The FGF family of ligands consists of at least 22 members, while there are four identified FGF receptors. The activity of Individual FGFs may also differ depending on their ability to bind heparan sulfateproteoglycans. The result is the activation of many downstream pathways and many cellular outcomes, including mitogenesis, differentiation, survival, apoptosis, and cell migration. Certain FGFs are also pro-angiogenic. Mutations in three of the four receptors result in more than a dozen human congenital disease. Medline=1319744 Medline=14745970 Medline=9620845 4.0 s65 PROTEIN p2 2 s65 PROTEIN p5 s65 PROTEIN p11 s66 PROTEIN p5 s66 PROTEIN p11 s74 PROTEIN p2 2 s74 PROTEIN p4 s74 PROTEIN p13 s74 PROTEIN p7 s74 PROTEIN p10 s74 PROTEIN p9 s74 PROTEIN p6 s74 PROTEIN p5 s74 PROTEIN p11 s75 PROTEIN p11 s75 PROTEIN p5 SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive active inactive active inactive active inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive active inactive inactive active active active active inactive active inactive active inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active active active active Cytoplasm Long Name: fibroblast growth factor Synonym: Synonym not specified Accession: P00623 inside PROTEIN p3 Long Name: phospholipase c gamma Synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma,phosphoinositide phospholipase C Accession: P00638 inside PROTEIN p4 Long Name: Src homology 2 domain-containing transforming protein 1 Synonym: pp46/52/66 Accession: P00639 inside PROTEIN p6 Long Name: phosphatidylinositol 3-kinase Synonym: 5-bisphosphate 3-kinase,Phosphatidylinositol-4 Accession: P00640 inside PROTEIN p7 Long Name: Src homology 2 domain-containing tyrosine phosphatase 2 Synonym: non-receptor type 11,protein tyrosine phosphatase,protein-tyrosine phosphatase 2C Accession: P00647 inside PROTEIN p9 Long Name: fibroblast growth factor receptor substrate Synonym: suc1-associated neurotrophic factor target Accession: P00635 inside PROTEIN p10 Long Name: sprouty Synonym: antagonist of FGF signaling Accession: P00626 inside PROTEIN p8 Long Name: sprouty Synonym: antagonist of FGF signaling Accession: P00626 inside PROTEIN p8 Long Name: p120 Ras GTPase-activating protein Synonym: Synonym not specified Accession: P00646 inside PROTEIN p13 Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00632 inside PROTEIN p15 Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00632 inside PROTEIN p15 Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase,MAP kinase kinase Accession: P00642 inside PROTEIN p17 Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase,MAP kinase kinase Accession: P00642 inside PROTEIN p17 Long Name: Extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,pp42/44 Accession: P00627 inside PROTEIN p18 Long Name: Extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,pp42/44 Accession: P00627 inside PROTEIN p18 Long Name: Raf-1 kinase inhibitor protein Synonym: PEBP,Phosphatidylethanolamine-binding protein Accession: P00630 inside PROTEIN p19 Long Name: Raf-1 kinase inhibitor protein Synonym: PEBP,Phosphatidylethanolamine-binding protein Accession: P00630 inside PROTEIN p19 Long Name: protein phosphatase 2A Synonym: Serine/threonine protein phosphatase 2A Accession: P00629 inside PROTEIN p20 Long Name: 14-3-3 Synonym: activator of tyrosine and tryptophan hydroxylases,protein kinase C inhibitor protein-1 (KCIP-1) Accession: P00624 inside PROTEIN p21 Long Name: Mitogenesis Differentiation Synonym: Synonym not specified Accession: U02253 inside PHENOTYPE Mitogenesis_br_Differentiation Long Name: Mitogen-activated protein kinase kinase kinase Synonym: MAPK/ERK kinase kinase,MEK kinase Accession: P00634 inside PROTEIN p25 Long Name: Dual specificity mitogen-activated protein kinase kinase 4 and 7 Synonym: MAP kinase kinase 4 and 7,MAPK/ERK kinase 4 and 7,MAPKK 4 and 7 Accession: P00637 inside PROTEIN p26 Long Name: Dual specificity mitogen-activated protein kinase kinase 4 and 7 Synonym: MAP kinase kinase 4 and 7,MAPK/ERK kinase 4 and 7,MAPKK 4 and 7 Accession: P00637 inside PROTEIN p26 Long Name: Mitogen-activated protein kinase kinase kinase Synonym: MAPK/ERK kinase kinase,MEK kinase Accession: P00634 inside PROTEIN p25 Long Name: C-jun-amino-terminal kinase 1, 2, and 3 Synonym: SAPK,stress-activated protein kinase Accession: P00628 inside PROTEIN p27 Long Name: C-jun-amino-terminal kinase 1, 2, and 3 Synonym: SAPK,stress-activated protein kinase Accession: P00628 inside PROTEIN p27 Long Name: Dual specificity mitogen-activated protein kinase kinase 3 and 6 Synonym: MAP kinase kinase 3 and 6,MAPK/ERK kinase 3 and 6,MAPKK 3 and 6 Accession: P00625 inside PROTEIN p28 Long Name: Dual specificity mitogen-activated protein kinase kinase 3 and 6 Synonym: MAP kinase kinase 3 and 6,MAPK/ERK kinase 3 and 6,MAPKK 3 and 6 Accession: P00625 inside PROTEIN p28 Long Name: p38 MAP kinase Synonym: mitogen-activated protein kinase 11,mitogen-activated protein kinase 14 isoform 4 Accession: P00644 inside PROTEIN p29 Long Name: p38 MAP kinase Synonym: mitogen-activated protein kinase 11,mitogen-activated protein kinase 14 isoform 4 Accession: P00644 inside PROTEIN p29 Long Name: Survival Apoptosis cell migration Synonym: Synonym not specified Accession: U02252 inside PHENOTYPE Survival_br_Apoptosis_br_cell_space_migration Long Name: RAF proto-oncogene serine/threonine-protein kinase Synonym: C-Raf,MAP kinase kinase kinase,Raf-1 Accession: P00643 inside PROTEIN p16 Long Name: RAF proto-oncogene serine/threonine-protein kinase Synonym: C-Raf,MAP kinase kinase kinase,Raf-1 Accession: P00643 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05203 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P00631#sem-5#;FGFR1-4#PROTEIN#FGFR1-4#P00636##;SOS#PROTEIN#SOS#P00641## transmembrane COMPLEX Complex_br_(FGFR1_minus_4/Grb2/_br_SOS) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05202 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P00631#sem-5#;SOS#PROTEIN#SOS#P00641## inside COMPLEX Complex_br_(Grb2/SOS) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05205 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P00631#sem-5#;FRS2#PROTEIN#fibroblast growth factor receptor substrate#P00635#suc1-associated neurotrophic factor target#;FGFR1-4#PROTEIN#FGFR1-4#P00636##;PLCgamma#PROTEIN#phospholipase c gamma#P00638#1-phosphatidylinositol-4|5-bisphosphate phosphodiesterase gamma|phosphoinositide phospholipase C#;SHC#PROTEIN#Src homology 2 domain-containing transforming protein 1#P00639#pp46/52/66#;PI3K#PROTEIN#phosphatidylinositol 3-kinase#P00640#5-bisphosphate 3-kinase|Phosphatidylinositol-4#;SOS#PROTEIN#SOS#P00641##;RasGAP#PROTEIN#p120 Ras GTPase-activating protein#P00646##;SHP2#PROTEIN#Src homology 2 domain-containing tyrosine phosphatase 2#P00647#non-receptor type 11|protein tyrosine phosphatase|protein-tyrosine phosphatase 2C# transmembrane COMPLEX Complex_br_(FGFR1_minus_4/PLC_sub__gamma/_br_RasGAP/PI3K/_br_FRS2/SHP2/_br_SHC/Grb2/_br_SOS) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05204 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P00631#sem-5#;SOS#PROTEIN#SOS#P00641## inside COMPLEX Complex_br_(SOS/Grb2) Long Name: FGFR1-4 Synonym: Synonym not specified Accession: P00636 transmembrane PROTEIN p2 Long Name: phospholipase c gamma Synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma,phosphoinositide phospholipase C Accession: P00638 transmembrane PROTEIN p4 Long Name: Grb2 Synonym: sem-5 Accession: P00631 inside PROTEIN p5 Long Name: Ras Synonym: Synonym not specified Accession: P00633 inside PROTEIN p12 Long Name: GDP Synonym: Synonym not specified Accession: S01666 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S01667 inside SIMPLE_MOLECULE GTP Long Name: PKC Synonym: Synonym not specified Accession: P00648 inside PROTEIN p14 Long Name: Rac Synonym: Synonym not specified Accession: P00645 inside PROTEIN p24 Long Name: FGFR1-4 Synonym: Synonym not specified Accession: P00636 transmembrane PROTEIN p2 2 Long Name: SOS Synonym: Synonym not specified Accession: P00641 inside PROTEIN p11 STATE_TRANSITION 0.3333333333333335,8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 a10 a13 a95 STATE_TRANSITION 0.3333333333333327,-1.7763568394002505E-15 0.6666666666666662,0.0 a15 a17 a16 a18 a95 STATE_TRANSITION 0.33333333333333304,-5.551115123125783E-17 0.6666666666666665,-1.1102230246251565E-16 a22 a23 a95 STATE_TRANSITION 0.3333333333333335,0.0 0.666666666666667,2.220446049250313E-16 a24 a25 a95 STATE_TRANSITION 0.3333333333333337,0.0 0.6666666666666667,-4.440892098500626E-16 a26 a27 a25 a32 a16 a35 a34 STATE_TRANSITION 0.3333333333333328,1.3322676295501878E-15 0.6666666666666667,2.6645352591003757E-15 a28 a29 a27 STATE_TRANSITION 0.33333333333333326,-2.220446049250313E-15 0.6666666666666663,-4.884981308350689E-15 a32 a33 a23 STATE_TRANSITION 0.3333333333333339,-8.881784197001252E-16 0.666666666666667,0.0 a30 a31 a29 STATE_TRANSITION 0.3333333333333335,1.2212453270876722E-15 0.6666666666666669,2.220446049250313E-15 a4 a46 a3 STATE_TRANSITION 0.33333333333333304,1.5543122344752192E-15 0.6666666666666687,2.4424906541753444E-15 a47 a48 a49 STATE_TRANSITION 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666661,-8.881784197001252E-16 a54 a58 a57 a59 a77 STATE_TRANSITION 0.3333333333333339,8.881784197001252E-16 0.6666666666666687,8.881784197001252E-16 a39 a60 a57 STATE_TRANSITION 0.3333333333333339,-3.552713678800501E-15 0.6666666666666661,-5.329070518200751E-15 a41 a62 a61 STATE_TRANSITION 0.33333333333333304,-1.7763568394002505E-15 0.666666666666667,-3.552713678800501E-15 a42 a63 a62 STATE_TRANSITION 0.2957001475468184,-9.447661703703147E-4 0.7042998524531887,9.447661703774202E-4 a64 a65 a61 STATE_TRANSITION 0.6985490861126671,0.001017524024870653 a66 a67 a65 STATE_TRANSITION 0.3333333333333335,-3.9968028886505635E-15 0.6666666666666665,-7.993605777301127E-15 a40 a61 a60 HETERODIMER_ASSOCIATION 0.5743072559804503,-0.031098097058027463 0.5422808097894567,6.448166947388145E-4 0.44436258580412513,-0.010344737169696305 0.8887251716082627,-0.020689474339393943 0.3333333333333348,0.3333333333333348 a50 a51 a78 HETERODIMER_ASSOCIATION 0.5009226897918193,-0.04366226903236381 0.5894757872592606,0.058751123623096646 0.3851857198663442,-0.019691590856051766 0.6503972505837226,0.0013413763464085182 0.33333333333333215,0.33333333333333304 a48 a78 a77 HETERODIMER_ASSOCIATION 0.4839770648874495,0.04565881917399928 0.7242159573727327,0.017442694965348338 0.4363542808262668,0.026070963013946624 0.7301887972856225,0.03499567610525034 0.6553451408569833,0.007766094189396 0.7053760318523901,0.012482535592820199 0.33333333333333215,0.3333333333333337 a7 a72 a98 a13 HETERODIMER_ASSOCIATION 0.18558584380482213,0.027398400463601424 0.5359595466821796,0.013830288156481574 0.6886875902281879,-0.12801440981452927 0.07017756640585393,0.30065051218333877 a46 a98 a102 a9 a8 a12 a11 a19 a95 PHYSICAL_STIMULATION a63 a68 PHYSICAL_STIMULATION a67 a68 PHYSICAL_STIMULATION a31 a36