Toll-like Receptor Pathway Signaling. 4.0 Long Name: lipopolysaccharide Synonym: Synonym not specified Accession: S01859 s135 SIMPLE_MOLECULE LPS s18 PROTEIN p8 s18 PROTEIN p9 s35 PROTEIN p15 s35 PROTEIN p16 s77 SIMPLE_MOLECULE Poly I:C s77 PROTEIN p34 2 s104 SIMPLE_MOLECULE PAMP s104 PROTEIN p47 2 s114 SIMPLE_MOLECULE PG, LP s114 PROTEIN p50 2 s135 PROTEIN p59 s135 PROTEIN p48 s135 PROTEIN p32 2 s143 PROTEIN p41 s143 PROTEIN p39 s143 PROTEIN p38 s147 PROTEIN p19 s147 PROTEIN p44 s147 PROTEIN p43 s152 PROTEIN p19 s152 PROTEIN p44 s152 PROTEIN p43 s152 PROTEIN p56 s152 PROTEIN p52 s155 PROTEIN p1 2 s155 SIMPLE_MOLECULE PAMP s156 PROTEIN p3 s156 PROTEIN p4 s157 PROTEIN p30 s157 PROTEIN p37 s152 PROTEIN p7 OVAL SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive active inactive active inactive active inactive inactive active active inactive active active inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active active inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive nucleus cell surface Long Name: Toll-like receptor 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 Synonym: TLR Accession: P01346 transmembrane PROTEIN p1 Long Name: Pathogen-associated microbial pattern Synonym: Synonym not specified Accession: S01858 inside SIMPLE_MOLECULE PAMP Long Name: IL-1 receptor-associated kinase M Synonym: IRAKM Accession: P01378 inside PROTEIN p6 Long Name: Long Name: Ubc13 Synonym: Synonym not specified Accession: U05563 Heterodimer Member Info: Uev1A#PROTEIN#Uev1A#P01376#TRAF-6-regulated IKK activator|TRIKA1|Uev1A#;Ubc13#PROTEIN#Ubc13#P01381#TRAF-6-regulated IKK activator|TRIKA1# inside COMPLEX Complex_br_(Ubc13/Uev1A) Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01864 inside SIMPLE_MOLECULE Ubiquitin Long Name: IRAK1 Synonym: IL-1 receptor-associated kinase 1,IRAK1,Pelle Accession: P01343 inside PROTEIN p4 Long Name: IkappaB_beta kinase Synonym: IKK2 Accession: P01360 inside PROTEIN p12 Long Name: mitogen-activated protein kinase kinase 6 Synonym: MKK6 Accession: P01362 inside PROTEIN p14 Long Name: mitogen-activated protein kinase kinase 6 Synonym: MKK6 Accession: P01362 inside PROTEIN p14 Long Name: IkappaB Synonym: Inhibitor nuclear factor-kappaB,cactus Accession: P01338 inside PROTEIN p15 Long Name: Long Name: IkappaB Synonym: Synonym not specified Accession: U05567 Heterodimer Member Info: IkappaB#PROTEIN#IkappaB#P01338#Inhibitor nuclear factor-kappaB|cactus#;NF-kappaB#PROTEIN#NF-kappaB#P01354#NF-kB|nuclear factor-kappaB# inside COMPLEX Complex_br_(I_kappa_B/NF-_kappa_B) Long Name: c-jun N-terminal kinase Synonym: JNK,c-jun N-terminal kinase Accession: P01375 inside PROTEIN p17 Long Name: c-jun N-terminal kinase Synonym: JNK,c-jun N-terminal kinase Accession: P01375 inside PROTEIN p17 Long Name: activator protein-1 Synonym: AP1,activator protein-1,c-FOS,c-JUN Accession: P01355 inside PROTEIN p18 Long Name: activator protein-1 Synonym: AP1,activator protein-1,c-FOS,c-JUN Accession: P01355 inside PROTEIN p18 Long Name: IRAK4 Synonym: IL-1 receptor-associated kinase 4,IRAK4,Pelle Accession: P01342 inside PROTEIN p3 Long Name: p38 Synonym: Synonym not specified Accession: P01352 inside PROTEIN p20 Long Name: p38 Synonym: Synonym not specified Accession: P01352 inside PROTEIN p20 Long Name: mitogen-activated protein kinase kinase 3 Synonym: MKK3,mitogen-activated protein kinase kinase 3 Accession: P01367 inside PROTEIN p21 Long Name: mitogen-activated protein kinase kinase 3 Synonym: MKK3,mitogen-activated protein kinase kinase 3 Accession: P01367 inside PROTEIN p21 Long Name: TPL2 Synonym: EST,ESTF,Ewing sarcoma transformant,MAP3K8,MAPKKK,Tumor progression locus 2,cot (cancer Osaka thyroid) oncogene,mitogen-activated protein kinase kinase kinase 8 Accession: P01364 inside PROTEIN p22 Long Name: TPL2 Synonym: EST,ESTF,Ewing sarcoma transformant,MAP3K8,MAPKKK,Tumor progression locus 2,cot (cancer Osaka thyroid) oncogene,mitogen-activated protein kinase kinase kinase 8 Accession: P01364 inside PROTEIN p22 Long Name: mitogen-activated protein kinase kinase 1 Synonym: MKK1 Accession: P01369 inside PROTEIN p23 Long Name: mitogen-activated protein kinase kinase 1 Synonym: MKK1 Accession: P01369 inside PROTEIN p23 Long Name: mitogen-activated protein kinase kinase 2 Synonym: MKK2 Accession: P01368 inside PROTEIN p24 Long Name: mitogen-activated protein kinase kinase 2 Synonym: MKK2 Accession: P01368 inside PROTEIN p24 Long Name: extracellular signal-regulated kinase 1 Synonym: ERK-1,ERK1,MAP kinase 1,MAPK1,p42 Accession: P01358 inside PROTEIN p25 Long Name: extracellular signal-regulated kinase 2 Synonym: ERK2,p44 Accession: P01356 inside PROTEIN p26 Long Name: extracellular signal-regulated kinase 1 Synonym: ERK-1,ERK1,MAP kinase 1,MAPK1,p42 Accession: P01358 inside PROTEIN p25 Long Name: extracellular signal-regulated kinase 2 Synonym: ERK2,p44 Accession: P01356 inside PROTEIN p26 Long Name: ? Synonym: Synonym not specified Accession: P01382 inside PROTEIN p27 Long Name: Long Name: Poly I:C Synonym: Synonym not specified Accession: U05568 Heterodimer Member Info: TLR3#PROTEIN#Toll-like receptor 3#P01340#TLR3|Toll-like receptor 3#;Poly I:C#SIMPLE_MOLECULE#Poly I:C#S01861## transmembrane COMPLEX Complex_br_(Poly I:C/TLR3) Long Name: TIR domain-containing adaptor inducing interferon (IFN)-beta Synonym: TICAM-1,TIR-containing adaptor molecule ,TRIF Accession: P01344 inside PROTEIN p33 2 Long Name: myeloid differentiation factor 88 Synonym: DmMyD88 Accession: P01377 inside PROTEIN p37 2 Long Name: TIR domain-containing adaptor inducing interferon (IFN)-beta Synonym: TICAM-1,TIR-containing adaptor molecule ,TRIF Accession: P01344 inside PROTEIN p33 Long Name: TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR Synonym: ITRAF,TANK,TRAF-INTERACTING PROTEIN Accession: P01353 inside PROTEIN p38 Long Name: TANK-binding kinase 1 Synonym: TBK1 Accession: P01361 inside PROTEIN p39 Long Name: IkappaB_epsilon Kinase Synonym: IKK-epsilon Accession: P01372 inside PROTEIN p41 Long Name: IkappaB_gamma Kinase Synonym: IKK-gamma,NEMO,NF-kappaB essential modulator Accession: P01359 inside PROTEIN p42 Long Name: TAK1 binding protein 2 Synonym: Synonym not specified Accession: P01363 inside PROTEIN p44 Long Name: transforming-growth factor beta-activated kinase 1 Synonym: MAP3K,MAPK kinase kinase,MAPKKK,TAK1,mitogen-activated protein kinase kinase kinase 7,transforming-growth factor beta-activated kinase Accession: P01370 inside PROTEIN p19 Long Name: transforming-growth factor beta-activated kinase 1 Synonym: MAP3K,MAPK kinase kinase,MAPKKK,TAK1,mitogen-activated protein kinase kinase kinase 7,transforming-growth factor beta-activated kinase Accession: P01370 inside PROTEIN p19 Long Name: Long Name: Pathogen-associated microbial pattern Synonym: Synonym not specified Accession: U05561 Heterodimer Member Info: PAMP#SIMPLE_MOLECULE#Pathogen-associated microbial pattern#S01858##;TLR2,4,7#PROTEIN#Toll-like receptor 2, 4, 7#P01351#TLR2,47# transmembrane COMPLEX Complex_br_(PAMP/TLR2,4,7) Long Name: Toll-interacting protein Synonym: Tollip Accession: P01379 inside PROTEIN p5 Long Name: Long Name: peptidoglycan Synonym: Synonym not specified Accession: U05569 Heterodimer Member Info: PG, LP#SIMPLE_MOLECULE#peptidoglycan#S01863##;TLR1,2,6#PROTEIN#Toll-like receptor 1, 2, 6#P01380#TLR1,2,6# transmembrane COMPLEX Complex_br_(PG, LP/TLR1,2,6) Long Name: Toll-interacting protein Synonym: Tollip Accession: P01379 inside PROTEIN p5 Long Name: IkappaB_beta kinase Synonym: IKK2 Accession: P01360 inside PROTEIN p12 Long Name: evolutionarily conserved signaling intermediate in Toll pathways Synonym: ECSIT Accession: P01349 inside PROTEIN p52 Long Name: ELK1 Synonym: ELK-1,ETS-like gene 1 Accession: P01341 inside PROTEIN p53 Long Name: ELK1 Synonym: ELK-1,ETS-like gene 1 Accession: P01341 inside PROTEIN p53 Long Name: mitogen-activated or extracellular signal-regulated kinase kinase kinase 1 Synonym: MAP3K,MEKK1 Accession: P01357 inside PROTEIN p56 Long Name: mitogen-activated protein kinase kinase 4 Synonym: MKK4 Accession: P01366 inside PROTEIN p57 Long Name: mitogen-activated protein kinase kinase 4 Synonym: MKK4 Accession: P01366 inside PROTEIN p57 Long Name: IkappaB_alpha Kinase Synonym: IKKalpha,IkappaB_alpha Kinase Accession: P01345 inside PROTEIN p51 Long Name: IkappaB_alpha Kinase Synonym: IKKalpha,IkappaB_alpha Kinase Accession: P01345 inside PROTEIN p51 Long Name: IRAK4 Synonym: IL-1 receptor-associated kinase 4,IRAK4,Pelle Accession: P01342 inside PROTEIN p3 Long Name: IRAK1 Synonym: IL-1 receptor-associated kinase 1,IRAK1,Pelle Accession: P01343 inside PROTEIN p4 Long Name: ATP Synonym: Synonym not specified Accession: S01860 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01862 inside SIMPLE_MOLECULE ADP Long Name: myeloid differentiation factor 88 Synonym: DmMyD88 Accession: P01377 inside PROTEIN p37 Long Name: A20 Synonym: tumor necrosis factor, alpha-induced protein 3 Accession: P01348 inside PROTEIN p58 Long Name: Long Name: Toll-like receptor 4 Synonym: Synonym not specified Accession: U05572 Heterodimer Member Info: TLR4#PROTEIN#Toll-like receptor 4#P01339#TLR4#;MD-2#PROTEIN#MD-2#P01347#MD2|lyphocyte antigen 96#;CD14#PROTEIN#CD14#P01373#LPS receptor|LPS-R # transmembrane COMPLEX Complex_br_(MD-2/CD14/_br_TLR4) Long Name: TIR domain-containing adaptor protein Synonym: MAL,MyD88-adaptor-like,TIRAP Accession: P01350 inside PROTEIN p30 Long Name: Interferon (INF) regulatory factor 3 Synonym: IRF3 Accession: P01374 inside PROTEIN p46 Long Name: Interferon (INF) regulatory factor 3 Synonym: IRF3 Accession: P01374 inside PROTEIN p46 Long Name: NF-kappaB Synonym: NF-kB,nuclear factor-kappaB Accession: P01354 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05566 Heterodimer Member Info: TANK#PROTEIN#TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR#P01353#ITRAF|TANK|TRAF-INTERACTING PROTEIN#;TBK1#PROTEIN#TANK-binding kinase 1#P01361#TBK1#;IKKepsilon#PROTEIN#IkappaB_epsilon Kinase#P01372#IKK-epsilon# inside COMPLEX Complex_br_(IKK_epsilon_/TBK1/_br_TANK) Long Name: TAK1 binding protein 2 Synonym: Synonym not specified Accession: P01363 inside PROTEIN p44 Long Name: Transforming growth factor-beta-activated kinase (TAK)-binding protein 1 (TAB1) Synonym: Synonym not specified Accession: P01365 inside PROTEIN p43 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05565 Heterodimer Member Info: TAB2#PROTEIN#TAK1 binding protein 2 #P01363##;TAB1#PROTEIN#Transforming growth factor-beta-activated kinase (TAK)-binding protein 1 (TAB1)#P01365##;TAK1#PROTEIN#transforming-growth factor beta-activated kinase 1#P01370#MAP3K|MAPK kinase kinase|MAPKKK|TAK1|mitogen-activated protein kinase kinase kinase 7|transforming-growth factor beta-activated kinase# inside COMPLEX Complex_br_(TAK1/TAB2/_br_TAB1) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05564 Heterodimer Member Info: ECSIT#PROTEIN#evolutionarily conserved signaling intermediate in Toll pathways#P01349#ECSIT#;MEKK1#PROTEIN#mitogen-activated or extracellular signal-regulated kinase kinase kinase 1#P01357#MAP3K|MEKK1#;TAB2#PROTEIN#TAK1 binding protein 2 #P01363##;TAB1#PROTEIN#Transforming growth factor-beta-activated kinase (TAK)-binding protein 1 (TAB1)#P01365##;TAK1#PROTEIN#transforming-growth factor beta-activated kinase 1#P01370#MAP3K|MAPK kinase kinase|MAPKKK|TAK1|mitogen-activated protein kinase kinase kinase 7|transforming-growth factor beta-activated kinase#;TRAF6#PROTEIN#tumor necrosis factor (TNF) receptor-associated factor 6#P01371#TRAF6|dTRAF|tumor necrosis factor (TNF) receptor-associated factor 6# inside COMPLEX Complex_br_(TAK1/TRAF6/_br_TAB2/TAB1/_br_MEKK1/ECSIT) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05562 Heterodimer Member Info: PAMP#SIMPLE_MOLECULE#Pathogen-associated microbial pattern#S01858##;TLR#PROTEIN#Toll-like receptor 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12#P01346#TLR# transmembrane COMPLEX Complex_br_(TLR/PAMP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05570 Heterodimer Member Info: IRAK4#PROTEIN#IRAK4#P01342#IL-1 receptor-associated kinase 4|IRAK4|Pelle#;IRAK1#PROTEIN#IRAK1#P01343#IL-1 receptor-associated kinase 1|IRAK1|Pelle# inside COMPLEX Complex_br_(IRAK4/IRAK1) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05571 Heterodimer Member Info: TIRAP#PROTEIN#TIR domain-containing adaptor protein#P01350#MAL|MyD88-adaptor-like|TIRAP#;MyD88#PROTEIN#myeloid differentiation factor 88 #P01377#DmMyD88# inside COMPLEX Complex_br_(TIRAP/MyD88) inside RNA rn1 inside GENE gn1 Long Name: tumor necrosis factor (TNF) receptor-associated factor 6 Synonym: TRAF6,dTRAF,tumor necrosis factor (TNF) receptor-associated factor 6 Accession: P01371 inside PROTEIN p7 Long Name: tumor necrosis factor (TNF) receptor-associated factor 6 Synonym: TRAF6,dTRAF,tumor necrosis factor (TNF) receptor-associated factor 6 Accession: P01371 inside PROTEIN p7 Long Name: tumor necrosis factor (TNF) receptor-associated factor 6 Synonym: TRAF6,dTRAF,tumor necrosis factor (TNF) receptor-associated factor 6 Accession: P01371 inside PROTEIN p7 STATE_TRANSITION 0.33192809451712213,0.03135873838646219 0.5525986499440512,0.038011199923182915 a24 a29 a28 a27 STATE_TRANSITION 0.33754944099452455,0.010528206204700297 0.6087215481775079,0.014651182288200282 a40 a42 a41 a43 a65 STATE_TRANSITION 0.4044442966851971,5.243014960880643E-4 0.5880372152150892,-0.005674594371486652 a49 a53 a48 a54 a198 a35 a183 a203 STATE_TRANSITION 0.29748008793432223,-0.0029926823844173 0.5585835011699531,-0.003760596625120627 a55 a57 a56 a58 a41 a180 a69 STATE_TRANSITION 0.36102584126233506,-3.1488533956114395E-4 0.6922758711886692,-0.011950727773776038 a59 a61 a60 a62 a68 a56 STATE_TRANSITION 0.2854124756365737,1.0497100901751821E-4 0.6326148586182132,-0.007529190940301689 a67 a71 a69 a70 a65 STATE_TRANSITION 0.2777823368778609,5.835648093821533E-4 0.6580175426242008,-0.013070783419273369 a66 a72 a68 a73 a69 STATE_TRANSITION 0.19909838924370415,0.007207902114999776 0.6868611514916418,-0.005412403282591072 a74 a150 a75 a142 a84 STATE_TRANSITION 0.3143901692636448,0.009093570348404967 0.5513492630636998,9.803655218423302E-4 a76 a136 a77 a141 a75 STATE_TRANSITION 0.3828334491681719,-0.013580888932207102 0.6338491035677156,-0.011054471178085556 a78 a135 a79 a140 a75 STATE_TRANSITION 0.3754068112149893,-0.01208048942497264 0.7039991243755828,-0.014830516620178535 a80 a149 a83 a147 a77 STATE_TRANSITION 0.3683709674572524,-0.01804631907275489 0.6083750128941403,-0.020865591346779233 a81 a148 a82 a146 a79 STATE_TRANSITION 0.38561195468890297,-0.011182687049255957 0.5868451353522133,-0.017839213692450562 a113 a139 a24 a143 a92 STATE_TRANSITION 0.3805138808255888,9.138857227455333E-4 0.761030628801304,0.0016744744855410332 a131 a138 a65 a145 a92 STATE_TRANSITION 0.27691529603200415,-0.01096061134454418 0.5537015988580372,-0.017496755724318414 a22 a158 a157 a160 a3 HETERODIMER_ASSOCIATION 0.3715991960953211,0.25700832615561 a126 a171 a172 STATE_TRANSITION 0.18545494318879108,0.006710261488774627 0.6023951592829935,0.007899536277580665 a172 a36 a35 a37 a65 a223 STATE_TRANSITION 0.268347667109893,-0.004733544362494513 0.5880061671738996,-0.0046701433815012905 a174 a176 a175 a177 a82 a83 STATE_TRANSITION 0.3131476999399032,0.003739226404329443 0.5988403050531899,0.005811891860100893 a179 a181 a180 a182 a223 STATE_TRANSITION 0.33333333333332504,3.552713678800501E-15 0.666666666666659,2.6645352591003757E-15 a171 a184 a183 a185 a65 a223 STATE_TRANSITION 0.32880570508964313,-0.0014941808515072097 0.7609110501403316,0.0072074900350873605 a193 a194 a151 a195 a203 HETERODIMER_ASSOCIATION 0.5484672630700054,0.004571452830123945 0.4716430864412384,0.5371284478934832 a201 a125 a122 a203 STATE_TRANSITION 0.3108205927669001,0.008314159432666113 0.6216314726406722,0.013034548407308222 a130 a137 a207 a144 a92 HETERODIMER_ASSOCIATION -0.006656826828956852,0.38674966135391076 a207 a208 a65 a211 HETERODIMER_ASSOCIATION 0.4094687811308928,0.0743555093140098 a28 a211 a173 a178 a223 STATE_TRANSITION 0.3741841054734758,-0.16706192622179894 0.6452809950032194,-0.11319556398610042 a1 a15 a226 STATE_TRANSITION 0.4076678427786389,-0.04602797528021707 0.7034512931740826,-0.03250316737797165 a120 a119 a226 STATE_TRANSITION a17 a3 a119 a232 STATE_TRANSITION 0.33333333333334636,-8.881784197001252E-16 0.6666666666666821,-2.6645352591003757E-15 a121 a116 a112 a156 HETERODIMER_ASSOCIATION 0.24602203182374582,0.38882088943288395 a4 a3 a229 DISSOCIATION -0.047225203611337724,0.47111560073236713 a229 a19 a92 a93 a20 HETERODIMER_ASSOCIATION 0.4780782438670901,-0.034371995425557245 0.5871370317643567,-0.019869296954464488 0.5975742017615033,0.015531940031838332 0.32577033531197497,0.33585653521591485 a164 a88 a232 a170 a189 TRANSCRIPTION a51 sa142 a60 a198 a151 a175 UNKNOWN_TRANSITION sa143 a125 a116 UNKNOWN_TRANSITION a28 sa144 a186 UNKNOWN_TRANSITION a93 sa145 a23 UNKNOWN_TRANSITION a92 sa146 a23