Panther Pathway: P00011 The blood coagulation cascade and fibrinolytic pathway. Medline=10856975 Medline=12871284 free text=Loscalzo J., Schafer A.I. (ed). Thrombosis and Hemorrhage (Third Edition). Lippincott Williams & Wilkins (2003). PMID: 10856975 PMID: 12871284 4.0 s193 PROTEIN p91 Long Name: Factor XIIa Synonym: Hageman Factor Accession: P00441 s204 PROTEIN p19 Long Name: Zn2+ Synonym: Synonym not specified Accession: U02178 s204 ION Zn_super_2_plus_ s52 PROTEIN p43 s52 PROTEIN p40 s77 PROTEIN p22 s77 PROTEIN p17 s101 PROTEIN p81 s101 PROTEIN p80 s115 PROTEIN p88 s115 PROTEIN p90 s116 PROTEIN p91 s116 PROTEIN p89 s120 PROTEIN p39 s120 PROTEIN p92 s121 PROTEIN p25 s121 PROTEIN p22 s126 PROTEIN p87 s126 PROTEIN p86 s131 PROTEIN p86 s131 PROTEIN p87 s131 PROTEIN p15 s137 PROTEIN p36 s137 ION Ca_super_2_plus_ s137 SIMPLE_MOLECULE PL s140 PROTEIN p36 s140 PROTEIN p29 s140 ION Ca_super_2_plus_ s140 SIMPLE_MOLECULE PL s141 PROTEIN p49 s141 PROTEIN p48 s145 PROTEIN p26 s145 SIMPLE_MOLECULE PL s145 ION Ca_super_2_plus_ s148 PROTEIN p27 s148 PROTEIN p26 s148 SIMPLE_MOLECULE PL s148 ION Ca_super_2_plus_ s154 PROTEIN p26 s154 PROTEIN p27 s154 SIMPLE_MOLECULE PL s154 ION Ca_super_2_plus_ s154 PROTEIN p5 s159 PROTEIN p44 s159 PROTEIN p26 s159 PROTEIN p27 s159 PROTEIN p5 s159 SIMPLE_MOLECULE PL s159 ION Ca_super_2_plus_ s163 PROTEIN p5 s163 PROTEIN p6 s163 ION Ca_super_2_plus_ s163 SIMPLE_MOLECULE PL s177 PROTEIN p69 s177 PROTEIN p70 s180 PROTEIN p69 s180 PROTEIN p70 s180 PROTEIN p5 s180 ION Ca_super_2_plus_ s180 SIMPLE_MOLECULE PL s184 PROTEIN p12 s184 ION Ca_super_2_plus_ s184 PROTEIN p13 s184 SIMPLE_MOLECULE PL s193 PROTEIN p89 s193 PROTEIN p88 s193 PROTEIN p90 s198 PROTEIN p89 s198 PROTEIN p91 s198 PROTEIN p88 s198 PROTEIN p90 s198 PROTEIN p49 Long Name: heparan Synonym: Synonym not specified Accession: S01612 s201 SIMPLE_MOLECULE Heparan Long Name: Antithrombin III Synonym: ATIII Accession: P00440 s201 PROTEIN p58 OVAL inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive active inactive inactive active active inactive inactive inactive active inactive inactive active inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active active inactive active inactive inactive active inactive inactive active inactive inactive inactive active inactive active inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Davidson Colin SRI International activated platelet Long Name: Zn2+ Synonym: Synonym not specified Accession: U02178 inside ION Zn_super_2_plus_ inside COMPLEX FXIIa_br_Zn2+_br_complex inside COMPLEX ATiii_br_heparin_br_complex Long Name: Factor Va Synonym: FVa,accelerator (Ac-) globulin,labile factor,proaccelerin Accession: P00435 inside PROTEIN p6 Long Name: ? Synonym: Synonym not specified Accession: P00459 inside PROTEIN p95 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05128 Heterodimer Member Info: GP V#PROTEIN#Glycoprotein V#P00420##;GP 1bbeta#PROTEIN#Glycoprotein 1bbeta#P00436#GP Ibbeta|GPIb#;vWF#PROTEIN#von Willebrand Factor#P00448##;GP Ibalpha#PROTEIN#Glycoprotein Ibalpha#P00449#GP 1balpha|GPIb#;GP IX#PROTEIN#Glycoprotein IX#P00455#CD42a|GP IX|GP9# transmembrane COMPLEX Complex_br_(GP IX/GP V/_br_GP 1b_beta_/GP Ib_alpha_/_br_vWF) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05112 Heterodimer Member Info: GP V#PROTEIN#Glycoprotein V#P00420##;GP 1bbeta#PROTEIN#Glycoprotein 1bbeta#P00436#GP Ibbeta|GPIb#;GP Ibalpha#PROTEIN#Glycoprotein Ibalpha#P00449#GP 1balpha|GPIb#;GP IX#PROTEIN#Glycoprotein IX#P00455#CD42a|GP IX|GP9# transmembrane COMPLEX Complex_br_(GP IX/GP 1b_beta_/_br_GP Ib_alpha_/GP V) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05125 Heterodimer Member Info: FIXa#PROTEIN#Factor IXa#P00422#Christmas Factor|FIXa|antihemophilic factor B|plasma thromboplastin component, PTC#;PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;Ca2+#ION#calcium#U02177##;FVIIIa#PROTEIN#FVIIIa#P00446## inside COMPLEX Complex_br_(FIXa/Ca_super_2_plus_/_br_FVIIIa/PL) Long Name: urokinase-type plasminogen activator receptor Synonym: CD87,uPAR Accession: P00433 inside PROTEIN p80 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05118 Heterodimer Member Info: PZ#PROTEIN#Protein Z#P00407##;ZPI#PROTEIN#protein Z-dependent protease inhibitor#P00425#ZPI#;PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;Ca2+#ION#calcium#U02177##;FXa#PROTEIN#Factor Xa#P00445#Stuart-Prower Factor# inside COMPLEX Complex_br_(ZPI/PZ/_br_FXa/Ca_super_2_plus_/_br_PL) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05115 Heterodimer Member Info: PZ#PROTEIN#Protein Z#P00407##;ZPI#PROTEIN#protein Z-dependent protease inhibitor#P00425#ZPI# inside COMPLEX Complex_br_(ZPI/PZ) Long Name: Endothelial cell protein C receptor Synonym: EPCR Accession: P00403 inside PROTEIN p92 Long Name: Activated Protein C Synonym: FXIV,anticoagulant protein C,autoprothrombin IIA,vitamin K-dependent protein C Accession: P00423 inside PROTEIN p40 Long Name: Protein S Synonym: PS Accession: P00412 inside PROTEIN p43 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05117 Heterodimer Member Info: PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;FVa#PROTEIN#Factor Va#P00435#FVa|accelerator (Ac-) globulin|labile factor|proaccelerin#;Ca2+#ION#calcium#U02177##;FXa#PROTEIN#Factor Xa#P00445#Stuart-Prower Factor# inside COMPLEX Complex_br_(FXa/FVa/_br_Ca_super_2_plus_/PL) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05116 Heterodimer Member Info: TFPI#PROTEIN#Tissue Factor Pathway Inhibitor#P00417#TFPI|anticonvertin|extrinsic pathway inhibitor (EPI)|lipoprotein-associated coagulation inhibitor (LACI)#;PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;Ca2+#ION#calcium#U02177##;FXa#PROTEIN#Factor Xa#P00445#Stuart-Prower Factor#;FVIIa#PROTEIN#Factor VIIa#P00447#Proconvertin|cothromboplastin|serum prothrombin conversion accelerator (SPCA)#;Tissue Factor#PROTEIN#Tissue Factor#P00450#CD142|Factor III|thromboplastin# inside COMPLEX Complex_br_(TFPI/Tissue Factor/_br_FVIIa/FXa/_br_PL/Ca_super_2_plus_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05121 Heterodimer Member Info: PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;Ca2+#ION#calcium#U02177##;FXa#PROTEIN#Factor Xa#P00445#Stuart-Prower Factor#;FVIIa#PROTEIN#Factor VIIa#P00447#Proconvertin|cothromboplastin|serum prothrombin conversion accelerator (SPCA)#;Tissue Factor#PROTEIN#Tissue Factor#P00450#CD142|Factor III|thromboplastin# inside COMPLEX Complex_br_(Tissue Factor/FVIIa/_br_PL/Ca_super_2_plus_/_br_FXa) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05122 Heterodimer Member Info: PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;Ca2+#ION#calcium#U02177##;FVIIa#PROTEIN#Factor VIIa#P00447#Proconvertin|cothromboplastin|serum prothrombin conversion accelerator (SPCA)#;Tissue Factor#PROTEIN#Tissue Factor#P00450#CD142|Factor III|thromboplastin# inside COMPLEX Complex_br_(FVIIa/Tissue Factor/_br_PL/Ca_super_2_plus_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05123 Heterodimer Member Info: PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;Ca2+#ION#calcium#U02177##;Tissue Factor#PROTEIN#Tissue Factor#P00450#CD142|Factor III|thromboplastin# inside COMPLEX Complex_br_(Tissue Factor/PL/_br_Ca_super_2_plus_) Long Name: FVIIIa Synonym: Synonym not specified Accession: P00446 inside PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05109 Heterodimer Member Info: FVIII#PROTEIN#Factor VIII#P00405##;vWF#PROTEIN#von Willebrand Factor#P00448## inside COMPLEX Complex_br_(vWF/FVIII) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05126 Heterodimer Member Info: Thrombin#PROTEIN#Thrombin#P00414#Factor IIa#;PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;Ca2+#ION#calcium#U02177##;Thrombomodulin#PROTEIN#Thrombomodulin#P00457#CD141|TM|fetomodulin# inside COMPLEX Complex_br_(Thrombomodulin/Thrombin/_br_Ca_super_2_plus_/PL) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05111 Heterodimer Member Info: PL#SIMPLE_MOLECULE#anionic phospholipids#S01611##;Ca2+#ION#calcium#U02177##;Thrombomodulin#PROTEIN#Thrombomodulin#P00457#CD141|TM|fetomodulin# inside COMPLEX Complex_br_(Thrombomodulin/Ca_super_2_plus_/_br_PL) Long Name: activated platelet response Synonym: Synonym not specified Accession: U02180 inside PHENOTYPE activated platelet_br_response Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05127 Heterodimer Member Info: Fibrinogen#PROTEIN#Fibrinogen#P00406#Factor I#;GP IIb#PROTEIN#Glycoprotein IIb#P00410#CD41|GPalphaIIb|integrin alpha-2B#;GP IIIa#PROTEIN#Glycoprotein IIIa#P00458#CD61|GP3A|GPIIIa|beta 3 integrin# transmembrane COMPLEX Complex_br_(GP IIIa/GP IIb/_br_Fibrinogen) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05130 Heterodimer Member Info: GP IIb#PROTEIN#Glycoprotein IIb#P00410#CD41|GPalphaIIb|integrin alpha-2B#;GP IIIa#PROTEIN#Glycoprotein IIIa#P00458#CD61|GP3A|GPIIIa|beta 3 integrin# transmembrane COMPLEX Complex_br_(GP IIb/GP IIIa) Long Name: Bradykinin Synonym: Synonym not specified Accession: P00438 inside PROTEIN p94 Long Name: Kininogen Synonym: Alpha-2-thiol proteinase inhibitor,KNG Accession: P00451 inside PROTEIN p93 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05129 Heterodimer Member Info: HMWK#PROTEIN#High molecular weight kininogen#P00413#Fitzgerald, Flaujeac Williams factor|HMWK|contact activation cofactor|plasma thromboplastin antecedent#;Kallikrein#PROTEIN#kallikrein#P00437#Fletcher factor# inside COMPLEX Complex_br_(Kallikrein/HMWK) Long Name: Long Name: Protein C Synonym: Synonym not specified Accession: U05120 Heterodimer Member Info: EPCR#PROTEIN#Endothelial cell protein C receptor #P00403#EPCR#;PC#PROTEIN#Protein C#P00426#FXIV|PC|anticoagulant protein C|autoprothrombin IIA|vitamin K-dependent protein C# inside COMPLEX Complex_br_(PC/EPCR) Long Name: Long Name: glycoprotein IX Synonym: Synonym not specified Accession: U05110 Heterodimer Member Info: GP V#PROTEIN#Glycoprotein V#P00420##;GP IX#PROTEIN#Glycoprotein IX#P00455#CD42a|GP IX|GP9# transmembrane COMPLEX Complex_br_(GP V/GP IX) Long Name: Long Name: glycoprotein 1b-beta Synonym: Synonym not specified Accession: U05114 Heterodimer Member Info: GP 1bbeta#PROTEIN#Glycoprotein 1bbeta#P00436#GP Ibbeta|GPIb#;GP Ibalpha#PROTEIN#Glycoprotein Ibalpha#P00449#GP 1balpha|GPIb# transmembrane COMPLEX Complex_br_(GP 1b_beta_/GP Ib_alpha_) Long Name: mouse Protease-activated receptor 3 Synonym: mPAR-3 Accession: P00452 transmembrane PROTEIN p84 Long Name: Long Name: urokinase plasminogen activator Synonym: Synonym not specified Accession: U05113 Heterodimer Member Info: uPA#PROTEIN#urokinase plasminogen activator#P00424#uPA#;uPAR#PROTEIN#urokinase-type plasminogen activator receptor#P00433#CD87|uPAR# inside COMPLEX Complex_br_(uPA/uPAR) Long Name: urokinase plasminogen activator Synonym: uPA Accession: P00424 inside PROTEIN p81 Long Name: protein Z-dependent protease inhibitor Synonym: ZPI Accession: P00425 inside PROTEIN p69 Long Name: Protease nexin II Synonym: A4,AAA,AD1,Alzheimer's disease amyloid A4 protein precursor ,CVAP,PN2,amyloid beta (A4) precursor protein (APP) Accession: P00429 inside PROTEIN p67 Long Name: Long Name: Factor XI Synonym: Synonym not specified Accession: U05124 Heterodimer Member Info: HMWK#PROTEIN#High molecular weight kininogen#P00413#Fitzgerald, Flaujeac Williams factor|HMWK|contact activation cofactor|plasma thromboplastin antecedent#;FXI#PROTEIN#Factor XI#P00460#plasma thromboplastin antecedent# inside COMPLEX Complex_br_(HMWK/FXI) Long Name: Protease-activated receptor4 Synonym: PAR-4,coagulation factor II receptor-like 3,thrombin receptor-like 3 Accession: P00461 transmembrane PROTEIN p66 Long Name: Protease-activated receptor1 Synonym: PAR-1,coagulation factor II receptor,thrombin receptor Accession: P00404 transmembrane PROTEIN p64 Long Name: alpha1-antitrypsin Synonym: AAT,APS,alpha-1-antiproteinase,alpha-1-protease inhibitor,alpha1-AT Accession: P00421 inside PROTEIN p62 Long Name: heparin cofactor II Synonym: HCII Accession: P00456 inside PROTEIN p59 Long Name: plasminogen activator-inhibitors type 2 Synonym: PAI-2,serine (or cysteine) protease inhibitor, clade B, member 2 Accession: P00409 inside PROTEIN p57 Long Name: alpha-2-macroglobulin Synonym: alpha2M Accession: P00427 inside PROTEIN p56 Long Name: alpha2-antiplasmin Synonym: Alpha-2-AP,Alpha-2-PI,plasmin inhibitor alpha2,serine (or cysteine) protease inhibitor, clade F, member 2 Accession: P00428 inside PROTEIN p55 Long Name: plasminogen activator inhibitor type-1 Synonym: PAI-1,endothelial plasminogen activator inhibitor,serine (or cysteine) protease inhibitor, clade E, member 1 Accession: P00411 inside PROTEIN p53 Long Name: Tissue plasminogen activator Synonym: tPA Accession: P00431 inside PROTEIN p51 Long Name: Plasmin Synonym: Synonym not specified Accession: P00415 inside PROTEIN p50 Long Name: von Willebrand Factor Synonym: Synonym not specified Accession: P00448 inside PROTEIN p49 Long Name: Plasminogen Synonym: Synonym not specified Accession: P00408 inside PROTEIN p46 Long Name: Fibrin degradation Synonym: Synonym not specified Accession: U02179 inside DEGRADED a52_degraded Long Name: Tissue Factor Pathway Inhibitor Synonym: TFPI,anticonvertin,extrinsic pathway inhibitor (EPI),lipoprotein-associated coagulation inhibitor (LACI) Accession: P00417 inside PROTEIN p44 Long Name: Long Name: Protein S Synonym: Synonym not specified Accession: U05119 Heterodimer Member Info: PS#PROTEIN#Protein S#P00412#PS#;APC#PROTEIN#Activated Protein C#P00423#FXIV|anticoagulant protein C|autoprothrombin IIA|vitamin K-dependent protein C# inside COMPLEX Complex_br_(PS/APC) Long Name: Protein C Synonym: FXIV,PC,anticoagulant protein C,autoprothrombin IIA,vitamin K-dependent protein C Accession: P00426 inside PROTEIN p39 Long Name: Factor XIIIa Synonym: FXIIIa,Protransglutaminase,fibrin stabilizing factor, FSF,fibrinoligase Accession: P00419 inside PROTEIN p33 Long Name: Factor XIII Synonym: FXIII,Protransglutaminase,fibrin stabilizing factor, FSF,fibrinoligase Accession: P00453 inside PROTEIN p32 Long Name: Fibrin polymer cross-linked Synonym: Synonym not specified Accession: P00443 inside PROTEIN p35 Long Name: kallikrein Synonym: Fletcher factor Accession: P00437 inside PROTEIN p25 Long Name: High molecular weight kininogen Synonym: Fitzgerald, Flaujeac Williams factor,HMWK,contact activation cofactor,plasma thromboplastin antecedent Accession: P00413 inside PROTEIN p22 Long Name: Prekallikrein Synonym: Fletcher factor Accession: P00439 inside PROTEIN p24 Long Name: Factor XII Synonym: Hageman Factor Accession: P00442 inside PROTEIN p20 Long Name: FXIa Synonym: plasma thromboplastin antecedent Accession: P00434 inside PROTEIN p18 Long Name: Fibrin monomer Synonym: Synonym not specified Accession: P00418 inside PROTEIN p30 Long Name: Fibrinogen Synonym: Factor I Accession: P00406 inside PROTEIN p15 Long Name: Factor IXa Synonym: Christmas Factor,FIXa,antihemophilic factor B,plasma thromboplastin component, PTC Accession: P00422 inside PROTEIN p12 Long Name: Factor IX Synonym: Christmas Factor,antihemophilic factor B,plasma thromboplastin component (PTC Accession: P00444 inside PROTEIN p11 Long Name: FVII Synonym: Proconvertin,cothromboplastin,serum prothrombin conversion accelerator (SPCA) Accession: P00454 inside PROTEIN p9 Long Name: Factor Xa Synonym: Stuart-Prower Factor Accession: P00445 inside PROTEIN p5 Long Name: Factor X Synonym: Stuart-Prower Factor Accession: P00430 inside PROTEIN p4 Long Name: Factor V Synonym: FV,Proaccelerin,accelerator (Ac-) globulin,labile factor Accession: P00432 inside PROTEIN p3 Long Name: Thrombin Synonym: Factor IIa Accession: P00414 inside PROTEIN p29 Long Name: Prothrombin Synonym: Factor II Accession: P00416 inside PROTEIN p28 STATE_TRANSITION a52 a87 a93 STATE_TRANSITION 0.45515158448489146,-0.003961604785761352 a154 a94 a93 a156 a157 a99 a96 STATE_TRANSITION a155 a150 a157 a93 a96 HETERODIMER_ASSOCIATION 0.6462417672535299,0.35029001477836785 a47 a48 a179 HETERODIMER_ASSOCIATION 0.4493535192572402,0.6196720899669685 a199 a2 a206 HETERODIMER_ASSOCIATION -0.0011331196791717346,0.5845979981744578 a224 a6 a231 HETERODIMER_ASSOCIATION 0.5590251191477331,0.43453000221064286 a79 a231 a242 STATE_TRANSITION a243 a4 a2 HETERODIMER_ASSOCIATION 0.2536810373725311,0.5526189372459935 a4 a6 a248 DISSOCIATION 0.4433921505721288,0.3301400919687776 a177 a255 a252 a264 STATE_TRANSITION a71 a252 a264 HETERODIMER_ASSOCIATION 0.5277917014759126,0.45873015873015177 a251 a252 a78 HETERODIMER_ASSOCIATION -0.050589099171807206,0.6439399814296829 a2 a257 a264 HETERODIMER_ASSOCIATION -0.21716178755389137,0.6503741285228348 a6 a283 a292 HETERODIMER_ASSOCIATION 0.6531786198486813,0.34354426762005374 a295 a150 a152 HETERODIMER_ASSOCIATION -0.01249999999999396,0.5159782200525709 a298 a297 a74 HETERODIMER_ASSOCIATION 0.364700054691629,0.2568321863097003 a21 a213 a306 HETERODIMER_ASSOCIATION 0.9295155860514583,0.7795247574667066 a172 a171 a316 HETERODIMER_ASSOCIATION 0.3327608237861419,0.3078281772223743 a316 a145 a325 STATE_TRANSITION 0.782102743881758,-0.013187159342141541 a158 a326 a2 STATE_TRANSITION a108 a187 a2 STATE_TRANSITION a110 a327 a2 TRUNCATION -0.018252046636544783,0.44290944808097477 a44 a328 a48 csa27 TRUNCATION 0.3735225197886394,-0.0035575691741329685 -0.01001445174243365,0.5917176973057914 a37 sa171 a329 csa27 a48 TRUNCATION 0.0243873508404846,0.6573367087854809 a115 a330 a34 a332 csa27 TRUNCATION -0.02424242424243772,0.4899178323480218 a67 a333 a298 a206 TRUNCATION 0.00516851622282033,0.5587812285941869 a207 a334 a213 a209 a2 TRUNCATION 0.5518969961864602,-1.0809774235731595E-5 -0.023448320565645275,0.5173952506958415 a20 a335 a21 a34 a224 csa28 TRUNCATION -0.010868661244634481,0.4689078253882615 a218 a221 a336 a224 TRUNCATION -0.01725660486760283,0.5660474244822931 a5 a337 a6 a224 a306 TRUNCATION 0.2407406966435932,0.0033743812014197516 -0.04797449653993979,0.6778633076744036 a53 a338 a54 a2 HETERODIMER_ASSOCIATION 0.47332050046604124,0.354192661904456 a30 a190 a196 UNKNOWN_TRANSITION a30 a31 a2 UNKNOWN_TRANSITION a31 a52 a54 TRUNCATION 0.013462915934077557,0.33981246337176785 a88 a340 a93 a150 a94 DISSOCIATION -0.006402144732636117,0.6433964362685742 a248 a249 a343 a78 DISSOCIATION 0.29091347380545685,0.3279247242207104 a306 a300 a349 a74 TRUNCATION -0.1768932589581631,0.3769815007406154 a1 a352 a2 a248 TRUNCATION 0.15886153127675462,0.4178363559314717 a179 a183 a185 a180 a179 STATE_TRANSITION a93 sa169 a98 a97 STATE_TRANSITION a2 sa170 a106 a104 a105 csa28 STATE_TRANSITION a34 sa174 a117 a118 csa28 STATE_TRANSITION csa27 csa29 csa28 STATE_TRANSITION a224 csa30 csa28 PHYSICAL_STIMULATION a325 a197 PHYSICAL_STIMULATION a196 a197 PHYSICAL_STIMULATION a187 a197 PHYSICAL_STIMULATION a327 a197 PHYSICAL_STIMULATION a326 a197