Panther Pathway: P00006 Signal transduction pathways known to be associated with mediating the induction or inhibition of the cellular death processes. Primarily repesentative of the the death receptor pathways. Medline=10209152 Medline=10209153 Medline=10966458 Medline=11832206 Medline=12949498 Medline=14744432 Medline=14996498 Medline=9039262 Medline=9069264 Medline=9721089 Website=http://www-personal.umich.edu/~ino/List/AList.html Website=http://www.bdbiosciences.com/pdfs/newsletters/02-7900030-36-A1.pdf PMID: 10209152 PMID: 10209153 PMID: 10966458 PMID: 11832206 PMID: 12949498 PMID: 14744432 PMID: 14996498 PMID: 9039262 PMID: 9069264 PMID: 9721089 4.0 s70 PROTEIN p4 s70 PROTEIN p3 s74 PROTEIN p3 s74 PROTEIN p6 s74 PROTEIN p7 s74 PROTEIN p5 s99 PROTEIN p44 s123 PROTEIN p53 s123 PROTEIN p54 s171 PROTEIN p61 s174 PROTEIN p15 s174 PROTEIN p17 s175 PROTEIN p22 s175 PROTEIN p24 s193 PROTEIN p73 s203 PROTEIN p1 3 s203 PROTEIN p2 s206 PROTEIN p1 3 s206 PROTEIN p2 s206 PROTEIN p56 s209 PROTEIN p7 s211 PROTEIN p57 3 s211 PROTEIN p58 s214 PROTEIN p57 3 s214 PROTEIN p59 s214 PROTEIN p4 s214 PROTEIN p58 s99 PROTEIN p43 s209 PROTEIN p2 s209 PROTEIN p55 3 s208 PROTEIN p2 s208 PROTEIN p55 3 s171 PROTEIN p60 s193 PROTEIN p72 OVAL SQUARE_CLOSEUP_NORTH SQUARE_CLOSEUP_NORTH active active inactive active inactive active inactive inactive inactive active active active active active active inactive inactive active active inactive active active inactive active inactive active active inactive active inactive inactive inactive active active active inactive active active active active inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive active inactive inactive inactive inactive active active active inactive inactive active inactive inactive inactive active active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active active inactive active inactive inactive inactive active inactive inactive inactive inactive inactive active inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active inactive active active inactive inactive inactive inactive active active inactive inactive active inactive active inactive inactive active inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive Mi Huaiyu SRI International Mitochondria Nucleus Intracellular Long Name: Tumor necrosis factor receptor 1 Synonym: Synonym not specified Accession: P00288 transmembrane PROTEIN p1 Long Name: Tumor necrosis factor Synonym: Synonym not specified Accession: P00259 inside PROTEIN p2 Long Name: TNFR1 associated death domain Synonym: Synonym not specified Accession: P00319 inside PROTEIN p3 Long Name: Receptor interacting protein Synonym: RIPK1,Receptor-interacting serine/threonine kinase 1 Accession: P00315 inside PROTEIN p5 Long Name: RIP associated ICH-1/CED homologous protein with death domain Synonym: CRADD,Casp2 and RIPK1 domain-containing adaptor with death domain,Caspase and RIP adaptor with death domain Accession: P00294 inside PROTEIN p6 Long Name: Silencer of death domains Synonym: Bag4,Bcl2-associated athanogene 4 Accession: P00320 inside PROTEIN p9 Long Name: Bcl-2 antogonist/killer Synonym: Synonym not specified Accession: P00275 transmembrane PROTEIN p17 Long Name: Bcl-2/Bcl-xL associated death promoter Synonym: Bcl2 antagonist of cell death Accession: P00281 inside PROTEIN p18 Long Name: Bim Synonym: Bcl2 interacting protein,Bcl2-like 11 Accession: P00325 inside PROTEIN p19 Long Name: Bcl-2 related ovarian killer Synonym: Synonym not specified Accession: P00261 inside PROTEIN p20 Long Name: Bcl2-related protein short isoform Synonym: Synonym not specified Accession: P00323 inside PROTEIN p21 Long Name: Bcl-2 Synonym: B-cell Leukemia 2 Accession: P00270 inside PROTEIN p22 Long Name: Bcl2-related protein long isoform Synonym: Synonym not specified Accession: P00257 inside PROTEIN p23 Long Name: Bcl-2 interacting killer Synonym: Synonym not specified Accession: P00258 inside PROTEIN p24 Long Name: Bik-like killer protein Synonym: Synonym not specified Accession: P00290 inside PROTEIN p25 Long Name: Bcl-2 associated anthogene-1 Synonym: Bcl2- associated athanogen 1 Accession: P00278 inside PROTEIN p26 Long Name: Bcl2-related protein A1 Synonym: Bcl2A1,Bfl1 Accession: P00283 inside PROTEIN p27 Long Name: Myeloid cell leukemia 1 Synonym: Synonym not specified Accession: P00308 inside PROTEIN p28 Long Name: Bcl-w Synonym: Synonym not specified Accession: P00316 inside PROTEIN p29 Long Name: BH-3 interacting domain death agonist Synonym: Synonym not specified Accession: P00262 inside PROTEIN p16 Long Name: Apoptosis inducing factor Synonym: Synonym not specified Accession: P00286 inside PROTEIN p30 Long Name: Endonuclease G Synonym: Synonym not specified Accession: P00279 inside PROTEIN p31 Long Name: Second mitochondria-derived activator of caspase Synonym: Diablo,Direct IAP-binding protein with low PI,Smac Accession: P00309 inside PROTEIN p32 Long Name: Heat shock protein 70 Synonym: Synonym not specified Accession: P00321 inside PROTEIN p33 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05051 Heterodimer Member Info: TRADD#PROTEIN#TNFR1 associated death domain#P00319##;FADD#PROTEIN#Fas associated death domain#P00327## inside COMPLEX Complex_br_(FADD/TRADD) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05047 Heterodimer Member Info: RAIDD#PROTEIN#RIP associated ICH-1/CED homologous protein with death domain#P00294#CRADD|Casp2 and RIPK1 domain-containing adaptor with death domain|Caspase and RIP adaptor with death domain#;TRAF2#PROTEIN#TNF receptor-associated factor 2#P00306#TRAP#;RIP#PROTEIN#Receptor interacting protein#P00315#RIPK1|Receptor-interacting serine/threonine kinase 1#;TRADD#PROTEIN#TNFR1 associated death domain#P00319## inside COMPLEX Complex_br_(TRADD/RAIDD/_br_TRAF2/RIP) Long Name: Bcl-2 associated x protein Synonym: Synonym not specified Accession: P00271 transmembrane PROTEIN p15 Long Name: BH-3 interacting domain death agonist Synonym: Synonym not specified Accession: P00262 transmembrane PROTEIN p16 Long Name: Apoptosis inducing factor Synonym: Synonym not specified Accession: P00286 inside PROTEIN p30 Long Name: Endonuclease G Synonym: Synonym not specified Accession: P00279 inside PROTEIN p31 Long Name: Nuclear factor kappa-B Synonym: Nuclear factor of kappa light chain gene enhancer in B cells Accession: P00297 inside PROTEIN p44 Long Name: Nuclear factor kappa-B Synonym: Nuclear factor of kappa light chain gene enhancer in B cells Accession: P00297 inside PROTEIN p44 Long Name: Anti-apoptosis Synonym: Synonym not specified Accession: U02108 inside PHENOTYPE Anti-apoptosis Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05050 Heterodimer Member Info: IkappaB#PROTEIN#Inhibitor of kappa light chain gene enhancer in B cells#P00292#Nuclear factor of kappa light chain gene enhancer in B cells inhibitor#;NFkappaB#PROTEIN#Nuclear factor kappa-B#P00297#Nuclear factor of kappa light chain gene enhancer in B cells# inside COMPLEX Complex_br_(I_kappa_B/NF_kappa_B) Long Name: a127_degraded Synonym: Synonym not specified Accession: U02110 inside DEGRADED a127_degraded Long Name: SAPK/ERK kinasae 1 Synonym: JNK-activated kinase 1,JNKK1,MAPKK4,MEK4,MKK4,Mitogen activated protein kinase kinase 4 Accession: P00266 inside PROTEIN p51 Long Name: SAPK/ERK kinasae 1 Synonym: JNK-activated kinase 1,JNKK1,MAPKK4,MEK4,MKK4,Mitogen activated protein kinase kinase 4 Accession: P00266 inside PROTEIN p51 Long Name: Mitogen activated protein kinase kinase 7 Synonym: JNK-activating kinase 2,JNKK2,MAP kinase kinase 7,MAPKK7 Accession: P00312 inside PROTEIN p50 Long Name: Mitogen activated protein kinase kinase 7 Synonym: JNK-activating kinase 2,JNKK2,MAP kinase kinase 7,MAPKK7 Accession: P00312 inside PROTEIN p50 Long Name: Mitogen-activated protein kinase kinase kinase 1 Synonym: MAPKKK1,MEK kinase,Map/Erk kinase kinase 1 Accession: P00291 inside PROTEIN p48 Long Name: Mitogen-activated protein kinase kinase kinase 1 Synonym: MAPKKK1,MEK kinase,Map/Erk kinase kinase 1 Accession: P00291 inside PROTEIN p48 Long Name: Jun kinase Synonym: c-Jun amino-terminal kinase Accession: P00274 inside PROTEIN p49 Long Name: Jun kinase Synonym: c-Jun amino-terminal kinase Accession: P00274 inside PROTEIN p49 Long Name: Mitogen activated protein kinase Synonym: MAP kinase Accession: P00269 inside PROTEIN p47 Long Name: Mitogen activated protein kinase Synonym: MAP kinase Accession: P00269 inside PROTEIN p47 Long Name: Mitogen activated protein kinase kinase 3 Synonym: MAP kinase kinase 3,MAPKK3 Accession: P00314 inside PROTEIN p46 Long Name: Mitogen activated protein kinase kinase 3 Synonym: MAP kinase kinase 3,MAPKK3 Accession: P00314 inside PROTEIN p46 Long Name: Activating transcription factor Synonym: Synonym not specified Accession: P00302 inside PROTEIN p52 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05048 Heterodimer Member Info: c-Jun#PROTEIN#c-Jun#P00303##;Fos#PROTEIN#Fos#P00317#V-fos FBJ murine osteosarcoma viral oncogene homolog# inside COMPLEX Complex_br_(Fos/c-Jun) Long Name: Pro-apoptotic Synonym: Synonym not specified Accession: U02111 inside PHENOTYPE Pro-apoptotic Long Name: Tumor necrosis factor receptor 2 Synonym: Synonym not specified Accession: P00287 transmembrane PROTEIN p55 Long Name: Mitogen activated protein kinase activating death domain Synonym: DENN Accession: P00267 inside PROTEIN p56 Long Name: FAS Synonym: APO1,APT1,Apoptosis antigen 1,CD95,TNFRSF6,Tumor necrosis factor receptor superfamily member 6 Accession: P00289 transmembrane PROTEIN p57 Long Name: FAS ligand Synonym: APO-1 ligand,APT1LG1,CD95L,FASL,TNFSF6,Tumor necrosis factor ligand superfamily member 6 Accession: P00326 inside PROTEIN p58 Long Name: Death-associated protein 6 Synonym: Synonym not specified Accession: P00296 inside PROTEIN p59 Long Name: TRAIL-receptor Synonym: APO2,Death receptor 4,TNFRSF10A,Tumor necrosis factor receptor superfamily, member 10A Accession: P00276 transmembrane PROTEIN p60 Long Name: TNF-related apoptosis inducing ligand Synonym: APO2 ligand,APO2L Accession: P00263 inside PROTEIN p61 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05044 Heterodimer Member Info: TRAIL#PROTEIN#TNF-related apoptosis inducing ligand#P00263#APO2 ligand|APO2L#;TRAIL-R#PROTEIN#TRAIL-receptor#P00276#APO2|Death receptor 4|TNFRSF10A|Tumor necrosis factor receptor superfamily, member 10A# transmembrane COMPLEX Complex_br_(TRAIL-R/TRAIL) Long Name: Unknown adaptor Synonym: Synonym not specified Accession: U02109 inside UNKNOWN Unknown_br_adaptor Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05043 Heterodimer Member Info: Bax#PROTEIN#Bcl-2 associated x protein#P00271##;Bak#PROTEIN#Bcl-2 antogonist/killer#P00275## inside COMPLEX Complex_br_(Bax/Bak) Long Name: Cytochrome C Synonym: Synonym not specified Accession: P00322 inside PROTEIN p62 Long Name: Cytochrome C Synonym: Synonym not specified Accession: P00322 inside PROTEIN p62 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05049 Heterodimer Member Info: Bik#PROTEIN#Bcl-2 interacting killer#P00258##;Bcl-2#PROTEIN#Bcl-2#P00270#B-cell Leukemia 2# inside COMPLEX Complex_br_(Bcl-2/Bik) Long Name: Bax inhibitor-1 Synonym: Synonym not specified Accession: P00277 inside PROTEIN p64 Long Name: Diva Synonym: Bcl2-like 10,Bcl2L10 Accession: P00285 inside PROTEIN p67 Long Name: Granzyme B Synonym: CGL1,CTLA1,Cathepsin G-like 1,Cytotoxic T-Lymphocyte-associated serine esterase 1,GZMB Accession: P00265 inside PROTEIN p73 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05040 Heterodimer Member Info: Granzyme B#PROTEIN#Granzyme B#P00265#CGL1|CTLA1|Cathepsin G-like 1|Cytotoxic T-Lymphocyte-associated serine esterase 1|GZMB#;IGFR2#PROTEIN#Insulin-like growth factor II receptor#P00282#CIMPR|Cation independent mannose-6-phosphate receptor|MPRI|Mannose 6-phosphate receptor, cation independent# transmembrane COMPLEX Complex_br_(IGFR2/Granzyme B) Long Name: ds-RNA Synonym: Synonym not specified Accession: G01495 inside RNA rn1 Long Name: Tumor protein p53 Synonym: TP53,Transformation regulated protein 53 Accession: P00273 Pathway Link: P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway inside PROTEIN p78 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05046 Heterodimer Member Info: TNF#PROTEIN#Tumor necrosis factor#P00259##;TNFR1#PROTEIN#Tumor necrosis factor receptor 1#P00288## transmembrane COMPLEX Complex_br_(TNFR1/TNF) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05041 Heterodimer Member Info: TNF#PROTEIN#Tumor necrosis factor#P00259##;MADD#PROTEIN#Mitogen activated protein kinase activating death domain#P00267#DENN#;TNFR1#PROTEIN#Tumor necrosis factor receptor 1#P00288## transmembrane COMPLEX Complex_br_(TNFR1/TNF/_br_MADD) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05045 Heterodimer Member Info: TNF#PROTEIN#Tumor necrosis factor#P00259##;TNFR2#PROTEIN#Tumor necrosis factor receptor 2#P00287## transmembrane COMPLEX Complex_br_(TNFR2/TNF) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05052 Heterodimer Member Info: TNF#PROTEIN#Tumor necrosis factor#P00259##;TNFR2#PROTEIN#Tumor necrosis factor receptor 2#P00287##;TRAF2#PROTEIN#TNF receptor-associated factor 2#P00306#TRAP# transmembrane COMPLEX Complex_br_(TNFR2/TNF/_br_TRAF2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05042 Heterodimer Member Info: FAS#PROTEIN#FAS#P00289#APO1|APT1|Apoptosis antigen 1|CD95|TNFRSF6|Tumor necrosis factor receptor superfamily member 6#;FAS ligand#PROTEIN#FAS ligand#P00326#APO-1 ligand|APT1LG1|CD95L|FASL|TNFSF6|Tumor necrosis factor ligand superfamily member 6# transmembrane COMPLEX Complex_br_(FAS/FAS_br_ligand) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05039 Heterodimer Member Info: FAS#PROTEIN#FAS#P00289#APO1|APT1|Apoptosis antigen 1|CD95|TNFRSF6|Tumor necrosis factor receptor superfamily member 6#;DAXX#PROTEIN#Death-associated protein 6#P00296##;FAS ligand#PROTEIN#FAS ligand#P00326#APO-1 ligand|APT1LG1|CD95L|FASL|TNFSF6|Tumor necrosis factor ligand superfamily member 6#;FADD#PROTEIN#Fas associated death domain#P00327## transmembrane COMPLEX Complex_br_(FAS/DAXX/_br_FADD/FAS_br_ligand) Long Name: Fas associated death domain Synonym: Synonym not specified Accession: P00327 inside PROTEIN p4 Long Name: TNF receptor-associated factor 2 Synonym: TRAP Accession: P00306 inside PROTEIN p7 Long Name: Caspase 8 Synonym: Cysteinyl aspartic acid-protease-8 Accession: P00299 inside PROTEIN p8 Long Name: FLICE inhibitory protein Synonym: CFLAR,Casp8- and FADD-like apoptosis regulator,I-FLICE,Inhibitor of FLICE Accession: P00284 inside PROTEIN p10 Long Name: Phosphatidylinostol 3 kinase Synonym: Synonym not specified Accession: P00310 inside PROTEIN p11 Long Name: Protein kinase C Synonym: Synonym not specified Accession: P00318 inside PROTEIN p12 Long Name: Germinal center kinase Synonym: MAP4K2,Mitigen-activated protein kinase kinase kinase kinase 2,Rab8-interacting protein,Rab8IP Accession: P00268 inside PROTEIN p13 Long Name: NF kappa B inducing kinase Synonym: HSNIK,MAPKKK 14,Mitogen activated protein kinase kinase kinase 14 Accession: P00324 inside PROTEIN p14 Long Name: Caspase 10 Synonym: Cysteinyl aspartic acid-protease-10 Accession: P00295 inside PROTEIN p37 Long Name: Caspase 3 Synonym: Cysteinyl aspartic acid-protease-3 Accession: P00305 inside PROTEIN p38 Long Name: Caspase 7 Synonym: Cysteinyl aspartic acid-protease-7 Accession: P00300 inside PROTEIN p39 Long Name: Germinal center kinase related Synonym: MAP4K3,MAP4K4,Mitogen-activated protein kinase kinase kinase kinase 3,Mitogen-activated protein kinase kinase kinase kinase 4 Accession: P00311 inside PROTEIN p40 Long Name: Protein kinase B Synonym: PKB Accession: P00260 inside PROTEIN p41 Long Name: I-kappa B kinase Synonym: Synonym not specified Accession: P00313 inside PROTEIN p42 Long Name: Pro-apoptotic Synonym: Synonym not specified Accession: U02111 inside PHENOTYPE Pro-apoptotic Long Name: Apoptosis signal-regulating kinase-1 Synonym: MAP kinase kinase kinase 5,MAPKKK5,MEKK5,Mitogen activated protein kinase kinase kinase 5 Accession: P00272 inside PROTEIN p45 Long Name: Apoptosis signal-regulating kinase-1 Synonym: MAP kinase kinase kinase 5,MAPKKK5,MEKK5,Mitogen activated protein kinase kinase kinase 5 Accession: P00272 inside PROTEIN p45 Long Name: Apoptosis protease activating factor-1 Synonym: Synonym not specified Accession: P00301 inside PROTEIN p66 Long Name: Cellular inhibitor of apoptosis protein 1 and 2 Synonym: Synonym not specified Accession: P00264 inside PROTEIN p68 Long Name: Caspase 9 Synonym: Cysteinyl aspartic acid-protease-9 Accession: P00298 inside PROTEIN p69 Long Name: Granzyme B Synonym: CGL1,CTLA1,Cathepsin G-like 1,Cytotoxic T-Lymphocyte-associated serine esterase 1,GZMB Accession: P00265 inside PROTEIN p73 Long Name: Interferon-inducible double-stranded RNA-activated protein kinase Synonym: PKR,PRKR Accession: P00293 inside PROTEIN p75 Long Name: Translation initiation factor 2-alpha Synonym: eIF2 alpha Accession: P00307 inside PROTEIN p76 Long Name: X-linked inhibitor of apoptosis Synonym: BIRC4,Baculoviral IAP repeat-containing protein 4 Accession: P00304 inside PROTEIN p77 Long Name: Tumor protein p53 Synonym: TP53,Transformation regulated protein 53 Accession: P00273 Pathway Link: P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway inside PROTEIN p78 Long Name: Protein activator of interon-induced protein kinase Synonym: PKR protein activator,PRKRA,RAX,protein kinase, interferon-inducible double-strand RNA dependent activator Accession: P00280 inside PROTEIN p74 Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00292 inside PROTEIN p43 Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00292 inside PROTEIN p43 Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00292 inside PROTEIN p43 Long Name: Second mitochondria-derived activator of caspase Synonym: Diablo,Direct IAP-binding protein with low PI,Smac Accession: P00309 inside PROTEIN p32 transmembrane PROTEIN p72 STATE_TRANSITION a30 a31 a35 a89 STATE_TRANSITION a38 a39 a97 STATE_TRANSITION a40 a43 a97 STATE_TRANSITION a41 a44 a97 STATE_TRANSITION a42 a45 a97 a339 TRANSPORT a46 a47 a48 a57 STATE_TRANSITION 0.683328889311779,2.749478218255774E-4 a64 a50 a273 a252 a254 a56 TRANSPORT 0.19607843137255365,-4.440892098500626E-16 a67 a69 a68 TRANSPORT 0.5922306760791702,-1.6681785018946016E-4 a66 a68 a51 a72 TRANSPORT a70 a71 a51 HETERODIMER_ASSOCIATION 0.011064979144185472,0.3858970039569214 a7 a8 a89 a320 HETERODIMER_ASSOCIATION -0.011110195910952747,0.24536739088020593 a7 a28 a27 a26 a97 a320 STATE_TRANSITION a98 a101 a89 a35 STATE_TRANSITION a99 a102 a31 a101 STATE_TRANSITION a100 a103 a101 a31 STATE_TRANSITION a32 a31 a97 a37 STATE_TRANSITION a109 a101 a97 a37 STATE_TRANSITION a111 a112 a97 STATE_TRANSITION a114 a117 a43 a116 a45 STATE_TRANSITION a113 a116 a39 STATE_TRANSITION a118 a121 a117 TRANSPORT a120 a119 HETERODIMER_ASSOCIATION 0.279208650049231,0.43459722306246373 a118 a120 a124 STATE_TRANSITION a121 a127 STATE_TRANSITION a127 a128 STATE_TRANSITION a129 a136 a44 a112 STATE_TRANSITION a130 a137 a136 STATE_TRANSITION a131 a138 a137 STATE_TRANSITION a132 a139 a44 a112 STATE_TRANSITION a134 a140 a139 a220 STATE_TRANSITION a133 a142 a140 a141 STATE_TRANSITION a135 a141 a139 STATE_TRANSITION a143 a146 a138 STATE_TRANSITION a150 a149 a142 STATE_TRANSITION a219 a220 a350 a330 STATE_TRANSITION a253 a252 a258 a350 STATE_TRANSITION a255 a254 a258 a350 STATE_TRANSITION a263 a262 a254 a252 HETERODIMER_ASSOCIATION 0.192736025587128,0.40659956640370254 a266 a267 a270 KNOWN_TRANSITION_OMITTED a270 a273 HETERODIMER_ASSOCIATION 0.5718855190661962,0.3388820971424442 a51 a48 a275 a60 a63 a280 DISSOCIATION 0.5822888131462758,-2.6645352591003757E-15 -0.04595872478911378,0.7370868431776394 a275 a51 a48 a56 a50 a53 a52 a55 a54 HETERODIMER_ASSOCIATION 0.31002271360212674,0.3248314435257278 a58 a56 a278 STATE_TRANSITION a282 a283 a47 STATE_TRANSITION 0.5826581737252328,-0.001381382039848944 a285 a286 a71 STATE_TRANSITION a287 a288 a283 a286 a313 STATE_TRANSITION a292 a291 a286 a313 STATE_TRANSITION a289 a290 a286 a302 a313 HETERODIMER_ASSOCIATION 0.5797408128311581,0.3396839390234092 a297 a296 a301 DISSOCIATION 0.2285149559646431,0.27801558731182574 a301 a296 a298 STATE_TRANSITION a303 a302 a298 STATE_TRANSITION a306 a308 a305 STATE_TRANSITION a309 a305 a304 STATE_TRANSITION a310 a311 a308 a291 a290 STATE_TRANSITION 0.59999375656861,-3.552713678800501E-15 a312 a313 a71 STATE_TRANSITION a314 a315 a308 TRANSPORT a315 a316 HETERODIMER_ASSOCIATION 0.43842789423092676,0.3869746388307205 a5 a3 a320 HETERODIMER_ASSOCIATION -1.2916197382244659,1.9129782233184636 a320 a193 a330 HETERODIMER_ASSOCIATION 0.12086134198111775,0.4551038378111345 a154 a153 a333 HETERODIMER_ASSOCIATION -0.020681563182749052,0.41723292456567185 a333 a178 a339 HETERODIMER_ASSOCIATION 0.22025026295304784,0.38272918497118447 a228 a221 a342 STATE_TRANSITION 0.28961748633879836,0.0 a342 a235 a236 a350 STATE_TRANSITION sa171 a57 a59 a284 STATE_TRANSITION sa172 a53 a62 STATE_TRANSITION sa173 a56 a59 MODULATION a102 a115 MODULATION a103 a115 MODULATION a119 a125 MODULATION a146 a151 MODULATION a149 a151 MODULATION a262 a265 MODULATION a288 a293 MODULATION a290 a293 MODULATION a291 a293 MODULATION a316 a293