Panther Pathway: P00010 B cell activation entails the process by which a pre-B cell matures into a plasma cell. The signaling pathways that regulate this conversion are complex, but center around a complex of proteins referred to as the B cell receptor, or BCR. Ligation of the BCR by a cognate antigen initiates a number of downstream signaling events that lead, eventually, to an expansion in the number of B cells of the appropriate antigen specificity, and to their development of the ability to secrete antibody. Medline=11913948 Medline=12040177 Medline=12119152 PMID: 11913948 PMID: 12040177 PMID: 12119152 4.0 s118 PROTEIN p11 s118 PROTEIN p10 s125 PROTEIN p23 s125 ION Ca++ s125 ION Ca++ s127 PROTEIN p29 s127 SIMPLE_MOLECULE GDP s243 PROTEIN p29 s243 SIMPLE_MOLECULE GTP s148 PROTEIN p31 s148 PROTEIN p32 s150 PROTEIN p20 s150 SIMPLE_MOLECULE DAG s155 PROTEIN p34 s156 PROTEIN p34 s157 PROTEIN p8 s157 PROTEIN p33 s266 PROTEIN p41 s266 PROTEIN p40 s272 PROTEIN p29 s272 PROTEIN p30 s272 PROTEIN p27 s272 SIMPLE_MOLECULE GTP s23 PROTEIN p5 2 s23 PROTEIN p6 s23 PROTEIN p7 s28 PROTEIN p5 2 s28 PROTEIN p6 s28 PROTEIN p7 s44 PROTEIN p5 2 s44 PROTEIN p6 s44 PROTEIN p7 s44 PROTEIN p3 s44 PROTEIN p4 s44 PROTEIN p1 s44 PROTEIN p2 s53 PROTEIN p5 2 s53 PROTEIN p6 s53 PROTEIN p7 s53 PROTEIN p3 s53 PROTEIN p4 s53 PROTEIN p1 s53 PROTEIN p2 s76 PROTEIN p8 s76 PROTEIN p4 s76 PROTEIN p13 s76 PROTEIN p14 s76 PROTEIN p15 s299 PROTEIN p9 s299 PROTEIN p1 s299 PROTEIN p38 s310 PROTEIN p29 s310 SIMPLE_MOLECULE GTP s310 PROTEIN p30 s317 PROTEIN p8 s317 PROTEIN p13 s317 PROTEIN p4 s317 PROTEIN p14 s317 PROTEIN p15 s155 SIMPLE_MOLECULE GDP s156 SIMPLE_MOLECULE GTP SQUARE OVAL SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive active active active active inactive inactive inactive active active active inactive inactive active inactive active active active inactive inactive active inactive inactive active inactive inactive inactive inactive active active inactive inactive inactive active active inactive inactive inactive inactive active inactive active inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive Douglass Adam SRI International ER Nucleus B cell Long Name: Blk Synonym: p55blk Accession: P00390 inside PROTEIN p3 Long Name: CD22 Synonym: Synonym not specified Accession: P00387 transmembrane PROTEIN p10 Long Name: CD22 Synonym: Synonym not specified Accession: P00387 transmembrane PROTEIN p10 Long Name: Lyn Synonym: Synonym not specified Accession: P00374 inside PROTEIN p1 Long Name: Lyn Synonym: Synonym not specified Accession: P00374 inside PROTEIN p1 Long Name: CD45 Synonym: Leukocyte common antigen Accession: P00396 transmembrane PROTEIN p12 Long Name: Syk Synonym: Synonym not specified Accession: P00382 inside PROTEIN p2 Long Name: Syk Synonym: Synonym not specified Accession: P00382 inside PROTEIN p2 Long Name: BLNK Synonym: B Cell Linker Protein,BASH,SLP-65 Accession: P00394 inside PROTEIN p8 Long Name: Grb2 Synonym: Growth factor receptor-bound protein 2 Accession: P00372 inside PROTEIN p14 Long Name: SOS Synonym: Son of Sevenless Accession: P00379 inside PROTEIN p15 Long Name: Btk Synonym: bruton's tyrosine kinase Accession: P00400 inside PROTEIN p4 Long Name: PIP2 Synonym: Synonym not specified Accession: S01606 inside SIMPLE_MOLECULE PIP2 Long Name: IP3 Synonym: Synonym not specified Accession: S01603 inside SIMPLE_MOLECULE IP3 Long Name: PKC Synonym: Synonym not specified Accession: P00373 inside PROTEIN p20 Long Name: DAG Synonym: Synonym not specified Accession: S01604 inside SIMPLE_MOLECULE DAG Long Name: SHP-1 Synonym: SH2 domain-containing phosphatase Accession: P00378 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05069 Heterodimer Member Info: SHP-1#PROTEIN#SHP-1#P00378#SH2 domain-containing phosphatase#;CD22#PROTEIN#CD22#P00387## transmembrane COMPLEX Complex_br_(SHP-1/CD22) Long Name: Calmodulin Synonym: CaM Accession: P00375 inside PROTEIN p23 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P00367 inside PROTEIN p25 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P00367 inside PROTEIN p25 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05084 Heterodimer Member Info: Calmodulin#PROTEIN#Calmodulin#P00375#CaM#;Ca++#ION#Ca++#U02153## inside COMPLEX Complex_br_(Calmodulin/Ca++/_br_Ca++) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05079 Heterodimer Member Info: Ras#PROTEIN#Ras#P00376##;GDP#SIMPLE_MOLECULE#GDP#S01608## inside COMPLEX Complex_br_(Ras/GDP ) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05082 Heterodimer Member Info: Ras#PROTEIN#Ras#P00376##;GTP#SIMPLE_MOLECULE#GTP#S01609## inside COMPLEX Complex_br_(Ras/GTP) Long Name: MEK Synonym: MAP kinase kinase,MAPK/ERK Kinase Accession: P00383 inside PROTEIN p27 Long Name: Raf Synonym: Synonym not specified Accession: P00381 inside PROTEIN p30 Long Name: MEK Synonym: MAP kinase kinase,MAPK/ERK Kinase Accession: P00383 inside PROTEIN p27 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P00367 inside PROTEIN p25 Long Name: ERK Synonym: Extracellular signal-regulated kinase Accession: P00371 inside PROTEIN p28 Long Name: ERK Synonym: Extracellular signal-regulated kinase Accession: P00371 inside PROTEIN p28 Long Name: ERK Synonym: Extracellular signal-regulated kinase Accession: P00371 inside PROTEIN p28 Long Name: fos Synonym: c-fos Accession: P00380 inside PROTEIN p31 Long Name: jun Synonym: Synonym not specified Accession: P00401 inside PROTEIN p32 Long Name: jun Synonym: Synonym not specified Accession: P00401 inside PROTEIN p32 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05086 Heterodimer Member Info: fos#PROTEIN#fos#P00380#c-fos#;jun#PROTEIN#jun#P00401## inside COMPLEX Complex_br_(fos/jun) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05070 Heterodimer Member Info: PKC#PROTEIN#PKC#P00373##;DAG#SIMPLE_MOLECULE#DAG#S01604## inside COMPLEX Complex_br_(PKC/DAG) Long Name: BCR-responsive genes Synonym: Synonym not specified Accession: G01496 inside GENE gn1 Long Name: B cell activation, Differentiation into plasma cell Synonym: Synonym not specified Accession: U02154 inside PHENOTYPE B cell activation; Differentiation into plasma cell Long Name: vav Synonym: Synonym not specified Accession: P00368 inside PROTEIN p33 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05087 Heterodimer Member Info: Rac#PROTEIN#Rac#P00385##;GDP#SIMPLE_MOLECULE#GDP#S01608## inside COMPLEX Complex_br_(Rac/GDP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05072 Heterodimer Member Info: Rac#PROTEIN#Rac#P00385##;GTP#SIMPLE_MOLECULE#GTP#S01609## inside COMPLEX Complex_br_(Rac/GTP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05074 Heterodimer Member Info: vav#PROTEIN#vav#P00368##;BLNK#PROTEIN#BLNK#P00394#B Cell Linker Protein|BASH|SLP-65# innerSurface COMPLEX Complex_br_(BLNK/vav) Long Name: p38 Synonym: MAP kinase Accession: P00384 inside PROTEIN p36 Long Name: Jnk Synonym: Jun Kinase Accession: P00402 inside PROTEIN p37 Long Name: Jnk Synonym: Jun Kinase Accession: P00402 inside PROTEIN p37 Long Name: CD19 Synonym: Synonym not specified Accession: P00393 transmembrane PROTEIN p9 Long Name: CD19 Synonym: Synonym not specified Accession: P00393 transmembrane PROTEIN p9 Long Name: PI3K Synonym: Phosphatidyl inositol 3-kinase Accession: P00391 inside PROTEIN p38 Long Name: Ca++ Synonym: Synonym not specified Accession: U02153 inside ION Ca++ Long Name: NF-kappa B Synonym: Nuclear Factor kappa B Accession: P00370 inside PROTEIN p41 Long Name: I kappa B Synonym: IkB,Inhibitor of NF-kappa B Accession: P00392 inside PROTEIN p40 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05085 Heterodimer Member Info: NF-kappa B#PROTEIN#NF-kappa B#P00370#Nuclear Factor kappa B#;I kappa B#PROTEIN#I kappa B#P00392#IkB|Inhibitor of NF-kappa B# inside COMPLEX Complex_br_(NF-kappa B/I kappa B) Long Name: IKK Synonym: IKBK,Inhibitor of Kappa B kinase Accession: P00397 inside PROTEIN p39 Long Name: IKK Synonym: IKBK,Inhibitor of Kappa B kinase Accession: P00397 inside PROTEIN p39 Long Name: NF-kappa B Synonym: Nuclear Factor kappa B Accession: P00370 inside PROTEIN p41 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05073 Heterodimer Member Info: Ras#PROTEIN#Ras#P00376##;Raf#PROTEIN#Raf#P00381##;MEK#PROTEIN#MEK#P00383#MAP kinase kinase|MAPK/ERK Kinase#;GTP#SIMPLE_MOLECULE#GTP#S01609## inside COMPLEX Complex_br_(Ras/Raf/_br_MEK/GTP) Long Name: CD45 Synonym: Leukocyte common antigen Accession: P00396 transmembrane PROTEIN p12 2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05071 Heterodimer Member Info: Ig-beta#PROTEIN#Ig-beta#P00377#CD79b|Immunoglobulin beta#;mIgM#PROTEIN#mIgM#P00389#Membrane-bound Immunoglobulin M#;Ig-alpha#PROTEIN#Ig-alpha#P00399#CD79a|immunoglobulin alpha# transmembrane COMPLEX Complex_br_(mIgM/Ig-alpha/_br_Ig-beta) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05077 Heterodimer Member Info: Ig-beta#PROTEIN#Ig-beta#P00377#CD79b|Immunoglobulin beta#;mIgM#PROTEIN#mIgM#P00389#Membrane-bound Immunoglobulin M#;Ig-alpha#PROTEIN#Ig-alpha#P00399#CD79a|immunoglobulin alpha# transmembrane COMPLEX Complex_br_(mIgM/Ig-alpha/_br_Ig-beta) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05081 Heterodimer Member Info: Lyn#PROTEIN#Lyn#P00374##;Ig-beta#PROTEIN#Ig-beta#P00377#CD79b|Immunoglobulin beta#;Syk#PROTEIN#Syk#P00382##;mIgM#PROTEIN#mIgM#P00389#Membrane-bound Immunoglobulin M#;Blk#PROTEIN#Blk#P00390#p55blk#;Ig-alpha#PROTEIN#Ig-alpha#P00399#CD79a|immunoglobulin alpha#;Btk#PROTEIN#Btk#P00400#bruton's tyrosine kinase# transmembrane COMPLEX Complex_br_(mIgM/Ig-alpha/_br_Ig-beta/Blk/_br_Btk/Lyn/_br_Syk) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05083 Heterodimer Member Info: Lyn#PROTEIN#Lyn#P00374##;Ig-beta#PROTEIN#Ig-beta#P00377#CD79b|Immunoglobulin beta#;Syk#PROTEIN#Syk#P00382##;mIgM#PROTEIN#mIgM#P00389#Membrane-bound Immunoglobulin M#;Blk#PROTEIN#Blk#P00390#p55blk#;Ig-alpha#PROTEIN#Ig-alpha#P00399#CD79a|immunoglobulin alpha#;Btk#PROTEIN#Btk#P00400#bruton's tyrosine kinase# transmembrane COMPLEX Complex_br_(mIgM/Ig-alpha/_br_Ig-beta/Blk/_br_Btk/Lyn/_br_Syk) Long Name: PLC gamma2 Synonym: Phospholipase C gamma 2 Accession: P00388 inside PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05080 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P00372#Growth factor receptor-bound protein 2#;SOS#PROTEIN#SOS#P00379#Son of Sevenless#;PLC gamma2#PROTEIN#PLC gamma2#P00388#Phospholipase C gamma 2#;BLNK#PROTEIN#BLNK#P00394#B Cell Linker Protein|BASH|SLP-65#;Btk#PROTEIN#Btk#P00400#bruton's tyrosine kinase# innerSurface COMPLEX Complex_br_(BLNK/Btk/_br_PLC_br_gamma2/Grb2/_br_SOS) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05075 Heterodimer Member Info: Lyn#PROTEIN#Lyn#P00374##;PI3K#PROTEIN#PI3K#P00391#Phosphatidyl inositol 3-kinase#;CD19#PROTEIN#CD19#P00393## transmembrane COMPLEX Complex_br_(CD19/Lyn/_br_PI3K) Long Name: Btk Synonym: bruton's tyrosine kinase Accession: P00400 inside PROTEIN p4 Long Name: Lyn Synonym: Synonym not specified Accession: P00374 inside PROTEIN p1 Long Name: BLNK Synonym: B Cell Linker Protein,BASH,SLP-65 Accession: P00394 inside PROTEIN p8 Long Name: ATP Synonym: Synonym not specified Accession: S01605 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01607 inside SIMPLE_MOLECULE ADP Long Name: Pi Synonym: Synonym not specified Accession: S01602 inside SIMPLE_MOLECULE Pi Long Name: Ca++ Synonym: Synonym not specified Accession: U02153 inside ION Ca++ Long Name: Calcineurin Synonym: Synonym not specified Accession: P00386 inside PROTEIN p24 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05078 Heterodimer Member Info: Ras#PROTEIN#Ras#P00376##;Raf#PROTEIN#Raf#P00381##;GTP#SIMPLE_MOLECULE#GTP#S01609## inside COMPLEX Complex_br_(Ras/GTP/_br_Raf) Long Name: GDP Synonym: Synonym not specified Accession: S01608 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S01609 inside SIMPLE_MOLECULE GTP Long Name: MEKK Synonym: MAP Kinase kinase kinase,MEK kinase Accession: P00369 inside PROTEIN p35 Long Name: CRAC Synonym: Calcium release-activated calcium channel Accession: P00395 transmembrane PROTEIN p21 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05076 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P00372#Growth factor receptor-bound protein 2#;SOS#PROTEIN#SOS#P00379#Son of Sevenless#;PLC gamma2#PROTEIN#PLC gamma2#P00388#Phospholipase C gamma 2#;BLNK#PROTEIN#BLNK#P00394#B Cell Linker Protein|BASH|SLP-65#;Btk#PROTEIN#Btk#P00400#bruton's tyrosine kinase# innerSurface COMPLEX Complex_br_(BLNK/PLC_br_gamma2/_br_Btk/Grb2/_br_SOS) inside RNA rn1 Long Name: Jnk Synonym: Jun Kinase Accession: P00402 inside PROTEIN p37 Long Name: ADP Synonym: Synonym not specified Accession: S01607 inside SIMPLE_MOLECULE ADP Long Name: ATP Synonym: Synonym not specified Accession: S01605 inside SIMPLE_MOLECULE ATP Long Name: p38 Synonym: MAP kinase Accession: P00384 inside PROTEIN p36 Long Name: Ca++ Synonym: Synonym not specified Accession: U02153 inside ION Ca++ Long Name: IP3R Synonym: IP3 Receptor,Inositol (3,4,5) triphosphate Receptor Accession: P00398 transmembrane PROTEIN p19 STATE_TRANSITION 0.3635089106901326,8.178337286139925E-4 0.6157903911621148,0.003272567218889799 a10 a18 a12 a19 a17 STATE_TRANSITION 0.37386745304295954,-8.237919349070033E-4 0.5992869916075931,-0.002801062919624453 a1 a13 a46 a41 STATE_TRANSITION 0.37501153732843817,4.2136042200002777E-4 0.6250107437846253,-2.7812169320506896E-4 a13 a44 a14 a45 a14 STATE_TRANSITION 0.33355629714939683,0.022221341350318058 0.6971095732478942,0.01793772324587639 a33 a50 a24 a51 a14 HETERODIMER_ASSOCIATION 0.18618116280364205,0.0022279852730617833 0.011732065220159349,0.4430283578904999 a24 a3 a4 a52 a57 a66 STATE_TRANSITION 0.3234901868865805,-0.0025880035438117233 0.6617371664082299,-0.0022153451109639954 a66 a68 a85 a69 a70 a14 STATE_TRANSITION 0.386883151981805,-0.022265890062983296 0.5774686429669975,-0.02487319895035811 a86 a88 a31 a89 a85 STATE_TRANSITION 0.3746544478396512,-2.88424845314994E-4 0.6175548348047091,2.2085301312602112E-4 a108 a121 a109 a122 a14 TRUNCATION 0.3760964527897883,-6.728974332343984E-4 -0.059720916815037495,0.7574786223828767 a134 a136 a135 a145 STATE_TRANSITION 0.4158939065630456,-0.001345005351298556 0.5414547984847253,0.001035179162255595 a120 a146 a145 a147 a120 STATE_TRANSITION a187 a192 a191 HETERODIMER_ASSOCIATION 0.0779725114077987,0.28344361358405123 a12 a199 a201 STATE_TRANSITION 0.3686782967125808,3.0985569991548445E-4 0.6117015377903137,-3.109757192509832E-4 a206 a205 a240 a204 HETERODIMER_ASSOCIATION 0.45271387880134384,0.19245934347839366 a203 a209 a215 STATE_TRANSITION a216 a204 a215 STATE_TRANSITION 0.395473197652637,0.003977010043332285 0.6136979752369126,0.0017501027587023543 a228 a238 a229 a237 a239 HETERODIMER_ASSOCIATION 0.22512307153597533,0.40589301530412236 a229 a236 a230 STATE_TRANSITION 0.34028630639399937,-0.003946249687569292 0.5318970578914812,-0.007466782742245215 a243 a246 a244 a247 a234 HETERODIMER_ASSOCIATION 0.36915680232178916,0.24907878432140151 a259 a257 a262 a245 a286 STATE_TRANSITION 0.35820895522387985,-8.881784197001252E-16 0.5920398009950212,-1.9539925233402755E-14 a258 a288 a259 a289 a287 HETERODIMER_ASSOCIATION 0.34550701661018124,0.34487875052620964 a181 a135 a266 STATE_TRANSITION 0.3387968392872658,-0.0067136871003832255 0.5917455932862783,-0.0029481206103305624 a276 a274 a277 a273 a281 HETERODIMER_ASSOCIATION 0.0013539474393349238,0.4008019183505205 a279 a269 a281 STATE_TRANSITION a284 a285 a331 STATE_TRANSITION a291 a290 DISSOCIATION 0.3296662722412129,0.3007439302305208 a307 a305 a306 a300 STATE_TRANSITION a308 a300 a266 HETERODIMER_ASSOCIATION 0.10636445107011605,0.3913089409086723 a31 a109 a91 a92 a90 a120 TRANSPORT a205 a241 TRANSPORT a306 a309 HETERODIMER_ASSOCIATION -0.01987340145235006,0.5036067733436091 a230 a235 a315 DISSOCIATION -0.0010163159918694653,0.4908623120730944 a315 a234 a316 a315 TRANSPORT a244 a245 TRANSPORT a283 a286 TRANSPORT a285 a287 STATE_TRANSITION a317 a41 STATE_TRANSITION a168 a166 a136 HETERODIMER_ASSOCIATION 0.2957937325232507,-0.013542428220703062 0.2198565780531192,0.3214170705804875 a290 a297 a295 a330 TRANSPORT 0.48171151880645025,-7.646214584156041E-4 a202 a193 a192 STATE_TRANSITION a282 a331 a277 KNOWN_TRANSITION_OMITTED a331 a283 TRANSPORT 0.35465116279069786,0.0 a173 a175 a166 TRANSPORT a175 a191 TRANSPORT a193 a209 TRANSPORT a175 a209 TRANSCRIPTION a267 sa164 a262 a241 a309 PHYSICAL_STIMULATION sa164 a268