The cadherin gene family encode proteins that mediate calcium-ion-dependent adhesion. Three members of this family are E-cadherin, N-cadherin, and P-cadherin. Cadherin-catenin complex is the central part of this pathway. It's been shown that the pathway is involved in many biological processes, such as development, neurogenesis, cell adhesion, and inflammation. It has also been implicated to ve involved in many disease, such as cancer. In this pathway, we focus on Cadherin signaling pathway. For Wnt pathway, please see our "Wnt signaling pathway". Medline=12841864 Medline=12925579 Medline=15001769 Medline=7502046 OMIM=114020 4.0 s54 PROTEIN p2 s54 PROTEIN p4 s41 PROTEIN p3 s41 PROTEIN p2 s41 PROTEIN p4 s53 PROTEIN p1 s53 PROTEIN p3 s72 PROTEIN p1 s72 PROTEIN p1 s72 PROTEIN p3 s72 PROTEIN p2 s72 PROTEIN p4 s77 PROTEIN p1 s77 PROTEIN p3 s77 PROTEIN p2 s77 PROTEIN p4 s98 PROTEIN p1 s98 PROTEIN p5 s106 PROTEIN p16 s106 PROTEIN p15 s108 PROTEIN p3 s108 PROTEIN p14 s83 PROTEIN p3 s83 PROTEIN p13 s83 PROTEIN p5 SQUARE SQUARE OVAL inactive inactive inactive active inactive inactive active active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Cytoplasm nucleus Long Name: Glycogen synthase kinase 3-beta Synonym: GSK3B Accession: P00477 inside PROTEIN p6 Long Name: Src tyrosine kinase Synonym: Synonym not specified Accession: P00468 inside PROTEIN p8 Long Name: Epidermal growth factor receptor Synonym: Synonym not specified Accession: P00466 transmembrane PROTEIN p9 Long Name: Cell Adhesion Synonym: Synonym not specified Accession: U02192 inside PHENOTYPE Cell Adhesion Long Name: Fyn tyrosine kinase protooncogene Synonym: Syn Accession: P00464 inside PROTEIN p10 Long Name: Oncogene YES1 Synonym: Yamaguchi sarcoma oncogene Accession: P00476 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05138 Heterodimer Member Info: alphacatenin#PROTEIN#Alpha-catenin#P00467#Cadherin-associated protein#;F-actin#PROTEIN#Filamentous F-actin#P00470## inside COMPLEX Complex_br_(_alpha_catenin/F_minus_actin) Long Name: Casein kinase II Synonym: Synonym not specified Accession: P00462 inside PROTEIN p12 Long Name: FPS/FES-related tyrosine kinase Synonym: Protein tyrosine kinase 3,TYK3 Accession: P00469 inside PROTEIN p7 Long Name: FPS/FES-related tyrosine kinase Synonym: Protein tyrosine kinase 3,TYK3 Accession: P00469 inside PROTEIN p7 Long Name: Cadherin Synonym: Synonym not specified Accession: P00471 transmembrane PROTEIN p1 Long Name: Beta-catenin Synonym: Synonym not specified Accession: P00463 inside PROTEIN p3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05132 Heterodimer Member Info: betacatenin#PROTEIN#Beta-catenin#P00463##;alphacatenin#PROTEIN#Alpha-catenin#P00467#Cadherin-associated protein#;F-actin#PROTEIN#Filamentous F-actin#P00470## inside COMPLEX Complex_br_(_beta_catenin/_alpha_catenin/_br_F_minus_actin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05133 Heterodimer Member Info: betacatenin#PROTEIN#Beta-catenin#P00463##;Cadherin#PROTEIN#Cadherin#P00471## transmembrane COMPLEX Complex_br_(Cadherin/_beta_catenin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05137 Heterodimer Member Info: betacatenin#PROTEIN#Beta-catenin#P00463##;alphacatenin#PROTEIN#Alpha-catenin#P00467#Cadherin-associated protein#;F-actin#PROTEIN#Filamentous F-actin#P00470##;Cadherin#PROTEIN#Cadherin#P00471## transmembrane COMPLEX Complex_br_(Cadherin/Cadherin/_br__beta_catenin/_alpha_catenin/_br_F_minus_actin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05136 Heterodimer Member Info: betacatenin#PROTEIN#Beta-catenin#P00463##;alphacatenin#PROTEIN#Alpha-catenin#P00467#Cadherin-associated protein#;F-actin#PROTEIN#Filamentous F-actin#P00470##;Cadherin#PROTEIN#Cadherin#P00471## transmembrane COMPLEX Complex_br_(Cadherin/_beta_catenin/_br__alpha_catenin/F_minus_actin) Long Name: Beta-catenin Synonym: Synonym not specified Accession: P00463 inside PROTEIN p3 Long Name: Beta-catenin Synonym: Synonym not specified Accession: P00463 inside PROTEIN p3 Long Name: a133_degraded Synonym: Synonym not specified Accession: U02190 inside DEGRADED a133_degraded Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05139 Heterodimer Member Info: Cadherin#PROTEIN#Cadherin#P00471##;P120#PROTEIN#Delta-catenin#P00473#CAS|CTNND|Cadherin-associated Src substrate# transmembrane COMPLEX Complex_br_(Cadherin/P120) Long Name: Endocytosis Synonym: Synonym not specified Accession: U02193 inside PHENOTYPE Endocytosis Long Name: Frizzled Synonym: Synonym not specified Accession: P00475 transmembrane PROTEIN p15 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05131 Heterodimer Member Info: Wnt#PROTEIN#Wnt#P00474##;Frizzled#PROTEIN#Frizzled#P00475## transmembrane COMPLEX Complex_br_(Wnt/Frizzled) Long Name: Wnt Synonym: Synonym not specified Accession: P00474 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05135 Heterodimer Member Info: betacatenin#PROTEIN#Beta-catenin#P00463##;TCF/LEF#PROTEIN#Transcription factor 4/Lymphoid enhancer-binding factor#P00465## inside COMPLEX Complex_br_(_beta_catenin/TCF_slash_LEF) Long Name: Wnt Targetz transcription Synonym: Synonym not specified Accession: U02191 inside PHENOTYPE Wnt Targetz_br_transcription Long Name: Delta-catenin Synonym: CAS,CTNND,Cadherin-associated Src substrate Accession: P00473 inside PROTEIN p5 Long Name: Beta-catenin Synonym: Synonym not specified Accession: P00463 inside PROTEIN p3 Long Name: Beta-catenin Synonym: Synonym not specified Accession: P00463 inside PROTEIN p3 Long Name: Alpha-catenin Synonym: Cadherin-associated protein Accession: P00467 inside PROTEIN p2 Long Name: Filamentous F-actin Synonym: Synonym not specified Accession: P00470 inside PROTEIN p4 Long Name: Transcription factor 4/Lymphoid enhancer-binding factor Synonym: Synonym not specified Accession: P00465 inside PROTEIN p14 Long Name: Beta-catenin Synonym: Synonym not specified Accession: P00463 inside PROTEIN p3 Long Name: Delta-catenin Synonym: CAS,CTNND,Cadherin-associated Src substrate Accession: P00473 inside PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05134 Heterodimer Member Info: betacatenin#PROTEIN#Beta-catenin#P00463##;Tyrosine phosphatases#PROTEIN#Protein-tyrosine phosphatases, non-receptor type 1#P00472#PTP1B|PTPN1|Protein phosphotyrosylphosphatase 1B#;P120#PROTEIN#Delta-catenin#P00473#CAS|CTNND|Cadherin-associated Src substrate# inside COMPLEX Complex_br_(_beta_catenin/Tyrosine_br_phosphatases/_br_P120) Long Name: Protein-tyrosine phosphatases, non-receptor type 1 Synonym: PTP1B,PTPN1,Protein phosphotyrosylphosphatase 1B Accession: P00472 inside PROTEIN p13 STATE_TRANSITION a94 a7 a49 HETERODIMER_ASSOCIATION 0.4499507313330454,0.16986723929986347 a82 a83 a103 a118 a93 DISSOCIATION 0.4366629168566094,0.2525026424548016 a110 a82 a83 a9 a48 a8 HETERODIMER_ASSOCIATION 0.6453357553626264,0.2234350789340186 1.268740800064041,-0.05227629840211234 a110 a10 a103 STATE_TRANSITION a133 a134 KNOWN_TRANSITION_OMITTED a132 a133 STATE_TRANSITION a16 a132 a6 HETERODIMER_ASSOCIATION 0.3333333333333339,0.33333333333333304 a146 a150 a149 STATE_TRANSITION a132 a16 a149 HETERODIMER_ASSOCIATION 0.3333333333333333,0.3333333333333326 a155 a68 a110 a118 DISSOCIATION 0.33333333333333304,0.3333333333333335 a110 a155 a68 a7 HETERODIMER_ASSOCIATION 0.3333333333333335,0.3333333333333335 a155 a156 a154 DISSOCIATION 0.33333333333333326,0.33333333333333326 a68 a160 a161 a162 TRANSPORT a160 a16 TRANSPORT a16 a160 TRANSPORT a16 a157 HETERODIMER_ASSOCIATION 0.33333333333333304,0.3333333333333333 a167 a157 a153 TRANSPORT a16 a170 TRANSPORT a170 a16 HETERODIMER_ASSOCIATION 0.2492986583158,0.19888495920389282 a169 a170 a82 HETERODIMER_ASSOCIATION -0.019125425313209377,0.3782671322701816 a174 a173 a172 a118 TRIGGER a103 a30 TRIGGER a154 a141 PHYSICAL_STIMULATION a153 a142