EGFR belongs to the human epidermal receptor (HER) family of receptor tyrosine kinases, which consists of four closely related receptors (EGFR (HER1, erbB1), HER2 (neu, erbB2), HER3 (erbB3), and HER4 (erbB4)) that mediate cellular signaling pathways involved in growth and proliferation in response to the binding of a variety of growth factor ligands. There are currently six known endogenous ligands for EGFR: EGF, transforming growth factor- (TGF-), amphiregulin, betacellulin, heparin-binding EGF (HB-EGF), and epiregulin.Upon ligand binding, the EGFR forms homo- or heterodimeric complexes (usually with HER2), which leads to activation of the receptor tyrosine kinase, via autophosphorylation. Medline=12813928 Medline=14527402 Medline=14561424 Medline=14766123 4.0 s89 PROTEIN p2 2 s89 PROTEIN p5 s89 PROTEIN p11 s122 PROTEIN p2 2 s122 PROTEIN p4 s122 PROTEIN p31 s122 PROTEIN p7 s122 PROTEIN p30 s122 PROTEIN p34 s122 PROTEIN p5 s122 PROTEIN p11 s122 PROTEIN p32 s130 PROTEIN p5 s130 PROTEIN p11 SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive active inactive active inactive active inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive active inactive inactive active active active active inactive active inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active active active inactive active active active active active inactive Cytosol Long Name: phospholipase c gamma Synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma,phosphoinositide phospholipase C Accession: P00556 inside PROTEIN p4 Long Name: phosphatidylinositol 3-kinase Synonym: 5-bisphosphate 3-kinase,Phosphatidylinositol-4 Accession: P00557 inside PROTEIN p7 Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00551 inside PROTEIN p15 Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00551 inside PROTEIN p15 Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase Accession: P00559 inside PROTEIN p17 Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase Accession: P00559 inside PROTEIN p17 Long Name: Extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,pp42/44 Accession: P00543 inside PROTEIN p18 Long Name: Extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,pp42/44 Accession: P00543 inside PROTEIN p18 Long Name: Raf-1 kinase inhibitor protein Synonym: Hippocampal cholinergic stimulatory peptide precursor,PEBP,Phosphatidylethanolamine-binding protein,Terminal flower 1,neuropolypeptide h3,prostastic binding protein Accession: P00548 inside PROTEIN p19 Long Name: Raf-1 kinase inhibitor protein Synonym: Hippocampal cholinergic stimulatory peptide precursor,PEBP,Phosphatidylethanolamine-binding protein,Terminal flower 1,neuropolypeptide h3,prostastic binding protein Accession: P00548 inside PROTEIN p19 Long Name: protein phosphatase 2A Synonym: Serine/threonine protein phosphatase 2A Accession: P00547 inside PROTEIN p20 Long Name: 14-3-3 Synonym: PAR-5,Stratifin,protein kinase C inhibitor protein-1 (KCIP-1) Accession: P00539 inside PROTEIN p21 Long Name: Mitogenesis Differentiation Synonym: Synonym not specified Accession: U02228 inside PHENOTYPE Mitogenesis_br_Differentiation Long Name: Dual specificity mitogen-activated protein kinase kinase 4 and 7 Synonym: MAP kinase kinase 4 and 7,MAPK/ERK kinase 4 and 7,MAPKK 4 and 7 Accession: P00555 inside PROTEIN p26 Long Name: Dual specificity mitogen-activated protein kinase kinase 4 and 7 Synonym: MAP kinase kinase 4 and 7,MAPK/ERK kinase 4 and 7,MAPKK 4 and 7 Accession: P00555 inside PROTEIN p26 Long Name: C-jun-amino-terminal kinase 1, 2, and 3 Synonym: SAPK,stress-activated protein kinase Accession: P00545 inside PROTEIN p27 Long Name: C-jun-amino-terminal kinase 1, 2, and 3 Synonym: SAPK,stress-activated protein kinase Accession: P00545 inside PROTEIN p27 Long Name: Dual specificity mitogen-activated protein kinase kinase 3 and 6 Synonym: MAP kinase kinase 3 and 6,MAPK/ERK kinase 3 and 6,MAPKK 3 and 6 Accession: P00540 inside PROTEIN p28 Long Name: Dual specificity mitogen-activated protein kinase kinase 3 and 6 Synonym: MAP kinase kinase 3 and 6,MAPK/ERK kinase 3 and 6,MAPKK 3 and 6 Accession: P00540 inside PROTEIN p28 Long Name: p38 MAP kinase Synonym: HOG,mitogen-activated protein kinase 11,mitogen-activated protein kinase 14 isoform 4 Accession: P00562 inside PROTEIN p29 Long Name: p38 MAP kinase Synonym: HOG,mitogen-activated protein kinase 11,mitogen-activated protein kinase 14 isoform 4 Accession: P00562 inside PROTEIN p29 Long Name: Survival Apoptosis cell migration Synonym: Synonym not specified Accession: U02227 inside PHENOTYPE Survival_br_Apoptosis_br_cell_space_migration Long Name: RAF proto-oncogene serine/threonine-protein kinase Synonym: C-Raf,MAP kinase kinase kinase,Raf-1 Accession: P00560 inside PROTEIN p16 Long Name: RAF proto-oncogene serine/threonine-protein kinase Synonym: C-Raf,MAP kinase kinase kinase,Raf-1 Accession: P00560 inside PROTEIN p16 Long Name: Epidermal growth factor Synonym: gurken,transforming growth factor alpha Accession: P00549 inside PROTEIN p3 Long Name: Mitogen-activated protein kinase kinase kinase Synonym: MAPK/ERK kinase kinase,MEK kinase Accession: P00553 inside PROTEIN p25 Long Name: Mitogen-activated protein kinase kinase kinase Synonym: MAPK/ERK kinase kinase,MEK kinase Accession: P00553 inside PROTEIN p25 Long Name: signal transducer and activator of transcription Synonym: Acute-phase response factor,Mammary gland factor Accession: P00561 inside PROTEIN p31 Long Name: GAP Synonym: Synonym not specified Accession: P00546 inside PROTEIN p32 Long Name: Src homology 2 domain-containing transforming protein 1 Synonym: pp46/52/66 Accession: P00554 inside PROTEIN p30 Long Name: Transcription cell cycle progression Synonym: Synonym not specified Accession: U02225 inside PHENOTYPE Transcription_br_cell cycle progression Long Name: Cas-Br-M (murine) ecotropic retroviral transforming oncogene Synonym: Synonym not specified Accession: P00544 inside PROTEIN p33 Long Name: GRB2-associated binding protein Synonym: growth factor receptor bound protein 2-associated binding protein Accession: P00563 inside PROTEIN p34 Long Name: EGFR Synonym: Gurken receptor, Erb, Neu, neuregulin Accession: P00542 transmembrane PROTEIN p2 Long Name: sprouty Synonym: antagonist of FGF signaling Accession: P00541 inside PROTEIN p35 Long Name: a87_degraded Synonym: Synonym not specified Accession: U02226 inside DEGRADED a87_degraded Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05183 Heterodimer Member Info: EGFR#PROTEIN#EGFR#P00542#Gurken receptor, Erb, Neu, neuregulin#;Grb2#PROTEIN#Grb2#P00550#sem-5#;SOS#PROTEIN#SOS#P00558## transmembrane COMPLEX Complex_br_(EGFR/Grb2/_br_SOS) Long Name: Grb2 Synonym: sem-5 Accession: P00550 inside PROTEIN p5 Long Name: SOS Synonym: Synonym not specified Accession: P00558 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05182 Heterodimer Member Info: EGFR#PROTEIN#EGFR#P00542#Gurken receptor, Erb, Neu, neuregulin#;GAP#PROTEIN#GAP#P00546##;Grb2#PROTEIN#Grb2#P00550#sem-5#;SHC#PROTEIN#Src homology 2 domain-containing transforming protein 1#P00554#pp46/52/66#;PLCgamma#PROTEIN#phospholipase c gamma#P00556#1-phosphatidylinositol-4|5-bisphosphate phosphodiesterase gamma|phosphoinositide phospholipase C#;PI3K#PROTEIN#phosphatidylinositol 3-kinase#P00557#5-bisphosphate 3-kinase|Phosphatidylinositol-4#;SOS#PROTEIN#SOS#P00558##;STAT#PROTEIN#signal transducer and activator of transcription#P00561#Acute-phase response factor|Mammary gland factor#;Gab#PROTEIN#GRB2-associated binding protein#P00563#growth factor receptor bound protein 2-associated binding protein# transmembrane COMPLEX Complex_br_(EGFR/PLC_sub__gamma/_br_STAT/PI3K/_br_SHC/Gab/_br_Grb2/SOS/_br_GAP) Long Name: EGFR Synonym: Gurken receptor, Erb, Neu, neuregulin Accession: P00542 transmembrane PROTEIN p2 Long Name: Ras Synonym: Synonym not specified Accession: P00552 inside PROTEIN p12 Long Name: GDP Synonym: Synonym not specified Accession: S01652 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S01653 inside SIMPLE_MOLECULE GTP Long Name: PKC Synonym: Synonym not specified Accession: P00565 inside PROTEIN p14 Long Name: Rac Synonym: Synonym not specified Accession: P00564 inside PROTEIN p24 Long Name: EGFR Synonym: Gurken receptor, Erb, Neu, neuregulin Accession: P00542 transmembrane PROTEIN p2 2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05184 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P00550#sem-5#;SOS#PROTEIN#SOS#P00558## inside COMPLEX Complex_br_(Grb2/SOS) Long Name: SPRY Synonym: antagonist of FGF signaling Accession: G01511 inside GENE gn1 inside RNA rn1 STATE_TRANSITION 0.24718132237025303,3.976246659833649E-4 0.6420518063915006,1.1360704742280348E-4 a15 a17 a16 a18 a160 STATE_TRANSITION 0.33333333333333304,-5.551115123125783E-17 0.6666666666666665,-1.1102230246251565E-16 a22 a23 a160 STATE_TRANSITION 0.3333333333333335,0.0 0.666666666666667,2.220446049250313E-16 a24 a25 a160 STATE_TRANSITION 0.33333333333333304,0.0 0.666666666666667,-4.440892098500626E-16 a26 a27 a25 a32 a16 a35 a34 STATE_TRANSITION 0.3333333333333328,1.3322676295501878E-15 0.6666666666666667,2.6645352591003757E-15 a28 a29 a27 STATE_TRANSITION 0.33333333333333326,-2.220446049250313E-15 0.6666666666666663,-4.884981308350689E-15 a32 a33 a23 STATE_TRANSITION 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,0.0 a30 a31 a29 STATE_TRANSITION 0.3333333333333339,1.7763568394002505E-15 0.6666666666666667,3.1086244689504383E-15 a4 a46 a3 STATE_TRANSITION 0.33333333333333304,1.2212453270876722E-15 0.666666666666667,1.9984014443252818E-15 a47 a48 a49 STATE_TRANSITION 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666661,-8.881784197001252E-16 a54 a58 a57 a59 a112 STATE_TRANSITION 0.3333333333333339,1.3322676295501878E-15 0.666666666666667,8.881784197001252E-16 a39 a60 a57 KNOWN_TRANSITION_OMITTED 0.33333333333333304,3.1086244689504383E-15 0.666666666666667,4.884981308350689E-15 a40 a61 a60 STATE_TRANSITION 0.3333333333333348,-4.440892098500626E-16 0.6666666666666661,-3.9968028886505635E-15 a41 a62 a61 STATE_TRANSITION 0.33333333333333304,-1.7763568394002505E-15 0.666666666666667,-3.552713678800501E-15 a42 a63 a62 STATE_TRANSITION 0.27744133719061015,6.943105110863712E-4 0.7225586628093872,-6.943105110917003E-4 a64 a65 a61 STATE_TRANSITION 0.3333333333333304,-8.881784197001252E-16 0.6666666666666652,-8.881784197001252E-16 a66 a67 a65 STATE_TRANSITION 0.33333333333333326,-1.2212453270876722E-15 0.6666666666666666,-2.4424906541753444E-15 a4 a87 a84 a101 HETERODIMER_ASSOCIATION 0.33333333333333215,1.7763568394002505E-15 0.6666666666666643,0.0 0.33333333333333215,3.552713678800501E-15 0.6666666666666679,3.552713678800501E-15 0.3333333333333339,0.0 0.6666666666666679,0.0 0.33333333333333215,0.33333333333333215 a50 a51 a106 HETERODIMER_ASSOCIATION 0.5502105986863928,-0.0022233693042599256 0.5516194002545465,-0.05282654037265777 0.3333333333333339,0.3333333333333304 a48 a106 a112 STATE_TRANSITION 0.3333333333333332,0.0 0.6666666666666667,0.0 a87 a113 HETERODIMER_ASSOCIATION 0.5087314446126792,0.02849770809740304 0.40751504471243205,-0.03711797646380832 0.7733141289770132,-0.015316372178429738 0.6598710304825941,0.007162177920080948 0.056797257062941975,0.33294397608268533 a46 a6 a9 a76 a75 a73 a85 a116 a160 TRANSCRIPTION a161 sa73 a46 TRANSLATION sa73 a101 PHYSICAL_STIMULATION 0.5769889345884456,-0.051394792545044865 a160 a83 PHYSICAL_STIMULATION a67 a68 PHYSICAL_STIMULATION a63 a68 PHYSICAL_STIMULATION a31 a36