Panther Pathway: P00005 This diagram represents several receptors and signaling pathways that have been identified as key mediators of angiogenesis, which is the process of blood vessel generation and maturation. Medline=11282421 Medline=11283723 Medline=11741095 Medline=12213597 Medline=12549854 Medline=12778165 Medline=12807741 Medline=12865906 Medline=13678960 Medline=14988924 PMID: 11282421 PMID: 11283723 PMID: 11741095 PMID: 12213597 PMID: 12549854 PMID: 12778165 PMID: 12807741 PMID: 12865906 PMID: 13678960 PMID: 14988924 4.0 s148 PROTEIN p9 s148 PROTEIN p78 s154 PROTEIN p54 s154 PROTEIN p53 s159 PROTEIN p74 s163 PROTEIN p66 s163 PROTEIN p6 s165 PROTEIN p71 s165 PROTEIN p69 s165 PROTEIN p70 s172 PROTEIN p5 s172 PROTEIN p61 s181 PROTEIN p4 s181 PROTEIN p60 s203 PROTEIN p32 s203 ION Ca_super_2+_endsuper s206 PROTEIN p1 s206 PROTEIN p33 s207 PROTEIN p18 s207 ION Ca_super_2+_endsuper Long Name: Protease Activated Receptor Synonym: NR1I2,Nuclear Receptor Subfamily 1, Group I, Member 2,PXR,Pregnane X Receptor,SXR,Steroid and Xenobiotic Receptor Accession: P00192 s148 PROTEIN p8 s196 PROTEIN p3 s196 PROTEIN p34 s159 PROTEIN p7 SQUARE_CLOSEUP_NORTH OVAL SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive active inactive inactive inactive active active active active active inactive inactive active active inactive active active active active active active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive active active active active active active active active active inactive inactive inactive inactive inactive inactive active active active active inactive active inactive inactive active active inactive active active inactive active active active active active active active active active active active active active active active active active active active active active active active active active active active inactive active active active inactive active inactive active inactive inactive active active active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive Heckman Caroline SRI International Plasma Membrane ER Nuclear membrane inside COMPLEX Complex_br_(eNOS/Ca_super_2+_endsuper_ Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05032 Heterodimer Member Info: VEGFR-2#PROTEIN#Vascular Endothelial Growth Factor Receptor-2#P00222#FLK1|KDR|Kinase Insert Domain Receptor|Tyrosine Kinase Growth Factor Receptor#;VEGF#PROTEIN#Vascular Endothelial Growth Factor#P00241#VEGF-A# transmembrane COMPLEX Complex_br_(VEGFR-2/VEGF) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05034 Heterodimer Member Info: Ca2+#ION#Long Name: Calcium#U05038##;cPLA2#PROTEIN#Cytosolic Phospholipase A2#P00251#PLA2# inside COMPLEX Complex_br_(cPLA_sub_2_endsub/Ca_super_2+_endsuper) Long Name: Fibroblast Growth Factor Receptor Substrate 2 Synonym: FRS2-Alpha,FRS2A,SNT,SNT1,SUC1-Associated Neurotrophic Factor Target 1 Accession: P00240 inside PROTEIN p63 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05028 Heterodimer Member Info: Tie2#PROTEIN#Tie-2#P00247#TEK|TEK Tyrosine Kinase#;Ang-1#PROTEIN#Angiopoietin-1#P00248## transmembrane COMPLEX Complex_br_(Tie2/Ang-1) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05030 Heterodimer Member Info: PDGF#PROTEIN#Platelet-Derived Growth Factor#P00224#PDGFA|PDGFB|PDGFC|PDGFD#;PDGFR#PROTEIN#Platelet-Derived Growth Factor Receptor#P00230#PDGFRA|PDGFRB# transmembrane COMPLEX Complex_br_(PDGFR/PDGF) Long Name: DAG Synonym: Synonym not specified Accession: S01599 inside SIMPLE_MOLECULE DAG Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05037 Heterodimer Member Info: FGFR-1#PROTEIN#Fibroblast Growth Factor Receptor-1#P00186#FGFR-1|FLG|FLT2|FMS-Like Gene|FMS-Like Tyrosine Kinase 2#;FGF#PROTEIN#Fibroblast Growth Factor#P00213#ECGF|Endothelial Cell Growth Factor|HBGF|Heparin-Binding Growth Factor# transmembrane COMPLEX Complex_br_(FGFR-1/FGF) Long Name: Protein Kinase C Synonym: Synonym not specified Accession: P00219 inside PROTEIN p25 Long Name: Phosphatidylinositol (4,5)-diphosphate Synonym: Synonym not specified Accession: S01598 inside SIMPLE_MOLECULE PIP2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05027 Heterodimer Member Info: APC#PROTEIN#Adenomatous Polyposis of the Colon#P00195#FAP|FPC|Familial Adenomatous Polyposis|Familial Polyposis of the Colon#;GSK3beta#PROTEIN#Glycogen Synthase Kinase 3-beta#P00211#GSK3-beta#;Axin#PROTEIN#Axis inhibitor 1#P00253#Fused# inside COMPLEX Complex_br_(Axin/APC/_br_GSK3_beta_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05035 Heterodimer Member Info: Fzd#PROTEIN#Frizzled#P00189##;Wnt#PROTEIN#Wingless-Type MMTV Integration Site Family#P00206#Wnt# transmembrane COMPLEX Complex_br_(Wnt/Fzd) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05036 Heterodimer Member Info: EphR#PROTEIN#Ephrin Receptor#P00212#Eph#;Eph#PROTEIN#Ephrin#P00239#EFL|EFN|EPH-Related Receptor Tyrosine Kinase Ligand|EPLG|LERK|Ligand of EPH-Related Kinase# transmembrane COMPLEX Complex_br_(EphR/Eph) Long Name: Ras Synonym: H-Ras,K-Ras,N-Ras,p21 Accession: P00238 inside PROTEIN p27 Long Name: Ephrin Synonym: EFL,EFN,EPH-Related Receptor Tyrosine Kinase Ligand,EPLG,LERK,Ligand of EPH-Related Kinase Accession: P00239 inside PROTEIN p74 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05033 Heterodimer Member Info: c-Jun#PROTEIN#c-Jun Transcription Factor#P00220#AP-1|Activator Protein 1|Oncogene Jun|v-Jun Avian Sarcoma Virus 17 Oncogene Homolog#;c-Fos#PROTEIN#c-Fos Transcription Factor#P00235#Oncogene FOS|v-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog# inside COMPLEX Complex_br_(c-Jun/c-Fos) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05031 Heterodimer Member Info: Delta/Serrate#PROTEIN#Delta#P00226#Dll|JAG|JAGL|Jagged|Ser|Serrate#;Notch#PROTEIN#Notch Receptor#P00255## transmembrane COMPLEX Complex_br_(Notch/Delta/_br_Serrate) Long Name: Hypoxia Inducible Factor-1 Synonym: MOP1,Member of PAS Superfamily 1 Accession: P00214 inside PROTEIN p80 Long Name: CBF1, Suppressor of Hairless, Lag-1 Transcription Factor Family Synonym: C Promoter-Binding Factor 1,CBF1,IGKJRB,Immunoglobulin Kappa J Region Recombination Signal-Binding Protein,RBPJK,RBPSUH,Recombination Signal-Binding Protein 1 for J-Kappa,Recombination Signal-Binding Protein Suppressor of Hairless Accession: P00233 inside PROTEIN p79 Long Name: Delta Synonym: Dll,JAG,JAGL,Jagged,Ser,Serrate Accession: P00226 inside PROTEIN p78 Long Name: Rho guanosine triphosphatase Synonym: RAS Homolog Gene Family,Rho,Rho GTPase Accession: P00254 inside PROTEIN p77 Long Name: Factor VIIa Synonym: Coagulation Factor VII Accession: P00201 inside PROTEIN p76 Long Name: Tissue Factor Synonym: Coagulation Factor III,F3,Tissue Thromboplastin Accession: P00191 inside PROTEIN p75 Long Name: T-Cell Transcription Factor Synonym: TCF4,Transcription Factor 7-Like 2 Accession: P00242 inside PROTEIN p73 Long Name: Beta-catenin Synonym: Beta,CTNNB,Cadherin-Associated Protein Accession: P00187 inside PROTEIN p72 Long Name: Axis inhibitor 1 Synonym: Fused Accession: P00253 inside PROTEIN p71 Long Name: Glycogen Synthase Kinase 3-beta Synonym: GSK3-beta Accession: P00211 inside PROTEIN p70 Long Name: Adenomatous Polyposis of the Colon Synonym: FAP,FPC,Familial Adenomatous Polyposis,Familial Polyposis of the Colon Accession: P00195 inside PROTEIN p69 Long Name: Dishelvelled Synonym: Dvl Accession: P00200 inside PROTEIN p68 Long Name: Frizzled-Related Protein Synonym: Frzb,SARP,SFRP,Secreted Apoptosis-Related Protein,Secreted Frizzled-Related Protein Accession: P00237 inside PROTEIN p67 Long Name: Phospholipase D Synonym: Synonym not specified Accession: P00204 inside PROTEIN p65 Long Name: Phospholiase A2 Synonym: CPLA2,PLA2 Accession: P00227 inside PROTEIN p64 Long Name: Crk oncogene Synonym: CRKII Accession: P00207 inside PROTEIN p62 Long Name: Fibroblast Growth Factor Synonym: ECGF,Endothelial Cell Growth Factor,HBGF,Heparin-Binding Growth Factor Accession: P00213 inside PROTEIN p61 Long Name: Platelet-Derived Growth Factor Synonym: PDGFA,PDGFB,PDGFC,PDGFD Accession: P00224 inside PROTEIN p60 Long Name: Mitogen-Activated Kinase Kinase Kinase 1 Synonym: MAP/ERK Kinase Kinase 1,MAP3K1,MAPKKK1,MEK kinase Accession: P00208 inside PROTEIN p59 Long Name: v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 Synonym: Ets1 Oncogene Accession: P00188 inside PROTEIN p31 Long Name: Son of Sevenless, Drosophila, Homolog 1 Synonym: SOS1 Guanine Nucleotide Exchange Factor Accession: P00193 inside PROTEIN p57 Long Name: Growth Factor Receptor-Bound Protein 2 Synonym: ASH Protein,Abundant SRC Homology,Adaptor Protein 2 Accession: P00252 inside PROTEIN p56 Long Name: IP3 Synonym: Synonym not specified Accession: S01596 inside SIMPLE_MOLECULE IP3 Long Name: Phosphatidylinositol (4,5)-diphosphate Synonym: Synonym not specified Accession: S01598 innerSurface SIMPLE_MOLECULE PIP2 Long Name: Long Name: Calcium Synonym: Synonym not specified Accession: U05038 inside ION Ca_super_2+_endsuper Long Name: Extracellular regulated kinase Synonym: JNK-Activated Kinase1,JNKK1,MAP2K4,MAPK/ERK Kinase 4,MAPKK4,MEK4,MKK4,Mitogen-Activated ProteinKinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1 Accession: P00203 inside PROTEIN p30 Long Name: Mitogen Activated Protein Kinase Kinase Synonym: MAP kinase kinase,MAP/ERK Kinase,MAP2K,MAPKK,MKK,PRKMK,Protein Kinase, Mitogen-Activated, Kinase Accession: P00225 inside PROTEIN p29 Long Name: Raf Oncogene Synonym: CRAF,Oncogene MIL,Raf,Transforming Replication-Defective Murine Retrovirus 3611-MSV,v-Raf-1 Murine Leukemia Viral Oncogene Homolog Accession: P00243 inside PROTEIN p28 Long Name: Phospholipase C-gamma Synonym: PLC1,PLC148,PLCG1,Phospholipase C-148 Accession: P00256 inside PROTEIN p23 Long Name: Focal Adhesion Kinase Synonym: Cytoplasmic Protein-Tyrosine Kinase,FAK1,Focal Adhesion Kinase 1,PTK2 Accession: P00209 inside PROTEIN p19 Long Name: endothelial nitric oxide synthase Synonym: NOS3,Nitric Oxide Synthase 3,eNOS Accession: P00210 inside PROTEIN p18 Long Name: Caspase 9 Synonym: APAF3,Apoptotic Protease Activating Factor 3 Accession: P00216 inside PROTEIN p17 Long Name: Bcl-2 Antagonist of Cell Death Synonym: BCL2-Binding Component 6,BCL2-Binding Protein,BCL2L8 Accession: P00232 inside PROTEIN p16 Long Name: Protein Kinase B Synonym: Oncogene Akt,PKB,Rac serine/threonine kinase Accession: P00223 inside PROTEIN p15 Long Name: Src Homology Domain Containing Protein Synonym: SHC Transforming Protein Accession: P00183 inside PROTEIN p58 Long Name: GTPase-Activating Protein Synonym: Guanosine Triphosphatase-Activating Protein,RAS p21 Protein Activator 1,RASA1,RASGAP Accession: P00205 inside PROTEIN p55 Long Name: c-Jun Transcription Factor Synonym: AP-1,Activator Protein 1,Oncogene Jun,v-Jun Avian Sarcoma Virus 17 Oncogene Homolog Accession: P00220 inside PROTEIN p54 Long Name: c-Fos Transcription Factor Synonym: Oncogene FOS,v-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog Accession: P00235 inside PROTEIN p53 Long Name: c-Jun N-Terminal Kinase 1 Synonym: MAPK8,Mitogen-Activated Protein Kinase 8,PRKM8,Protein Kinase, Mitogen-Activated, 8,SAPK1,Stress-Activated Protein Kinase 1 Accession: P00221 inside PROTEIN p52 Long Name: c-Jun N-terminal Kinase Kinase 1 Synonym: MAP2K4,MAPK/ERK Kinase 4,MAPKK4,MEK4,MKK4,Mitogen-Activated Protein Kinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1 Accession: P00199 inside PROTEIN p51 Long Name: IP3 Synonym: Synonym not specified Accession: S01596 transmembrane SIMPLE_MOLECULE IP3 Long Name: Signal Transducer and Activator of Transcription 3 Synonym: APRF,Acute-Phase Response Factor Accession: P00217 inside PROTEIN p50 Long Name: Signal Transducer and Activator of Transcription 1 Synonym: Synonym not specified Accession: P00218 inside PROTEIN p49 Long Name: Janus Kinase 1 Synonym: Synonym not specified Accession: P00185 inside PROTEIN p48 Long Name: Tyrosine Phosphatase Shp2 Synonym: PTP2C,PTPN11,Protein-Tyrosine Phosphatase 2C,Protein-Tyrosine Phosphatase, Nonreceptor-Type, 11,Shp2 Accession: P00181 inside PROTEIN p47 Long Name: Baculoviral IAP Repeat-Containing Protein 5 Synonym: API4,Apoptosis inhibitor 4,BIRC5 Accession: P00198 inside PROTEIN p46 Long Name: Growth Factor Receptor-Bound Protein 7 Synonym: Adaptor Protein 7 Accession: P00228 inside PROTEIN p43 Long Name: Growth Factor Receptor-Bound Protein 14 Synonym: Adaptor Protein 14 Accession: P00197 inside PROTEIN p42 Long Name: p21-Activated Kinase Synonym: PAK Accession: P00249 inside PROTEIN p41 Long Name: Nck Adaptor Protein Synonym: Synonym not specified Accession: P00215 inside PROTEIN p40 Long Name: Docking Protein-R Synonym: Synonym not specified Accession: P00180 inside PROTEIN p39 Long Name: Ras GTPase-Activating Protein Synonym: GAP,GTPase-Activating Protein,Guanosine Triphosphatase-Activating Protein,RAS p21 Protein Activator 1,RASA1 Accession: P00190 inside PROTEIN p38 Long Name: Growth Factor Receptor-Bound Protein 2 Synonym: ASH Protein,Abundant SRC Homology,Adaptor Protein 2 Accession: P00234 inside PROTEIN p37 Long Name: Vascular Endothelial Protein Tyrosine Phosphatase Synonym: PTPRB,Protein-Tyrosine Phosphatase, Receptor-Type, Beta Accession: P00250 transmembrane PROTEIN p36 Long Name: Angiopoietin-2 Synonym: Synonym not specified Accession: P00246 inside PROTEIN p35 Long Name: Vascular Endothelial Growth Factor Synonym: VEGF-A Accession: P00241 inside PROTEIN p33 Long Name: Long Name: Calcium Synonym: Synonym not specified Accession: U05038 inside ION Ca_super_2+_endsuper Long Name: Phosphatidylinositol (3,4,5)-triphosphate Synonym: Synonym not specified Accession: S01597 innerSurface SIMPLE_MOLECULE PIP3 Long Name: Cytosolic Phospholipase A2 Synonym: PLA2 Accession: P00251 inside PROTEIN p32 Long Name: Sphingosine Kinase Synonym: SPHK Accession: P00229 inside PROTEIN p26 Long Name: Shc-like protein Synonym: Shc Adaptor Homolog Accession: P00202 inside PROTEIN p24 Long Name: VEGFR-Associated Protein Synonym: SH2 Domain Protein 2A,SH2D2A,T-Cell SH2 Domain Containing Adaptor Protein,TSAD,VRAP Accession: P00196 inside PROTEIN p22 Long Name: Src Kinase Synonym: Avian Sarcoma Viral Oncogene,Src Oncogene Accession: P00184 inside PROTEIN p21 Long Name: Paxillin Synonym: PXN Accession: P00194 inside PROTEIN p20 Long Name: Heat-Shock Protein 27 Synonym: HSPB1 Accession: P00231 inside PROTEIN p14 Long Name: Mitogen-Activated Protein Kinase-Activating Protein Kinase-2 and 3 Synonym: 3PK,MAPKAP Kinase 2/3,MAPKAP2/3 Accession: P00244 inside PROTEIN p13 Long Name: p38 Mitogen-Activated Protein Kinase Synonym: CSAID-Binding Protein1,CSBP1,Cytokine-Suppressive Anti-inflammatory Drug-Binding Protein 1,MAPK14,MXI2,Mitogen-Activated Protein Kinase 14,RK,SAPK2A,Stress-Activated Protein Kinase 2A,p38,p38 MAP Kinase,p38-Alpha Accession: P00182 inside PROTEIN p12 Long Name: Rho GTPase Synonym: CDC42,Cell Division Cycle 42 Accession: P00245 inside PROTEIN p11 Long Name: Phosphatidylinositol 3-Kinase Synonym: PI(3)K Accession: P00236 inside PROTEIN p10 transmembrane PROTEIN p9 Long Name: Protease Activated Receptor Synonym: NR1I2,Nuclear Receptor Subfamily 1, Group I, Member 2,PXR,Pregnane X Receptor,SXR,Steroid and Xenobiotic Receptor Accession: P00192 transmembrane PROTEIN p8 transmembrane PROTEIN p7 Long Name: Frizzled Synonym: Synonym not specified Accession: P00189 transmembrane PROTEIN p6 Long Name: Fibroblast Growth Factor Receptor-1 Synonym: FGFR-1,FLG,FLT2,FMS-Like Gene,FMS-Like Tyrosine Kinase 2 Accession: P00186 transmembrane PROTEIN p5 Long Name: Platelet-Derived Growth Factor Receptor Synonym: PDGFRA,PDGFRB Accession: P00230 transmembrane PROTEIN p4 Long Name: Tie-2 Synonym: TEK,TEK Tyrosine Kinase Accession: P00247 transmembrane PROTEIN p3 Long Name: Vascular Endothelial Growth Factor Receptor-2 Synonym: FLK1,KDR,Kinase Insert Domain Receptor,Tyrosine Kinase Growth Factor Receptor Accession: P00222 transmembrane PROTEIN p1 Long Name: Wingless-Type MMTV Integration Site Family Synonym: Wnt Accession: P00206 inside PROTEIN p66 Long Name: Angiopoietin-1 Synonym: Synonym not specified Accession: P00248 inside PROTEIN p34 STATE_TRANSITION a151 a15 a41 HETERODIMER_ASSOCIATION 0.5582888745279035,0.26382633309894743 a145 a9 a158 STATE_TRANSITION a146 a154 a158 STATE_TRANSITION a158 a159 a142 a141 STATE_TRANSITION a136 a160 a159 STATE_TRANSITION a137 a161 a160 STATE_TRANSITION a138 a162 a161 STATE_TRANSITION a139 a163 a162 HETERODIMER_ASSOCIATION 0.2915652996882159,7.815970093361102E-14 0.28368936582756143,0.3897302176311399 a163 a164 a166 STATE_TRANSITION a144 a168 a159 STATE_TRANSITION a143 a167 a168 HETERODIMER_ASSOCIATION 0.4621103012219052,0.37482257958962606 a170 a173 a187 STATE_TRANSITION 0.6864638512487176,-6.513002098553766E-4 a171 a127 a187 STATE_TRANSITION a183 a135 a134 STATE_TRANSITION a184 a130 a128 STATE_TRANSITION 0.6986789137833256,-3.1816217059077445E-4 a185 a129 a128 STATE_TRANSITION a177 a128 a187 STATE_TRANSITION a176 a131 a187 STATE_TRANSITION a175 a132 a131 STATE_TRANSITION a174 a133 a132 STATE_TRANSITION a180 a134 a133 HETERODIMER_ASSOCIATION 0.5575137054145713,0.3811625329763615 a117 a6 a191 STATE_TRANSITION a172 a119 a191 STATE_TRANSITION a186 a124 a181 HETERODIMER_ASSOCIATION 0.308498317708481,0.44223799682511356 a178 a179 a182 a193 HETERODIMER_ASSOCIATION 0.47221116858999324,0.44674359994693447 a100 a5 a206 STATE_TRANSITION a198 a109 a206 a235 DISSOCIATION 0.3865962086898378,0.13923838282164525 a196 a201 a200 a109 STATE_TRANSITION a205 a113 a201 STATE_TRANSITION 0.5931506413424827,-1.307062546951343E-5 a204 a115 a113 STATE_TRANSITION 0.6421071646796115,-1.4375072738470607E-4 a203 a114 a113 STATE_TRANSITION a202 a116 a206 STATE_TRANSITION a197 a217 a206 STATE_TRANSITION a199 a216 a206 a235 STATE_TRANSITION a213 a220 a217 STATE_TRANSITION a212 a221 a220 STATE_TRANSITION a211 a222 a216 a221 a235 STATE_TRANSITION a210 a223 a222 STATE_TRANSITION a207 a226 a223 a246 STATE_TRANSITION a208 a227 a226 STATE_TRANSITION a214 a228 a227 STATE_TRANSITION a218 a229 a228 STATE_TRANSITION a219 a230 a229 HETERODIMER_ASSOCIATION 0.5288493812184925,0.009666594015423025 0.5365311281908056,0.29751667808131366 a232 a231 a235 STATE_TRANSITION a236 a241 a228 STATE_TRANSITION a237 a242 a241 STATE_TRANSITION a238 a243 a242 STATE_TRANSITION a247 a246 a235 STATE_TRANSITION a239 a244 a243 HETERODIMER_ASSOCIATION 0.37470757048267433,0.3652212925900393 a244 a245 a249 STATE_TRANSITION a250 a78 a235 STATE_TRANSITION a75 a252 a235 STATE_TRANSITION a254 a76 a252 STATE_TRANSITION a77 a253 a252 STATE_TRANSITION 0.5244352309815952,0.014416386443524498 a64 a255 a256 STATE_TRANSITION 0.4310043473295906,-0.0019200698099846036 0.9082192419864192,-0.0017359536025081113 a69 a70 a261 a256 STATE_TRANSITION a60 a256 a262 STATE_TRANSITION a148 a262 a268 STATE_TRANSITION a59 a263 a262 a264 a265 STATE_TRANSITION a65 a265 a268 STATE_TRANSITION a56 a264 a268 HETERODIMER_ASSOCIATION 0.7199636177711071,-0.006139554105758949 0.26081670013796376,0.35823872563083015 a47 a3 a268 STATE_TRANSITION a55 a269 a268 STATE_TRANSITION a54 a270 a271 STATE_TRANSITION a53 a271 a272 STATE_TRANSITION a52 a272 a268 STATE_TRANSITION a50 a273 a268 STATE_TRANSITION a51 a274 a272 STATE_TRANSITION a31 a275 a277 STATE_TRANSITION a147 a276 a277 STATE_TRANSITION 0.3554147006261026,-5.142776362099255E-6 0.7573920981241482,0.010710688832023862 a32 a74 a280 a277 STATE_TRANSITION a30 a277 a281 STATE_TRANSITION a29 a281 a282 STATE_TRANSITION a28 a282 a272 a283 a284 STATE_TRANSITION a27 a283 a285 STATE_TRANSITION a25 a284 a42 STATE_TRANSITION a26 a285 a284 DISSOCIATION 0.35225489325160986,0.292173758550234 a44 a79 a42 a286 STATE_TRANSITION a23 a286 a290 STATE_TRANSITION a22 a287 a290 STATE_TRANSITION a24 a291 a290 STATE_TRANSITION a21 a292 a290 HETERODIMER_ASSOCIATION 0.463683018696162,0.3558187962994568 a46 a1 a290 STATE_TRANSITION a19 a294 a290 STATE_TRANSITION a20 a293 a294 STATE_TRANSITION a14 a295 a296 STATE_TRANSITION a13 a296 a297 STATE_TRANSITION a12 a297 a290 STATE_TRANSITION 0.3246613302054784,-0.01112655059560197 0.6698270028716549,-0.017453678314297782 a150 a298 a299 a15 STATE_TRANSITION a11 a300 a41 TRANSPORT a45 a37 a80 TRANSPORT a79 a80 STATE_TRANSITION a126 a301 a290 STATE_TRANSITION a40 a41 a301 STATE_TRANSITION sa226 a16 a15 STATE_TRANSITION a17 sa227 a15 STATE_TRANSITION a67 sa228 a256 STATE_TRANSITION 0.8333333333333357,1.0658141036401503E-14 sa229 a68 a256 STATE_TRANSITION a181 sa230 a193 STATE_TRANSITION a178 sa232 a172 STATE_TRANSITION a179 sa231 a172 STATE_TRANSITION 0.650495351334655,0.0038619298195081697 sa233 a47 a48 STATE_TRANSITION sa234 a117 a118 STATE_TRANSITION a268 csa14 a49