This pathway illustrates the intracellular signaling responses to hypoxia. Medline=13130303 Medline=14526383 Medline=14988927 4.0 s53 PROTEIN p1 s53 ION OH s59 PROTEIN p2 s59 PROTEIN p1 s59 PROTEIN p3 s45 ION OH s45 PROTEIN p1 SQUARE SQUARE_CLOSEUP_NORTH inactive active inactive inactive inactive active inactive active inactive inactive inactive inactive inactive active active inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Nucleus cytosol Long Name: p300 Synonym: CREB binding protein (CBP),EIA binding protein p300 Accession: P00814 inside PROTEIN p3 Long Name: hypoxia inducible factor-1-beta Synonym: TANGO,aryl hydrocarbon receptor nuclear translocator (ARNT),dioxin receptor nuclear translocator Accession: P00820 inside PROTEIN p2 Long Name: Inhibitory PAS Synonym: Synonym not specified Accession: P00815 inside PROTEIN p4 Long Name: Hypoxia Synonym: Synonym not specified Accession: U02367 inside UNKNOWN Hypoxia Long Name: thioredoxin Synonym: Synonym not specified Accession: P00825 inside PROTEIN p7 Long Name: thioredoxin Synonym: Synonym not specified Accession: P00825 inside PROTEIN p7 Long Name: redox factor 1 Synonym: AP Endonulcease, APE,APEX Accession: P00822 inside PROTEIN p8 Long Name: phosphoinositide-3-kinase Synonym: PI3K,PIK3 Accession: P00823 innerSurface PROTEIN p9 Long Name: Von Hippel Lindau protein Synonym: elongin binding protein Accession: P00816 inside PROTEIN p6 Long Name: phosphatidylinositol 2-phosphate Synonym: Synonym not specified Accession: S01721 inside SIMPLE_MOLECULE PIP2 Long Name: phosphatidylinositol 3-phosphate Synonym: Synonym not specified Accession: S01720 inside SIMPLE_MOLECULE PIP3 Long Name: phospatase and tensin homologue Synonym: BZS,MHAM,MMAC1,TEP1 Accession: P00824 inside PROTEIN p10 Long Name: v-akt murine thymoma viral oncogene homolog 1 Synonym: PRKBA,RAC-alpha serine/threonine-protein kinase (RAC-PK-alpha) ,Thymoma viral proto-oncogene,protein kinase B (PKB) Accession: P00819 inside PROTEIN p11 Long Name: mammalian target of rapamycin Synonym: FRAP1, FK506 binding protein 12-rapamycin associated protein 1,FRAP2,RAFT1,RAPT2 Accession: P00817 inside PROTEIN p12 Long Name: mammalian target of rapamycin Synonym: FRAP1, FK506 binding protein 12-rapamycin associated protein 1,FRAP2,RAFT1,RAPT2 Accession: P00817 inside PROTEIN p12 Long Name: Adenosine triphosphate Synonym: Synonym not specified Accession: S01717 inside SIMPLE_MOLECULE ATP Long Name: Adenosine diphosphate Synonym: Synonym not specified Accession: S01719 inside SIMPLE_MOLECULE ADP Long Name: ubiquitin Synonym: Synonym not specified Accession: S01718 inside SIMPLE_MOLECULE Ub Long Name: OH Synonym: Synonym not specified Accession: U02366 inside ION OH Long Name: Hypoxia inducible factor-1 alpha subunit Synonym: MOP1 Accession: P00818 inside PROTEIN p1 Long Name: Hypoxia inducible factor-1 alpha subunit Synonym: MOP1 Accession: P00818 inside PROTEIN p1 Long Name: Metabolism Genes Increased Glycolysis Synonym: Synonym not specified Accession: U02368 inside PHENOTYPE Metabolism Genes_br_Increased Glycolysis Long Name: Increased Angiogenesis Synonym: Synonym not specified Accession: U02365 inside PHENOTYPE Increased_br_Angiogenesis Long Name: Pro-apoptotic genes Synonym: Synonym not specified Accession: U02364 inside PHENOTYPE Pro-apoptotic_br_genes Long Name: HIF-1 alpha prolyl hydroxylase 2 Synonym: EGL nine homolog,HPH-2,PHD2 Accession: P00821 inside PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05302 Heterodimer Member Info: HIF-1alpha#PROTEIN#Hypoxia inducible factor-1 alpha subunit#P00818#MOP1#;OH#ION#OH#U02366## inside COMPLEX Complex_br_(HIF-1_alpha/OH) Long Name: a64_degraded Synonym: Synonym not specified Accession: U02369 inside DEGRADED a64_degraded Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05301 Heterodimer Member Info: P300#PROTEIN#p300#P00814#CREB binding protein (CBP)|EIA binding protein p300#;HIF-1alpha#PROTEIN#Hypoxia inducible factor-1 alpha subunit#P00818#MOP1#;HIF-1beta#PROTEIN#hypoxia inducible factor-1-beta#P00820#TANGO|aryl hydrocarbon receptor nuclear translocator (ARNT)|dioxin receptor nuclear translocator# inside COMPLEX Complex_br_(HIF-1_beta/HIF-1_alpha/_br_P300) Long Name: HRE gene/low transcription Synonym: Synonym not specified Accession: G01536 inside GENE gn1 inside RNA rn1 Long Name: HRE gene/high transcription Synonym: Synonym not specified Accession: G01537 inside RNA rn2 inside GENE gn3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05303 Heterodimer Member Info: HIF-1alpha#PROTEIN#Hypoxia inducible factor-1 alpha subunit#P00818#MOP1#;OH#ION#OH#U02366## inside COMPLEX Complex_br_(OH/HIF-1_alpha) STATE_TRANSITION a36 a46 a37 a47 a35 a38 STATE_TRANSITION a40 a44 a41 a45 a39 STATE_TRANSITION a42 a11 a41 STATE_TRANSITION a43 a39 a37 UNKNOWN_TRANSITION a50 a35 a21 STATE_TRANSITION a42 a51 a53 a19 TRANSPORT a32 a33 STATE_TRANSITION a53 a48 a24 a64 a29 STATE_TRANSITION a64 a65 HETERODIMER_ASSOCIATION 0.4135482686550298,0.3519773050200079 a10 a11 a6 a70 a17 STATE_TRANSITION sa41 a19 a21 STATE_TRANSITION sa42 a34 a33 TRANSCRIPTION a72 sa43 a70 TRANSCRIPTION sa44 a73 a70 sa43 PHYSICAL_STIMULATION a73 a60 PHYSICAL_STIMULATION a73 a59 PHYSICAL_STIMULATION a73 a58