The plasminogen activation cascade is a serine protease cascade in which the inactive zymogen plasminogen is converted into plasmin. Plasmin's primary function is thought to be the dissolution of blood clots. Plasmin is also thought to act as a proteolytic activator of other processes including tissue remodeling through its activation of the matrix metalloproteases. Medline=11382594 OMIM=173350 4.0 s51 PROTEIN p21 s51 PROTEIN p26 s15 PROTEIN p1 s15 SIMPLE_MOLECULE GPI linker s11 SIMPLE_MOLECULE GPI linker s11 PROTEIN p1 s11 PROTEIN p2 s21 SIMPLE_MOLECULE GPI linker s21 PROTEIN p1 s21 PROTEIN p3 s34 PROTEIN p1 s34 SIMPLE_MOLECULE GPI linker s34 PROTEIN p3 s34 PROTEIN p8 s72 SIMPLE_MOLECULE GPI linker s72 PROTEIN p1 s72 PROTEIN p3 s72 PROTEIN p30 s73 PROTEIN p8 s73 PROTEIN p20 SQUARE_CLOSEUP_SOUTHEAST SQUARE_CLOSEUP_SOUTHWEST SQUARE_CLOSEUP_NORTHEAST inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive active active active inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive endothelial cell epithelial cell fibroblast Long Name: Thrombus (fibrin clot) Synonym: Synonym not specified Accession: U02590 inside UNKNOWN Thrombus (fibrin clot) Long Name: Plasmin Synonym: Synonym not specified Accession: P01246 inside PROTEIN p21 Long Name: Plasminogen Synonym: Synonym not specified Accession: P01255 inside PROTEIN p22 Long Name: alpha2 antiplasmin Synonym: alpha_2 antiplasmin,alpha_2-PI,plasmin inhibitor alpha_2,serine protease inhibitor F2 Accession: P01264 inside PROTEIN p26 Long Name: Long Name: Plasmin Synonym: Synonym not specified Accession: U05504 Heterodimer Member Info: Plasmin#PROTEIN#Plasmin#P01246##;alpha2 antiplasmin#PROTEIN#alpha2 antiplasmin#P01264#alpha_2 antiplasmin|alpha_2-PI|plasmin inhibitor alpha_2|serine protease inhibitor F2# inside COMPLEX Complex_br_(Plasmin/_alpha_2_space_antiplasmin) Long Name: Fibrin Synonym: Fibrin degradation products Accession: P01253 inside PROTEIN p27 Long Name: Fibrin degradation products Synonym: Fibrin C-terminal truncation Accession: P01258 inside PROTEIN p28 Long Name: thrombin activatable fibrinolysis inhibitor Synonym: Thrombin activatable fibrinolysis inhibitor,carboxypeptidase R,carboxypeptidase U,procarboxypeptidase B2 Accession: P01247 inside PROTEIN p29 Long Name: Long Name: GPI linker Synonym: Synonym not specified Accession: U05502 Heterodimer Member Info: uPAR#PROTEIN#urokinase type plasminogen activator receptor#P01256#CD87|PLAU-R|PLAUR|UPA-R|soluble urokinase plasminogen activator|suPAR|urinary plasminogen activator receptor|urokinase plasminogen activator receptor|urokinase receptor#;GPI linker#SIMPLE_MOLECULE#GPI linker#S01824## transmembrane COMPLEX Complex_br_(uPAR/GPI linker) Long Name: pro-urokinase type plasminogen activator Synonym: pro plasminogen activator, urinary,pro-PLAU,pro-urokinase,pro-urokinase plasminogen activator Accession: P01262 inside PROTEIN p2 Long Name: Long Name: GPI linker Synonym: Synonym not specified Accession: U05508 Heterodimer Member Info: uPAR#PROTEIN#urokinase type plasminogen activator receptor#P01256#CD87|PLAU-R|PLAUR|UPA-R|soluble urokinase plasminogen activator|suPAR|urinary plasminogen activator receptor|urokinase plasminogen activator receptor|urokinase receptor#;GPI linker#SIMPLE_MOLECULE#GPI linker#S01824##;pro-uPA#PROTEIN#pro-urokinase type plasminogen activator#P01262#pro plasminogen activator, urinary|pro-PLAU|pro-urokinase|pro-urokinase plasminogen activator# transmembrane COMPLEX Complex_br_(GPI linker/uPAR/_br_pro_minus_uPA) Long Name: PAI-2 Synonym: Monocyte Arginine serpin,Monocyte derived Plasminogen activator inhibitor,PLANH2,Plasminogen activator inhibitor 2,Serpin B2,Urokinase inhibitor Accession: P01244 inside PROTEIN p30 Long Name: pro-tissue type plasminogen activator Synonym: pro-Tissue type plasminogen activator,pro-alteplase,pro-plasminogen activator, tissue,pro-tissue plasminogen activator Accession: P01249 inside PROTEIN p19 Long Name: PAI-1 Synonym: Endothelial plasminogen activator inhibitor,Plasminogen activator inhibitor 1,Serpin E1 Accession: P01245 inside PROTEIN p8 Long Name: pro-matrix metalloprotease 13 Synonym: pro-Collagenase 3,pro-Matrix metalloproteinase 13 Accession: P01254 inside PROTEIN p9 Long Name: pro-matrix metalloprotease 13 Synonym: pro-Collagenase 3,pro-Matrix metalloproteinase 13 Accession: P01254 inside PROTEIN p9 Long Name: pro-Matrix metalloprotease 3 Synonym: pro-Matrix metalloproteinase 3,pro-stromelysin,pro-stromelysin 1,pro-transin Accession: P01260 inside PROTEIN p11 Long Name: pro-Matrix metalloprotease 3 Synonym: pro-Matrix metalloproteinase 3,pro-stromelysin,pro-stromelysin 1,pro-transin Accession: P01260 inside PROTEIN p11 Long Name: pro-Matrix metalloprotease 1 Synonym: pro-Collagenase,pro-Fibroblast Collagenase,pro-Interstitial Collagenase,pro-Matrix metalloproteinase 1 Accession: P01263 inside PROTEIN p12 Long Name: pro-Matrix metalloprotease 1 Synonym: pro-Collagenase,pro-Fibroblast Collagenase,pro-Interstitial Collagenase,pro-Matrix metalloproteinase 1 Accession: P01263 inside PROTEIN p12 Long Name: pro-matrix metalloprotease 9 Synonym: pro-Gelatinase B,pro-Matrix metalloproteinase 9 Accession: P01259 inside PROTEIN p16 Long Name: pro-matrix metalloprotease 9 Synonym: pro-Gelatinase B,pro-Matrix metalloproteinase 9 Accession: P01259 inside PROTEIN p16 Long Name: ? Synonym: Synonym not specified Accession: P01261 inside PROTEIN p95 Long Name: Matrix metalloprotease 1 Synonym: Collagenase,Fibroblast Collagenase,Interstitial Collagenase,MMP-1,Matrix metalloproteinase 1 Accession: P01252 inside PROTEIN p15 Long Name: Matrix metalloprotease 9 Synonym: Collagenase type IV,Collagenase type IV-B,Collagenase type V,Gelatinase B,Gelatinase, 92kD,MMP-9,Matrix metalloproteinase 9 Accession: P01248 inside PROTEIN p17 Long Name: Matrix metalloprotease 13 Synonym: Collagenase 3,Matrix metalloproteinase 13 Accession: P01250 inside PROTEIN p10 Long Name: Matrix metalloprotease 3 Synonym: Fibroblast stromelysin,Matrix metalloprotease 3,Matrix metalloproteinase 3,Stromelysin,Transin Accession: P01251 inside PROTEIN p14 Long Name: Long Name: GPI linker Synonym: Synonym not specified Accession: U05507 Heterodimer Member Info: uPA#PROTEIN#urokinase type plasminogen activator#P01243#PLAU|plasminogen activator, urinary|urokinase#;uPAR#PROTEIN#urokinase type plasminogen activator receptor#P01256#CD87|PLAU-R|PLAUR|UPA-R|soluble urokinase plasminogen activator|suPAR|urinary plasminogen activator receptor|urokinase plasminogen activator receptor|urokinase receptor#;GPI linker#SIMPLE_MOLECULE#GPI linker#S01824## transmembrane COMPLEX Complex_br_(GPI linker/uPAR/_br_uPA) Long Name: Long Name: GPI linker Synonym: Synonym not specified Accession: U05506 Heterodimer Member Info: uPA#PROTEIN#urokinase type plasminogen activator#P01243#PLAU|plasminogen activator, urinary|urokinase#;PAI-1#PROTEIN#PAI-1#P01245#Endothelial plasminogen activator inhibitor|Plasminogen activator inhibitor 1|Serpin E1#;uPAR#PROTEIN#urokinase type plasminogen activator receptor#P01256#CD87|PLAU-R|PLAUR|UPA-R|soluble urokinase plasminogen activator|suPAR|urinary plasminogen activator receptor|urokinase plasminogen activator receptor|urokinase receptor#;GPI linker#SIMPLE_MOLECULE#GPI linker#S01824## transmembrane COMPLEX Complex_br_(uPAR/GPI linker/_br_uPA/PAI_minus_1) Long Name: Long Name: GPI linker Synonym: Synonym not specified Accession: U05505 Heterodimer Member Info: uPA#PROTEIN#urokinase type plasminogen activator#P01243#PLAU|plasminogen activator, urinary|urokinase#;PAI-2#PROTEIN#PAI-2#P01244#Monocyte Arginine serpin|Monocyte derived Plasminogen activator inhibitor|PLANH2|Plasminogen activator inhibitor 2|Serpin B2|Urokinase inhibitor#;uPAR#PROTEIN#urokinase type plasminogen activator receptor#P01256#CD87|PLAU-R|PLAUR|UPA-R|soluble urokinase plasminogen activator|suPAR|urinary plasminogen activator receptor|urokinase plasminogen activator receptor|urokinase receptor#;GPI linker#SIMPLE_MOLECULE#GPI linker#S01824## transmembrane COMPLEX Complex_br_(GPI linker/uPAR/_br_uPA/PAI_minus_2) Long Name: tissue type plasminogen activator Synonym: PLAT,Tissue plasminogen activator,alteplase,plasminogen activator, tissue type Accession: P01257 inside PROTEIN p20 Long Name: tissue type plasminogen activator Synonym: PLAT,Tissue plasminogen activator,alteplase,plasminogen activator, tissue type Accession: P01257 inside PROTEIN p20 Long Name: Long Name: tPA Synonym: Synonym not specified Accession: U05503 Heterodimer Member Info: PAI-1#PROTEIN#PAI-1#P01245#Endothelial plasminogen activator inhibitor|Plasminogen activator inhibitor 1|Serpin E1#;tPA#PROTEIN#tissue type plasminogen activator#P01257#PLAT|Tissue plasminogen activator|alteplase|plasminogen activator, tissue type# inside COMPLEX Complex_br_(PAI_minus_1/tPA) Long Name: ? Synonym: Synonym not specified Accession: P01261 inside PROTEIN p95 HETERODIMER_ASSOCIATION 0.38177149477288985,-0.06827784939177928 -0.8621871938730088,0.8601444919405148 a36 a44 a51 STATE_TRANSITION 0.3333333333333328,8.881784197001252E-16 0.6666666666666667,8.881784197001252E-16 a56 a57 a39 TRANSPORT 0.3333333333333326,8.881784197001252E-16 0.6666666666666659,8.881784197001252E-16 a65 a66 HETERODIMER_ASSOCIATION 0.33333333333333215,1.7763568394002505E-15 0.6666666666666656,1.7763568394002505E-15 0.3333333333333335,0.0 0.6666666666666665,0.0 0.3333333333333335,-1.3322676295501878E-15 0.6666666666666665,-2.6645352591003757E-15 0.33333333333333215,0.33333333333333304 a39 a67 a76 STATE_TRANSITION 0.22825897048015964,-0.10089687135608916 0.4932775938749865,-0.16143499416972418 a57 a77 a78 HETERODIMER_ASSOCIATION 0.33333333333333215,-8.881784197001252E-16 0.6666666666666661,0.0 0.3333333333333339,-4.440892098500626E-16 0.6666666666666665,-4.440892098500626E-16 0.4373576070278138,0.016741085555320723 0.8747152140556236,0.033482171110645 0.3360020226893454,0.3469296162815564 a27 a3 a21 TRANSPORT 0.3333333333333337,-2.220446049250313E-16 0.666666666666667,0.0 a90 a55 TRANSPORT 0.33333333333333304,1.1102230246251565E-16 0.6666666666666665,1.1102230246251565E-16 a89 a60 TRANSPORT 0.33333333333333326,0.0 0.6666666666666667,0.0 a88 a54 TRANSPORT 0.33333333333333326,3.469446951953614E-17 0.6666666666666667,2.0816681711721685E-17 a91 a52 HETERODIMER_ASSOCIATION 0.16350068473625257,-0.038375843622233674 0.3270013694725087,-0.07675168724446024 0.3333333333333335,1.1102230246251565E-16 0.6226709670681729,-0.08322342016091844 0.33333333333333326,0.0 0.6666666666666663,0.0 -0.05987419269224015,0.253904695701037 a93 a36 a107 HETERODIMER_ASSOCIATION 0.33333333333333215,-4.440892098500626E-16 0.6666666666666679,-1.3322676295501878E-15 0.3333333333333339,1.7763568394002505E-15 0.6666666666666679,3.552713678800501E-15 0.3333333333333328,0.0 0.6666666666666659,0.0 0.3333333333333339,0.33333333333333304 a109 a66 a111 TRUNCATION 0.33333333333333304,0.0 0.666666666666667,0.0 0.3333333333333286,5.329070518200751E-15 0.6666666666666572,-1.7763568394002505E-15 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666661,-1.7763568394002505E-15 0.09093606289868106,0.45408693072244155 a55 a112 a59 a39 TRUNCATION 0.33333333333333304,0.0 0.666666666666667,-1.7763568394002505E-15 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666652,0.0 0.3333333333333428,-8.881784197001252E-16 0.6666666666666714,-4.440892098500626E-15 0.5235251330347204,-0.08701810803567867 a60 a61 a113 a39 TRUNCATION 0.3333333333333339,-2.7755575615628914E-17 0.6666666666666661,6.38378239159465E-16 0.33333333333333215,0.0 0.6666666666666679,3.552713678800501E-15 0.3333333333333339,0.0 0.6666666666666661,0.0 0.0026018031100627503,0.5267441156894788 a54 a115 a58 a39 TRUNCATION 0.33333333333333304,-6.245004513516506E-17 0.6666666666666661,-2.8449465006019636E-16 0.3333333333333304,0.0 0.6666666666666643,0.0 0.3333333333333339,-2.220446049250313E-16 0.6666666666666661,0.0 0.04242424242424203,0.5257663338588199 a52 a114 a53 a39 TRUNCATION 0.3333333333333335,8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 0.3333333333333335,1.7763568394002505E-15 0.6666666666666665,1.7763568394002505E-15 0.3333333333333335,0.0 0.666666666666667,0.0 -0.030430166006267356,0.5668816201797338 a40 a57 a116 a39 a36 a66 TRUNCATION 0.04601194348123139,0.5085402293264418 a21 a117 a36 a39 TRUNCATION 0.3333333333333339,0.0 0.6666666666666679,0.0 0.3333333333333339,0.0 0.6666666666666661,-3.552713678800501E-15 0.33333333333333215,4.440892098500626E-16 0.6666666666666679,-8.881784197001252E-16 0.4345308137791015,0.03430931450589547 a63 a65 a118