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<celldesigner:protein id="p2" name="K_super_+_endsuper__br_channel" type="ION_CHANNEL"/>
<celldesigner:protein id="p4" name="SNARE_br_Complex" type="GENERIC"/>
<celldesigner:protein id="p3" name="5HT vesicular_br_transporter" type="GENERIC"/>
</celldesigner:listOfProteins>
<celldesigner:listOfGenes/>
<celldesigner:listOfRNAs/>
<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfLayers/>
<celldesigner:listOfBlockDiagrams/>
</celldesigner:extension>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#_space_5HT4_space_type_space_receptor_space_mediated_space_signaling_space_pathway">
<dc:creator>
<rdf:Bag>
<rdf:li rdf:parseType="Resource">
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>SRI International</vCard:Orgname>
</vCard:ORG>
</rdf:li>
</rdf:Bag>
</dc:creator>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfUnitDefinitions>
<unitDefinition metaid="substance" id="substance" name="substance">
<listOfUnits>
<unit metaid="CDMT00036" kind="mole"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="volume" id="volume" name="volume">
<listOfUnits>
<unit metaid="CDMT00037" kind="litre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="area" id="area" name="area">
<listOfUnits>
<unit metaid="CDMT00038" kind="metre" exponent="2"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="length" id="length" name="length">
<listOfUnits>
<unit metaid="CDMT00039" kind="metre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00040" kind="second"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment metaid="default" id="default" size="1" units="volume"/>
<compartment metaid="c1" id="c1" name="Neurons of the Colliculus" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>Neurons of the Colliculus</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c2" id="c2" name="Serotonergic Neurons of the Dorsal Raphae Nucleus" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>Serotonergic Neurons of the Dorsal Raphae Nucleus</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c4" id="c4" name="Dense core vesicle" size="1" units="volume" outside="c2">
<annotation>
<celldesigner:extension>
<celldesigner:name>Dense core vesicle</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species metaid="s2" id="s2" name="Cl-" compartment="default">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Cl-
Synonym:  Synonym not specified
Accession:  U04981
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Cl-</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s3" id="s3" name="5HT transporter" compartment="c2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  5HT transporter
Synonym:  Synonym not specified
Accession:  P04431
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re1"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s5" id="s5" name="Na_super_+" compartment="default">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Na+
Synonym:  Synonym not specified
Accession:  U04979
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Na_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s6" id="s6" name="K+ Channel" compartment="c2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  K+ channel
Synonym:  Kcnk3,Potassium channel subfamily K member 3,Potassium channel subfamily K member 9,TASK-1,TASK-3,TWIK
Accession:  P04426
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re2"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s7" id="s7" name="reserpine" compartment="c2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  reserpine
Synonym:  Synonym not specified
Accession:  S04744
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>reserpine</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re3"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s8" id="s8" name="K_super_+" compartment="default">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  K+
Synonym:  Synonym not specified
Accession:  U04980
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s10" id="s10" name="Complex_br_(GDP/G-protein/_br_5HT4 Receptor)" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U04976
Heterodimer Member Info:  GDP#SIMPLE_MOLECULE#GDP#S04745##;5HT4 Receptor#PROTEIN#5HT4 Receptor#P04427#5HT-4|serotonin receptor 4#;G-protein#PROTEIN#G-protein#P04430##
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GDP/G-protein/_br_5HT4 Receptor)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s11" id="s11" name="5HT_super_+" compartment="default">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  5HT+
Synonym:  Synonym not specified
Accession:  S04749
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>5HT_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s12" id="s12" name="Imipramine" compartment="c2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Imipramine
Synonym:  Synonym not specified
Accession:  S04750
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Imipramine</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re1"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s14" id="s14" name="Complex_br_(GDP/G-protein/_br_5HT4 Receptor/5HT+)" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U04977
Heterodimer Member Info:  GDP#SIMPLE_MOLECULE#GDP#S04745##;5HT4 Receptor#PROTEIN#5HT4 Receptor#P04427#5HT-4|serotonin receptor 4#;5HT+#SIMPLE_MOLECULE#5HT+#S04749##;G-protein#PROTEIN#G-protein#P04430##
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GDP/G-protein/_br_5HT4 Receptor/5HT+)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s16" id="s16" name="GTP" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S04747
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s17" id="s17" name="GDP" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S04745
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s19" id="s19" name="ATP" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S04746
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s20" id="s20" name="cAMP" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  cAMP
Synonym:  Synonym not specified
Accession:  S04748
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cAMP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s21" id="s21" name="Complex_br_(G-protein/GDP)" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U04974
Heterodimer Member Info:  GDP#SIMPLE_MOLECULE#GDP#S04745##;G-protein#PROTEIN#G-protein#P04430##
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(G-protein/GDP)</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re7"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s26" id="s26" name="AC" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  AC
Synonym:  adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase
Accession:  P04429
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re5"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s27" id="s27" name="5HT_super_+" compartment="c2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  5HT+
Synonym:  Synonym not specified
Accession:  S04749
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>5HT_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s29" id="s29" name="Effect unknown" compartment="c1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Effect unknown
Synonym:  Synonym not specified
Accession:  U04978
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Effect unknown</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s35" id="s35" name="Cl-" compartment="c2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Cl-
Synonym:  Synonym not specified
Accession:  U04981
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Cl-</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s36" id="s36" name="Na_super_+" compartment="c2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  Na+
Synonym:  Synonym not specified
Accession:  U04979
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Na_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s37" id="s37" name="K_super_+" compartment="c2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  K+
Synonym:  Synonym not specified
Accession:  U04980
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s39" id="s39" name="Complex_br_(5HT4 Receptor/_br_5HT+)" compartment="c1" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(5HT4 Receptor/_br_5HT+)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s40" id="s40" name="SNARE_br_Complex" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re4"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s41" id="s41" name="5HT vesicular_br_transporter" compartment="c4" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re3"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s42" id="s42" name="5HT_super_+" compartment="c4" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>Long Name:  5HT+
Synonym:  Synonym not specified
Accession:  S04749
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>5HT_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction metaid="re1" id="re1" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s11" alias="a5"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s27" alias="a10"/>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s2" alias="a7" targetLineIndex="-1,0">
<celldesigner:line width="1.0" color="ff000000" type="Curve"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s5" alias="a13" targetLineIndex="-1,0">
<celldesigner:line width="1.0" color="ff000000" type="Curve"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink product="s36" alias="a12" targetLineIndex="-1,1">
<celldesigner:line width="1.0" color="ff000000" type="Curve"/>
</celldesigner:productLink>
<celldesigner:productLink product="s35" alias="a6" targetLineIndex="-1,1">
<celldesigner:line width="1.0" color="ff000000" type="Curve"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.09215695641507904,0.001385614678943048 0.4692928442728803,6.309936320660903E-4 0.6957915692266563,-0.0018821794510581746</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s3" aliases="a8" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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</annotation>
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<annotation>
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</annotation>
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</annotation>
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<annotation>
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</annotation>
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<annotation>
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</reaction>
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</reaction>
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</annotation>
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</reaction>
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</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>

