General Transcription Factors for RNA Polymerase II. This pathway focus on the synthesis of messenger RNA in eukaryotic cells in the nucleus. Medline=10364255 Medline=14963331 Medline=1876184 Medline=1956398 OMIM=189972 4.0 Long Name: TATA box Promoter gene Synonym: Synonym not specified Accession: G01521 s105 GENE gn2 Long Name: elongating mRNA Synonym: Synonym not specified Accession: G01525 s105 RNA rn1 Long Name: RNA Synonym: Synonym not specified Accession: G01522 s110 RNA rn2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05216 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s102 COMPLEX Complex_br_(TBP-associated factors/TBP) s41 PROTEIN p22 s41 PROTEIN p22 s43 PROTEIN p21 s43 PROTEIN p21 s44 PROTEIN p4 s44 PROTEIN p3 s55 PROTEIN p3 s55 PROTEIN p4 s55 GENE gn1 s55 PROTEIN p19 s59 PROTEIN p3 s59 PROTEIN p4 s59 GENE gn1 s59 PROTEIN p7 s59 PROTEIN p19 s60 PROTEIN p12 s60 PROTEIN p8 s77 GENE gn1 s77 PROTEIN p4 s77 PROTEIN p3 s77 PROTEIN p19 s77 PROTEIN p13 s77 PROTEIN p7 s77 PROTEIN p8 s77 PROTEIN p12 s77 PROTEIN p20 s91 GENE gn1 s91 PROTEIN p8 s91 PROTEIN p12 s91 PROTEIN p4 s91 PROTEIN p3 s91 PROTEIN p13 s91 PROTEIN p19 s91 PROTEIN p7 s100 PROTEIN p3 s100 PROTEIN p4 Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P00660 s102 PROTEIN p8 Long Name: TATA box Promoter gene Synonym: Synonym not specified Accession: G01521 s102 GENE gn2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05208 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s105 COMPLEX Complex_br_(TBP/TBP-associated factors) s107 PROTEIN p3 Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P00660 s105 PROTEIN p8 s105 PROTEIN p4 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05208 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s110 COMPLEX Complex_br_(TBP/TBP-associated factors) s111 PROTEIN p3 s111 PROTEIN p4 Long Name: TATA box Promoter gene termination Synonym: Synonym not specified Accession: G01520 s110 GENE gn3 Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P00660 s110 PROTEIN p8 Long Name: TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II Synonym: HuF2,TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II,human factor 2 lodestar protein Accession: P00661 s110 PROTEIN p23 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive Long Name: TATA box Promoter Synonym: Synonym not specified Accession: G01524 inside GENE gn1 Long Name: TBP Synonym: GTF2D,GTF2D1,SCA17,TATA box binding protein,TFIID,spinocerebellar ataxia 17 Accession: P00670 inside PROTEIN p4 Long Name: TFIIF Synonym: TF2F,TRANSCRIPTION FACTOR IIF Accession: P00665 inside PROTEIN p12 Long Name: ATP Synonym: Synonym not specified Accession: S01668 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01672 inside SIMPLE_MOLECULE ADP Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P00660 inside PROTEIN p8 Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P00660 inside PROTEIN p8 Long Name: CTP Synonym: Synonym not specified Accession: S01670 inside SIMPLE_MOLECULE CTP Long Name: GTP Synonym: Synonym not specified Accession: S01671 inside SIMPLE_MOLECULE GTP Long Name: UTP Synonym: Synonym not specified Accession: S01669 inside SIMPLE_MOLECULE UTP Long Name: TBP-associated factors Synonym: TATA box binding protein-associated factors Accession: P00658 inside PROTEIN p3 Long Name: General Transcription factor IIF, polypeptide 1, 74-KD Synonym: BTF4,GTF2F1,RAP74,TFIIF ALPHA,TRANSCRIPTION FACTOR IIF Accession: P00663 inside PROTEIN p16 Long Name: TFIIFbeta Synonym: BETA SUBUNIT,RAP30,TF2F2,TFIIF BETA,TRANSCRIPTION FACTOR IIF Accession: P00667 inside PROTEIN p18 Long Name: TFIIB Synonym: GTF2B,RNA polymerase II transcription factor IIB,TF2B,Transcription factor II B,general transcription factor IIB Accession: P00668 inside PROTEIN p7 Long Name: TFIIE Synonym: TF2E,TRANSCRIPTION FACTOR IIE Accession: P00666 inside PROTEIN p20 Long Name: Long Name: TFIIEbeta Synonym: Synonym not specified Accession: U05214 Heterodimer Member Info: TFIIEbeta#PROTEIN#TFIIEbeta#P00659#GENERAL TRANSCRIPTION FACTOR IIE|GTF2E2|POLYPEPTIDE 2|TF2E2|TFIIE BETA SUBUNIT|TRANSCRIPTION FACTOR IIE BETA SUBUNIT# inside COMPLEX Complex_br_(TFIIE_beta/TFIIE_beta) Long Name: Long Name: TFIIEalpha Synonym: Synonym not specified Accession: U05210 Heterodimer Member Info: TFIIEalpha#PROTEIN#TFIIEalpha#P00669#ALPHA SUBUNIT|GENERAL TRANSCRIPTION FACTOR IIE|GTF2E1|POLYPEPTIDE 1|TF2E1|TFIIE|TRANSCRIPTION FACTOR IIE ALPHA SUBUNIT# inside COMPLEX Complex_br_(TFIIE_alpha_/TFIIE_alpha_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05208 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# inside COMPLEX Complex_br_(TBP/TBP-associated factors) Long Name: TATA box Promoter gene termination Synonym: Synonym not specified Accession: G01520 inside GENE gn3 Long Name: mRNA Synonym: Synonym not specified Accession: G01523 inside RNA rn3 Long Name: TFIIH Synonym: GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1,GTF2H 62-KD SUBUNIT,GTF2H1,TFIIH 62-KD SUBUNIT,TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT Accession: P00664 inside PROTEIN p13 Long Name: TFIIA Synonym: ALF,GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT,GTF2A1-like factor,MGC26254,TFIIA large subunit isoform ALF,TFIIA-alpha/beta-like factor,Transcription factor II A Accession: P00662 inside PROTEIN p19 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05211 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TFIIA complex#PROTEIN#TFIIA#P00662#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor|Transcription factor II A#;TATA box Promoter#GENE#TATA box Promoter#G01524##;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# inside COMPLEX Complex_br_(TBP-associated factors/TBP/_br_TATA box Promoter/TFIIA complex) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05209 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;TFIIA complex#PROTEIN#TFIIA#P00662#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor|Transcription factor II A#;TFIIB#PROTEIN#TFIIB#P00668#GTF2B|RNA polymerase II transcription factor IIB|TF2B|Transcription factor II B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01524##;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# inside COMPLEX Complex_br_(TBP-associated factors/TBP/_br_TATA box Promoter/TFIIB/_br_TFIIA complex) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05215 Heterodimer Member Info: RNA Polymerase II#PROTEIN#RNA Polymerase II#P00660##;TFIIF#PROTEIN#TFIIF#P00665#TF2F|TRANSCRIPTION FACTOR IIF# inside COMPLEX Complex_br_(TFIIF/RNA Polymerase II) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05213 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;RNA Polymerase II#PROTEIN#RNA Polymerase II#P00660##;TFIIA complex#PROTEIN#TFIIA#P00662#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor|Transcription factor II A#;TFIIH complex#PROTEIN#TFIIH#P00664#GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1|GTF2H 62-KD SUBUNIT|GTF2H1|TFIIH 62-KD SUBUNIT|TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT#;TFIIF#PROTEIN#TFIIF#P00665#TF2F|TRANSCRIPTION FACTOR IIF#;TFIIE#PROTEIN#TFIIE#P00666#TF2E|TRANSCRIPTION FACTOR IIE#;TFIIB#PROTEIN#TFIIB#P00668#GTF2B|RNA polymerase II transcription factor IIB|TF2B|Transcription factor II B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01524##;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# inside COMPLEX Complex_br_(TATA box Promoter/TBP/_br_TBP-associated factors/TFIIA complex/_br_TFIIH complex/TFIIB/_br_RNA Polymerase II/TFIIF/_br_TFIIE) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05212 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P00658#TATA box binding protein-associated factors#;RNA Polymerase II#PROTEIN#RNA Polymerase II#P00660##;TFIIA complex#PROTEIN#TFIIA#P00662#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNIT|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor|Transcription factor II A#;TFIIH complex#PROTEIN#TFIIH#P00664#GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1|GTF2H 62-KD SUBUNIT|GTF2H1|TFIIH 62-KD SUBUNIT|TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT#;TFIIF#PROTEIN#TFIIF#P00665#TF2F|TRANSCRIPTION FACTOR IIF#;TFIIB#PROTEIN#TFIIB#P00668#GTF2B|RNA polymerase II transcription factor IIB|TF2B|Transcription factor II B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01524##;TBP#PROTEIN#TBP#P00670#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# inside COMPLEX Complex_br_(TATA box Promoter/RNA Polymerase II/_br_TFIIF/TBP/_br_TBP-associated factors/TFIIH complex/_br_TFIIA complex/TFIIB) Long Name: TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II Synonym: HuF2,TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II,human factor 2 lodestar protein Accession: P00661 inside PROTEIN p23 inside COMPLEX transcription complex inside COMPLEX transcription elongation complex inside COMPLEX transcription new RNA complex HETERODIMER_ASSOCIATION 0.46909113132074154,0.02611724741507926 0.643040070660696,-0.0030164555954930172 0.678643844013763,0.0816239920780788 0.8310463526194098,0.09661904088272877 0.3333333333333304,1.7763568394002505E-15 0.6666666666666643,0.0 0.3333333333333326,0.3333333333333339 a84 a86 a42 HETERODIMER_ASSOCIATION 0.5870185836228607,0.0020416364385988928 0.8218923532236957,-0.021847099598816477 0.5822380227597286,-0.026558119576254313 0.9065782662887685,-0.021884383584302114 0.5303462288561676,-0.008096034707241406 0.33333333333333304,0.3333333333333339 a18 a19 a106 HETERODIMER_ASSOCIATION 0.13286566864268168,-0.024704362349124764 0.2657313372853627,-0.049408724698251305 0.6103482307481105,-0.05539389133609607 0.7493920759385411,-0.056276155112577 0.480231779749551,0.018193916046841174 0.3866346140138157,0.42328985367060645 a113 a114 a112 HETERODIMER_ASSOCIATION 0.3380200019203836,0.014688281204285822 0.6760400038407681,0.029376562408571824 0.4627772075210843,-0.038364481953561125 0.6279130518818898,-0.05446354531396169 0.5410359996712806,-0.00558899667985191 0.8513147672139698,-0.008770337314226495 0.3333333333333336,0.3333333333333335 a17 a106 a87 a141 STATE_TRANSITION 0.3333333333333339,-1.7763568394002505E-15 0.666666666666667,0.0 a141 a24 a147 HETERODIMER_ASSOCIATION 0.33333333333333437,0.0 0.6666666666666674,0.0 0.3333333333333339,-8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16 0.5982019906697538,0.03496707116742215 0.7206427225805943,0.017391114233785032 0.3333333333333366,0.3333333333333335 a29 a42 a148 HETERODIMER_ASSOCIATION 0.6927487575766342,0.004598247546542922 0.33333333333333326,6.661338147750939E-16 0.6666666666666665,6.661338147750939E-16 0.7478406629585983,0.002009268247285867 -0.002396850720814969,0.4570257656167567 a147 a148 a112 a44 a176 STATE_TRANSITION 0.33333333333333215,0.0 0.6666666666666661,4.440892098500626E-16 a176 a66 a200 a67 a223 STATE_TRANSITION 0.3406271625468209,-0.027856672578847164 0.6845423274486722,-0.044109485414358884 a200 csa13 a220 a221 a219 STATE_TRANSITION 0.3537207096106365,-0.011448931230454207 0.7150166955754775,0.013173527423901987 csa13 a81 a80 a79 a78 csa14 STATE_TRANSITION 0.29760344495492674,0.022946176398329854 0.5525266164684286,0.01758388903619057 csa14 a226 csa15 STATE_TRANSITION csa15 a131 a133 a130 a132 sa77