Cell proliferation is tightly regulated by exposure to serum, growth factors, survival factors and other cues from the cellular environment. The Ras signaling pathway plays an important role in transducing these extracellular cues, and stimulating cellular proliferation, differentiation and survival. Activating mutations in the Ras gene are frequently found in human cancers, leading to constitutive signaling throught the pathway and unregulated cell proliferation and survival. Medline=15519853 Medline=9685325 4.0 s27 PROTEIN p15 s27 PROTEIN p16 s27 PROTEIN p17 s100 PROTEIN p5 2 s100 PROTEIN p6 SQUARE_CLOSEUP_NORTHEAST SQUARE_CLOSEUP_NORTHEAST active inactive inactive active inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive active active active active inactive active inactive active inactive inactive inactive inactive active active inactive inactive active active active active inactive inactive inactive active active active active inactive active inactive active inactive active inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active inactive active inactive inactive inactive inactive inactive inactive inactive active inactive Plasma Membrane Nucleus Long Name: Phosphoinositide-3 kinase Synonym: PI3 kinase,PI3K Accession: P04567 inside PROTEIN p10 Long Name: Ral guanine nucleotide dissociation stimulator Synonym: RalGDS Accession: P04551 inside PROTEIN p13 Long Name: T-cell lymphoma invasion and metastasis Synonym: T-cell lymphoma invasion and metastasis Accession: P04571 inside PROTEIN p14 Long Name: Son of sevenless Synonym: SOS Accession: P04552 inside PROTEIN p17 Long Name: Growth factor receptor-bound protein-2 Synonym: Synonym not specified Accession: P04544 inside PROTEIN p16 Long Name: Mitogen activated protein kinase kinase kinase Synonym: MAPKKK,MEK kinase,MEKK1,MEKK4 Accession: P04543 inside PROTEIN p12 Long Name: GTP Synonym: Synonym not specified Accession: S04844 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S04845 inside SIMPLE_MOLECULE GDP Long Name: Rac Synonym: Synonym not specified Accession: P04559 inside PROTEIN p19 Long Name: Rho Synonym: Synonym not specified Accession: P04578 inside PROTEIN p20 Long Name: Cdc42 Synonym: Synonym not specified Accession: P04569 inside PROTEIN p21 Long Name: P21 activated kinase Synonym: PAK Accession: P04553 inside PROTEIN p22 Long Name: Mitogen activated protein kinase kinase 4/7 Synonym: JNK kinase,JNKK,MKK4,MKK7,SEK1 Accession: P04565 inside PROTEIN p23 Long Name: Mitogen activated protein kinase kinase 4/7 Synonym: JNK kinase,JNKK,MKK4,MKK7,SEK1 Accession: P04565 inside PROTEIN p23 Long Name: Jun kinase n-terminal kinase Synonym: JNK,SAPK,stress activated protein kinase Accession: P04572 inside PROTEIN p24 Long Name: Jun kinase n-terminal kinase Synonym: JNK,SAPK,stress activated protein kinase Accession: P04572 inside PROTEIN p24 Long Name: Mixed lineage kinase Synonym: MLK3 Accession: P04562 inside PROTEIN p25 Long Name: TAK Synonym: Synonym not specified Accession: P04575 inside PROTEIN p26 Long Name: Mitogen activated protein kinase kinase Synonym: MAP kinase kinase,MAPKK,MEK Accession: P04557 inside PROTEIN p27 Long Name: Extracellular signal-regulated kinase Synonym: ERK,MAP kinase,MAPK,Mitogen activated protein kinase Accession: P04542 inside PROTEIN p28 Long Name: Mitogen activated protein kinase kinase Synonym: MAP kinase kinase,MAPKK,MEK Accession: P04557 inside PROTEIN p27 Long Name: Extracellular signal-regulated kinase Synonym: ERK,MAP kinase,MAPK,Mitogen activated protein kinase Accession: P04542 inside PROTEIN p28 Long Name: p90 ribosomal S6 kinase Synonym: MAPK-activated protein kinase-1,MAPKAP-KI,p90RSK Accession: P04541 inside PROTEIN p30 Long Name: p90 ribosomal S6 kinase Synonym: MAPK-activated protein kinase-1,MAPKAP-KI,p90RSK Accession: P04541 inside PROTEIN p30 Long Name: Phospholipase D Synonym: PLD Accession: P04574 inside PROTEIN p31 Long Name: Sec5 Synonym: Synonym not specified Accession: P04545 inside PROTEIN p32 Long Name: Ral binding protein 1 Synonym: RLIP76,RalBP1 Accession: P04554 inside PROTEIN p33 Long Name: Raf Synonym: A-Raf,B-Raf,C-RAF,MAPKKK,MEKK,Mitogen activated protein kinase kinase kinase Accession: P04556 inside PROTEIN p11 Long Name: Phosphoinositide dependent kinase Synonym: PDK Accession: P04555 inside PROTEIN p34 Long Name: Mitogen activated protein kinase kinase 3/6 Synonym: MAPKK3/6,MKK3/6 Accession: P04568 inside PROTEIN p37 Long Name: Mitogen activated protein kinase kinase 3/6 Synonym: MAPKK3/6,MKK3/6 Accession: P04568 inside PROTEIN p37 Long Name: p38 mitogen activated protein kinase Synonym: p38,p38MAPK Accession: P04558 inside PROTEIN p38 Long Name: Vesicle Trafficking Synonym: Synonym not specified Accession: U05512 inside PHENOTYPE Vesicle Trafficking Long Name: Survival Synonym: Synonym not specified Accession: U05516 inside PHENOTYPE Survival Long Name: Apoptosis Synonym: Synonym not specified Accession: U05511 inside PHENOTYPE Apoptosis Long Name: Proliferation Synonym: Synonym not specified Accession: U05513 inside PHENOTYPE Proliferation Long Name: Cytoskeletal Reorganization Synonym: Synonym not specified Accession: U05515 inside PHENOTYPE Cytoskeletal Reorganization Long Name: Ets Synonym: Synonym not specified Accession: P04563 inside PROTEIN p39 Long Name: Ets Synonym: Synonym not specified Accession: P04563 inside PROTEIN p39 Long Name: Elk-1 Synonym: Synonym not specified Accession: P04573 inside PROTEIN p45 Long Name: Elk-1 Synonym: Synonym not specified Accession: P04573 inside PROTEIN p45 Long Name: Serum response factor Synonym: SRF Accession: P04561 inside PROTEIN p42 Long Name: Mitogen activated protein kinase activated protein kinase Synonym: MK Accession: P04564 inside PROTEIN p29 Long Name: Mitogen activated protein kinase activated protein kinase Synonym: MK Accession: P04564 inside PROTEIN p29 Long Name: AP1 Synonym: Synonym not specified Accession: P04560 inside PROTEIN p41 Long Name: AP1 Synonym: Synonym not specified Accession: P04560 inside PROTEIN p41 Long Name: Signal transducer and activator of transcription Synonym: STAT Accession: P04566 inside PROTEIN p43 Long Name: Signal transducer and activator of transcription Synonym: STAT Accession: P04566 inside PROTEIN p43 Long Name: Activating transcription factor 2 Synonym: Synonym not specified Accession: P04548 inside PROTEIN p40 Long Name: Activating transcription factor 2 Synonym: Synonym not specified Accession: P04548 inside PROTEIN p40 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05510 Heterodimer Member Info: Grb2#PROTEIN#Growth factor receptor-bound protein-2#P04544##;SOS#PROTEIN#Son of sevenless#P04552#SOS#;Shc#PROTEIN#Shc#P04579## inside COMPLEX Complex_br_(Shc/Grb2/_br_SOS) Long Name: Shc Synonym: Synonym not specified Accession: P04579 inside PROTEIN p15 Long Name: Ras Synonym: Synonym not specified Accession: P04547 inside PROTEIN p4 Long Name: Growth factor receptor Synonym: Synonym not specified Accession: P04549 transmembrane PROTEIN p5 Long Name: Growth factor Synonym: Synonym not specified Accession: P04577 inside PROTEIN p6 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05509 Heterodimer Member Info: Growth factor receptor#PROTEIN#Growth factor receptor#P04549##;Growth factor#PROTEIN#Growth factor#P04577## transmembrane COMPLEX Complex_br_(Growth Factor Receptor/Growth Factor) Long Name: Ral Synonym: Synonym not specified Accession: P04550 inside PROTEIN p18 Long Name: Glycogen synthase kinase 3 Synonym: GSK3 Accession: P04546 inside PROTEIN p36 Long Name: Glycogen synthase kinase 3 Synonym: GSK3 Accession: P04546 inside PROTEIN p36 Long Name: AKT Synonym: PKB,Protein Kinase B Accession: P04570 inside PROTEIN p35 Long Name: AKT Synonym: PKB,Protein Kinase B Accession: P04570 inside PROTEIN p35 Long Name: p38 mitogen activated protein kinase Synonym: p38,p38MAPK Accession: P04558 inside PROTEIN p38 Long Name: Pip2 Synonym: Synonym not specified Accession: S04843 inside SIMPLE_MOLECULE Pip2 Long Name: Pip3 Synonym: Synonym not specified Accession: S04842 inside SIMPLE_MOLECULE Pip3 Long Name: Serum response factor Synonym: SRF Accession: P04561 inside PROTEIN p42 Long Name: p14/19 ARF Synonym: Synonym not specified Accession: P04576 Pathway Link: P04398|P04655|p53 pathway feedback loops 2*P00059|P01482|p53 pathway inside PROTEIN p46 Long Name: p53 pathway Synonym: Synonym not specified Accession: U05514 inside PHENOTYPE p53 pathway STATE_TRANSITION 0.3333333333333335,-1.3322676295501878E-15 0.6666666666666665,-3.1086244689504383E-15 a4 a52 a5 a53 a42 STATE_TRANSITION 0.3333333333333339,0.0 0.6666666666666674,0.0 a16 a30 a5 STATE_TRANSITION 0.33333333333333304,0.0 0.6666666666666661,0.0 a18 a31 a5 STATE_TRANSITION 0.33333333333333304,1.7763568394002505E-15 0.666666666666667,2.6645352591003757E-15 a19 a32 a5 HETERODIMER_ASSOCIATION 0.3333333333333339,-4.440892098500626E-16 0.6666666666666665,0.0 0.3333333333333339,0.0 0.666666666666667,8.881784197001252E-16 0.3333333333333335,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 0.3333333333333339,0.3333333333333335 a35 a36 a34 a42 a120 STATE_TRANSITION 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666665,-2.6645352591003757E-15 a17 a46 a58 a5 STATE_TRANSITION 0.3333333333333339,7.105427357601002E-15 0.6666666666666679,1.2434497875801753E-14 a47 a49 a48 a50 a31 STATE_TRANSITION 0.33333333333333215,0.0 0.6666666666666661,0.0 a54 a58 a32 a60 a59 STATE_TRANSITION 0.3333333333333339,0.0 0.6666666666666679,0.0 a55 a59 a58 STATE_TRANSITION 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666661,-5.329070518200751E-15 a56 a60 a58 STATE_TRANSITION 0.3333333333333339,0.0 0.6666666666666661,-1.7763568394002505E-15 a57 a62 a58 STATE_TRANSITION 0.3333333333333335,-2.6645352591003757E-15 0.6666666666666665,-3.552713678800501E-15 a63 a64 a46 STATE_TRANSITION 0.3333333333333335,3.552713678800501E-15 0.6666666666666661,7.993605777301127E-15 a65 a68 a62 a64 STATE_TRANSITION 0.33333333333333326,-3.552713678800501E-15 0.6666666666666665,-6.217248937900877E-15 a71 a74 a30 STATE_TRANSITION 0.33333333333333326,-2.6645352591003757E-15 0.6666666666666665,-6.217248937900877E-15 a72 a76 a74 STATE_TRANSITION 0.33333333333333304,8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16 a70 a79 a5 STATE_TRANSITION 0.33333333333333304,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a69 a80 a5 STATE_TRANSITION 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 a78 a81 a76 STATE_TRANSITION 0.3333333333333357,-1.7763568394002505E-15 0.6666666666666679,-3.552713678800501E-15 a85 a88 a48 STATE_TRANSITION 0.3333333333333339,-3.552713678800501E-15 0.6666666666666661,-8.881784197001252E-15 a84 a87 a48 STATE_TRANSITION 0.3333333333333357,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 a83 a86 a48 STATE_TRANSITION 0.4522680458627013,-0.009432290582944702 0.7261340229313515,-0.004716145291475016 a77 a82 a76 STATE_TRANSITION 0.2524360910102379,-3.6358311156359235E-4 0.5048721820204762,-7.271662231254084E-4 a15 a89 STATE_TRANSITION 0.2524360910102379,-3.6358311156359235E-4 0.5048721820204762,-7.271662231254084E-4 a15 a89 a5 STATE_TRANSITION 0.33333333333333304,0.0 0.666666666666667,0.0 a90 a91 a122 STATE_TRANSITION 0.3333333333333335,0.0 0.666666666666667,0.0 a92 a93 a91 STATE_TRANSITION 0.3333333333333328,-8.881784197001252E-16 0.6666666666666663,0.0 a94 a95 a93 STATE_TRANSITION 0.33333333333333304,0.0 0.6666666666666661,0.0 a96 a97 a46 a80 a79 STATE_TRANSITION 0.33333333333333304,0.0 0.6666666666666652,0.0 a98 a99 a97 STATE_TRANSITION 0.33333333333333337,0.0 0.6666666666666669,3.552713678800501E-15 a105 a111 a76 INHIBITION 0.33333333333333337,-1.1102230246251565E-16 0.6666666666666669,-3.3306690738754696E-16 a93 a103 STATE_TRANSITION 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666665,-1.7763568394002505E-15 a117 a118 a68 a99 a76 INHIBITION 0.049998102722747295,0.07168143970962615 0.6717601466800571,-0.22384961902087336 a95 a102 INHIBITION 0.025045944861505354,0.06749017378834848 0.7636802510682645,-0.10986423260605593 a95 a104 STATE_TRANSITION 0.3333333333333339,1.7763568394002505E-15 0.6666666666666661,1.7763568394002505E-15 a108 a115 a82 a81 STATE_TRANSITION 0.33333333333333304,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 a107 a114 a68 a81 a76 STATE_TRANSITION 0.3333333333333339,5.329070518200751E-15 0.666666666666667,8.881784197001252E-15 a109 a113 a99 a76 a68 STATE_TRANSITION 0.33333333333333304,0.0 0.6666666666666661,1.7763568394002505E-15 a106 a112 a99 a68 HETERODIMER_ASSOCIATION 0.48212390984412323,0.03843003788804267 0.5913788214107094,0.013005220696007846 0.4736088379295813,-0.02565129779061731 0.3333333333333332,0.33333333333333337 a10 a6 a120 STATE_TRANSITION 0.33333333333333304,8.881784197001252E-16 0.6666666666666663,8.881784197001252E-16 a121 a122 a89 UNKNOWN_TRANSITION 0.26743757028430715,-0.04760885105171753 0.8431701713131132,0.027189716684833998 a5 a123 PHYSICAL_STIMULATION a123 a124 PHYSICAL_STIMULATION a118 a102 PHYSICAL_STIMULATION a115 a102 PHYSICAL_STIMULATION a114 a102 PHYSICAL_STIMULATION a118 a104 PHYSICAL_STIMULATION a115 a104 PHYSICAL_STIMULATION a114 a104 PHYSICAL_STIMULATION a60 a104 PHYSICAL_STIMULATION a59 a104 PHYSICAL_STIMULATION 0.5061168327064283,-0.31854878444473855 a60 a101 PHYSICAL_STIMULATION a58 a104 PHYSICAL_STIMULATION a86 a104 PHYSICAL_STIMULATION 0.3957841820758805,-0.2940237535638539 a59 a101 PHYSICAL_STIMULATION 0.34342313507158906,-0.31762388386931484 a58 a101 PHYSICAL_STIMULATION a87 a100 PHYSICAL_STIMULATION a88 a100