Upon binding to a family of G-protein coupled seven-transmembrane receptors, chemokines (chemotactic cytokines) control and direct trafficking and migration of immune cells. This pathway illustrates chemokine-induced adhesion and migration of leukocytes resuling in the infiltration to the tissue and transcriptional activation enablingrecruitment of more leukocytes. Thus inhibiting specific chemokines and receptors could prevent the excessive recruitment of leukocytes to sites of inflammation. Medline=11905818 Medline=12049209 4.0 s13 PROTEIN p1 s13 PROTEIN p3 s13 SIMPLE_MOLECULE GDP s13 PROTEIN p5 s19 PROTEIN p1 s19 PROTEIN p2 s19 PROTEIN p3 s19 SIMPLE_MOLECULE GDP s19 PROTEIN p5 s33 PROTEIN p7 s33 SIMPLE_MOLECULE GTP s34 PROTEIN p6 s34 SIMPLE_MOLECULE GTP s35 PROTEIN p3 s35 SIMPLE_MOLECULE GTP s80 PROTEIN p32 s80 PROTEIN p33 s151 PROTEIN p49 s151 PROTEIN p51 s151 PROTEIN p50 s109 PROTEIN p41 2 s109 PROTEIN p42 s112 PROTEIN p41 2 s112 PROTEIN p43 s112 PROTEIN p43 s112 PROTEIN p42 s118 PROTEIN p41 2 s118 PROTEIN p43 s118 PROTEIN p43 s118 PROTEIN p44 s118 PROTEIN p42 s192 PROTEIN p41 s192 PROTEIN p43 s192 PROTEIN p43 s192 PROTEIN p48 s193 PROTEIN p41 s193 PROTEIN p48 s196 PROTEIN p41 s196 PROTEIN p48 s196 PROTEIN p44 s196 PROTEIN p43 s196 PROTEIN p43 s203 PROTEIN p39 s203 PROTEIN p38 s24 PROTEIN p1 s24 PROTEIN p2 SQUARE OVAL OVAL inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive active inactive inactive active inactive inactive inactive active inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive active inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive active active active active active active active inactive inactive active active inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive active inactive active inactive active inactive active inactive active inactive active active active inactive active active active active inactive active active active inactive active active active active active active inactive active inactive active inactive active active active active inactive inactive inactive inactive inactive Cytoplasm Nucleus ER Long Name: Chemokine Synonym: Synonym not specified Accession: P00856 inside PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05310 Heterodimer Member Info: Gbetagamma#PROTEIN#G beta/gamma subunits#P00836##;GDP#SIMPLE_MOLECULE#GDP#S01725##;CHKR#PROTEIN#Chemokine receptor#P00854##;Galphai/q#PROTEIN#Gi/q alpha subunits#P00873## transmembrane COMPLEX Complex_br_(CHKR/G_alpha__sub_i/_br_q/GDP/_br_G_beta__gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05315 Heterodimer Member Info: Gbetagamma#PROTEIN#G beta/gamma subunits#P00836##;GDP#SIMPLE_MOLECULE#GDP#S01725##;CHKR#PROTEIN#Chemokine receptor#P00854##;CHK#PROTEIN#Chemokine#P00856##;Galphai/q#PROTEIN#Gi/q alpha subunits#P00873## transmembrane COMPLEX Complex_br_(CHKR/CHK/_br_G_alpha__sub_i/q/_br_GDP/G_beta__gamma_) Long Name: GDP Synonym: Synonym not specified Accession: S01725 inside SIMPLE_MOLECULE GDP Long Name: G beta/gamma subunits Synonym: Synonym not specified Accession: P00836 inside PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05306 Heterodimer Member Info: CHKR#PROTEIN#Chemokine receptor#P00854##;CHK#PROTEIN#Chemokine#P00856## transmembrane COMPLEX Complex_br_(CHKR/CHK) Long Name: GTP Synonym: Synonym not specified Accession: S01727 inside SIMPLE_MOLECULE GTP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05316 Heterodimer Member Info: Galphaq#PROTEIN#Gq alpha subunit#P00826##;GTP#SIMPLE_MOLECULE#GTP#S01727## inside COMPLEX Complex_br_(G_alpha__sub_q/GTP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05313 Heterodimer Member Info: Galphai#PROTEIN#Gi alpha subunit#P00828##;GTP#SIMPLE_MOLECULE#GTP#S01727## inside COMPLEX Complex_br_(G_alpha__sub_i/GTP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05311 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01727##;Galphai/q#PROTEIN#Gi/q alpha subunits#P00873## inside COMPLEX Complex_br_(G_alpha__sub_i/q/_br_GTP) Long Name: Regulator of G-protein Signaling Synonym: Synonym not specified Accession: P00833 inside PROTEIN p8 Long Name: Adenylyl cyclase Synonym: Synonym not specified Accession: P00841 innerSurface PROTEIN p9 Long Name: ATP Synonym: Synonym not specified Accession: S01730 inside SIMPLE_MOLECULE ATP Long Name: cAMP Synonym: Synonym not specified Accession: S01732 inside SIMPLE_MOLECULE cAMP Long Name: Protein kinase A Synonym: PKA Accession: P00862 inside PROTEIN p10 Long Name: Src family tyrosine kinase Synonym: Synonym not specified Accession: P00844 inside PROTEIN p11 Long Name: Cell Adhesion Cell Shape Change Chemotaxis Degranulation Synonym: Synonym not specified Accession: U02384 inside PHENOTYPE Cell Adhesion_br_Cell Shape Change_br_Chemotaxis_br_Degranulation Long Name: Proline-rich tyrosine kinase 2 Synonym: PYK2 Accession: P00852 inside PROTEIN p12 Long Name: G-protein receptor kinase Synonym: Synonym not specified Accession: P00840 inside PROTEIN p13 Long Name: Arrestin Synonym: Synonym not specified Accession: P00880 inside PROTEIN p14 Long Name: Phospholipase C Synonym: PLC Accession: P00874 inside PROTEIN p15 Long Name: PIP2 Synonym: Synonym not specified Accession: S01729 inside SIMPLE_MOLECULE PIP2 Long Name: IP3 Synonym: Synonym not specified Accession: S01726 inside SIMPLE_MOLECULE IP3 Long Name: DAG Synonym: Synonym not specified Accession: S01731 inside SIMPLE_MOLECULE DAG Long Name: Protein kinase C Synonym: PKC Accession: P00861 inside PROTEIN p16 Long Name: Inositol 1,4,5-triphosphate receptor Synonym: IP3 receptor Accession: P00842 transmembrane PROTEIN p17 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02385 inside ION Ca_super_2+ Long Name: Ca2+ Synonym: Synonym not specified Accession: U02385 inside ION Ca_super_2+ Long Name: Calcium/calModulin-dependent Kinase II Synonym: Synonym not specified Accession: P00847 inside PROTEIN p18 Long Name: Phosphoinositide 3-kinase Synonym: PI3K Accession: P00868 inside PROTEIN p19 Long Name: PIP3 Synonym: Synonym not specified Accession: S01728 inside SIMPLE_MOLECULE PIP3 Long Name: protein kinase B Synonym: AKT,PKB Accession: P00827 inside PROTEIN p20 Long Name: Guanine nucleotide exchange factor Synonym: GEF Accession: P00875 inside PROTEIN p21 Long Name: Rho Synonym: Synonym not specified Accession: P00860 inside PROTEIN p22 Long Name: Ras related C3 botulinum substrate 1 Synonym: Rac Accession: P00872 inside PROTEIN p23 Long Name: Cell division cycle 42 Synonym: 25 KD GTP-binding protein,G25K Accession: P00834 inside PROTEIN p24 Long Name: P21-activated kinase Synonym: PAK Accession: P00837 inside PROTEIN p25 Long Name: Rho-associated coiled-coil Ser/Thr specific kinase Synonym: ROCK Accession: P00881 inside PROTEIN p26 Long Name: Myosin light chain kinase Synonym: Synonym not specified Accession: P00877 inside PROTEIN p27 Long Name: Actin related protein 2/3 complex Synonym: Synonym not specified Accession: P00876 inside PROTEIN p28 Long Name: F-actin Synonym: Synonym not specified Accession: P00858 inside PROTEIN p30 Long Name: Myosin Synonym: Synonym not specified Accession: P00867 inside PROTEIN p29 Long Name: Myosin Synonym: Synonym not specified Accession: P00867 inside PROTEIN p29 Long Name: Protein Kinase C zeta Synonym: Synonym not specified Accession: P00829 inside PROTEIN p31 Long Name: ExtraCellular matrix protein Synonym: Synonym not specified Accession: P00863 inside PROTEIN p33 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05318 Heterodimer Member Info: Integrin#PROTEIN#Integrin#P00853##;EMC#PROTEIN#ExtraCellular matrix protein#P00863## transmembrane COMPLEX Complex_br_(Integrin/EMC) Long Name: Integrin Synonym: Synonym not specified Accession: P00853 transmembrane PROTEIN p32 Long Name: Phosphatase and tensin homologue Synonym: PTEN Accession: P00849 inside PROTEIN p35 Long Name: SH2 domain-containing inositol 5-phosphatase Synonym: SHIP Accession: P00839 inside PROTEIN p36 Long Name: Phosphoinositide-dependent protein kinases Synonym: PDPK1 Accession: P00831 inside PROTEIN p34 Long Name: Nuclear factor kappa-B Synonym: Nuclear factor of kappa light chain gene enhancer in B cells Accession: P00859 inside PROTEIN p39 Long Name: Nuclear factor kappa-B Synonym: Nuclear factor of kappa light chain gene enhancer in B cells Accession: P00859 inside PROTEIN p39 Long Name: Pro-inflammatory anti-apoptotic genes Synonym: Synonym not specified Accession: G01539 inside GENE gn1 Long Name: Secretion of New Cytokines and Chemokines Synonym: Synonym not specified Accession: U02386 transmembrane PHENOTYPE Secretion of New_br_Cytokines and Chemokines Long Name: Nuclear factor of activated T cells Synonym: NFAT Accession: P00851 inside PROTEIN p40 Long Name: Interferon gamma Synonym: Synonym not specified Accession: P00878 inside PROTEIN p42 Long Name: Janus kinase Synonym: Synonym not specified Accession: P00846 inside PROTEIN p43 Long Name: Signal transducers and activaotrs of transcription Synonym: Synonym not specified Accession: P00832 inside PROTEIN p44 Long Name: Suppressor of cytokine siganling Synonym: Synonym not specified Accession: P00879 inside PROTEIN p45 Long Name: Signal transducers and activaotrs of transcription Synonym: Synonym not specified Accession: P00832 inside PROTEIN p44 2 Long Name: Signal transducers and activaotrs of transcription Synonym: Synonym not specified Accession: P00832 inside PROTEIN p44 2 Long Name: Pro-inflammatory genes Synonym: Synonym not specified Accession: G01538 inside GENE gn2 Long Name: Interleukin 2 Synonym: Synonym not specified Accession: P00870 inside PROTEIN p48 Long Name: SH2 homology domain containing transforming protein Synonym: Synonym not specified Accession: P00865 inside PROTEIN p49 Long Name: Growth factor receptor-bound protein Synonym: ASH,Abundant SRC homology,Grb Accession: P00848 inside PROTEIN p50 Long Name: Son of Sevenless Synonym: Synonym not specified Accession: P00850 inside PROTEIN p51 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05317 Heterodimer Member Info: Grb#PROTEIN#Growth factor receptor-bound protein#P00848#ASH|Abundant SRC homology|Grb#;Sos#PROTEIN#Son of Sevenless#P00850##;Shc#PROTEIN#SH2 homology domain containing transforming protein#P00865## inside COMPLEX Complex_br_(Shc/Sos/_br_Grb) Long Name: Rat Sarcoma GTP-binding protein Synonym: Rat Sarcoma GTP-binding protein Accession: P00869 inside PROTEIN p52 Long Name: Raf-1 Synonym: v-raf-1 Accession: P00843 inside PROTEIN p53 Long Name: Activator protein-1 Synonym: Synonym not specified Accession: P00838 inside PROTEIN p56 Long Name: Phospholipase A2 Synonym: Synonym not specified Accession: P00855 transmembrane PROTEIN p57 Long Name: Cyclooxygenase Synonym: COX Accession: P00845 inside PROTEIN p59 Long Name: Lipoxygenase Synonym: Synonym not specified Accession: P00830 inside PROTEIN p60 Long Name: Arachidonic acid Synonym: Synonym not specified Accession: S01733 inside SIMPLE_MOLECULE Arachidonic acid Long Name: Prostaglandin Synonym: Synonym not specified Accession: S01722 inside SIMPLE_MOLECULE Prostaglandin Long Name: Plasma membrane phospholipid Synonym: Synonym not specified Accession: S01724 innerSurface SIMPLE_MOLECULE Plasma membrane_br_phospholipid Long Name: Leukotriene Synonym: Synonym not specified Accession: S01723 inside SIMPLE_MOLECULE Leukotriene Long Name: Cytokine receptor Synonym: Synonym not specified Accession: P00866 transmembrane PROTEIN p41 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05314 Heterodimer Member Info: Cytokine receptor#PROTEIN#Cytokine receptor#P00866##;INFgamma#PROTEIN#Interferon gamma#P00878## transmembrane COMPLEX Complex_br_(Cytokine_br_receptor/INF_gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05304 Heterodimer Member Info: JAK#PROTEIN#Janus kinase#P00846##;Cytokine receptor#PROTEIN#Cytokine receptor#P00866##;INFgamma#PROTEIN#Interferon gamma#P00878## transmembrane COMPLEX Complex_br_(Cytokine_br_receptor/JAK/_br_JAK/INF_gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05312 Heterodimer Member Info: STAT#PROTEIN#Signal transducers and activaotrs of transcription#P00832##;JAK#PROTEIN#Janus kinase#P00846##;Cytokine receptor#PROTEIN#Cytokine receptor#P00866##;INFgamma#PROTEIN#Interferon gamma#P00878## transmembrane COMPLEX Complex_br_(Cytokine_br_receptor/JAK/_br_JAK/STAT/_br_INF_gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05305 Heterodimer Member Info: JAK#PROTEIN#Janus kinase#P00846##;Cytokine receptor#PROTEIN#Cytokine receptor#P00866##;IL2#PROTEIN#Interleukin 2#P00870## transmembrane COMPLEX Complex_br_(Cytokine_br_receptor/JAK/_br_JAK/IL2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05308 Heterodimer Member Info: Cytokine receptor#PROTEIN#Cytokine receptor#P00866##;IL2#PROTEIN#Interleukin 2#P00870## transmembrane COMPLEX Complex_br_(Cytokine_br_receptor/IL2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05307 Heterodimer Member Info: STAT#PROTEIN#Signal transducers and activaotrs of transcription#P00832##;JAK#PROTEIN#Janus kinase#P00846##;Cytokine receptor#PROTEIN#Cytokine receptor#P00866##;IL2#PROTEIN#Interleukin 2#P00870## transmembrane COMPLEX Complex_br_(Cytokine_br_receptor/IL2/_br_STAT/JAK/_br_JAK) Long Name: Mitogen activated protein kinase Synonym: MAP kinase Accession: P00835 inside PROTEIN p55 Long Name: Mitogen activated protein kinase Synonym: MAP kinase Accession: P00835 inside PROTEIN p55 Long Name: MAP kinase/Erk kinase kinase Synonym: MAP kinase kinase,MAPKK,Mitogen-activated protein kinase kinase Accession: P00864 inside PROTEIN p54 Long Name: MAP kinase/Erk kinase kinase Synonym: MAP kinase kinase,MAPKK,Mitogen-activated protein kinase kinase Accession: P00864 inside PROTEIN p54 Long Name: I-kappa B kinase Synonym: IKK Accession: P00871 inside PROTEIN p37 Long Name: I-kappa B kinase Synonym: IKK Accession: P00871 inside PROTEIN p37 Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: NFKBI,Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00857 inside PROTEIN p38 Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: NFKBI,Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00857 inside PROTEIN p38 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05309 Heterodimer Member Info: IkappaB#PROTEIN#Inhibitor of kappa light chain gene enhancer in B cells#P00857#NFKBI|Nuclear factor of kappa light chain gene enhancer in B cells inhibitor#;NFkappaB#PROTEIN#Nuclear factor kappa-B#P00859#Nuclear factor of kappa light chain gene enhancer in B cells# inside COMPLEX Complex_br_(NF_kappa_B/I_kappa_B) Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: NFKBI,Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00857 inside PROTEIN p38 Long Name: a296_degraded Synonym: Synonym not specified Accession: U05319 inside DEGRADED a296_degraded inside RNA rn1 inside RNA rn2 HETERODIMER_ASSOCIATION 0.3834426569004261,0.31045473024878145 a2 a15 a26 DISSOCIATION 0.47821198401396214,0.6126880339522716 a26 a45 a60 a40 a36 a37 UNKNOWN_TRANSITION a60 a59 a61 UNKNOWN_TRANSITION a60 a58 a61 STATE_TRANSITION a62 a63 a59 a37 STATE_TRANSITION a64 a65 a63 STATE_TRANSITION a66 a67 a65 STATE_TRANSITION a68 a69 a59 INHIBITION 0.16655884051426484,0.16396232887121243 0.45886871396307427,0.20122449883265714 a67 a70 STATE_TRANSITION a71 a72 a59 a37 a85 STATE_TRANSITION a75 a76 a37 a242 a58 STATE_TRANSITION a77 a78 a79 a76 STATE_TRANSITION a80 a81 a79 a85 STATE_TRANSITION a82 a83 a78 TRANSPORT a84 a85 a83 STATE_TRANSITION a86 a87 a85 STATE_TRANSITION a88 a89 a37 a242 STATE_TRANSITION a77 a90 a89 STATE_TRANSITION a91 a92 a89 a90 a127 STATE_TRANSITION a93 a94 a90 STATE_TRANSITION a95 a102 a94 STATE_TRANSITION a96 a103 a94 STATE_TRANSITION a97 a104 a94 STATE_TRANSITION a100 a106 a105 STATE_TRANSITION a99 a105 a102 a107 STATE_TRANSITION a98 a107 a103 a104 STATE_TRANSITION a101 a108 a103 a104 STATE_TRANSITION a109 a111 a106 STATE_TRANSITION a110 a113 a107 a108 STATE_TRANSITION a114 a115 a102 HETERODIMER_ASSOCIATION 0.33333333333333304,0.33333333333333304 a117 a116 a125 a115 STATE_TRANSITION a126 a127 a90 STATE_TRANSITION a130 a131 a92 a243 STATE_TRANSITION a132 a133 a131 TRANSPORT a135 a136 STATE_TRANSITION a139 a140 a87 STATE_TRANSITION a148 a150 a151 HETERODIMER_ASSOCIATION 0.3333333333333339,0.3333333333333339 a142 a141 a159 HETERODIMER_ASSOCIATION 0.6781438549302016,-0.2612137407987394 a159 a150 a163 HETERODIMER_ASSOCIATION 0.640681934904245,-0.05831263435141398 a163 a149 a173 DISSOCIATION 0.45078632949035047,0.1663390302938172 a173 a175 a174 TRANSPORT a174 a176 HETERODIMER_ASSOCIATION 0.33333333333333304,0.3333333333333357 a209 a188 a214 a221 a275 STATE_TRANSITION a233 a242 a221 STATE_TRANSITION a234 a241 a242 STATE_TRANSITION a235 a240 a241 STATE_TRANSITION a236 a239 a240 STATE_TRANSITION a238 a237 a239 STATE_TRANSITION a248 a249 a246 STATE_TRANSITION a251 a248 a244 STATE_TRANSITION a248 a252 a247 HETERODIMER_ASSOCIATION 0.33333333333333215,0.33333333333333304 a183 a184 a278 HETERODIMER_ASSOCIATION 0.3333333333333339,0.33333333333333326 a149 a278 a150 a287 a150 DISSOCIATION 0.3333333333333339,0.33333333333333304 a287 a275 a174 HETERODIMER_ASSOCIATION 0.3333333333333357,0.33333333333333215 a132 a135 a295 STATE_TRANSITION a133 a296 STATE_TRANSITION a296 a297 STATE_TRANSITION a40 csa17 a74 a73 TRANSCRIPTION a137 sa161 a140 a136 TRANSCRIPTION a182 sa162 a176 STATE_TRANSITION a90 a77 a128 a129 PHYSICAL_STIMULATION a69 a70 PHYSICAL_STIMULATION sa161 a138