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Boversion of vitamin B1, thiamin, into its coenzyme merely requires the addition of pyrophosphate to the thiamine, at the expense of ATP, by a pyrophosphate transferase.
Website=KEGG - Kyoto Encyclopedia of Genes and Genomes http://www.genome.jp/kegg/
free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal
free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm
free text=Human Metabolism by Ramsey Bronk
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<unit metaid="CDMT00059" kind="mole"/>
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<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00063" kind="second"/>
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<compartment metaid="c8" id="c8" name="Purine metabolism" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>Purine metabolism</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c9" id="c9" name="Glycolysis" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>Glycolysis</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
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<listOfSpecies>
<species metaid="s264" id="s264" name="1-(5&apos;-Phosphoribosyl)-_br_5-aminoimidazole (AIR)" compartment="c8" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  1-(5&apos;-Phosphoribosyl)-5-aminoimidazole (AIR)
Synonym:  Synonym not specified
Accession:  S04210
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>1-(5&apos;-Phosphoribosyl)-_br_5-aminoimidazole (AIR)</celldesigner:name>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s265" id="s265" name="4-Amino-5-hydroxymethyl-_br_2-methylpyrimidine" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  4-Amino-5-hydroxymethyl-2-methylpyrimidine
Synonym:  Synonym not specified
Accession:  S04214
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>4-Amino-5-hydroxymethyl-_br_2-methylpyrimidine</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s266" id="s266" name="4-Amino-2-methyl-_br_5-phosphomethylpyrimidine" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  4-Amino-2-methyl-5-phosphomethylpyrimidine
Synonym:  Synonym not specified
Accession:  S04215
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>4-Amino-2-methyl-_br_5-phosphomethylpyrimidine</celldesigner:name>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s268" id="s268" name="2-Methyl-4-amino_br_5-hydroxymethylpyrimidine_br_diphosphate" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  2-Methyl-4-amino 5-hydroxymethylpyrimidine diphosphate
Synonym:  Synonym not specified
Accession:  S04218
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>2-Methyl-4-amino_br_5-hydroxymethylpyrimidine_br_diphosphate</celldesigner:name>
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</celldesigner:extension>
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</species>
<species metaid="s271" id="s271" name="4-Methyl_br_5-(2-phosphoethyl)-_br_thiazole" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  4-Methyl 5-(2-phosphoethyl)-thiazole
Synonym:  Synonym not specified
Accession:  S04219
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>4-Methyl_br_5-(2-phosphoethyl)-_br_thiazole</celldesigner:name>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s272" id="s272" name="Thiamine_br_phosphate" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine phosphate
Synonym:  Synonym not specified
Accession:  S04208
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Thiamine_br_phosphate</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s273" id="s273" name="Thiamine_br_diphosphate" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine diphosphate
Synonym:  Synonym not specified
Accession:  S04207
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Thiamine_br_diphosphate</celldesigner:name>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s274" id="s274" name="Thiamine_br_triphosphate" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine triphosphate
Synonym:  Synonym not specified
Accession:  S04212
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Thiamine_br_triphosphate</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s277" id="s277" name="Heteropyrithiamine" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Heteropyrithiamine
Synonym:  Synonym not specified
Accession:  S04216
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Heteropyrithiamine</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s278" id="s278" name="Thiamine" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine
Synonym:  Synonym not specified
Accession:  S04220
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s279" id="s279" name="Thiaminealdehyde" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiaminealdehyde
Synonym:  Synonym not specified
Accession:  S04209
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Thiaminealdehyde</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s280" id="s280" name="Thiamine_br_acetic acid" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine acetic acid
Synonym:  Synonym not specified
Accession:  S04217
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Thiamine_br_acetic acid</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s282" id="s282" name="Pyruvate" compartment="c9" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Pyruvate
Synonym:  Synonym not specified
Accession:  S04211
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Pyruvate</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s284" id="s284" name="Glyceraldehyde-3P" compartment="c9" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Glyceraldehyde-3P
Synonym:  Synonym not specified
Accession:  S04206
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Glyceraldehyde-3P</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s285" id="s285" name="Hydroxymethyl_br_pyrimidine kinase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Hydroxymethyl pyrimidine kinase
Synonym:  Synonym not specified
Accession:  P03181
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:catalyzed reaction="r153"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s287" id="s287" name="Phosphomethyl_br_pyrimidine kinase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Phosphomethyl pyrimidine kinase
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Accession:  P03179
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s288" id="s288" name="Hydroxyethyl_br_thiazole kinase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Hydroxyethyl thiazole kinase
Synonym:  Synonym not specified
Accession:  P03183
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p93</celldesigner:proteinReference>
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<celldesigner:catalyzed reaction="r156"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s289" id="s289" name="5-(2-Hydroxyethyl)-_br_4-methylthiazole" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  5-(2-Hydroxyethyl)-4-methylthiazole
Synonym:  Synonym not specified
Accession:  S04213
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>5-(2-Hydroxyethyl)-_br_4-methylthiazole</celldesigner:name>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s290" id="s290" name="Thiamine_br_phosphate diphosphorylase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine phosphate diphosphorylase
Synonym:  Synonym not specified
Accession:  P03187
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:catalyzed reaction="r155"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s291" id="s291" name="Thiamine_br_phosphate kinase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine phosphate kinase
Synonym:  Thiamine monophosphokinase
Accession:  P03178
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p95</celldesigner:proteinReference>
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</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s292" id="s292" name="Thiamine_br_triphosphatase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine triphosphatase
Synonym:  Synonym not specified
Accession:  P03184
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p96</celldesigner:proteinReference>
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</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s294" id="s294" name="Thiamine_br_diphosphate kinase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine diphosphate kinase
Synonym:  Thiamine pyrophosphate kinase
Accession:  P03177
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p98</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
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<celldesigner:catalyzed reaction="r169"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s295" id="s295" name="Nucleoside_br_triphosphatase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Nucleoside triphosphatase
Synonym:  Synonym not specified
Accession:  P03180
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s296" id="s296" name="Thiamine_br_kinase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine kinase
Synonym:  Synonym not specified
Accession:  P03176
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s297" id="s297" name="Thiamine_br_oxidase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine oxidase
Synonym:  Thiamine dehydrogenase
Accession:  P03186
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s298" id="s298" name="Thiamine_br_pyridinylase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiamine pyridinylase
Synonym:  Synonym not specified
Accession:  P03182
</body>
</html>
</notes>
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s299" id="s299" name="Thiaminase" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Thiaminase
Synonym:  Synonym not specified
Accession:  P03185
</body>
</html>
</notes>
<annotation>
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<celldesigner:editPoints>0.33333333333333326,0.0 0.6666666666666665,1.1102230246251565E-16</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s299" aliases="a295" targetLineIndex="-1,3">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00053" species="s278">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a275</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00054" species="s289">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a269</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00055" species="s299">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a295</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="r173" id="r173" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s278" alias="a275"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s265" alias="a266"/>
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<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
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<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
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</celldesigner:connectScheme>
<celldesigner:editPoints>0.2576248715654095,4.640217427331894E-5 0.5909582048987432,4.640217427265281E-5</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:modification type="CATALYSIS" modifiers="s299" aliases="a295" targetLineIndex="-1,2">
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<celldesigner:line width="1.0" color="ff000000"/>
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<listOfReactants>
<speciesReference metaid="CDMT00056" species="s278">
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<celldesigner:alias>a275</celldesigner:alias>
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</speciesReference>
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<listOfProducts>
<speciesReference metaid="CDMT00057" species="s265">
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<celldesigner:extension>
<celldesigner:alias>a266</celldesigner:alias>
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</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00058" species="s299">
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<celldesigner:extension>
<celldesigner:alias>a295</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
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</reaction>
</listOfReactions>
</model>
</sbml>

