Panther Pathway: P00008 This pathway illustrates the intracellular signaling during neuronal axon growth guided by Slit through the Roundabout (Robo) transmembrane receptor. Medline=12677003 Medline=14682358 PMID: 12677003 PMID: 14682358 4.0 s14 PROTEIN p3 s14 PROTEIN p2 s19 PROTEIN p3 s19 PROTEIN p1 s19 PROTEIN p8 s29 PROTEIN p12 s29 PROTEIN p11 s45 PROTEIN p3 s45 PROTEIN p1 s45 PROTEIN p2 s46 PROTEIN p1 s46 PROTEIN p14 s36 PROTEIN p13 s36 PROTEIN p2 s52 PROTEIN p14 Long Name: Roundabout Synonym: Synonym not specified Accession: P00348 s52 PROTEIN p1 SQUARE OVAL active active active active inactive inactive inactive inactive inactive inactive inactive active active active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Mi Huaiyu SRI International cell membrane Endosome Long Name: Deleted in colorectal carcinoma Synonym: Synonym not specified Accession: P00352 transmembrane PROTEIN p2 Long Name: Slit Synonym: Synonym not specified Accession: P00342 inside PROTEIN p3 Long Name: Abelson murine leukemia viral oncogene homolog 1 Synonym: c-ABL,p150 Accession: P00347 inside PROTEIN p5 Long Name: Ras-related C3 botulinum toxin substrate Synonym: Synonym not specified Accession: P00354 inside PROTEIN p6 Long Name: Cell division cycle 42 Synonym: G25K Accession: P00349 inside PROTEIN p7 Long Name: Receptor-linked protein-tyrosine phosphatase 10D Synonym: Synonym not specified Accession: P00343 transmembrane PROTEIN p9 Long Name: Ras homologue gene family, member A Synonym: ARH,Aplysia ras-related homolog Accession: P00355 inside PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05054 Heterodimer Member Info: Slit#PROTEIN#Slit#P00342##;DCC#PROTEIN#Deleted in colorectal carcinoma#P00352## transmembrane COMPLEX Complex_br_(Slit/DCC) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05057 Heterodimer Member Info: Slit#PROTEIN#Slit#P00342##;Robo#PROTEIN#Roundabout#P00348##;SrGAP#PROTEIN#Slit-Robo GTPase activating protein#P00350## transmembrane COMPLEX Complex_br_(Slit/Robo/_br_SrGAP) Long Name: Mammalian enabled Synonym: Ena Accession: P00345 inside PROTEIN p4 Long Name: Mammalian enabled Synonym: Ena Accession: P00345 inside PROTEIN p4 Long Name: Cytoskeletal dynamics Synonym: Synonym not specified Accession: U02126 inside PHENOTYPE Cytoskeletal dynamics Long Name: Axonal plasticity Synonym: Synonym not specified Accession: U02127 inside PHENOTYPE Axonal plasticity Long Name: Chemokine, CXC motif, receptor4 Synonym: CXC chemokine receptor 4,LAP3,LPS-associated protein 3,NPY3R,Neuropeptide Y receptor Y3 Accession: P00351 transmembrane PROTEIN p11 Long Name: Sdf1 Synonym: CXCL12,Chemokine, CXC motif, ligand 12,PBSF,Pre-B cell growth-stimulating factor,Stromal cell-derived factor1 Accession: P00346 inside PROTEIN p12 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05059 Heterodimer Member Info: Sdf1#PROTEIN#Sdf1#P00346#CXCL12|Chemokine, CXC motif, ligand 12|PBSF|Pre-B cell growth-stimulating factor|Stromal cell-derived factor1#;Cxcr4#PROTEIN#Chemokine, CXC motif, receptor4#P00351#CXC chemokine receptor 4|LAP3|LPS-associated protein 3|NPY3R|Neuropeptide Y receptor Y3# transmembrane COMPLEX Complex_br_(Sdf1/Cxcr4) Long Name: Roundabout Synonym: Synonym not specified Accession: P00348 transmembrane PROTEIN p1 Long Name: Slit-Robo GTPase activating protein Synonym: Synonym not specified Accession: P00350 inside PROTEIN p8 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05056 Heterodimer Member Info: Netrin#PROTEIN#Netrin#P00344#Netrin-1#;DCC#PROTEIN#Deleted in colorectal carcinoma#P00352## transmembrane COMPLEX Complex_br_(Netrin/DCC) Long Name: Commissureless Synonym: Synonym not specified Accession: P00353 inside PROTEIN p14 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05055 Heterodimer Member Info: Slit#PROTEIN#Slit#P00342##;Robo#PROTEIN#Roundabout#P00348##;DCC#PROTEIN#Deleted in colorectal carcinoma#P00352## transmembrane COMPLEX Complex_br_(Slit/Robo/_br_DCC) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05053 Heterodimer Member Info: Robo#PROTEIN#Roundabout#P00348##;Comm#PROTEIN#Commissureless#P00353## transmembrane COMPLEX Complex_br_(Robo/Comm) Long Name: a59_degraded Synonym: Synonym not specified Accession: U02128 inside DEGRADED a59_degraded Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05053 Heterodimer Member Info: Robo#PROTEIN#Roundabout#P00348##;Comm#PROTEIN#Commissureless#P00353## transmembrane COMPLEX Complex_br_(Robo/Comm) STATE_TRANSITION a4 a25 a5 STATE_TRANSITION a25 a4 a9 STATE_TRANSITION a26 a5 a22 KNOWN_TRANSITION_OMITTED a27 a28 HETERODIMER_ASSOCIATION 0.5952596467236413,0.41021170561483977 a30 a29 a33 HETERODIMER_ASSOCIATION 0.051718729673229547,-0.21808683983482202 0.21276088612902866,0.0022638049478602706 0.7114868488295363,0.10876677903486032 a3 a35 a36 a22 HETERODIMER_ASSOCIATION 0.08720579360289493,0.28213639106819655 0.5960881887996101,0.36794597173243915 a3 a2 a14 HETERODIMER_ASSOCIATION 0.9586486357408933,0.2013095057536456 0.051000106261574585,-0.0024344195012415693 -0.043145525298701415,0.2582431699023767 a22 a2 a58 a36 TRANSPORT a46 a59 STATE_TRANSITION a59 a60 STATE_TRANSITION a62 a6 a22 STATE_TRANSITION a7 sa37 a22 STATE_TRANSITION a10 sa38 a22 STATE_TRANSITION csa8 a41 a58 HETERODIMER_ASSOCIATION 0.12426009740674537,0.4285149046877965 a35 a42 a46 PHYSICAL_STIMULATION a10 a27 PHYSICAL_STIMULATION a6 a27 PHYSICAL_STIMULATION a25 a27 PHYSICAL_STIMULATION a7 a27 PHYSICAL_STIMULATION a41 a27 PHYSICAL_STIMULATION 0.5062764286021342,-0.49996060489202776 a33 a27 PHYSICAL_STIMULATION 0.6590235997188696,-0.47403744022223915 a14 a27