This pathway describes axon growth cone collapse induced by semaphorin 3A and semaphorin 4D. Medline=12677003 Medline=14682358 Medline=14687984 4.0 s3 PROTEIN p1 s17 PROTEIN p3 s17 PROTEIN p1 s17 PROTEIN p2 s37 PROTEIN p14 s37 PROTEIN p13 s40 PROTEIN p13 s40 PROTEIN p14 s53 PROTEIN p4 s53 PROTEIN p5 s53 PROTEIN p16 s58 PROTEIN p4 s58 PROTEIN p5 s58 PROTEIN p17 SQUARE active inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active inactive inactive inactive active active active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active active inactive active active active inactive cytosol Long Name: Long Name: Plexin A1, plexin 1 Synonym: Synonym not specified Accession: U05065 Heterodimer Member Info: PlexinA1#PROTEIN#Plexin A1#P00334#NOV|PLXN1|PLXNA1|Plexin 1|Transmembrane protein NOV#;Neuropilin 1#PROTEIN#Neuropilin 1#P00338#NRP1# transmembrane COMPLEX Complex_br_(PlexinA1/Neuropilin 1) Long Name: Semaphorin 3A Synonym: Collapsin 1,Sema D,Sema III,Semaphorin D,Semaphorin III Accession: P00337 inside PROTEIN p3 Long Name: Semaphorin 4D Synonym: CD100,Coll4,Collapsin 4,Leukocyte activation antigen CD100,Sema J,Semaphorin J Accession: P00329 inside PROTEIN p4 Long Name: Plexin B1 Synonym: PLXN5,PLXNB1,Plexin 5,SEP,Transmembrane protein SEP Accession: P00328 transmembrane PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05063 Heterodimer Member Info: PlexinA1#PROTEIN#Plexin A1#P00334#NOV|PLXN1|PLXNA1|Plexin 1|Transmembrane protein NOV#;Sema3A#PROTEIN#Semaphorin 3A#P00337#Collapsin 1|Sema D|Sema III|Semaphorin D|Semaphorin III#;Neuropilin 1#PROTEIN#Neuropilin 1#P00338#NRP1# transmembrane COMPLEX Complex_br_(Sema3A/Neuropilin 1/_br_PlexinA1) Long Name: Fyn tyrosine kinase protooncogene Synonym: FYN oncogene related to Src, FGR, YES,SYN Accession: P00335 inside PROTEIN p6 Long Name: Oncogene FES Synonym: Feline sarcoma oncogene Accession: P00332 inside PROTEIN p12 Long Name: p21-activated kinase Synonym: Synonym not specified Accession: P00331 inside PROTEIN p8 Long Name: p21-activated kinase Synonym: Synonym not specified Accession: P00331 inside PROTEIN p8 Long Name: Cyclin-dependent kinase 5 Synonym: Cell division kinase 5,PSSALRE Accession: P00336 inside PROTEIN p7 Long Name: Cyclin-dependent kinase 5 Synonym: Cell division kinase 5,PSSALRE Accession: P00336 inside PROTEIN p7 Long Name: ATP Synonym: Synonym not specified Accession: S01600 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01601 inside SIMPLE_MOLECULE ADP Long Name: Cytoskeletal dynamics Synonym: Synonym not specified Accession: U02118 inside PHENOTYPE Cytoskeletal dynamics Long Name: Long Name: CRMP Synonym: Synonym not specified Accession: U05068 Heterodimer Member Info: CRAM#PROTEIN#CRMP 3-associated molecule#P00330#CRMP5|Collapsin response mediator protein 5|Dihydropyrimidinase-like 5#;CRMP#PROTEIN#Collapsin response mediator protein#P00339#Dihydropyrimidinase related protein# inside COMPLEX Complex_br_(CRAM/CRMP) Long Name: Long Name: CRAM Synonym: Synonym not specified Accession: U05067 Heterodimer Member Info: CRAM#PROTEIN#CRMP 3-associated molecule#P00330#CRMP5|Collapsin response mediator protein 5|Dihydropyrimidinase-like 5#;CRMP#PROTEIN#Collapsin response mediator protein#P00339#Dihydropyrimidinase related protein# inside COMPLEX Complex_br_(CRMP/CRAM) Long Name: Ras homologue gene family, member A Synonym: ARHA Accession: P00341 inside PROTEIN p15 Long Name: Ras-related C3 botulinum toxin substrate Synonym: Rho family small GTP-binding protein Accession: P00340 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05064 Heterodimer Member Info: plexinB1#PROTEIN#Plexin B1#P00328#PLXN5|PLXNB1|Plexin 5|SEP|Transmembrane protein SEP#;Sema4D#PROTEIN#Semaphorin 4D#P00329#CD100|Coll4|Collapsin 4|Leukocyte activation antigen CD100|Sema J|Semaphorin J#;Rac#PROTEIN#Ras-related C3 botulinum toxin substrate#P00340#Rho family small GTP-binding protein# transmembrane COMPLEX Complex_br_(Sema4D/plexinB1/_br_Rac) Long Name: Long Name: Rho GEF Synonym: Synonym not specified Accession: U05066 Heterodimer Member Info: plexinB1#PROTEIN#Plexin B1#P00328#PLXN5|PLXNB1|Plexin 5|SEP|Transmembrane protein SEP#;Sema4D#PROTEIN#Semaphorin 4D#P00329#CD100|Coll4|Collapsin 4|Leukocyte activation antigen CD100|Sema J|Semaphorin J#;RhoGEF#PROTEIN#Rho guanine nucleotide exchange factor#P00333#Guanine nucleotide exchange factor, 115KD|p115-RhoGEF# transmembrane COMPLEX Complex_br_(Sema4D/plexinB1/_br_RhoGEF) Long Name: Rho guanine nucleotide exchange factor Synonym: Guanine nucleotide exchange factor, 115KD,p115-RhoGEF Accession: P00333 inside PROTEIN p17 transmembrane PROTEIN p2 HETERODIMER_ASSOCIATION 0.49183687513134355,0.02596110934098128 0.33213930262118985,0.34243071018776083 a3 a4 a16 STATE_TRANSITION 0.34828374003732687,-0.02176868866843229 0.6589558121825112,-0.03386754287547378 a19 a27 a24 a28 a18 a41 STATE_TRANSITION 0.3333333333333357,3.9968028886505635E-15 0.6666666666666679,1.0125233984581428E-13 a25 a27 a18 a28 a26 STATE_TRANSITION 0.3333333333333304,-1.7763568394002505E-15 0.6666666666666661,-1.7763568394002505E-15 a17 a26 a16 STATE_TRANSITION a23 a31 a16 STATE_TRANSITION a34 a47 a38 a49 a31 HETERODIMER_ASSOCIATION 0.36960320051199247,0.2820222779949475 a5 a6 a73 a68 HETERODIMER_ASSOCIATION 0.39940610291586154,0.22289883655860265 a5 a6 a41 a61 STATE_TRANSITION sa35 a39 a16 a68 PHYSICAL_STIMULATION a24 a30 PHYSICAL_STIMULATION a38 a30 PHYSICAL_STIMULATION a39 a30