Various proteins are covalently modified on lysine side chain residues with the 76 amino acid peptide ubiquitin. This can lead to targeting for degradation by the proteasome machinery or can merely be the basis for regulatory control such as activation of receptor endocytosis. Medline=14685250 Medline=14723977 Medline=14744430 4.0 s9 SIMPLE_MOLECULE ubiquitin s9 PROTEIN p1 s7 PROTEIN p6 s7 PROTEIN p5 SQUARE_CLOSEUP_NORTH inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive cytosol Long Name: Ubiquitin protein ligase E3 Synonym: E6AP Accession: P01490 inside PROTEIN p3 Long Name: ubiquitin Synonym: Synonym not specified Accession: S01886 inside SIMPLE_MOLECULE ubiquitin Long Name: ATP Synonym: Synonym not specified Accession: S01887 inside SIMPLE_MOLECULE ATP Long Name: Ubiquitin activating enzyme E1 Synonym: Synonym not specified Accession: P01492 inside PROTEIN p1 Long Name: Ubiquitin activating enzyme E1 Synonym: Synonym not specified Accession: P01492 inside PROTEIN p1 Long Name: AMP Synonym: Synonym not specified Accession: S01888 inside SIMPLE_MOLECULE AMP Long Name: Ubiquitin-conjugating enzyme E2 Synonym: Synonym not specified Accession: P01491 inside PROTEIN p2 Long Name: Ubiquitin-conjugating enzyme E2 Synonym: Synonym not specified Accession: P01491 inside PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05702 Heterodimer Member Info: ubiquitin#SIMPLE_MOLECULE#ubiquitin#S01886##;E1#PROTEIN#Ubiquitin activating enzyme E1#P01492## inside COMPLEX Complex_br_(ubiquitin/E1) Long Name: Long Name: proteasome Synonym: Synonym not specified Accession: U05701 Heterodimer Member Info: 26S proteasome#PROTEIN#26S proteasome#P01489#Proteasome 26S ATPase subunit#;19S proteasome#PROTEIN#19S proteasome#P01494## inside COMPLEX Complex_br_(26S proteasome/19S proteasome) Long Name: Protein target Synonym: Synonym not specified Accession: P01493 inside PROTEIN p4 Long Name: Protein target Synonym: Synonym not specified Accession: P01493 inside PROTEIN p4 Long Name: a24_degraded Synonym: Synonym not specified Accession: U02719 inside DEGRADED a24_degraded Long Name: ADP Synonym: Synonym not specified Accession: S01890 inside SIMPLE_MOLECULE ADP Long Name: Pi Synonym: Synonym not specified Accession: U02720 inside ION Pi Long Name: PPi Synonym: Synonym not specified Accession: S01889 inside SIMPLE_MOLECULE PPi STATE_TRANSITION a24 a26 a27 a30 a31 a32 a7 TRANSPORT a22 a24 STATE_TRANSITION a1 a12 a8 a11 a13 STATE_TRANSITION a11 a17 a18 STATE_TRANSITION a2 a17 a19 a33 STATE_TRANSITION a4 a19 a22 a23 a3