This pathway represents the signal transduction cascade initiated afterthe vascaular endothelial growth factor (VEGF) binds to its receptor VEGFR-2. VEGF can also bind to VEGFR-1, but less is known about the pathway resulting from the activation of that receptor. Activation of VEGFR-2 results in the increased proliferation, survival and migration of blood endothelial cells required for angiogenesis. Medline=11741095 Medline=12778165 Medline=13678960 4.0 s44 PROTEIN p1 s44 PROTEIN p2 s50 PROTEIN p11 s50 ION Ca_super_2+_endsuper s71 PROTEIN p24 s71 ION Ca_super_2+_endsuper OVAL SQUARE_CLOSEUP_NORTHWEST SQUARE_CLOSEUP_NORTH inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active inactive active inactive inactive inactive inactive active active active active active inactive active active inactive inactive inactive active inactive active inactive active inactive active active ER Nucleus Cytoplasm Long Name: Vascular Endothelial Growth Factor Receptor-2 Synonym: Flk-1,KDR,Kinase Insert Domain Receptor,Tyrosine Kinase Growth Factor Receptor Accession: P01403 transmembrane PROTEIN p1 Long Name: Vascular Endothelial Growth Factor Synonym: VEGF-A Accession: P01406 inside PROTEIN p2 Long Name: Caspase 9 Synonym: APAF3,Apoptotic Protease Activating Factor 3 Accession: P01410 inside PROTEIN p9 Long Name: Bcl-2 antagonist of cell death Synonym: BCL2-Binding Component 6,BCL2-Binding Protein,BCL2L8 Accession: P01416 inside PROTEIN p10 Long Name: endothelial nitric oxide synthase Synonym: NOS3,Nitric Oxide Synthase 3,eNOS Accession: P01422 inside PROTEIN p11 Long Name: VEGFR-Associated Protein Synonym: SH2 Domain Protein 2A,SH2D2A,T-Cell SH2 Domain-Containing Adaptor Protein,TSAD Accession: P01405 inside PROTEIN p14 Long Name: Phosphatidylinositol (3,4,5)-triphosphate Synonym: Synonym not specified Accession: S01873 inside SIMPLE_MOLECULE PIP3 Long Name: sn-1,2-diacylglycerol Synonym: Synonym not specified Accession: S01872 inside SIMPLE_MOLECULE DAG Long Name: Inositol (1,4,5)-triphosphate Synonym: Synonym not specified Accession: S01874 inside SIMPLE_MOLECULE IP3 Long Name: v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 Synonym: Ets1 Oncogene Accession: P01419 inside PROTEIN p25 Long Name: Hypoxia-Inducible Factor 1 Synonym: MOP1,Member of PAS Superfamily 1 Accession: P01401 inside PROTEIN p26 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05586 Heterodimer Member Info: VEGFR-2#PROTEIN#Vascular Endothelial Growth Factor Receptor-2#P01403#Flk-1|KDR|Kinase Insert Domain Receptor|Tyrosine Kinase Growth Factor Receptor#;VEGF#PROTEIN#Vascular Endothelial Growth Factor#P01406#VEGF-A# transmembrane COMPLEX Complex_br_(VEGFR-2/VEGF) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05587 Heterodimer Member Info: Ca2+#ION#Long Name: Ca2+#U05589##;eNOS#PROTEIN#endothelial nitric oxide synthase#P01422#NOS3|Nitric Oxide Synthase 3|eNOS# inside COMPLEX Complex_br_(eNOS/Ca_super_2+_endsuper) Long Name: Phosphatidylinositol 3-Kinase Synonym: Synonym not specified Accession: P01413 inside PROTEIN p3 Long Name: p38 Mitogen-Activated Protein Kinase Synonym: CSAID-Binding Protein 1,CSBP1,Cytokine-Suppressive Anti-Inflammatory Drug-Binding Protein 1,MAPK14,MXI2,Mitogen-Activated Protein Kinase 14,RK,SAPK2A,Stress-Activated Protein Kinase 2A,p38,p38-Alpha Accession: P01423 inside PROTEIN p4 Long Name: Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 and 3 Synonym: 3PK,MAPKAP KINASE 2/3,MAPKAP3 Accession: P01415 inside PROTEIN p5 Long Name: Heat-Shock Protein 27 Synonym: HSPB1 Accession: P01412 inside PROTEIN p6 Long Name: Rho GTPase Synonym: CDC42,Cell Division Cycle 42 Accession: P01421 inside PROTEIN p7 Long Name: Thymoma Viral Proto-Oncogene Synonym: Oncogene Akt,PKB,Protein Kinase B,RAC Serine/Threonine Protein Kinase Accession: P01408 inside PROTEIN p8 Long Name: Focal Adhesion Kinase Synonym: Cytoplasmic Protein-Tyrosine Kinase ,FAK1,Focal Adhesion Kinase 1,PTK2 Accession: P01420 inside PROTEIN p12 Long Name: Paxillin Synonym: PXN Accession: P01418 inside PROTEIN p13 Long Name: Phospholipase C-gamma Synonym: PHOSPHOLIPASE C-148,PLC1,PLC148,PLCG1 Accession: P01414 inside PROTEIN p15 Long Name: Shc-Like Protein Synonym: Shc Adaptor Homolog Accession: P01424 inside PROTEIN p16 Long Name: Protein Kinase C Synonym: Synonym not specified Accession: P01425 inside PROTEIN p17 Long Name: Sphingosine Kinase Synonym: SPHK Accession: P01404 inside PROTEIN p18 Long Name: Ras Synonym: H-Ras,K-Ras,N-Ras,p21 Accession: P01411 inside PROTEIN p19 Long Name: Raf Oncogene Synonym: CRAF,Oncogene MIL,Oncogene Raf1,Transforming Replication-Defective Murine Retrovirus 3611-MSV,v-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 Accession: P01417 inside PROTEIN p20 Long Name: MAPK/ERK Kinase Synonym: MAP2K,MAPKK,MKK,Mitogen-Activated Protein Kinase Kinase,PRKMK,Protein Kinase, Mitogen-Activated, Kinase Accession: P01402 inside PROTEIN p21 Long Name: Extracellular Signal-Regulated Kinase Synonym: JNK-Activated Kinase1,JNKK1,MAP2K4,MAPK/ERK KINASE 4,MAPKK4,MEK4,MKK4,Mitogen-Activated Protein Kinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1 Accession: P01407 inside PROTEIN p22 Long Name: Cytoplasmic Phospholipase A2 Synonym: CPLA2,PLA2 Accession: P01409 inside PROTEIN p24 Long Name: Long Name: PIP2 Synonym: Synonym not specified Accession: S04857 inside SIMPLE_MOLECULE PIP_sub_2_endsub Long Name: Long Name: Ca2+ Synonym: Synonym not specified Accession: U05589 inside ION Ca_super_2+_endsuper Long Name: Long Name: Ca2+ Synonym: Synonym not specified Accession: U05589 inside ION Ca_super_2+_endsuper Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05588 Heterodimer Member Info: cPLA2#PROTEIN#Cytoplasmic Phospholipase A2#P01409#CPLA2|PLA2#;Ca2+#ION#Long Name: Ca2+#U05589## inside COMPLEX Complex_br_(cPLA_sub_2_endsub/Ca_super_2+_endsuper) STATE_TRANSITION 0.3333333333333335,0.0 0.666666666666667,0.0 a46 a79 a17 a28 STATE_TRANSITION 0.3333333333333335,0.0 0.666666666666667,-3.552713678800501E-15 a49 a18 a17 STATE_TRANSITION 0.33333333333333215,0.0 0.6666666666666643,0.0 a19 a52 a18 STATE_TRANSITION 0.33333333333333215,0.0 0.6666666666666643,0.0 a20 a51 a52 STATE_TRANSITION 0.33333333333333215,0.0 0.6666666666666679,0.0 a21 a50 a51 STATE_TRANSITION 0.3333333333333339,-8.881784197001252E-16 0.6666666666666696,-3.552713678800501E-15 a22 a53 a50 STATE_TRANSITION 0.27802231792334275,0.0027124128577868944 0.5560446358466837,0.005424825715573789 a42 a54 a53 STATE_TRANSITION 0.3333333333333304,1.7763568394002505E-15 0.6666666666666661,1.7763568394002505E-15 a41 a55 a53 DISSOCIATION 0.3333333333333339,3.885780586188048E-16 0.6666666666666679,3.885780586188048E-16 0.33333333333333215,0.0 0.6666666666666679,0.0 0.3333333333333357,0.0 0.6666666666666679,-8.881784197001252E-16 0.3333333333333339,0.33333333333333304 a26 a28 a39 a15 TRANSPORT 0.3333333333333357,-2.220446049250313E-16 0.6666666666666679,1.1102230246251565E-15 a40 a36 a39 HETERODIMER_ASSOCIATION 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666665,0.0 0.33333333333333215,-2.6645352591003757E-15 0.6666666666666661,-2.6645352591003757E-15 0.3333333333333348,-1.1102230246251565E-16 0.666666666666667,3.3306690738754696E-16 0.33333333333333304,0.3333333333333335 a60 a59 a63 STATE_TRANSITION 0.3333333333333339,0.0 0.6666666666666679,-1.7763568394002505E-15 a56 a15 a63 STATE_TRANSITION 0.33333333333333304,0.0 0.6666666666666661,-4.440892098500626E-16 a14 a57 a63 STATE_TRANSITION 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,-4.440892098500626E-16 a58 a16 a63 STATE_TRANSITION 0.3333333333333335,1.3322676295501878E-15 0.666666666666667,1.7763568394002505E-15 a13 a65 a64 STATE_TRANSITION 0.33333333333333304,4.440892098500626E-16 0.6666666666666665,1.7763568394002505E-15 a12 a64 a63 STATE_TRANSITION a4 a66 a63 STATE_TRANSITION a5 a67 a66 STATE_TRANSITION 0.3333333333333326,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 a6 a68 a67 STATE_TRANSITION 0.2962672503599322,-0.012048427812828777 0.592534500719863,-0.024096855625656666 a70 a3 a63 STATE_TRANSITION 0.3333333333333335,-2.6645352591003757E-15 0.666666666666667,-6.217248937900877E-15 a25 a27 a3 STATE_TRANSITION 0.3333333333333335,4.440892098500626E-16 0.666666666666667,1.3322676295501878E-15 a7 a71 a27 STATE_TRANSITION 0.33333333333333326,1.3322676295501878E-15 0.6666666666666667,2.6645352591003757E-15 a8 a72 a27 STATE_TRANSITION 0.18878325050579092,-0.001171562657090952 0.6183905253841389,0.0034598632249132066 a73 a76 a77 a72 STATE_TRANSITION 0.4730940763078282,0.007357079356143714 0.7365470381539136,0.0036785396780736335 a24 a31 a78 a53 STATE_TRANSITION a9 sa62 a8 STATE_TRANSITION a10 sa63 a8