Actin and microtubules are major cytoskeletal elements of most cells including neurons. In order for a cell to move and change shape, its cytoskeleton must undergo rearrangements that involve breaking down and reforming filaments. This pathway illustrates such change regulated by Rho GTPase. Medline=12677003 Medline=12796474 Medline=14598374 4.0 s17 PROTEIN p2 s17 SIMPLE_MOLECULE GTP s19 PROTEIN p1 s19 SIMPLE_MOLECULE GTP s20 PROTEIN p3 s20 SIMPLE_MOLECULE GTP s22 SIMPLE_MOLECULE GDP s22 PROTEIN p2 s23 SIMPLE_MOLECULE GDP s23 PROTEIN p1 s24 SIMPLE_MOLECULE GDP s24 PROTEIN p3 s26 PROTEIN p8 s26 PROTEIN p9 s27 PROTEIN p13 2 s27 PROTEIN p13 2 s30 PROTEIN p12 s30 PROTEIN p13 s37 PROTEIN p16 2 s37 PROTEIN p16 2 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive active inactive active inactive inactive active inactive inactive active active inactive inactive active inactive active inactive active inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive Long Name: Rho-GTPase-activating proteins Synonym: ARHGAPs Accession: P00520 inside PROTEIN p4 Long Name: Rho guanine nucleotide exchange factors Synonym: ARHGEF Accession: P00518 inside PROTEIN p5 Long Name: Rho-associated coiled-coil-containing protein kinase Synonym: Synonym not specified Accession: P00519 inside PROTEIN p6 Long Name: Wiskott-Aldrich syndrome protein family member 1 Synonym: SCAR,WASF1,WASP family, verprolin homology domain-containing protein,WAVE Accession: P00525 inside PROTEIN p8 Long Name: Profilin Synonym: PFN Accession: P00521 inside PROTEIN p12 Long Name: Actin Synonym: Synonym not specified Accession: P00512 inside PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05168 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01643##;Rac#PROTEIN#Ras-related C3 Botulinum toxin substrate 1#P00523#Rho family small GTP-binding protein Rac1# inside COMPLEX Complex_br_(Rac/GTP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05161 Heterodimer Member Info: Rho#PROTEIN#Ras homologue gene family#P00507#ARH|Aplysia Ras homologue#;GTP#SIMPLE_MOLECULE#GTP#S01643## inside COMPLEX Complex_br_(Rho/GTP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05167 Heterodimer Member Info: Cdc42#PROTEIN#Cell division cycle 42#P00515#G25K|GTP-binding protein 25K#;GTP#SIMPLE_MOLECULE#GTP#S01643## inside COMPLEX Complex_br_(Cdc42/GTP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05164 Heterodimer Member Info: GDP#SIMPLE_MOLECULE#GDP#S01642##;Rac#PROTEIN#Ras-related C3 Botulinum toxin substrate 1#P00523#Rho family small GTP-binding protein Rac1# inside COMPLEX Complex_br_(GDP/Rac) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05162 Heterodimer Member Info: Rho#PROTEIN#Ras homologue gene family#P00507#ARH|Aplysia Ras homologue#;GDP#SIMPLE_MOLECULE#GDP#S01642## inside COMPLEX Complex_br_(GDP/Rho) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05159 Heterodimer Member Info: GDP#SIMPLE_MOLECULE#GDP#S01642##;Cdc42#PROTEIN#Cell division cycle 42#P00515#G25K|GTP-binding protein 25K# inside COMPLEX Complex_br_(GDP/Cdc42) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05163 Heterodimer Member Info: ARP2/3#PROTEIN#Actin related protein 2/3 complex#P00511##;N-WASP#PROTEIN#Wiskott-Aldrich syndrome protein family member 1#P00525#SCAR|WASF1|WASP family, verprolin homology domain-containing protein|WAVE# inside COMPLEX Complex_br_(N-WASP/ARP2/_br_3) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05160 Heterodimer Member Info: Actin#PROTEIN#Actin#P00512## inside COMPLEX Complex_br_(Actin/Actin) Long Name: Axonal plasticity Synonym: Synonym not specified Accession: U02218 inside PHENOTYPE Axonal plasticity Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05165 Heterodimer Member Info: Actin#PROTEIN#Actin#P00512##;Profilin#PROTEIN#Profilin#P00521#PFN# inside COMPLEX Complex_br_(Profilin/Actin) Long Name: Enabled/vasodialator stimulated phosphoprotein Synonym: Synonym not specified Accession: P00516 inside PROTEIN p11 Long Name: p21 activated kinase Synonym: Synonym not specified Accession: P00517 inside PROTEIN p14 Long Name: Cofilin Synonym: Actin depolymerizing factor,CFL Accession: P00508 inside PROTEIN p10 Long Name: Cofilin Synonym: Actin depolymerizing factor,CFL Accession: P00508 inside PROTEIN p10 Long Name: LIM domain kinase 1 Synonym: LIM kinase Accession: P00524 inside PROTEIN p7 Long Name: LIM domain kinase 1 Synonym: LIM kinase Accession: P00524 inside PROTEIN p7 Long Name: Slingshot Synonym: SSH Accession: P00509 inside PROTEIN p15 Long Name: Tubulin Synonym: Synonym not specified Accession: P00526 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05166 Heterodimer Member Info: tubulin#PROTEIN#Tubulin#P00526## inside COMPLEX Complex_br_(tubulin/tubulin) Long Name: Stathmin Synonym: LAP18,Leukemia associated phosphoprotein p18,SMN Accession: P00513 inside PROTEIN p17 Long Name: Stathmin Synonym: LAP18,Leukemia associated phosphoprotein p18,SMN Accession: P00513 inside PROTEIN p17 Long Name: Myosin light chain kinase Synonym: MYLK Accession: P00514 inside PROTEIN p19 Long Name: Myosin light chain Synonym: Synonym not specified Accession: P00522 inside PROTEIN p18 Long Name: Myosin light chain Synonym: Synonym not specified Accession: P00522 inside PROTEIN p18 Long Name: Mammalian diaphanous Synonym: DIAPH Accession: P00510 inside PROTEIN p20 Long Name: Actin related protein 2/3 complex Synonym: Synonym not specified Accession: P00511 inside PROTEIN p9 Long Name: Pi Synonym: Synonym not specified Accession: U02219 inside ION Pi STATE_TRANSITION 0.3454533191402748,0.04390412376502681 0.6787866524736069,0.04390412376502453 a28 a34 a36 a4 STATE_TRANSITION 0.33564984079844806,-0.02246689198633428 0.6689831741317809,-0.022466891986335003 a26 a33 a36 a4 STATE_TRANSITION 0.31037293080046213,-0.031063982208017094 0.6553530716342733,-0.030969737920793494 a29 a35 a36 a4 STATE_TRANSITION 0.33104263739833195,0.02292005579105716 0.6643759707316648,0.02292005579105466 a34 a28 a5 STATE_TRANSITION 0.3357733936726235,-0.032690347695957134 0.6691067270059561,-0.03269034769595758 a33 a26 a5 STATE_TRANSITION 0.3452236247886058,-0.02246699821183884 0.6902037656224156,-0.02237275392461524 a35 a29 a5 STATE_TRANSITION 0.33058680939751417,0.03633840598852789 0.6639201427308454,0.036338405988527 a13 a45 a39 a12 a38 HETERODIMER_ASSOCIATION 0.5431990098314952,0.02888032715627631 0.5502790973552969,0.04040087664376009 0.6291201860459417,0.008556767808407528 0.3333333333333339,0.3333333333333357 a12 a42 a45 a11 STATE_TRANSITION 0.33829010478037924,0.05714151486944674 0.6716234381137016,0.057141514869447185 a39 a13 a10 a62 STATE_TRANSITION 0.3333333333333335,4.440892098500626E-16 0.666666666666667,8.881784197001252E-16 a7 a48 a46 a52 STATE_TRANSITION 0.33333333333333326,2.220446049250313E-16 0.6666666666666667,0.0 a51 a46 a29 a26 STATE_TRANSITION 0.3333333333333335,1.3322676295501878E-15 0.6666666666666665,2.220446049250313E-15 a10 a47 a48 STATE_TRANSITION 0.33333333333333337,-1.3877787807814457E-17 0.6666666666666669,-6.938893903907228E-17 a6 a52 a28 STATE_TRANSITION 0.33333333333333326,1.3322676295501878E-15 0.6666666666666663,2.220446049250313E-15 a47 a10 a53 STATE_TRANSITION 0.33531936213809876,-0.03718937735167671 0.6686526954714318,-0.03718937735167671 a54 a57 a65 STATE_TRANSITION 0.3346504796151737,-0.06574513819735611 0.6679838129485073,-0.06574513819735622 a57 a54 a58 STATE_TRANSITION 0.3333333333333334,-8.881784197001252E-16 0.6666666666666667,-4.440892098500626E-16 a58 a59 a46 STATE_TRANSITION 0.33333333333333215,0.0 0.6666666666666661,0.0 a60 a62 a61 STATE_TRANSITION 0.33333333333333304,0.0 0.666666666666667,7.105427357601002E-15 a63 a61 a52 STATE_TRANSITION 0.3333333333333335,-1.1102230246251565E-16 0.6666666666666665,-1.6653345369377348E-16 a64 a65 a28 HETERODIMER_ASSOCIATION 0.44637214431560324,-0.03359102974035366 0.6326631333966741,0.07808227713840665 0.5312485604421013,0.0066502873078317926 0.6629501142846586,0.0027338130007796835 0.33333333333333304,0.3333333333333338 a8 a68 a38 a26 a29 MODULATION 0.002797802920115,-0.12007147236369509 1.0023261543658757,-0.08843335918624318 a10 a41 MODULATION 0.011798222118220458,-0.1549197067329111 1.005548488262813,-0.057609570441293334 a39 a41 MODULATION 0.09356974393434492,0.15257042392703513 0.6663400817474154,0.126695491322709 a57 a41 MODULATION 0.03309302938659866,0.11739482779460178 0.8130112695445537,0.06632834136937628 a54 a41