The secreted protein Wnt activates the heptahelical receptor Frizzled on nieghboring cells. Activation of Frizzled causes the recruitment of additional membrane proteins which in turn result in 1) the activation of the protein Dishevelled via phosphorylation and 2) the activation of a heterotrimeric G protein of unknown type. Activation of Dishevelled results in the down-regulation of the Beta-Catenin destruction complex which causes ubiquitination of Beta-Catenin and its ultimate degradation via the proteasome. Inhibition of the Beta-Catenin destruction complex yields a higher cytosolic concentration of Beta-Catenin, which enters the nucleus, binds various transcriptional regulatory molecules including the TCF/LEF class of proteins, and results in the transcription of TCF/LEF target genes. Activation of the heterotrimeric G-protein pathway in turn activates Phospholipase C which in turn catalyzes the catalysis of PI(4,5)P2 into DAG and IP3. Medline=12356903 Medline=12573432 Website=http://www.biocarta.com/pathfiles/h_wntPathway.asp Website=http://www.infobiogen.fr/services/chromcancer/Deep/WNTsignPathID20042.html 4.0 s16 PROTEIN p5 s16 PROTEIN p1 s21 PROTEIN p10 s21 PROTEIN p7 s27 PROTEIN p1 s27 PROTEIN p5 s27 PROTEIN p6 s75 PROTEIN p24 s75 PROTEIN p23 s101 PROTEIN p23 s101 PROTEIN p24 s107 PROTEIN p2 s107 PROTEIN p12 s107 PROTEIN p28 s108 PROTEIN p12 s108 PROTEIN p2 s120 PROTEIN p18 s120 PROTEIN p29 s121 PROTEIN p18 s121 PROTEIN p29 s121 PROTEIN p17 s155 PROTEIN p17 s155 PROTEIN p18 s155 PROTEIN p22 s155 PROTEIN p15 s155 PROTEIN p20 s155 PROTEIN p29 s164 PROTEIN p17 s164 PROTEIN p18 s164 PROTEIN p29 s175 PROTEIN p30 s175 PROTEIN p31 s174 PROTEIN p32 s174 PROTEIN p34 s123 PROTEIN p17 s123 PROTEIN p18 s123 PROTEIN p19 s123 PROTEIN p29 s129 PROTEIN p17 s129 PROTEIN p18 s129 PROTEIN p22 s129 PROTEIN p19 s129 PROTEIN p29 s159 PROTEIN p17 s159 PROTEIN p18 s159 PROTEIN p29 s159 PROTEIN p19 s159 PROTEIN p23 s159 PROTEIN p24 s176 PROTEIN p32 s176 PROTEIN p34 s176 PROTEIN p19 s179 PROTEIN p32 s179 PROTEIN p19 s179 PROTEIN p34 s179 PROTEIN p35 s183 PROTEIN p35 s183 PROTEIN p19 s183 PROTEIN p32 s183 PROTEIN p34 s183 PROTEIN p36 s188 PROTEIN p19 s188 PROTEIN p32 s188 PROTEIN p34 s188 PROTEIN p35 s188 PROTEIN p36 s188 PROTEIN p38 s194 PROTEIN p35 s194 PROTEIN p36 s194 PROTEIN p19 s194 PROTEIN p38 s194 PROTEIN p37 s194 PROTEIN p32 s194 PROTEIN p34 s245 PROTEIN p17 s245 PROTEIN p19 s245 PROTEIN p18 s245 PROTEIN p29 s245 PROTEIN p22 s245 PROTEIN p15 s252 PROTEIN p17 s252 PROTEIN p19 s252 PROTEIN p20 s252 PROTEIN p18 s252 PROTEIN p29 s252 PROTEIN p22 s252 PROTEIN p15 s275 PROTEIN p17 s275 PROTEIN p19 s275 PROTEIN p23 s275 PROTEIN p24 s275 PROTEIN p18 s275 PROTEIN p29 s278 PROTEIN p17 s278 PROTEIN p19 s278 PROTEIN p18 s278 PROTEIN p29 s282 PROTEIN p19 s282 PROTEIN p50 s282 PROTEIN p52 s283 PROTEIN p19 s283 PROTEIN p50 s286 PROTEIN p2 s286 PROTEIN p12 s286 PROTEIN p28 s288 PROTEIN p2 s288 PROTEIN p12 s288 PROTEIN p28 s288 PROTEIN p16 s292 PROTEIN p2 s292 PROTEIN p16 s292 PROTEIN p12 s292 PROTEIN p28 s292 PROTEIN p27 s203 PROTEIN p42 s203 PROTEIN p43 s215 PROTEIN p44 s215 PROTEIN p45 s212 PROTEIN p44 s212 PROTEIN p45 s212 PROTEIN p42 s259 PROTEIN p17 s259 PROTEIN p18 s259 PROTEIN p29 s259 PROTEIN p22 s259 PROTEIN p15 s259 PROTEIN p19 s259 PROTEIN p25 s259 PROTEIN p20 s266 PROTEIN p17 s266 PROTEIN p18 s266 PROTEIN p29 s266 PROTEIN p22 s266 PROTEIN p15 s266 PROTEIN p19 s266 PROTEIN p25 s266 PROTEIN p20 s267 PROTEIN p25 s267 PROTEIN p19 SQUARE_CLOSEUP_NORTH SQUARE SQUARE OVAL active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active active active active active active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive Plasma Membrane Endoplasmic Reticulum Nucleus Cell Membrane Long Name: Wingless-type MMTV integration site family member Synonym: Wingless Accession: P01444 inside PROTEIN p5 Long Name: Kremen Synonym: Synonym not specified Accession: P01463 transmembrane PROTEIN p7 Long Name: Beta-Arrestin Synonym: BetaArr1,BetaArr2 Accession: P01456 inside PROTEIN p12 Long Name: Dapper Synonym: Synonym not specified Accession: P01469 inside PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05624 Heterodimer Member Info: Frizzled#PROTEIN#Frizzled#P01428##;Wnt#PROTEIN#Wingless-type MMTV integration site family member#P01444#Wingless# transmembrane COMPLEX Complex_br_(Wnt/Frizzled) Long Name: Frizzled Synonym: Synonym not specified Accession: P01428 transmembrane PROTEIN p1 Long Name: Frizzled-related protein Synonym: Frizzled-related protein B Accession: P01461 inside PROTEIN p9 Long Name: Dickkopf Synonym: Dkk1,Dkk2 Accession: P01462 inside PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05632 Heterodimer Member Info: Dickkopf#PROTEIN#Dickkopf#P01462#Dkk1|Dkk2#;Kremen#PROTEIN#Kremen#P01463## transmembrane COMPLEX Complex_br_(Dickkopf/Kremen) Long Name: Cerberus Synonym: Synonym not specified Accession: P01445 inside PROTEIN p8 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05626 Heterodimer Member Info: Frizzled#PROTEIN#Frizzled#P01428##;LRP5/6#PROTEIN#Low density lipoprotein receptor related protein#P01431#Arrow#;Wnt#PROTEIN#Wingless-type MMTV integration site family member#P01444#Wingless# transmembrane COMPLEX Complex_br_(Frizzled/Wnt/_br_LRP5/6) Long Name: Low density lipoprotein receptor related protein Synonym: Arrow Accession: P01431 transmembrane PROTEIN p6 Long Name: secreted frizzled-related protein Synonym: Synonym not specified Accession: P01434 inside PROTEIN p14 Long Name: Casein Kinase 1 Synonym: CK1 Accession: P01460 inside PROTEIN p15 Long Name: Casein Kinase 2 Synonym: Casein Kinase II,Protein Kinase CK2 Accession: P01459 inside PROTEIN p16 Long Name: ATP Synonym: Synonym not specified Accession: S01878 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01880 inside SIMPLE_MOLECULE ADP Long Name: Dishevelled Synonym: Dvl Accession: P01447 inside PROTEIN p2 Long Name: Glycogen Synthase Kinase-3Beta Synonym: GSK3B,GSK3Beta,Sgg,Shaggy,Zeste White 3,Zw3 Accession: P01441 inside PROTEIN p20 Long Name: Adenomatous Polyposis Coli Synonym: APC Accession: P01468 inside PROTEIN p17 Long Name: Axin Synonym: Axis Inhibitor Protein,Conductin Accession: P01429 inside PROTEIN p18 Long Name: Naked Synonym: naked cuticle,nkd Accession: P01427 inside PROTEIN p21 Long Name: Diversin Synonym: Ankrd6 Accession: P01466 inside PROTEIN p22 Long Name: Seven in absentia homolog 1 Synonym: seven in absentia,seven in absentia homolog,siah,sina Accession: P01433 inside PROTEIN p23 Long Name: Ebi Synonym: IRA1 Accession: P01453 inside PROTEIN p24 Long Name: Tumor suppressor p53 Synonym: Synonym not specified Accession: P01430 inside PROTEIN p26 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05622 Heterodimer Member Info: Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;Ebi#PROTEIN#Ebi#P01453#IRA1# inside COMPLEX Complex_br_(Ebi/Siah-1) Long Name: a146_degraded Synonym: Synonym not specified Accession: U02699 inside DEGRADED a146_degraded Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05612 Heterodimer Member Info: Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;Ebi#PROTEIN#Ebi#P01453#IRA1# inside COMPLEX Complex_br_(Siah-1/Ebi) Long Name: Frequently rearranged in advanced T-cell lymphomas Synonym: Frequently rearranged in advanced T-cell lymphomas Accession: P01467 inside PROTEIN p27 Long Name: Frodo Synonym: frd Accession: P01470 inside PROTEIN p28 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05637 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Frodo#PROTEIN#Frodo#P01470#frd# inside COMPLEX Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05634 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2# inside COMPLEX Complex_br_(Beta-Arrestin/Dishevelled) Long Name: Protein phosphatase 2A Synonym: PP2A,PP2A B56 subunit,Protein Phosphatase 2A Accession: P01438 inside PROTEIN p29 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05630 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A# inside COMPLEX Complex_br_(Axin/PP2A) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05614 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Axin/PP2A/_br_Adenomatous Polyposis Coli) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05615 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/Casein Kinase 1/_br_Glycogen Synthase Kinase-3_Beta_/PP2A) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05611 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A) Long Name: Histone deacetylase Synonym: Reduced potassium dependency 3,Rpd3 Accession: P01472 inside PROTEIN p30 Long Name: Transducin-like Enhance of Split 1-3 Synonym: Groucho,TLE-1,TLE-2,TLE-3,Transducin-like Enhancer of Split 1,Transducin-like Enhancer of Split 2,Transducin-like Enhancer of Split 3 Accession: P01436 inside PROTEIN p31 Long Name: C-terminal Binding Protein Synonym: CtBP Accession: P01439 inside PROTEIN p33 Long Name: Mothers against decapentaplegic homolog 4 Synonym: MAD homolog 1,MAD homolog 4,Mothers against decapentaplegic homolog 1,Mothers against decapentaplegic homolog 4,Smad1 Accession: P01455 inside PROTEIN p34 Long Name: Pygopus Synonym: Pygopus Accession: P01464 inside PROTEIN p36 Long Name: CREB binding protein Synonym: CREB binding protein Accession: P01448 inside PROTEIN p37 Long Name: Switched/Sucrose Non Fermentation Synonym: Switched/Sucrose Non Fermentation Accession: P01435 inside PROTEIN p38 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05628 Heterodimer Member Info: Transducin-like Enhance of Split 1-3#PROTEIN#Transducin-like Enhance of Split 1-3#P01436#Groucho|TLE-1|TLE-2|TLE-3|Transducin-like Enhancer of Split 1|Transducin-like Enhancer of Split 2|Transducin-like Enhancer of Split 3#;Histone deacetylase#PROTEIN#Histone deacetylase#P01472#Reduced potassium dependency 3|Rpd3# inside COMPLEX Complex_br_(Histone deacetylase/Transducin-like Enhance of Split 1-3) Long Name: B-cell lymphoma 9 Synonym: B-cell lymphoma 9,Legless,Lgs Accession: P01450 inside PROTEIN p35 Long Name: Wnt Target Genes Synonym: Axin,Conductin,CyclinD1,En-2,ID2,MMP7,Myc,Naked,Nkd,PPAR Delta,Siamois,TCF-1,Twin,Ubx,Xbra,Xnr3 Accession: G01558 inside GENE gn1 Long Name: T cell factor Synonym: LEF,Lymphocyte Enhance Binding Factor,Pangolin,T Cell Factor Accession: P01437 inside PROTEIN p32 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05613 Heterodimer Member Info: TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1# inside COMPLEX Complex_br_(TCF/Smad4) Long Name: T cell factor Synonym: LEF,Lymphocyte Enhance Binding Factor,Pangolin,T Cell Factor Accession: P01437 inside PROTEIN p32 Long Name: Nemo-like Kinase Synonym: NLK Accession: P01449 inside PROTEIN p39 Long Name: Nemo-like Kinase Synonym: NLK Accession: P01449 inside PROTEIN p39 Long Name: Phospholipase C Synonym: PLC,PLC Beta,Phospholipase C Beta Accession: P01443 inside PROTEIN p43 Long Name: GTP Synonym: Synonym not specified Accession: S01881 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01882 inside SIMPLE_MOLECULE GDP Long Name: IP3 Synonym: Synonym not specified Accession: S01879 inside SIMPLE_MOLECULE IP_sub_3_endsub_ Long Name: PI(4,5)P2 Synonym: Synonym not specified Accession: S01875 inside SIMPLE_MOLECULE PI(4,5)P_sub_2_endsub_ Long Name: DAG Synonym: Synonym not specified Accession: S01877 inside SIMPLE_MOLECULE DAG Long Name: Protein Kinase C Synonym: PKC Accession: P01458 inside PROTEIN p46 Long Name: IP3 Gated Calcium Channel Synonym: IP-3-R,IP3-Gated Ca Channel,Ins3PR Accession: P01426 transmembrane PROTEIN p47 Long Name: Calcineurin Synonym: Synonym not specified Accession: P01446 inside PROTEIN p48 Long Name: NFAT Synonym: NF-AT,Nuclear Factor of Activated T-Cells Accession: P01452 inside PROTEIN p49 Long Name: NFAT Synonym: NF-AT,Nuclear Factor of Activated T-Cells Accession: P01452 inside PROTEIN p49 Long Name: Pi Synonym: Synonym not specified Accession: S01876 inside SIMPLE_MOLECULE P_sub_i Long Name: ATP Synonym: Synonym not specified Accession: S01878 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01880 inside SIMPLE_MOLECULE ADP Long Name: Nemo-like Kinase Synonym: NLK Accession: P01449 inside PROTEIN p39 Long Name: NFAT Target Genes Synonym: ANF,Adss1,ET-1,TNF alpha,alpha-actin,beta-myosin Accession: G01559 inside GENE gn2 Long Name: NFAT Synonym: NF-AT,Nuclear Factor of Activated T-Cells Accession: P01452 inside PROTEIN p49 Long Name: Wingless-type MMTV integration site family member Synonym: Wingless Accession: P01444 inside PROTEIN p5 Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432 inside PROTEIN p19 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05633 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/Axin/_br__Beta_-Catenin/PP2A) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05625 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/Axin/_br_Diversin/_Beta_-Catenin/_br_PP2A) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05617 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Ebi#PROTEIN#Ebi#P01453#IRA1#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/_Beta_-Catenin/_br_Siah-1/Ebi) Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432 inside PROTEIN p19 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05606 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1# inside COMPLEX Complex_br_(TCF/Smad4/_br__Beta_-Catenin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05636 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1# inside COMPLEX Complex_br_(TCF/_Beta_-Catenin/_br_Smad4/Bcl9) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05619 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus# inside COMPLEX Complex_br_(Bcl9/_Beta_-Catenin/_br_TCF/Smad4/_br_Pygo) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05623 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;SWI/SNF#PROTEIN#Switched/Sucrose Non Fermentation#P01435#Switched/Sucrose Non Fermentation#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus# inside COMPLEX Complex_br_(_Beta_-Catenin/TCF/_br_Smad4/Bcl9/_br_Pygo/SWI/_br_SNF) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05621 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;SWI/SNF#PROTEIN#Switched/Sucrose Non Fermentation#P01435#Switched/Sucrose Non Fermentation#;TCF#PROTEIN#T cell factor#P01437#LEF|Lymphocyte Enhance Binding Factor|Pangolin|T Cell Factor#;CBP#PROTEIN#CREB binding protein#P01448#CREB binding protein#;Bcl9#PROTEIN#B-cell lymphoma 9#P01450#B-cell lymphoma 9|Legless|Lgs#;Smad4#PROTEIN#Mothers against decapentaplegic homolog 4#P01455#MAD homolog 1|MAD homolog 4|Mothers against decapentaplegic homolog 1|Mothers against decapentaplegic homolog 4|Smad1#;Pygo#PROTEIN#Pygopus#P01464#Pygopus# inside COMPLEX Complex_br_(Bcl9/Pygo/_br__Beta_-Catenin/SWI/_br_SNF/CBP/_br_TCF/Smad4) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05616 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A/_br_Diversin/Casein Kinase 1) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05639 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Glycogen Synthase Kinase-3_Beta_/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1) Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01883 inside SIMPLE_MOLECULE Ubiquitin Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432 inside PROTEIN p19 Long Name: a561_degraded Synonym: Synonym not specified Accession: U02698 inside DEGRADED a561_degraded Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432 inside PROTEIN p19 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05609 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Siah-1#PROTEIN#Seven in absentia homolog 1#P01433#seven in absentia|seven in absentia homolog|siah|sina#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Ebi#PROTEIN#Ebi#P01453#IRA1#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Siah-1/Ebi/_br_Axin/PP2A) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05635 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/_Beta_-Catenin/_br_Axin/PP2A) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05638 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Cadherin#PROTEIN#Cadherin#P01440##;alpha-Catenin#PROTEIN#alpha-Catenin#P01471## inside COMPLEX Complex_br_(_Beta_-Catenin/Cadherin/_br__alpha_-Catenin) Long Name: alpha-Catenin Synonym: Synonym not specified Accession: P01471 inside PROTEIN p52 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05618 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;Cadherin#PROTEIN#Cadherin#P01440## inside COMPLEX Complex_br_(_Beta_-Catenin/Cadherin) Long Name: Cadherin Synonym: Synonym not specified Accession: P01440 inside PROTEIN p50 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05629 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Frodo#PROTEIN#Frodo#P01470#frd# inside COMPLEX Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05641 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Casein Kinase 2#PROTEIN#Casein Kinase 2#P01459#Casein Kinase II|Protein Kinase CK2#;Frodo#PROTEIN#Frodo#P01470#frd# inside COMPLEX Complex_br_(Dishevelled/Beta-Arrestin/_br_Frodo/Casein Kinase 2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05620 Heterodimer Member Info: Dishevelled#PROTEIN#Dishevelled#P01447#Dvl#;Beta-Arrestin#PROTEIN#Beta-Arrestin#P01456#BetaArr1|BetaArr2#;Casein Kinase 2#PROTEIN#Casein Kinase 2#P01459#Casein Kinase II|Protein Kinase CK2#;FRAT#PROTEIN#Frequently rearranged in advanced T-cell lymphomas#P01467#Frequently rearranged in advanced T-cell lymphomas#;Frodo#PROTEIN#Frodo#P01470#frd# inside COMPLEX Complex_br_(Dishevelled/Casein Kinase 2/_br_Beta-Arrestin/Frodo/_br_FRAT) Long Name: Galpha Synonym: G11,G15,Galpha11,Galpha15,Galphaq,Gq Accession: P01451 inside PROTEIN p42 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05631 Heterodimer Member Info: Phospholipase C#PROTEIN#Phospholipase C#P01443#PLC|PLC Beta|Phospholipase C Beta#;Galpha#PROTEIN#Galpha#P01451#G11|G15|Galpha11|Galpha15|Galphaq|Gq# innerSurface COMPLEX Complex_br_(G_alpha_/Phospholipase C) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05610 Heterodimer Member Info: GBeta#PROTEIN#G_Beta#P01457#Gb|Gbeta#;Ggamma#PROTEIN#Ggamma#P01465#Gg# inside COMPLEX Complex_br_(G_Beta/G_gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05640 Heterodimer Member Info: Galpha#PROTEIN#Galpha#P01451#G11|G15|Galpha11|Galpha15|Galphaq|Gq#;GBeta#PROTEIN#G_Beta#P01457#Gb|Gbeta#;Ggamma#PROTEIN#Ggamma#P01465#Gg# innerSurface COMPLEX Complex_br_(G_Beta/G_gamma_/_br_G_alpha_) Long Name: betaTransducin repeat-containing protein Synonym: BTrCP,Beta Transducin Repeat-Containing Protein,Slimb Accession: P01454 inside PROTEIN p25 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05608 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05607 Heterodimer Member Info: Axin#PROTEIN#Axin#P01429#Axis Inhibitor Protein|Conductin#;Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;PP2A#PROTEIN#Protein phosphatase 2A#P01438#PP2A|PP2A B56 subunit|Protein Phosphatase 2A#;Glycogen Synthase Kinase-3Beta#PROTEIN#Glycogen Synthase Kinase-3Beta#P01441#GSK3B|GSK3Beta|Sgg|Shaggy|Zeste White 3|Zw3#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb#;Casein Kinase 1#PROTEIN#Casein Kinase 1#P01460#CK1#;Diversin#PROTEIN#Diversin#P01466#Ankrd6#;Adenomatous Polyposis Coli#PROTEIN#Adenomatous Polyposis Coli#P01468#APC# inside COMPLEX Complex_br_(Adenomatous Polyposis Coli/Axin/_br_PP2A/Diversin/_br_Casein Kinase 1/_Beta_-Catenin/_br__beta_TrCP/Glycogen Synthase Kinase-3_Beta_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05627 Heterodimer Member Info: Beta-Catenin#PROTEIN#Beta-Catenin#P01432#Armadillo#;betaTrCP#PROTEIN#betaTransducin repeat-containing protein#P01454#BTrCP|Beta Transducin Repeat-Containing Protein|Slimb# inside COMPLEX Complex_br_(_beta_TrCP/_Beta_-Catenin) Long Name: Transforming growth factor beta activated kinase 1 Synonym: MAPKKK 7,Mitogen-Activated Protein Kinase Kinase Kinase 7,TAK1 Accession: P01442 inside PROTEIN p40 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02700 inside ION Ca_super_2_plus_ Long Name: Ca2+ Synonym: Synonym not specified Accession: U02700 inside ION Ca_super_2_plus_ inside RNA rn1 inside RNA rn2 inside SIMPLE_MOLECULE ATP 3 inside SIMPLE_MOLECULE ADP 3 HETERODIMER_ASSOCIATION 0.33333333333333326,0.33333333333333304 a5 a1 a16 HETERODIMER_ASSOCIATION -16.281649736909493,9.756928593092837 a6 a16 a28 HETERODIMER_ASSOCIATION 0.24817146854925887,0.3896657308219988 a10 a7 a21 INHIBITION a21 a6 STATE_TRANSITION a102 a134 a132 HETERODIMER_ASSOCIATION 0.43697671868755794,0.34281262855153205 a134 a133 a136 STATE_TRANSITION a146 a148 HETERODIMER_ASSOCIATION 0.3487215788180773,0.26981323029008264 a214 a12 a227 HETERODIMER_ASSOCIATION 0.44480919445668565,0.21134768510760482 a227 a212 a224 HETERODIMER_ASSOCIATION 0.33333333333333215,0.3333333333333339 a259 a258 a261 HETERODIMER_ASSOCIATION 0.3333333333333339,0.3333333333333328 a35 a261 a266 HETERODIMER_ASSOCIATION 0.33333333333333415,0.3333333333333348 a266 a37 a275 HETERODIMER_ASSOCIATION 0.33333333333333304,0.33333333333333415 a275 a63 a292 HETERODIMER_ASSOCIATION 0.3333333333333328,0.33333333333333437 a275 a136 a368 TRANSPORT a37 a380 HETERODIMER_ASSOCIATION 0.3736592927769422,0.27219947808183065 a385 a383 a392 HETERODIMER_ASSOCIATION 0.33333333333333215,0.3333333333333357 a381 a382 a395 HETERODIMER_ASSOCIATION 0.3433876508021818,0.21941862091801312 a392 a380 a403 HETERODIMER_ASSOCIATION 0.33333333333333215,0.3333333333333339 a403 a416 a410 HETERODIMER_ASSOCIATION 0.33333333333333215,0.33333333333333615 a410 a387 a421 HETERODIMER_ASSOCIATION 0.3333333333333339,0.3333333333333335 a421 a389 a435 HETERODIMER_ASSOCIATION 0.4975091268085645,0.22667093748847522 a435 a388 a448 STATE_TRANSITION 0.3038309567620274,0.012142475098460892 0.6964234333004775,3.22909649934644E-4 a383 a452 a450 a453 a497 STATE_TRANSITION 0.3970422768855393,7.429615447573923E-4 0.613986991951144,-7.13973876208307E-4 a455 a456 a451 a457 a454 HETERODIMER_ASSOCIATION -8.085710624349517,3.8145504930998797 a459 a460 a463 DISSOCIATION 0.33333333333333215,0.3333333333333335 a473 a479 a459 a478 a480 a28 STATE_TRANSITION a487 a486 a485 a618 STATE_TRANSITION a488 a489 a483 STATE_TRANSITION a492 a493 a618 STATE_TRANSITION a494 a495 a496 a493 STATE_TRANSITION 0.32742577152268026,4.907690906623685E-4 0.6316583585858027,-0.006010836561794353 a292 a87 a511 a88 a62 STATE_TRANSITION 0.39236095679132177,0.007734275835550086 0.6518514764038343,0.007569019400419208 a511 a107 a524 a108 a38 HETERODIMER_ASSOCIATION 0.2743171331541525,0.35710203561234977 a524 a104 a539 STATE_TRANSITION 0.39330919676936915,-0.01893095563750613 a539 a558 a555 DISSOCIATION 0.3333333333333357,0.3333333333333349 a555 a356 a557 DISSOCIATION 0.3333333333333357,0.3333333333333328 a557 a560 a561 STATE_TRANSITION a561 a562 STATE_TRANSITION 0.20331133229926746,-2.8083620846253154E-4 a368 a564 a579 DISSOCIATION 0.33333333333333304,0.3333333333333339 a579 a205 a582 DISSOCIATION 0.33333333333333304,0.3333333333333339 a582 a378 a146 DISSOCIATION 0.33333333333333126,0.3333333333333348 a587 a592 a591 DISSOCIATION 0.33333333333333304,0.3333333333333339 a592 a37 a595 HETERODIMER_ASSOCIATION 0.33333333333333215,0.3333333333333339 a609 a32 a612 HETERODIMER_ASSOCIATION 0.33333333333333304,0.33333333333333304 a612 a253 a616 STATE_TRANSITION 0.31242372467660573,-0.0034171344886528843 0.6881527532163592,-0.007921919496768126 a224 a33 a609 a34 a31 a28 INHIBITION a616 a38 TRANSPORT a500 a5 TRANSPORT a451 a497 TRANSPORT a495 a498 DISSOCIATION 0.33333333333325754,0.3333333333334849 a484 a483 a485 a463 TRANSPORT a617 a618 a489 STATE_TRANSITION a5 sa229 a30 a8 a9 STATE_TRANSITION a214 sa230 a13 a61 STATE_TRANSITION sa231 a62 a612 STATE_TRANSITION a392 csa37 a395 a384 TRANSCRIPTION a449 sa234 a448 TRANSCRIPTION a499 sa235 a498