A series of integrated protein-protein and protein-DNA interactions and enzymatic reactions to ensure high accuracy of DNA replication. 4.0 Long Name: nascent DNA Synonym: Synonym not specified Accession: G01509 s81 GENE gn5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05180 Heterodimer Member Info: RFC#PROTEIN#RFC#P00529#Replication Factor C#;Pol delta#PROTEIN#Pol delta#P00533##;PCNA#PROTEIN#PCNA#P00534## s61 COMPLEX Complex_br_(PCNA/RFC/_br_Pol _delta_) s37 PROTEIN p5 s37 PROTEIN p6 s58 PROTEIN p14 s58 PROTEIN p13 s58 PROTEIN p15 Long Name: nascent DNA Synonym: Synonym not specified Accession: G01509 s61 GENE gn5 Long Name: ssDNA Synonym: Synonym not specified Accession: G01508 s61 GENE gn4 Long Name: Helicase Synonym: Helicase Accession: P00532 s61 PROTEIN p7 Long Name: dsDNA Synonym: Synonym not specified Accession: G01507 s61 GENE gn3 Long Name: Topoisomerase Synonym: Synonym not specified Accession: P00530 s61 PROTEIN p8 Long Name: RPA Synonym: Replication Protein A Accession: P00537 s61 PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05181 Heterodimer Member Info: Primase#PROTEIN#Primase#P00528##;Pol alpha#PROTEIN#Pol alpha#P00531## s61 COMPLEX Complex_br_(Pol _alpha_/Primase) s68 PROTEIN p5 s68 PROTEIN p6 Long Name: dsDNA Synonym: Synonym not specified Accession: G01507 s81 GENE gn3 Long Name: Helicase Synonym: Helicase Accession: P00532 s81 PROTEIN p7 Long Name: Topoisomerase Synonym: Synonym not specified Accession: P00530 s81 PROTEIN p8 Long Name: RFC Synonym: Replication Factor C Accession: P00529 s81 PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05181 Heterodimer Member Info: Primase#PROTEIN#Primase#P00528##;Pol alpha#PROTEIN#Pol alpha#P00531## s81 COMPLEX Complex_br_(Pol _alpha_/Primase) s78 PROTEIN p5 s78 PROTEIN p6 Long Name: ssDNA Synonym: Synonym not specified Accession: G01508 s81 GENE gn4 Long Name: RPA Synonym: Replication Protein A Accession: P00537 s81 PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05181 Heterodimer Member Info: Primase#PROTEIN#Primase#P00528##;Pol alpha#PROTEIN#Pol alpha#P00531## s84 COMPLEX Complex_br_(Pol _alpha_/Primase) s90 PROTEIN p5 s90 PROTEIN p6 Long Name: Topoisomerase Synonym: Synonym not specified Accession: P00530 s93 PROTEIN p8 Long Name: dsDNA Synonym: Synonym not specified Accession: G01507 s93 GENE gn3 Long Name: Helicase Synonym: Helicase Accession: P00532 s93 PROTEIN p7 Long Name: ssDNA Synonym: Synonym not specified Accession: G01508 s93 GENE gn4 Long Name: RPA Synonym: Replication Protein A Accession: P00537 s93 PROTEIN p9 s84 COMPLEX dsDNA Long Name: dsDNA Synonym: Synonym not specified Accession: G01507 s99 GENE gn3 Long Name: Helicase Synonym: Helicase Accession: P00532 s99 PROTEIN p7 Long Name: ssDNA Synonym: Synonym not specified Accession: G01508 s99 GENE gn4 Long Name: RPA Synonym: Replication Protein A Accession: P00537 s99 PROTEIN p9 Long Name: Topoisomerase Synonym: Synonym not specified Accession: P00530 s99 PROTEIN p8 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Long Name: Chromatin (DNA + Histones + Other Proteins) Synonym: Synonym not specified Accession: G01505 inside GENE gn1 Long Name: Chromatin (DNA + Histones + Other Proteins) Replication_Competant_State Synonym: Synonym not specified Accession: G01506 inside GENE gn2 Long Name: ATP Synonym: Synonym not specified Accession: S01645 inside SIMPLE_MOLECULE ATP Long Name: Long Name: ADP + Pi Synonym: Synonym not specified Accession: S04781 inside SIMPLE_MOLECULE ADP + P_sub_i_endsub Long Name: dsDNA Synonym: Synonym not specified Accession: G01507 inside GENE gn3 Long Name: Helicase Synonym: Helicase Accession: P00532 inside PROTEIN p7 Long Name: Topoisomerase Synonym: Synonym not specified Accession: P00530 inside PROTEIN p8 Long Name: RPA Synonym: Replication Protein A Accession: P00537 inside PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05181 Heterodimer Member Info: Primase#PROTEIN#Primase#P00528##;Pol alpha#PROTEIN#Pol alpha#P00531## inside COMPLEX Complex_br_(Pol _alpha_/Primase) Long Name: RFC Synonym: Replication Factor C Accession: P00529 inside PROTEIN p13 Long Name: PCNA Synonym: Synonym not specified Accession: P00534 inside PROTEIN p14 Long Name: Pol delta Synonym: Synonym not specified Accession: P00533 inside PROTEIN p15 Long Name: Long Name: nPPi Synonym: Synonym not specified Accession: S04780 inside SIMPLE_MOLECULE nPP_sub_i_endsub Long Name: Long Name: n dNTP + Mg++ Synonym: Synonym not specified Accession: S04783 inside SIMPLE_MOLECULE n dNTP + Mg_super_++_endsuper Long Name: RNA primer Synonym: Synonym not specified Accession: G01510 inside GENE gn6 Long Name: n H2O Synonym: Synonym not specified Accession: S01649 inside SIMPLE_MOLECULE n H_sub_2_endsub_O Long Name: n NMP Synonym: Synonym not specified Accession: S01648 inside SIMPLE_MOLECULE n NMP Long Name: Histones Synonym: Synonym not specified Accession: P00527 inside PROTEIN p18 Long Name: DNA Topoisomerase Synonym: Synonym not specified Accession: P00536 inside PROTEIN p19 Long Name: ATPs Synonym: Synonym not specified Accession: S01646 inside SIMPLE_MOLECULE ATPs Long Name: Long Name: ADPs + Pi Synonym: Synonym not specified Accession: S04782 inside SIMPLE_MOLECULE ADPs + P_sub_i_endsub Long Name: RNase H Synonym: Synonym not specified Accession: P00538 inside PROTEIN p20 Long Name: 5' to 3' Exoribonuclease Synonym: Synonym not specified Accession: P00535 inside PROTEIN p17 inside COMPLEX dsDNA-replication complex inside COMPLEX dsDNA-primase-RFC complex inside COMPLEX dsDNA-primase complex inside COMPLEX dsDNA Initiation STATE_TRANSITION a1 a2 HETERODIMER_ASSOCIATION 0.18873576227789957,-0.04335084656415411 0.5111054868727414,-0.02146063490678518 0.324303499477097,0.06998003870176328 0.6486069989541909,0.13996007740352567 0.4094935387442451,-0.019173901947480587 0.5248406908728169,-0.04982532197703815 -0.5077594045865217,0.8166379545548597 a2 a68 a67 a69 a23 csa13 a24 STATE_TRANSITION 0.3344778949071099,-0.008649258398515602 0.6335169164972463,-0.007247159041217088 csa11 a168 a170 a174 csa10 a175 STATE_TRANSITION csa10 a176 STATE_TRANSITION 0.31238485447024567,1.0899946081277534E-4 0.6247694354562368,1.5201374877005236E-4 a176 a181 a180 a182 a179 a204 STATE_TRANSITION 0.5131847173572861,-8.617719676418389E-4 0.7444758114780835,-0.0019304347580887116 a180 a183 a185 a1 a186 a184 STATE_TRANSITION csa12 a149 a148 csa11 a150 STATE_TRANSITION csa13 a191 a123 csa12 a192