Not only does pyruvate join the glycolytic pathway to the TCA cycle, but it is also linked to amino acid metabolism by the transamination reaction and to lipid metabolism by its decarboxylation to acetyl-coA. Another imporatnt feature of the role played by pyruvate is the fact that it is produced in the cytoplasm but both its decarboxylation to acetyl-coA and its carboxylation oxaloacetate take place in the mitochondrial matrix. Thus, pyruvate provides the link between metabolism in the cytoplasm and the pathways that are restricted to the mitochondrial matrix. free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm free text=Human Metabolism by Ramsey Bronk 4.0 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Long Name: Phosphoenolpyruvate Synonym: Synonym not specified Accession: S04097 inside SIMPLE_MOLECULE Phosphoenolpyruvate Long Name: Lactate Synonym: Synonym not specified Accession: S04117 inside SIMPLE_MOLECULE Lactate Long Name: Pyruvate Synonym: Synonym not specified Accession: S04103 inside SIMPLE_MOLECULE Pyruvate Long Name: Alanine Synonym: Synonym not specified Accession: S04113 inside SIMPLE_MOLECULE Alanine Long Name: Malate Synonym: Synonym not specified Accession: S04111 inside SIMPLE_MOLECULE Malate Long Name: Oxaloacetate Synonym: Synonym not specified Accession: S04102 inside SIMPLE_MOLECULE Oxaloacetate Long Name: Acetyl-CoA Synonym: Synonym not specified Accession: S04112 inside SIMPLE_MOLECULE Acetyl-CoA Long Name: Citrate Synonym: Synonym not specified Accession: S04110 inside SIMPLE_MOLECULE Citrate Long Name: ATP Synonym: Synonym not specified Accession: S04104 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S04114 inside SIMPLE_MOLECULE ADP Long Name: NAD+ Synonym: Synonym not specified Accession: S04101 inside SIMPLE_MOLECULE NAD_super_+ Long Name: NADPH + H+ Synonym: Synonym not specified Accession: S04100 inside SIMPLE_MOLECULE NADPH + H_super_+ Long Name: Pyruvate Kinase Synonym: PK Accession: P03132 inside PROTEIN p47 Long Name: Lactate Dehydrogenase Synonym: LDH Accession: P03139 inside PROTEIN p48 Long Name: NADP+ Synonym: Synonym not specified Accession: S04115 inside SIMPLE_MOLECULE NADP_super_+ Long Name: NADPH + H++ CO2 Synonym: Synonym not specified Accession: S04108 inside SIMPLE_MOLECULE NADPH + H_super_+_endsuper_+ CO_sub_2_endsub Long Name: Malic enzyme Synonym: Synonym not specified Accession: P03136 inside PROTEIN p49 Long Name: Aminotransferase Synonym: Synonym not specified Accession: P03134 inside PROTEIN p50 Long Name: ADP + Pi Synonym: Synonym not specified Accession: S04106 inside SIMPLE_MOLECULE ADP + P_sub_i_endsub Long Name: NAD+ + CoA-SH Synonym: Synonym not specified Accession: S04105 inside SIMPLE_MOLECULE NAD_super_+_endsuper_ + CoA-SH Long Name: ATP + HCO3 - Synonym: Synonym not specified Accession: S04107 inside SIMPLE_MOLECULE ATP + HCO_sub_3_endsub_ _super_- Long Name: NADH + CO2 Synonym: Synonym not specified Accession: S04116 inside SIMPLE_MOLECULE NADH + CO_sub_2_endsub Long Name: Pyruvate Dehydrogenase Synonym: Synonym not specified Accession: P03133 inside PROTEIN p54 Long Name: Malate Dehydrogenase Synonym: Synonym not specified Accession: P03138 inside PROTEIN p55 Long Name: Citrate Synthetase Synonym: Synonym not specified Accession: P03141 inside PROTEIN p56 Long Name: ATP + CoA-SH Synonym: Synonym not specified Accession: S04099 inside SIMPLE_MOLECULE ATP + CoA-SH Long Name: Pyruvate Carboxylase Synonym: Synonym not specified Accession: P03140 inside PROTEIN p57 Long Name: Citrate Lyase Synonym: Synonym not specified Accession: P03137 inside PROTEIN p58 Long Name: GTP Synonym: Synonym not specified Accession: S04109 inside SIMPLE_MOLECULE GTP Long Name: GDP + CO2 Synonym: Synonym not specified Accession: S04098 inside SIMPLE_MOLECULE GDP + CO_sub_2_endsub Long Name: Phosphoenolpyruvate Carboxykinase Synonym: PEPCK Accession: P03135 inside PROTEIN p59 STATE_TRANSITION 0.4158177533526737,-0.02921910300069841 0.711034463231565,-0.01689022809203261 a3 a128 a120 a129 a132 STATE_TRANSITION 0.33333333333333304,-4.440892098500626E-16 0.6666666666666665,-2.220446049250313E-16 a119 a130 a120 a131 a133 STATE_TRANSITION 0.33333333333333337,0.0 0.6666666666666667,0.0 a122 a134 a120 a135 a136 STATE_TRANSITION 0.33321299194381293,0.018291891207162125 0.6665463252771464,0.01829189120716279 a120 a121 STATE_TRANSITION 0.33333333333333326,-1.1102230246251565E-16 0.6666666666666667,-1.1102230246251565E-16 a122 a138 a123 a139 a141 STATE_TRANSITION 0.33333333333333326,4.440892098500626E-16 0.6666666666666667,0.0 a120 a142 a123 a143 a152 STATE_TRANSITION 0.33333333333333326,-8.326672684688674E-17 0.6666666666666667,-1.942890293094024E-16 a120 a145 a124 a147 a148 STATE_TRANSITION 0.28379786701190346,-0.0054226346576662365 0.5676502113935586,-0.00891132268917394 a123 a127 HETERODIMER_ASSOCIATION 0.29619788262703817,0.02589115984766277 0.5923957652540766,0.05178231969532554 0.3333333333333339,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 0.3333333333333348,-4.440892098500626E-16 0.6666666666666679,-4.440892098500626E-16 0.334644918204798,0.37015309772499627 a127 a126 a150 a123 a151 a153 STATE_TRANSITION 0.32065737363714275,0.07308733723562733 0.6539907069704753,0.07308733723562355 a121 a120 a137 HETERODIMER_ASSOCIATION 0.3333333333333335,2.220446049250313E-16 0.6666666666666667,4.440892098500626E-16 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,0.0 0.33333333333333304,2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 0.3333333333333339,0.33333333333333304 a123 a124 a126 a149 STATE_TRANSITION 0.48281007152966815,-0.3486290050545613 0.8407275908873304,-0.2539298437581452 a127 a154 a3 a155 a156