The biosynthesis of the cofactor lipoate. Lipoate is active when bound to its congnate proteins and functions to bind and transport acyl groups via a thioester linkage. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry 4.0 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Long Name: 2 SAM Synonym: Synonym not specified Accession: S03760 inside SIMPLE_MOLECULE 2 SAM Long Name: octanoyl-ACP Synonym: Synonym not specified Accession: S03764 inside SIMPLE_MOLECULE octanoyl-ACP Long Name: 2 methionine Synonym: Synonym not specified Accession: S03765 inside SIMPLE_MOLECULE 2 methionine Long Name: Lipoate synthase Synonym: Synonym not specified Accession: P03004 inside PROTEIN p1 Long Name: Lipoyl-protein ligase Synonym: Synonym not specified Accession: P03003 inside PROTEIN p2 Long Name: Octanoic Acid Synonym: Synonym not specified Accession: S03761 inside SIMPLE_MOLECULE Octanoic Acid Long Name: ACP Synonym: Synonym not specified Accession: S03759 inside SIMPLE_MOLECULE ACP Long Name: Acyl carrier protein acyltransferase Synonym: Synonym not specified Accession: P03005 inside PROTEIN p3 Long Name: Lipoyl-ACP Synonym: Synonym not specified Accession: S03767 inside SIMPLE_MOLECULE Lipoyl-ACP Long Name: Apo Lipoyl dependent proteins Synonym: Synonym not specified Accession: S03762 inside SIMPLE_MOLECULE Apo Lipoyl_br_dependent proteins Long Name: Lipoyl proteins Synonym: Synonym not specified Accession: S03766 inside SIMPLE_MOLECULE Lipoyl proteins Long Name: 2 CH3-Ado Synonym: Synonym not specified Accession: S03763 inside SIMPLE_MOLECULE 2 methyladenosyl STATE_TRANSITION 0.33333333333333326,-4.440892098500626E-16 0.6666666666666665,-8.881784197001252E-16 a11 a12 a2 a13 STATE_TRANSITION 0.33333333333333337,-2.220446049250313E-16 0.6666666666666666,-2.220446049250313E-16 a2 a1 a14 a4 a3 a9 STATE_TRANSITION 0.3333333333333335,0.0 0.6666666666666665,-2.220446049250313E-16 a14 a17 a15 a18 a10