113619010113432,0.5536653097749635 a3 a2 a14 HETERODIMER_ASSOCIATION 0.8652709314906173,0.1596338415373666 0.27327282559271515,-0.019159021979119784 1.1882702249590738,0.6700157235015596 a22 a2 a58 a36 TRANSPORT 0.25108664701430694,0.29530553245145263 0.6726153185139238,0.22727551545249747 a46 a59 STATE_TRANSITION 0.5228427800051003,-0.04146727604433398 a59 a60 STATE_TRANSITION a62 a6 a22 STATE_TRANSITION a7 sa37 a22 STATE_TRANSITION a10 sa38 a22 STATE_TRANSITION csa8 a41 a58 HETERODIMER_ASSOCIATION 0.4147636493728546,0.3213314174666597 a35 a42 a46 PHYSICAL_STIMULATION a10 a27 PHYSICAL_STIMULATION 0.2764173225812683,0.16501374041871264 a6 a27 PHYSICAL_STIMULATION a25 a27 PHYSICAL_STIMULATION 0.2931227698440194,-0.11642466674848073 a7 a27 PHYSICAL_STIMULATION a41 a27 PHYSICAL_STIMULATION 0.4233922803530341,-0.2469974580292289 a33 a27 PHYSICAL_STIMULATION 0.04245288628536584,-0.36616207063921524 0.4764639362560382,-0.42558835752592983 a14 a27