The insulin receptor (IR), insulin-like growth factor receptor (IGFR), and insulin-receptor-related receptor (IRR) form a subgroup of receptor tyrosine kinases that activate the mitogenic MAP kinase signalling cascade. The activated IR regulates cellular uptake and metabolism of fuels, while the activated IGFR promotes cell growth. Medline=11737239 Medline=11739335 Medline=11897402 Medline=12169433 Medline=12175645 Medline=12360255 4.0 s13 PROTEIN p6 s13 PROTEIN p5 s5 PROTEIN p2 s5 PROTEIN p1 SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive inactive active inactive active inactive active inactive inactive inactive inactive active Cytosol Long Name: ATP Synonym: Synonym not specified Accession: S01734 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01735 inside SIMPLE_MOLECULE ADP Long Name: Ras Synonym: Synonym not specified Accession: P00886 inside PROTEIN p7 Long Name: Raf Synonym: Raf oncogene Accession: P00893 inside PROTEIN p8 Long Name: Raf Synonym: Raf oncogene Accession: P00893 inside PROTEIN p8 Long Name: Mitogen-activated protein kinase kinase Synonym: MAP kinase kinase,MAP/ERK kinase,MAPKK,Mitogen-activated ERK activating kinase Accession: P00891 inside PROTEIN p9 Long Name: Mitogen-activated protein kinase kinase Synonym: MAP kinase kinase,MAP/ERK kinase,MAPKK,Mitogen-activated ERK activating kinase Accession: P00891 inside PROTEIN p9 Long Name: ELK1, member of ETS oncogen family Synonym: ELK1,Oncogen ELK1 Accession: P00890 inside PROTEIN p11 Long Name: ELK1, member of ETS oncogen family Synonym: ELK1,Oncogen ELK1 Accession: P00890 inside PROTEIN p11 Long Name: 90 kDa ribosomal protein S6 kinase Synonym: Synonym not specified Accession: P00888 inside PROTEIN p12 Long Name: 90 kDa ribosomal protein S6 kinase Synonym: Synonym not specified Accession: P00888 inside PROTEIN p12 Long Name: c-fos Synonym: Synonym not specified Accession: P00884 inside PROTEIN p13 Long Name: c-fos Synonym: Synonym not specified Accession: P00884 inside PROTEIN p13 Long Name: Gene transcription Synonym: Synonym not specified Accession: U02389 inside PHENOTYPE Gene_space_transcription Long Name: Insulin/Insulin like growth factor Synonym: IGF,IGF1,IGF2,Insulin like growth factor 1,Insulin like growth factor 2 Accession: P00882 inside PROTEIN p2 Long Name: Son of sevenless Synonym: SOS,SOS1 guanine nucleotide exchange factor Accession: P00883 inside PROTEIN p6 Long Name: Growth factor receptor bound protein 2 Synonym: ASH protein,Abundant Src homology,Grb2 Accession: P00892 inside PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05328 Heterodimer Member Info: SOS#PROTEIN#Son of sevenless#P00883#SOS|SOS1 guanine nucleotide exchange factor#;Grb2#PROTEIN#Growth factor receptor bound protein 2#P00892#ASH protein|Abundant Src homology|Grb2# inside COMPLEX Complex_br_(SOS/Grb2) Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00887 inside PROTEIN p4 Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00887 inside PROTEIN p4 Long Name: Insulin receptor/Insulin like growth factor receptor/insulin related receptor Synonym: IGF-R,IGF-R1,IGF-R2,INSR,IRR,Insulin R,Insulin like growth factor receptor 1,Insulin like growth factor receptor 2 Accession: P00885 transmembrane PROTEIN p1 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05329 Heterodimer Member Info: Insulin IGF#PROTEIN#Insulin/Insulin like growth factor#P00882#IGF|IGF1|IGF2|Insulin like growth factor 1|Insulin like growth factor 2#;INSR IGF-R IRR#PROTEIN#Insulin receptor/Insulin like growth factor receptor/insulin related receptor#P00885#IGF-R|IGF-R1|IGF-R2|INSR|IRR|Insulin R|Insulin like growth factor receptor 1|Insulin like growth factor receptor 2# transmembrane COMPLEX Complex_br_(Insulin_br_IGF/INSR_br_IGF_minus_R_br_IRR) Long Name: Mitogen-activated protein kinase Synonym: Extracellular signal-regulated kinase,MAP kinase,MAPK Accession: P00889 inside PROTEIN p10 Long Name: Mitogen-activated protein kinase Synonym: Extracellular signal-regulated kinase,MAP kinase,MAPK Accession: P00889 inside PROTEIN p10 HETERODIMER_ASSOCIATION 0.33333333333333304,8.881784197001252E-16 0.6666666666666665,1.3322676295501878E-15 0.5695451140756171,0.03573753809365421 0.4573910961411527,0.011908661066370063 0.3750870458573311,0.33655148446742245 a2 a1 a5 STATE_TRANSITION 0.3333333333333326,4.884981308350689E-15 0.6666666666666665,9.547918011776346E-15 a7 a9 a8 a10 a5 STATE_TRANSITION 0.3333333333333335,3.552713678800501E-15 0.6666666666666665,6.217248937900877E-15 a12 a13 a8 HETERODIMER_ASSOCIATION 0.375012772820543,0.2642560787118735 a14 a13 a17 STATE_TRANSITION a18 a19 a17 STATE_TRANSITION 0.33333333333333326,1.3322676295501878E-15 0.6666666666666663,4.440892098500626E-15 a20 a25 a21 a24 a19 STATE_TRANSITION 0.3333333333333335,-4.440892098500626E-15 0.666666666666667,-8.43769498715119E-15 a26 a29 a27 a30 a21 STATE_TRANSITION 0.3333333333333335,-4.440892098500626E-16 0.6666666666666672,-1.3322676295501878E-15 a31 a34 a32 a35 a27 STATE_TRANSITION 0.33492310101047096,-0.02399103949127568 0.6674615505052355,-0.011995519745639616 a36 a37 a32 STATE_TRANSITION 0.342960893270126,-0.02925941041660174 0.6714804466350621,-0.01462970520830087 a39 a40 a32 STATE_TRANSITION 0.3333333333333339,8.881784197001252E-16 0.666666666666667,1.7763568394002505E-15 a42 a43 a40 PHYSICAL_STIMULATION a43 a45 PHYSICAL_STIMULATION a37 a45