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<celldesigner:proteinReference>p24</celldesigner:proteinReference>
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<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r9"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s73" id="s73" name="FKBP12" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r9"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s41" id="s41" name="RSmads" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s39" id="s39" name="RSmads" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s46" id="s46" name="Complex_br_(Co-Smads/RSmads)" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(Co-Smads/RSmads)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s48" id="s48" name="Complex_br_(Co-Smads/RSmads)" compartment="c3" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(Co-Smads/RSmads)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s56" id="s56" name="Complex_br_(Co-activators_br_corepressors/Co-Smads/_br_RSmads)" compartment="c3" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(Co-activators_br_corepressors/Co-Smads/_br_RSmads)</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re26"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s77" id="s77" name="a92_degraded" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>DEGRADED</celldesigner:class>
<celldesigner:name>a92_degraded</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s58" id="s58" name="I-Smads" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
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<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r12"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s75" id="s75" name="Smurfs" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p26</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s76" id="s76" name="Complex_br_(Smurfs/RSmads)" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(Smurfs/RSmads)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s66" id="s66" name="p42/p44MAPKs" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p17</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
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</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re26"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s60" id="s60" name="p42/p44MAPKs" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p17</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s16" id="s16" name="TGF_beta" compartment="default" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s36" id="s36" name="Complex_br_(TGF_beta_receptor I/TGF_beta_receptor II/_br_TGF_beta)" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(TGF_beta_receptor I/TGF_beta_receptor II/_br_TGF_beta)</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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<celldesigner:catalyzed reaction="r18"/>
<celldesigner:catalyzed reaction="r22"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s78" id="s78" name="I-SMAD" compartment="c3" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn1</celldesigner:geneReference>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s79" id="s79" name="I-SMAD" compartment="c3" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn1</celldesigner:rnaReference>
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</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
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<annotation>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<annotation>
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</annotation>
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</annotation>
</speciesReference>
</listOfReactants>
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<speciesReference metaid="CDMT00004" species="s36">
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<celldesigner:extension>
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</annotation>
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<annotation>
<celldesigner:extension>
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</annotation>
</modifierSpeciesReference>
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</annotation>
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<speciesReference metaid="CDMT00006" species="s39">
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</annotation>
</speciesReference>
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<celldesigner:alias>a42</celldesigner:alias>
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</annotation>
</speciesReference>
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<modifierSpeciesReference metaid="CDMT00008" species="s36">
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</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>a45</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
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</reaction>
<reaction metaid="r12" id="r12" reversible="false">
<annotation>
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<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</annotation>
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</speciesReference>
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<annotation>
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</annotation>
</modifierSpeciesReference>
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<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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</speciesReference>
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</speciesReference>
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<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</annotation>
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<annotation>
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<celldesigner:alias>a57</celldesigner:alias>
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</speciesReference>
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<annotation>
<celldesigner:extension>
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</annotation>
</speciesReference>
</listOfProducts>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<speciesReference metaid="CDMT00019" species="s65">
<annotation>
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<celldesigner:alias>a75</celldesigner:alias>
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</annotation>
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<speciesReference metaid="CDMT00020" species="s59">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a68</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
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<annotation>
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<annotation>
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<modifierSpeciesReference metaid="CDMT00029" species="s36">
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<annotation>
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<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<speciesReference metaid="CDMT00030" species="s67">
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<celldesigner:extension>
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</annotation>
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<speciesReference metaid="CDMT00032" species="s68">
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<reaction metaid="r25" id="r25" reversible="false">
<annotation>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:alias>a72</celldesigner:alias>
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<speciesReference metaid="CDMT00034" species="s70">
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<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00035" species="s68">
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</modifierSpeciesReference>
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<reaction metaid="r26" id="r26" reversible="false">
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<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s69" alias="a82">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s56" aliases="a65" targetLineIndex="-1,4">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s56" alias="a65">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00046" species="s78">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a94</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00047" species="s79">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00048" species="s66">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a69</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00049" species="s70">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a81</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00058" species="s69">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a82</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00059" species="s56">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a65</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re27" id="re27" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSLATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s79" alias="sa40">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s58" alias="a67">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00060" species="s79">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00061" species="s58">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>

