Protein-coding genes contain introns which must be removed from pre-mRNAs to produce mRNAs for translation into proteins. Introns contain conserved splicing signals which ensure fidelity of splicing. Introns are removed in a large complex. The major splicing components are the U1, U2, U4/U6 and U5snRNPs (small nuclear ribonucleoprotein particles). Medline=11607023 Medline=14681577 Medline=8266100 Medline=8791582 OMIM=1411506 4.0 s5 RNA rn1 s5 RNA rn2 s5 RNA rn3 s16 PROTEIN p5 s16 PROTEIN p3 s24 RNA rn2 s24 PROTEIN p2 s24 PROTEIN p4 s24 PROTEIN p5 s25 RNA rn3 s25 RNA rn1 s32 PROTEIN p8 s32 PROTEIN p9 s34 PROTEIN p3 s34 PROTEIN p5 s34 PROTEIN p4 s37 PROTEIN p5 s37 PROTEIN p3 s37 PROTEIN p2 s37 PROTEIN p4 s37 PROTEIN p1 s39 PROTEIN p4 s39 PROTEIN p2 s39 PROTEIN p5 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05648 Heterodimer Member Info: intron#RNA#intron#G01560##;Exon-2#RNA#Exon-2#G01561##;Exon-1#RNA#Exon-1#G01562## inside COMPLEX Complex_br_(Exon-1/intron/_br_Exon-2) Long Name: U1 Synonym: RNU1,Rnu1a1,U1 SMALL NUCLEAR,snRNA Accession: P01479 inside PROTEIN p1 Long Name: U2 Synonym: RNU2,U2 SMALL NUCLEAR,snRNA Accession: P01478 inside PROTEIN p2 Long Name: U4 Synonym: AT-AC FORM,SMALL NUCLEAR RNA U4,U4ATAC Accession: P01476 inside PROTEIN p3 Long Name: U5 Synonym: KIAA0031,U5 snRNP-SPECIFIC PROTEIN Accession: P01474 inside PROTEIN p4 Long Name: U6 Synonym: RNA U6 SMALL NUCLEAR,RNU6 snRNA Accession: P01473 inside PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05644 Heterodimer Member Info: U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U4#PROTEIN#U4#P01476#AT-AC FORM|SMALL NUCLEAR RNA U4|U4ATAC# inside COMPLEX Complex_br_(U6/U4) Long Name: Exon-1 Synonym: Synonym not specified Accession: G01562 inside RNA rn1 Long Name: intron Synonym: Synonym not specified Accession: G01560 inside RNA rn2 Long Name: Exon-2 Synonym: Synonym not specified Accession: G01561 inside RNA rn3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05647 Heterodimer Member Info: intron#RNA#intron#G01560##;U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U5#PROTEIN#U5#P01474#KIAA0031|U5 snRNP-SPECIFIC PROTEIN#;U2#PROTEIN#U2#P01478#RNU2|U2 SMALL NUCLEAR|snRNA# inside COMPLEX Complex_br_(intron/U2/_br_U5/U6) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05646 Heterodimer Member Info: Exon-2#RNA#Exon-2#G01561##;Exon-1#RNA#Exon-1#G01562## inside COMPLEX Complex_br_(Exon-2/Exon-1) Long Name: U2AF35 Synonym: U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT,U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1,U2AF1,U2AF35,splicing factor U2AF 35kDa subunit Accession: P01477 inside PROTEIN p8 Long Name: U2AF65 Synonym: U2AF65-ASSOCIATED PROTEIN,UAP65 Accession: P01475 inside PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05642 Heterodimer Member Info: U2AF65#PROTEIN#U2AF65#P01475#U2AF65-ASSOCIATED PROTEIN|UAP65#;U2AF35#PROTEIN#U2AF35#P01477#U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT|U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1|U2AF1|U2AF35|splicing factor U2AF 35kDa subunit# inside COMPLEX Complex_br_(U2AF35/U2AF65) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05649 Heterodimer Member Info: U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U5#PROTEIN#U5#P01474#KIAA0031|U5 snRNP-SPECIFIC PROTEIN#;U4#PROTEIN#U4#P01476#AT-AC FORM|SMALL NUCLEAR RNA U4|U4ATAC# inside COMPLEX Complex_br_(U4/U6/_br_U5) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05645 Heterodimer Member Info: U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U5#PROTEIN#U5#P01474#KIAA0031|U5 snRNP-SPECIFIC PROTEIN#;U4#PROTEIN#U4#P01476#AT-AC FORM|SMALL NUCLEAR RNA U4|U4ATAC#;U2#PROTEIN#U2#P01478#RNU2|U2 SMALL NUCLEAR|snRNA#;U1#PROTEIN#U1#P01479#RNU1|Rnu1a1|U1 SMALL NUCLEAR|snRNA# inside COMPLEX Complex_br_(U6/U4/_br_U2/U5/_br_U1) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05643 Heterodimer Member Info: U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U5#PROTEIN#U5#P01474#KIAA0031|U5 snRNP-SPECIFIC PROTEIN#;U2#PROTEIN#U2#P01478#RNU2|U2 SMALL NUCLEAR|snRNA# inside COMPLEX Complex_br_(U5/U2/_br_U6) STATE_TRANSITION a5 a9 a6 STATE_TRANSITION 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-4.440892098500626E-16 a6 a15 a7 HETERODIMER_ASSOCIATION 0.3333333333333304,-3.552713678800501E-15 0.6666666666666661,0.0 0.3333333333333357,-4.440892098500626E-16 0.6666666666666679,4.440892098500626E-16 0.3333333333333304,-2.6645352591003757E-15 0.6666666666666652,-3.9968028886505635E-15 0.3333333333333304,0.3333333333333326 a11 a13 a29 STATE_TRANSITION 0.33333333333333215,-6.661338147750939E-16 0.6666666666666661,-2.220446049250313E-16 a60 a81 a80 HETERODIMER_ASSOCIATION 0.3686781633567371,-0.02624371222226518 0.40688445425579367,-0.028689748506605106 0.33333333333333126,2.220446049250313E-15 0.6666666666666652,3.9968028886505635E-15 0.2297923349883897,0.4240578792151082 a88 a89 a94 STATE_TRANSITION a85 a94 a5 HETERODIMER_ASSOCIATION 0.5529832852232346,-0.013302791060127106 a29 a12 a104 STATE_TRANSITION 0.3333333333333328,-2.220446049250313E-16 0.6666666666666667,-3.3306690738754696E-16 a108 a110 a47 a45 HETERODIMER_ASSOCIATION 0.3333333333333366,-2.220446049250313E-16 0.3928018953870964,-0.010769452211810915 0.33333333333333304,1.3322676295501878E-15 0.6666666666666656,4.440892098500626E-16 0.33333333333333304,0.33333333333333304 a16 a10 a104 a108